- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00965120
The Effect of Ischaemic-Reperfusion in Man - A Bradykinin Dependent Pathway
October 22, 2010 updated by: University of Edinburgh
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart.
Current treatments are designed to relieve this blockage as quickly as possible to minimize damage to the heart muscle.
However in restoring the supply of blood local damage known as "ischaemia-reperfusion injury" may occur.
The aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin.
This will help the investigators to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
12
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Edinburgh, United Kingdom, EH16 4SB
- University of Edinburgh, 49 Little France Crescent
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 65 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- healthy males between 18-65 years of ages
- non-smokers
Exclusion Criteria:
- any concurrent illness or chronic medical condition
- concurrent use of vasoactive medication
- smoking history
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: 1
Ischaemia 20 minutes.
Blood pressure cuff will be inflated to 200mmHg around the upper arm for 20 minutes to induce ischaemia.
Systemic infusion of placebo (saline).
|
Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of vasodilators (Ach).
Venous blood sampling via cannula in antecubital fossa.
Systemic infusion of placebo (saline).
|
Active Comparator: 2
Ischaemia 20 minutes.
Blood pressure cuff will be inflated to 200mmHg around the upper arm for 20 minutes to induce ischaemia.
Systemic infusion of bradykinin receptor antagonist (HOE-140).
|
Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of vasodilators (Ach).
Venous blood sampling via cannula in antecubital fossa.
Systemic infusion of bradykinin receptor antagonist (HOE-140).
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Change in forearm blood flow in response to vasodilators (ACh) and ischaemia reperfusion
Time Frame: 20 fixed timepoints during each study visit (3hrs)
|
20 fixed timepoints during each study visit (3hrs)
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Change in platelet-monocyte-binding after ischaemia reperfusion
Time Frame: 4 fixed timepoints during each study visit (3hrs)
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4 fixed timepoints during each study visit (3hrs)
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Director: David E Newby, PhD, FRCP, University of Edinburgh
- Study Director: Rajesh K Kharbanda, PhD, FRCP, University of Oxford
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2009
Primary Completion (Actual)
October 1, 2010
Study Completion (Actual)
October 1, 2010
Study Registration Dates
First Submitted
August 21, 2009
First Submitted That Met QC Criteria
August 24, 2009
First Posted (Estimate)
August 25, 2009
Study Record Updates
Last Update Posted (Estimate)
October 25, 2010
Last Update Submitted That Met QC Criteria
October 22, 2010
Last Verified
October 1, 2010
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Cardiovascular Diseases
- Vascular Diseases
- Arteriosclerosis
- Arterial Occlusive Diseases
- Coronary Disease
- Heart Diseases
- Coronary Artery Disease
- Myocardial Ischemia
- Ischemia
- Molecular Mechanisms of Pharmacological Action
- Vasodilator Agents
- Enzyme Inhibitors
- Protease Inhibitors
- Cysteine Proteinase Inhibitors
- Bradykinin
- Kininogens
- Bradykinin Receptor Antagonists
Other Study ID Numbers
- CMP 3
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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