Effects Of Unilateral Vibration On Contralateral Forearm Muscle Activity (BMRR3)

February 24, 2012 updated by: ILHAN KARACAN, Vakif Gureba Training and Research Hospital

Effects Of Unilateral Forearm Vibration On Electrical Activity Of Untrained Contralateral Forearm Muscle

This study hypothesize that radius subjecting to mechanical loading may affect excitability of alpha motor neuron innervating muscle, based on its bone mineral density or bone mineral content.

A total of 80 voluntaries are planned to include in this study. Vibration will be applied the right forearm. Muscle electrical activity will be measured on ipsilateral and contralateral flexor carpi radialis (FCR) muscle at rest as EMGrms by surface electromyography (EMG). The rest-EMGrms will be measured at before and during vibration. An increase in muscle electrical activity at rest indicates an increase in motor neuron pool activation. The right distal radius bone mineral content (BMC) and density will be measured by dual energy X-ray absorptiometry (DXA).

The right radius bone mineral density (BMD) and BMC will be evaluated by bone densitometer (GE-LUNAR DPX PRO).

Motor unit potentials will be measured by electromyography at left flexor carpi radialis. Neurotrac ETS device will be used.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

A functional cooperation exists between bones and skeletal muscles. Bones work together with muscles as a simple mechanical lever system to produce body movement. One of the important functions of bones is to exert resistance against gravity in order to carry the body. In order to carry out their mechanical functions, bones need to have considerable resistance to deformation under load. It is well-known that muscle activity (i.e., exercises) improves the resistance of bone to mechanical loading, and that it is also important for treating and preventing osteoporosis. Resistance and impact training have been shown to induce bone formation and/or prevent bone resorption. Skeletal muscles have positive effects on bone structure and function. Can bones have an effect on muscle activity? There is only one study about the effect of bones on muscles. In this study, it was shown that bones may affect muscle strength gain in healthy young adult males.

Vibration has a strong osteogenic effect. Vibration-induced bone formation is neuronally regulated. Vibration can also effectively enhance muscle strength and power. Previous studies have shown that vibration increases muscle electromyographic (EMG) activity. But, it has not been reported whether bone has an effect on the increase in muscle EMG activity caused by vibration or not. The aim of this study was to determine whether radius bone exposed to cyclic mechanical loading affects muscle electrical activity of contralateral untrained m. flexor carpi radialis in healthy adult volunteers.

Study Type

Interventional

Enrollment (Actual)

90

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
      • İstanbul, Turkey, 34000
        • Vakif Gureba Training & Research Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 50 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy subjects
  • Right handed
  • Young adult women and men

Exclusion Criteria:

  • secondary osteoporosis
  • neuropathy (central or peripheral)
  • myopathy
  • systemic diseases (arthritis, endocrine-metabolic diseases, bone diseases)
  • professional sportswoman/sportsman
  • subjects doing regular sports activities
  • tendinopathy
  • amputee, endoprosthesis, metal implants

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: NA
  • Interventional Model: SINGLE_GROUP
  • Masking: DOUBLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Healthy young adult subjects
Forearm vibration will be applied in healthy young adult subjects
Procedure: Forearm vibration
Mechanical loading with forearm vibration will be applied right radius in all groups
Other Names:
  • Cyclic mechanical loading

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Changes in rest muscle electrical activity in the contralateral untrained flexor carpi radialis during the right forearm vibration
Time Frame: 2 or 3 weeks
Rest muscle electrical activity changes will be examined in the contralateral untrained flexor carpi radialis during the right forearm vibration
2 or 3 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Vakif Gureba Training and Research Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

March 1, 2010

Primary Completion (ACTUAL)

June 1, 2010

Study Completion (ACTUAL)

July 1, 2010

Study Registration Dates

First Submitted

March 27, 2010

First Submitted That Met QC Criteria

March 31, 2010

First Posted (ESTIMATE)

April 1, 2010

Study Record Updates

Last Update Posted (ESTIMATE)

February 27, 2012

Last Update Submitted That Met QC Criteria

February 24, 2012

Last Verified

February 1, 2012

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • VGEAH FTR-3

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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