Post-marketing Surveillance of Long-term Administration of Donepezil Hydrochloride -Investigation of the Clinical Condition and Safety in Patients With Alzheimer's Disease-

The purpose of this study is to investigate the following about donepezil hydrochloride administration in patients with mild or moderate Alzheimer's Disease in clinical practice: cognitive function, Functional Assessment Staging (FAST) score, adverse events/adverse drug reactions, and patient background.

Study Overview

• Status: Completed
• Conditions: Alzheimer's Disease
• Intervention / Treatment: Drug: donepezil hydrochloride

• Study Type: Observational
• Enrollment (Actual): 10238

Contacts and Locations

Study Locations

• Japan
  • Aichi, Japan
  • Akita, Japan
  • Aomori, Japan
  • Chiba, Japan
  • Fukui, Japan
  • Fukuoka, Japan
  • Fukushima, Japan
  • Gifu, Japan
  • Hiroshima, Japan
  • Ishikawa, Japan
  • Iwate, Japan
  • Kagoshima, Japan
  • Kochi, Japan
  • Kumamoto, Japan
  • Kyoto, Japan
  • Mie, Japan
  • Miyagi, Japan
  • Miyazaki, Japan
  • Nagano, Japan
  • Nagasaki, Japan
  • Nara, Japan
  • Niigata, Japan
  • Oita, Japan
  • Okayama, Japan
  • Okinawa, Japan
  • Osaka, Japan
  • Saga, Japan
  • Saitama, Japan
  • Shizuoka, Japan
  • Tochigi, Japan
  • Tokushima, Japan
  • Tottori, Japan
  • Toyama, Japan
  • Wakayama, Japan
  • Yamagata, Japan
  • Yamaguchi, Japan
  • Aichi
    • Aisai, Aichi, Japan
    • Chita, Aichi, Japan
    • Gamagori, Aichi, Japan
    • Handa, Aichi, Japan
    • Ichinomiya, Aichi, Japan
    • Inazawa, Aichi, Japan
    • Inuyama, Aichi, Japan
    • Kariya, Aichi, Japan
    • Kasugai, Aichi, Japan
    • Komaki, Aichi, Japan
    • Konan, Aichi, Japan
    • Nagoya, Aichi, Japan
    • Nishio, Aichi, Japan
    • Nisshin, Aichi, Japan
    • Obu, Aichi, Japan
    • Okazaki, Aichi, Japan
    • Owariasahi, Aichi, Japan
    • Seto, Aichi, Japan
    • Shinshiro, Aichi, Japan
    • Tahara, Aichi, Japan
    • Tokai, Aichi, Japan
    • Tokoname, Aichi, Japan
    • Toyoake, Aichi, Japan
    • Toyohashi, Aichi, Japan
    • Toyokawa, Aichi, Japan
    • Toyota, Aichi, Japan
    • Yatomi, Aichi, Japan
  • Akita
    • Daisen, Akita, Japan
    • Katagami, Akita, Japan
    • Odate, Akita, Japan
    • Oga, Akita, Japan
    • Semboku, Akita, Japan
    • Yokote, Akita, Japan
    • Yurihonjo, Akita, Japan
    • Yuzawa, Akita, Japan
  • Aomori
    • Goshogawara, Aomori, Japan
    • Hachinohe, Aomori, Japan
    • Hirosaki, Aomori, Japan
    • Kamikita, Aomori, Japan
    • Kitatsugaru, Aomori, Japan
    • Mutsu, Aomori, Japan
    • Sannohe, Aomori, Japan
    • Towada, Aomori, Japan
  • Chiba
    • Abiko, Chiba, Japan
    • Asahi, Chiba, Japan
    • Choshi, Chiba, Japan
    • Funabashi, Chiba, Japan
    • Ichihara, Chiba, Japan
    • Ichikawa, Chiba, Japan
    • Inzai, Chiba, Japan
    • Isumi, Chiba, Japan
    • Kashiwa, Chiba, Japan
    • Katori, Chiba, Japan
    • Kimitsu, Chiba, Japan
    • Kisarazu, Chiba, Japan
    • Matsudo, Chiba, Japan
    • Mobara, Chiba, Japan
    • Nagareyama, Chiba, Japan
    • Narita, Chiba, Japan
    • Sakura, Chiba, Japan
    • Sambu, Chiba, Japan
    • Sammu, Chiba, Japan
    • Tateyama, Chiba, Japan
    • Togane, Chiba, Japan
    • Yachimata, Chiba, Japan
    • Yachiyo, Chiba, Japan
    • Yotsukaido, Chiba, Japan
  • Ehime
    • Imabari, Ehime, Japan
    • Iyo, Ehime, Japan
    • Kamiukena, Ehime, Japan
    • Matsuyama, Ehime, Japan
    • Minamiuwa, Ehime, Japan
    • Niihama, Ehime, Japan
    • Ozu, Ehime, Japan
    • Saijo, Ehime, Japan
    • Seiyo, Ehime, Japan
    • Shikokuchuo, Ehime, Japan
    • Toon, Ehime, Japan
    • Uwajima, Ehime, Japan
    • Yawatahama, Ehime, Japan
  • Fukui
    • Echizen, Fukui, Japan
    • Katsuyama, Fukui, Japan
    • Mikatakaminaka, Fukui, Japan
    • Obama, Fukui, Japan
    • Sabae, Fukui, Japan
    • Sakai, Fukui, Japan
    • Tsuruga, Fukui, Japan
  • Fukuoka
    • Asakura, Fukuoka, Japan
    • Chikugo, Fukuoka, Japan
    • Chikushi, Fukuoka, Japan
    • Chikushino, Fukuoka, Japan
    • Fukutsu, Fukuoka, Japan
    • Iizuka, Fukuoka, Japan
    • Itoshima, Fukuoka, Japan
    • Kasuga, Fukuoka, Japan
    • Kasuya, Fukuoka, Japan
    • Kitakyushu, Fukuoka, Japan
    • Kurume, Fukuoka, Japan
    • Miyako, Fukuoka, Japan
    • Miyama, Fukuoka, Japan
    • Nakama, Fukuoka, Japan
    • Nogata, Fukuoka, Japan
    • Ogori, Fukuoka, Japan
    • Omuta, Fukuoka, Japan
    • Onga, Fukuoka, Japan
    • Onojo, Fukuoka, Japan
    • Tagawa, Fukuoka, Japan
    • Ukiha, Fukuoka, Japan
    • Yanagawa, Fukuoka, Japan
    • Yukuhashi, Fukuoka, Japan
  • Fukushima
    • Aizuwakamatsu, Fukushima, Japan
    • Date, Fukushima, Japan
    • Futaba, Fukushima, Japan
    • Higashishirakawa, Fukushima, Japan
    • Ishikawa, Fukushima, Japan
    • Iwaki, Fukushima, Japan
    • Kitakata, Fukushima, Japan
    • Koriyama, Fukushima, Japan
    • Nihonmatsu, Fukushima, Japan
    • Onuma, Fukushima, Japan
    • Soma, Fukushima, Japan
    • Sukagawa, Fukushima, Japan
    • Tamura, Fukushima, Japan
    • Yama, Fukushima, Japan
  • Gifu
    • Ena, Gifu, Japan
    • Gujo, Gifu, Japan
    • Hashima, Gifu, Japan
    • Minokamo, Gifu, Japan
    • Mizuho, Gifu, Japan
    • Nakatsugawa, Gifu, Japan
    • Ogaki, Gifu, Japan
    • Seki, Gifu, Japan
    • Tajimi, Gifu, Japan
    • Takayama, Gifu, Japan
    • Toki, Gifu, Japan
    • Yamagata, Gifu, Japan
  • Gumma
    • Fujioka, Gumma, Japan
    • Isesaki, Gumma, Japan
    • Kiryu, Gumma, Japan
    • Kitagumma, Gumma, Japan
    • Maebashi, Gumma, Japan
    • Numata, Gumma, Japan
    • Ora, Gumma, Japan
    • Ota, Gumma, Japan
    • Shibukawa, Gumma, Japan
    • Takasaki, Gumma, Japan
    • Tatebayashi, Gumma, Japan
    • Tomioka, Gumma, Japan
    • Tone, Gumma, Japan
  • Hiroshima
    • Aki, Hiroshima, Japan
    • Fuchu, Hiroshima, Japan
    • Fukuyama, Hiroshima, Japan
    • Higashihiroshima, Hiroshima, Japan
    • Kure, Hiroshima, Japan
    • Mihara, Hiroshima, Japan
    • Miyoshi, Hiroshima, Japan
    • Onomichi, Hiroshima, Japan
    • Otake, Hiroshima, Japan
    • Shobara, Hiroshima, Japan
    • Takehara, Hiroshima, Japan
  • Hokkaido
    • Abashiri, Hokkaido, Japan
    • Akkeshi, Hokkaido, Japan
    • Asahikawa, Hokkaido, Japan
    • Ashibetsu, Hokkaido, Japan
    • Bibai, Hokkaido, Japan
    • Chitose, Hokkaido, Japan
    • Date, Hokkaido, Japan
    • Ebetsu, Hokkaido, Japan
    • Eniwa, Hokkaido, Japan
    • Fukagawa, Hokkaido, Japan
    • Furano, Hokkaido, Japan
    • Hakodate, Hokkaido, Japan
    • Hiroo, Hokkaido, Japan
    • Hokuto, Hokkaido, Japan
    • Ishikari, Hokkaido, Japan
    • Iwamizawa, Hokkaido, Japan
    • Kameda, Hokkaido, Japan
    • Kamikawa, Hokkaido, Japan
    • Kato, Hokkaido, Japan
    • Kawakami, Hokkaido, Japan
    • Kitami, Hokkaido, Japan
    • Kushiro, Hokkaido, Japan
    • Mombetsu, Hokkaido, Japan
    • Muroran, Hokkaido, Japan
    • Nakagawa, Hokkaido, Japan
    • Nayoro, Hokkaido, Japan
    • Noboribetsu, Hokkaido, Japan
    • Obihiro, Hokkaido, Japan
    • Otaru, Hokkaido, Japan
    • Rumoi, Hokkaido, Japan
    • Sapporo, Hokkaido, Japan
    • Shibetsu, Hokkaido, Japan
    • Sorachi, Hokkaido, Japan
    • Soya, Hokkaido, Japan
    • Sunagawa, Hokkaido, Japan
    • Tomakomai, Hokkaido, Japan
    • Yoichi, Hokkaido, Japan
    • Yufutsu, Hokkaido, Japan
  • Hyogo
    • Akashi, Hyogo, Japan
    • Ako, Hyogo, Japan
    • Amagasaki, Hyogo, Japan
    • Asago, Hyogo, Japan
    • Ashiya, Hyogo, Japan
    • Awaji, Hyogo, Japan
    • Himeji, Hyogo, Japan
    • Itami, Hyogo, Japan
    • Kako, Hyogo, Japan
    • Kakogawa, Hyogo, Japan
    • Kasai, Hyogo, Japan
    • Kato, Hyogo, Japan
    • Kawabe, Hyogo, Japan
    • Kawanishi, Hyogo, Japan
    • Kobe, Hyogo, Japan
    • Miki, Hyogo, Japan
    • Nishinomiya, Hyogo, Japan
    • Sanda, Hyogo, Japan
    • Shiso, Hyogo, Japan
    • Sumoto, Hyogo, Japan
    • Takarazuka, Hyogo, Japan
    • Takasago, Hyogo, Japan
    • Tamba, Hyogo, Japan
    • Tatsuno, Hyogo, Japan
    • Toyooka, Hyogo, Japan
    • Yabu, Hyogo, Japan
  • Ibaraki
    • Bando, Ibaraki, Japan
    • Chikusei, Ibaraki, Japan
    • Higashiibaraki, Ibaraki, Japan
    • Hitachi, Ibaraki, Japan
    • Hitachinaka, Ibaraki, Japan
    • Hitachiota, Ibaraki, Japan
    • Inashiki, Ibaraki, Japan
    • Ishioka, Ibaraki, Japan
    • Joso, Ibaraki, Japan
    • Kamisu, Ibaraki, Japan
    • Kasama, Ibaraki, Japan
    • Koga, Ibaraki, Japan
    • Mito, Ibaraki, Japan
    • Moriya, Ibaraki, Japan
    • Naka, Ibaraki, Japan
    • Ryugasaki, Ibaraki, Japan
    • Sashima, Ibaraki, Japan
    • Takahagi, Ibaraki, Japan
    • Toride, Ibaraki, Japan
    • Tsuchiura, Ibaraki, Japan
    • Tsukuba, Ibaraki, Japan
    • Tsukubamirai, Ibaraki, Japan
    • Ushiku, Ibaraki, Japan
    • Yuki, Ibaraki, Japan
  • Ishikawa
    • Hakusan, Ishikawa, Japan
    • Kahoku, Ishikawa, Japan
    • Kanazawa, Ishikawa, Japan
    • Komatsu, Ishikawa, Japan
    • Nanao, Ishikawa, Japan
    • Suzu, Ishikawa, Japan
    • Wajima, Ishikawa, Japan
  • Iwate
    • Hanamaki, Iwate, Japan
    • Ichinoseki, Iwate, Japan
    • Kamaishi, Iwate, Japan
    • Kitakami, Iwate, Japan
    • Miyako, Iwate, Japan
    • Morioka, Iwate, Japan
    • Ninohe, Iwate, Japan
    • Oshu, Iwate, Japan
    • Tono, Iwate, Japan
  • Kagawa
    • Ayauta, Kagawa, Japan
    • Kanonji, Kagawa, Japan
    • Kita, Kagawa, Japan
    • Marugame, Kagawa, Japan
    • Mitoyo, Kagawa, Japan
    • Sakaide, Kagawa, Japan
    • Sanuki, Kagawa, Japan
    • Shozu, Kagawa, Japan
    • Takamatsu, Kagawa, Japan
  • Kagoshima
    • Aira, Kagoshima, Japan
    • Amami, Kagoshima, Japan
    • Hioki, Kagoshima, Japan
    • Ibusuki, Kagoshima, Japan
    • Ichikikushikino, Kagoshima, Japan
    • Izumi, Kagoshima, Japan
    • Kanoya, Kagoshima, Japan
    • Kirishima, Kagoshima, Japan
    • Makurazaki, Kagoshima, Japan
    • Minamikyushu, Kagoshima, Japan
    • Nishinomote, Kagoshima, Japan
    • Satsuma, Kagoshima, Japan
    • Satsumasendai, Kagoshima, Japan
    • Shibushi, Kagoshima, Japan
    • So, Kagoshima, Japan
    • Soh, Kagoshima, Japan
  • Kanagawa
    • Ashigarashimo, Kanagawa, Japan
    • Atsugi, Kanagawa, Japan
    • Chigasaki, Kanagawa, Japan
    • Ebina, Kanagawa, Japan
    • Fujisawa, Kanagawa, Japan
    • Hiratsuka, Kanagawa, Japan
    • Isehara, Kanagawa, Japan
    • Kamakura, Kanagawa, Japan
    • Kawasaki, Kanagawa, Japan
    • Miura, Kanagawa, Japan
    • Naka, Kanagawa, Japan
    • Odawara, Kanagawa, Japan
    • Sagamihara, Kanagawa, Japan
    • Yamato, Kanagawa, Japan
    • Yokohama, Kanagawa, Japan
    • Yokosuka, Kanagawa, Japan
    • Zama, Kanagawa, Japan
  • Kochi
    • Aki, Kochi, Japan
    • Muroto, Kochi, Japan
    • Nagaoka, Kochi, Japan
    • Nankoku, Kochi, Japan
    • Takaoka, Kochi, Japan
  • Kumamoto
    • Amakusa, Kumamoto, Japan
    • Arao, Kumamoto, Japan
    • Aso, Kumamoto, Japan
    • Hitoyoshi, Kumamoto, Japan
    • Kamiamakusa, Kumamoto, Japan
    • Kamimashiki, Kumamoto, Japan
    • Koshi, Kumamoto, Japan
    • Minamata, Kumamoto, Japan
    • Tamana, Kumamoto, Japan
    • Uki, Kumamoto, Japan
    • Yamaga, Kumamoto, Japan
    • Yatsushiro, Kumamoto, Japan
  • Kyoto
    • Fukuchiyama, Kyoto, Japan
    • Joyo, Kyoto, Japan
    • Kameoka, Kyoto, Japan
    • Kizugawa, Kyoto, Japan
    • Kyotanabe, Kyoto, Japan
    • Maizuru, Kyoto, Japan
    • Nagaokakyo, Kyoto, Japan
    • Nantan, Kyoto, Japan
    • Soraku, Kyoto, Japan
    • Tsuzuki, Kyoto, Japan
    • Uji, Kyoto, Japan
    • Yosa, Kyoto, Japan
  • Mie
    • Iga, Mie, Japan
    • Ise, Mie, Japan
    • Kameyama, Mie, Japan
    • Kumano, Mie, Japan
    • Kuwana, Mie, Japan
    • Matsusaka, Mie, Japan
    • Suzuka, Mie, Japan
    • Tsu, Mie, Japan
    • Watarai, Mie, Japan
    • Yokkaichi, Mie, Japan
  • Miyagi
    • Ishinomaki, Miyagi, Japan
    • Iwanuma, Miyagi, Japan
    • Kesennuma, Miyagi, Japan
    • Kurihara, Miyagi, Japan
    • Kurokawa, Miyagi, Japan
    • Natori, Miyagi, Japan
    • Osaki, Miyagi, Japan
    • Oshika, Miyagi, Japan
    • Sendai, Miyagi, Japan
    • Shibata, Miyagi, Japan
    • Shiogama, Miyagi, Japan
    • Toda, Miyagi, Japan
    • Tome, Miyagi, Japan
  • Miyazaki
    • Higashimorokata, Miyazaki, Japan
    • Hyuga, Miyazaki, Japan
    • Kobayashi, Miyazaki, Japan
    • Koyu, Miyazaki, Japan
    • Kushima, Miyazaki, Japan
    • Miyakonojo, Miyazaki, Japan
    • Nichinan, Miyazaki, Japan
    • Nishiusuki, Miyazaki, Japan
    • Nobeoka, Miyazaki, Japan
    • Saito, Miyazaki, Japan
  • Nagano
    • Azumino, Nagano, Japan
    • Chikuma, Nagano, Japan
    • Chino, Nagano, Japan
    • Hanishina, Nagano, Japan
    • Higashichikuma, Nagano, Japan
    • Iida, Nagano, Japan
    • Ina, Nagano, Japan
    • Kamiminochi, Nagano, Japan
    • Kiso, Nagano, Japan
    • Kitaazumi, Nagano, Japan
    • Kitasaku, Nagano, Japan
    • Komagane, Nagano, Japan
    • Komoro, Nagano, Japan
    • Matsumoto, Nagano, Japan
    • Okaya, Nagano, Japan
    • Saku, Nagano, Japan
    • Shimoina, Nagano, Japan
    • Shiojiri, Nagano, Japan
    • Suwa, Nagano, Japan
    • Suzaka, Nagano, Japan
    • Ueda, Nagano, Japan
  • Nagasaki
    • Goto, Nagasaki, Japan
    • Higashisonogi, Nagasaki, Japan
    • Isahaya, Nagasaki, Japan
    • Kitamatsuura, Nagasaki, Japan
    • Minamishimabara, Nagasaki, Japan
    • Nishisonogi, Nagasaki, Japan
    • Omura, Nagasaki, Japan
    • Sasebo, Nagasaki, Japan
    • Shimabara, Nagasaki, Japan
    • Tsushima, Nagasaki, Japan
    • Unzen, Nagasaki, Japan
  • Nara
    • Gose, Nara, Japan
    • Ikoma, Nara, Japan
    • Kashiba, Nara, Japan
    • Kashihara, Nara, Japan
    • Kitakatsuragi, Nara, Japan
    • Sakurai, Nara, Japan
    • Tenri, Nara, Japan
    • Uda, Nara, Japan
    • Yamatokoriyama, Nara, Japan
    • Yamatotakada, Nara, Japan
    • Yoshino, Nara, Japan
  • Niigata
    • Gosen, Niigata, Japan
    • Joetsu, Niigata, Japan
    • Kashiwazaki, Niigata, Japan
    • Minamiuonuma, Niigata, Japan
    • Mitsuke, Niigata, Japan
    • Murakami, Niigata, Japan
    • Nagaoka, Niigata, Japan
    • Ojiya, Niigata, Japan
    • Sado, Niigata, Japan
    • Sanjo, Niigata, Japan
    • Shibata, Niigata, Japan
    • Uonuma, Niigata, Japan
  • Oita
    • Hita, Oita, Japan
    • Kunisaki, Oita, Japan
    • Kusu, Oita, Japan
    • Nakatsu, Oita, Japan
    • Saiki, Oita, Japan
    • Tsukumi, Oita, Japan
    • Usa, Oita, Japan
    • Usuki, Oita, Japan
    • Yufu, Oita, Japan
  • Okayama
    • Akaiwa, Okayama, Japan
    • Asakuchi, Okayama, Japan
    • Bizen, Okayama, Japan
    • Kaga, Okayama, Japan
    • Kasaoka, Okayama, Japan
    • Kume, Okayama, Japan
    • Kurashiki, Okayama, Japan
    • Mimasaka, Okayama, Japan
    • Niimi, Okayama, Japan
    • Soja, Okayama, Japan
    • Takahashi, Okayama, Japan
    • Tamano, Okayama, Japan
    • Tomata, Okayama, Japan
    • Tsuyama, Okayama, Japan
  • Okinawa
    • Ginowan, Okinawa, Japan
    • Ishigaki, Okinawa, Japan
    • Itoman, Okinawa, Japan
    • Kunigami, Okinawa, Japan
    • Miyakojima, Okinawa, Japan
    • Naha, Okinawa, Japan
    • Nakagami, Okinawa, Japan
    • Nanjo, Okinawa, Japan
    • Tomigusuku, Okinawa, Japan
    • Urasoe, Okinawa, Japan
    • Uruma, Okinawa, Japan
  • Osaka
    • Daito, Osaka, Japan
    • Fujiidera, Osaka, Japan
    • Habikino, Osaka, Japan
    • Hannan, Osaka, Japan
    • Higashiosaka, Osaka, Japan
    • Hirakata, Osaka, Japan
    • Ibaraki, Osaka, Japan
    • Ikeda, Osaka, Japan
    • Izumi, Osaka, Japan
    • Izumiotsu, Osaka, Japan
    • Izumisano, Osaka, Japan
    • Kadoma, Osaka, Japan
    • Kaizuka, Osaka, Japan
    • Kashiwara, Osaka, Japan
    • Katano, Osaka, Japan
    • Kawachinagano, Osaka, Japan
    • Kishiwada, Osaka, Japan
    • Matsubara, Osaka, Japan
    • Mino, Osaka, Japan
    • Moriguchi, Osaka, Japan
    • Neyagawa, Osaka, Japan
    • Osakasayama, Osaka, Japan
    • Sakai, Osaka, Japan
    • Sennan, Osaka, Japan
    • Settsu, Osaka, Japan
    • Suita, Osaka, Japan
    • Takaishi, Osaka, Japan
    • Takatsuki, Osaka, Japan
    • Tondabayashi, Osaka, Japan
    • Toyonaka, Osaka, Japan
    • Toyono, Osaka, Japan
    • Yao, Osaka, Japan
  • Saga
    • Imari, Saga, Japan
    • Kanzaki, Saga, Japan
    • Karatsu, Saga, Japan
    • Kishima, Saga, Japan
    • Nishimatsuura, Saga, Japan
    • Ogi, Saga, Japan
    • Takeo, Saga, Japan
    • Taku, Saga, Japan
    • Tosu, Saga, Japan
    • Ureshino, Saga, Japan
  • Saitama
    • Ageo, Saitama, Japan
    • Asaka, Saitama, Japan
    • Chichibu, Saitama, Japan
    • Fujimi, Saitama, Japan
    • Fujimino, Saitama, Japan
    • Fukaya, Saitama, Japan
    • Gyoda, Saitama, Japan
    • Hanno, Saitama, Japan
    • Hanyu, Saitama, Japan
    • Hasuda, Saitama, Japan
    • Hidaka, Saitama, Japan
    • Hiki, Saitama, Japan
    • Honjo, Saitama, Japan
    • Iruma, Saitama, Japan
    • Kasukabe, Saitama, Japan
    • Kawagoe, Saitama, Japan
    • Kawaguchi, Saitama, Japan
    • Kazo, Saitama, Japan
    • Kitaadachi, Saitama, Japan
    • Kitamoto, Saitama, Japan
    • Konosu, Saitama, Japan
    • Koshigaya, Saitama, Japan
    • Kuki, Saitama, Japan
    • Kumagaya, Saitama, Japan
    • Minamisaitama, Saitama, Japan
    • Niiza, Saitama, Japan
    • Sakado, Saitama, Japan
    • Sayama, Saitama, Japan
    • Soka, Saitama, Japan
    • Toda, Saitama, Japan
    • Tokorozawa, Saitama, Japan
    • Tsurugashima, Saitama, Japan
    • Wako, Saitama, Japan
    • Yoshikawa, Saitama, Japan
  • Shiga
    • Higashiomi, Shiga, Japan
    • Hikone, Shiga, Japan
    • Inukami, Shiga, Japan
    • Koka, Shiga, Japan
    • Kusatsu, Shiga, Japan
    • Moriyama, Shiga, Japan
    • Nagahama, Shiga, Japan
    • Omihachiman, Shiga, Japan
    • Otsu, Shiga, Japan
    • Ritto, Shiga, Japan
    • Takashima, Shiga, Japan
  • Shimane
    • Hamada, Shimane, Japan
    • Izumo, Shimane, Japan
    • Kanoashi, Shimane, Japan
    • Matsue, Shimane, Japan
    • Nita, Shimane, Japan
    • Oda, Shimane, Japan
    • Unnan, Shimane, Japan
    • Yasugi, Shimane, Japan
  • Shizuoka
    • Atami, Shizuoka, Japan
    • Fuji, Shizuoka, Japan
    • Fujieda, Shizuoka, Japan
    • Fujinomiya, Shizuoka, Japan
    • Fukuroi, Shizuoka, Japan
    • Gotemba, Shizuoka, Japan
    • Haibara, Shizuoka, Japan
    • Hamamatsu, Shizuoka, Japan
    • Ito, Shizuoka, Japan
    • Iwata, Shizuoka, Japan
    • Izu, Shizuoka, Japan
    • Kakegawa, Shizuoka, Japan
    • Kamo, Shizuoka, Japan
    • Kikugawa, Shizuoka, Japan
    • Kosai, Shizuoka, Japan
    • Mishima, Shizuoka, Japan
    • Numazu, Shizuoka, Japan
    • Omaezaki, Shizuoka, Japan
    • Shimada, Shizuoka, Japan
    • Shimoda, Shizuoka, Japan
    • Susono, Shizuoka, Japan
    • Tagata, Shizuoka, Japan
  • Tochigi
    • Ashikaga, Tochigi, Japan
    • Haga, Tochigi, Japan
    • Kanuma, Tochigi, Japan
    • Kawachi, Tochigi, Japan
    • Moka, Tochigi, Japan
    • Nasu, Tochigi, Japan
    • Nasukarasuyama, Tochigi, Japan
    • Nikko, Tochigi, Japan
    • Otawara, Tochigi, Japan
    • Oyama, Tochigi, Japan
    • Sano, Tochigi, Japan
    • Utsunomiya, Tochigi, Japan
  • Tokushima
    • Anan, Tokushima, Japan
    • Awa, Tokushima, Japan
    • Itano, Tokushima, Japan
    • Mima, Tokushima, Japan
    • Miyoshi, Tokushima, Japan
    • Myozai, Tokushima, Japan
    • Naka, Tokushima, Japan
    • Naruto, Tokushima, Japan
    • Yoshinogawa, Tokushima, Japan
  • Tokyo
    • Adachi, Tokyo, Japan
    • Akiruno, Tokyo, Japan
    • Akishima, Tokyo, Japan
    • Arakawa, Tokyo, Japan
    • Bunkyo, Tokyo, Japan
    • Chiyoda, Tokyo, Japan
    • Chofu, Tokyo, Japan
    • Chuo, Tokyo, Japan
    • Edogawa, Tokyo, Japan
    • Fuchu, Tokyo, Japan
    • Fussa, Tokyo, Japan
    • Hachioji, Tokyo, Japan
    • Higashiyamato, Tokyo, Japan
    • Hino, Tokyo, Japan
    • Inagi, Tokyo, Japan
    • Itabashi, Tokyo, Japan
    • Katsushika, Tokyo, Japan
    • Kita, Tokyo, Japan
    • Kiyose, Tokyo, Japan
    • Kodaira, Tokyo, Japan
    • Koganei, Tokyo, Japan
    • Kokubunji, Tokyo, Japan
    • Komae, Tokyo, Japan
    • Koto, Tokyo, Japan
    • Kunitachi, Tokyo, Japan
    • Machida, Tokyo, Japan
    • Meguro, Tokyo, Japan
    • Minato, Tokyo, Japan
    • Mitaka, Tokyo, Japan
    • Musashino, Tokyo, Japan
    • Nakano, Tokyo, Japan
    • Nerima, Tokyo, Japan
    • Nishitokyo, Tokyo, Japan
    • Ome, Tokyo, Japan
    • Ota, Tokyo, Japan
    • Setagaya, Tokyo, Japan
    • Shibuya, Tokyo, Japan
    • Shinagawa, Tokyo, Japan
    • Shinjuku, Tokyo, Japan
    • Suginami, Tokyo, Japan
    • Sumida, Tokyo, Japan
    • Tachikawa, Tokyo, Japan
    • Tama, Tokyo, Japan
    • Toshima, Tokyo, Japan
  • Tottori
    • Hino, Tottori, Japan
    • Iwami, Tottori, Japan
    • Kurayoshi, Tottori, Japan
    • Saihaku, Tottori, Japan
    • Sakaiminato, Tottori, Japan
    • Yazu, Tottori, Japan
    • Yonago, Tottori, Japan
  • Toyama
    • Himi, Toyama, Japan
    • Imizu, Toyama, Japan
    • Nakaniikawa, Toyama, Japan
    • Namerikawa, Toyama, Japan
    • Nanto, Toyama, Japan
    • Takaoka, Toyama, Japan
    • Uozu, Toyama, Japan
  • Wakayama
    • Arida, Wakayama, Japan
    • Gobo, Wakayama, Japan
    • Ito, Wakayama, Japan
    • Iwade, Wakayama, Japan
    • Kainan, Wakayama, Japan
    • Kinokawa, Wakayama, Japan
    • Nishimuro, Wakayama, Japan
    • Tanabe, Wakayama, Japan
  • Yamagata
    • Nanyo, Yamagata, Japan
    • Sakata, Yamagata, Japan
    • Tendo, Yamagata, Japan
    • Tsuruoka, Yamagata, Japan
    • Yonezawa, Yamagata, Japan
  • Yamaguchi
    • Hagi, Yamaguchi, Japan
    • Hikari, Yamaguchi, Japan
    • Hofu, Yamaguchi, Japan
    • Iwakuni, Yamaguchi, Japan
    • Nagato, Yamaguchi, Japan
    • SanyoOnoda, Yamaguchi, Japan
    • Shimonoseki, Yamaguchi, Japan
    • Shunan, Yamaguchi, Japan
    • Ube, Yamaguchi, Japan
    • Yanai, Yamaguchi, Japan
  • Yamanashi
    • Chuo, Yamanashi, Japan
    • Fuefuki, Yamanashi, Japan
    • Fujiyoshida, Yamanashi, Japan
    • Hokuto, Yamanashi, Japan
    • Kai, Yamanashi, Japan
    • Kofu, Yamanashi, Japan
    • Minamitsuru, Yamanashi, Japan
    • Nirasaki, Yamanashi, Japan
    • Otsuki, Yamanashi, Japan
    • Tsuru, Yamanashi, Japan

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: ADULT; OLDER_ADULT; CHILD
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Hospital, Clinical. Japan

Description

Inclusion criteria:

Patients diagnosed with Alzheimer's Disease by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Patients diagnosed with mild or moderate Alzheimer's Disease, applicable to FAST score 4 or 5.

Exclusion criteria:

Patients with history of hypersensitivity to component of Aricept or piperidine derivative. Patients registered for this survey before.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
1	Drug: donepezil hydrochloride; This is a multicenter, open-labeled, practice-based, post-marketing surveillance study. Therefore, dosing is not specified.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
The transition of clinical condition is evaluated comparing the result of HDS-R,MMSE with the time of study initiation	48 months(12 weeks and every 6 months)

Collaborators and Investigators

• Sponsor: Eisai Co., Ltd.
• Investigators: Study Director: Kenta Sumitomo, Drug Fostering and Evolution Coordination Department, Eisai Co., Ltd.

Publications and helpful links

General Publications

• Arai H, Hashimoto N, Sumitomo K, Takase T, Ishii M. Disease state changes and safety of long-term donepezil hydrochloride administration in patients with Alzheimer's disease: Japan-Great Outcome of Long-term trial with Donepezil (J-GOLD). Psychogeriatrics. 2018 Sep;18(5):402-411. doi: 10.1111/psyg.12340. Epub 2018 Jul 11.

Study record dates

Study Major Dates

• Study Start (ACTUAL): June 10, 2010
• Primary Completion (ACTUAL): September 25, 2015
• Study Completion (ACTUAL): June 23, 2016

Study Registration Dates

• First Submitted: May 21, 2010
• First Submitted That Met QC Criteria: May 21, 2010
• First Posted (ESTIMATE): May 24, 2010

Study Record Updates

• Last Update Posted (ACTUAL): November 5, 2018
• Last Update Submitted That Met QC Criteria: November 2, 2018
• Last Verified: January 1, 2017

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Neurodegenerative Diseases; Dementia; Tauopathies; Alzheimer Disease; Physiological Effects of Drugs; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Cholinergic Agents; Enzyme Inhibitors; Nootropic Agents; Cholinesterase Inhibitors; Donepezil
• Other Study ID Numbers: ART05T