- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01139333
Blood and Tumor Tissue Samples From Young Patients With Acute Myeloid Leukemia
Evaluation of Mer and Axl Expression in Acute Myeloid Leukemia Patient Samples
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is studying blood and tumor tissue samples from young patients with acute myeloid leukemia.
Study Overview
Status
Conditions
Detailed Description
OBJECTIVES:
- To evaluate Mer and Axl expression in samples from pediatric patients with acute myeloid leukemia (AML).
- To determine if abnormal expression of Mer and Axl is associated with poor clinical characteristics (e.g., induction failure or relapse) of AML in these patients.
OUTLINE: This is a multicenter study.
Archived samples from pediatric patients with acute myeloid leukemia are analyzed for Mer and Axl expression by flow cytometry and western blot assays.
Study Type
Enrollment (Anticipated)
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
DISEASE CHARACTERISTICS:
- Diagnosis of acute myeloid leukemia
- Children Oncology Group (COG) patient samples
PATIENT CHARACTERISTICS:
- Available clinical data
PRIOR CONCURRENT THERAPY:
- Not specified
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
Expression of Mer and Axl
|
Association of abnormal expression of Mer and Axl with induction failure or relapse
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Kristen M. Eisenman, MD, University of Colorado, Denver
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- AAML10B4
- COG-AAML10B4 (Other Identifier: Children's Oncology Group)
- CDR0000671452 (Other Identifier: Clinical Trials.gov)
- NCI-2011-02222 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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