Effect of Oral Adenosine-triphosphate (ATP) on Human Muscle Performance

Effect of Oral ATP on Human Muscle Performance

Adenosine-triphosphate (ATP) serves as the sole energy source for muscle contraction. Therefore human performance of brief maximal exercise is limited, in part, by the availability of ATP to the contracting muscle. Because muscle ATP storage is small (enough to sustain maximal exercise for less than 1 second), factors that enhance either storage or resynthesis of ATP may have a positive impact on repeated muscle contractions. The current study will test the hypothesis that increasing ATP availability to muscle via oral supplementation will improve performance of repeated high intensity exercise as measured by a) work performed in each of the three 50 contraction fatigue tests, b) sum of total work performed, and c) percentage decrement in total work from the first to third third 50 contraction test.

Study Overview

• Status: Completed
• Conditions: Healthy Subjects
• Intervention / Treatment: Dietary supplement: Placebo; Dietary supplement: PeakATP 250; Dietary supplement: PeakATP 400; Dietary supplement: PeakATP 400 plus proprietary blend

Detailed Description

To date we have studied 10 subjects who have followed through with all 3 of the original interventions (Placebo, 250 mg PeakATP/d and 400 mg PeakATP/d). Currently we have received approval and are expanding the study with 5 additional subjects who will receive the Placebo, 400 mg PeakATP/d and the 400 mg PealATP/d plus proprietary blend interventions.

• Study Type: Interventional
• Enrollment (Actual): 16
• Phase: Phase 1

Contacts and Locations

Study Locations

• United States
  • Iowa
    • Ames, Iowa, United States, 50010
      • Iowa State University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 30 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• No major medical conditions;
• Able to perform fatigue testing procedures;
• Not currently taking prescription medications;
• Not currently taking dietary supplements (a daily multi-vitamin not exceeding RDA is permitted)

Exclusion Criteria:

• Major medical condition affecting metabolism or general function;
• Not able to perform fatigue testing;
• Taking prescription medications;
• Taking a dietary supplement other than a multi-vitamin not exceeding RDA

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Triple

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo; Oral placebo capsules similar in color and size to the intervention	Dietary supplement: Placebo; Placebo capsules that are comparable in size and color to the active comparator for blinding purposes
Active Comparator: PeakATP 250; Oral supplement capsules containing 250 mg/day of PeakATP	Dietary supplement: PeakATP 250; The nutritional intervention provides for oral ingestion of 250 mg PeakATP per day
Active Comparator: PeakATP 400; Oral supplement capsules containing 400 mg/day of PeakATP	Dietary supplement: PeakATP 400; The nutritional intervention provides for oral ingestion of 400 mg PeakATP per day
Active Comparator: PeakATP 400 plus proprietary blend; Oral supplement capsules containing 400 mg/day of PeakATP plus a proprietary blend	Dietary supplement: PeakATP 400 plus proprietary blend; The nutritional intervention provides for oral ingestion of 400 mg PeakATP per day plus a proprietary blend of additional nutrients

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Work Performed	The work and total work performed in 3 exercise fatigue tests given after 15 days of nutritional intervention.	Measured after 15 days of intervention

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Decrease in work performed in each successive test	The decrease in total work performed in each of 3 successive fatigue tests will be measured and used as a measure of muscle fatigability after 15 days of nutritional intervention	Measured after 15 days of intervention

Collaborators and Investigators

• Sponsor: Metabolic Technologies Inc.
• Collaborators: Iowa State University
• Investigators: Principal Investigator: John A Rathmacher, PhD, Metabolic Technologies Inc.

Study record dates

Study Major Dates

• Study Start: June 1, 2010
• Primary Completion (Actual): October 1, 2011
• Study Completion (Actual): October 1, 2011

Study Registration Dates

• First Submitted: June 9, 2010
• First Submitted That Met QC Criteria: June 9, 2010
• First Posted (Estimate): June 10, 2010

Study Record Updates

• Last Update Posted (Estimate): January 10, 2012
• Last Update Submitted That Met QC Criteria: January 9, 2012
• Last Verified: January 1, 2012

More Information

Terms related to this study

• Keywords: Supplemental ATP; Muscle Work Performed; Muscle Fatigue
• Other Study ID Numbers: MTI2010-CS01