- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01314612
Initial Study of Insomnia/Nightmare Group Treatment for Posttraumatic Stress Disorder (PTSD)
March 16, 2011 updated by: Michael E. DeBakey VA Medical Center
An Investigation Of The Effectiveness of a Cognitive Behavioral Group Treatment Addressing Insomnia and Nightmares In Veterans With PTSD
Many combat Veterans suffer from posttraumatic stress disorder (PTSD), an anxiety disorder that develops after an extremely stressful event or events.
PTSD is associated with problems falling asleep or staying asleep.
Veterans with PTSD also commonly have nightmares from stressful experiences.
These symptoms can cause problems in daily life.
Behavioral treatments that do not involve taking medication have been shown to help improve problems related to sleep and nightmares.
However, very few of these treatments address both sleep problems and nightmares at the same time, even though many people suffer from both problems.
The purpose of this study is to examine the effectiveness of a combined treatment for sleep problems and nightmares in Veterans suffering from combat-related PTSD that is presented in a group format.
The investigators hypothesize that the completion of this treatment will lead to increases in sleep quality and decreases in the frequency and severity of nightmares as measured by standard questionnaires.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
30
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Texas
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Houston, Texas, United States, 77030
- Michael E. DeBakey VA Medical Center
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Must be enrolled in the Michael E. DeBakey VAMC Trauma Recovery Program and qualify for a diagnosis of combat-related PTSD related to service in Vietnam-era conflicts as measured by responses to the Clinician-Administered PTSD Scale (CAPS) and total score ≥ 50 on the Posttraumatic Stress Disorder Checklist Stressor Specific Version (PCL-S)
- Have a clinically significant sleep problem as measured by a total score > 5 on the Pittsburgh Sleep Quality Index (PSQI)
- Have a repetitive trauma-related nightmare at least once per week on average, as measured by the Nightmare Frequency Questionnaire (NFQ), and which significantly impairs sleep as measured by response ≥ 2 on question 1a of the Nightmare Effects Survey (NES)
- Be stable on current regimen of psychotropic medication (i.e., no changes to medications and/or dosages) if applicable
- Must sign consent to be audio-recorded as part of the course of the treatment
Exclusion Criteria:
- Current substance dependence
- Planned or ongoing participation in Prolonged Exposure or Cognitive Processing Therapy during treatment participation
- Organic psychosis
- Bipolar I disorder
- Epilepsy
- Currently on benzodiazepine or hypnotic medication to treat sleep
- Currently take prazosin
- Indication of undiagnosed sleep apnea defined as score ≥ .5 across items 1, 5, and 8 of the Multivariable Apnea Risk Index
- Uncontrolled sleep apnea
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Group Intervention
Subjects randomly assigned to this arm of the study will receive the 9-week insomnia and nightmare intervention group once per week for 90 minutes in addition to continuing treatment as usual with medical and mental health providers.
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Group based cognitive-behavioral therapy meeting weekly for 90 minutes over the course of 9 weeks.
Utilizes stimulus control, sleep scheduling, and progressive muscle relaxation to address symptoms of insomnia.
Imagery rehearsal and rescripting are used to address nightmare symptoms.
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No Intervention: Treatment as Usual
This group is randomly assigned to receive only treatment as usual and does not receive the active intervention of the insomnia and nightmare group treatment.
This treatment will be made available to these members once the study is completed
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Pittsburgh Sleep Quality Index, with Addendum for PTSD
Time Frame: baseline and 20 weeks
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Self report measure of sleep quality and degree to which sleep is affected by PTSD.
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baseline and 20 weeks
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Nightmare Effects Survey
Time Frame: baseline and 20 weeks
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Self-report assessment of psychosocial impairment resulting from experience of nightmares
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baseline and 20 weeks
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Posttraumatic Stress Disorder Checklist- Stressor Specific Version
Time Frame: baseline and 20 weeks
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Self-report measure of Posttraumatic Stress Disorder symptoms.
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baseline and 20 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Clinician Administered PTSD Scale
Time Frame: baseline and 10 weeks
|
Structured Clinical Interview focused on symptoms of Posttraumatic Stress Disorder
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baseline and 10 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Robert D Beck, Ph.D, Michael E. DeBakey VA Medical Center
- Principal Investigator: Whitney L Brown, Psy.D, Michael E. DeBakey VA Medical Center
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
March 1, 2011
Primary Completion (Anticipated)
August 1, 2011
Study Completion (Anticipated)
August 1, 2011
Study Registration Dates
First Submitted
March 9, 2011
First Submitted That Met QC Criteria
March 11, 2011
First Posted (Estimate)
March 14, 2011
Study Record Updates
Last Update Posted (Estimate)
March 17, 2011
Last Update Submitted That Met QC Criteria
March 16, 2011
Last Verified
March 1, 2011
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- H-28115
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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