Iron Metabolism in Dragon Boat Athletes

Iron Metabolism in Dragon Boat Athletes - An Analysis of Changes in Blood Count Parameters Under Sport-specific Stress

The purpose of the study is:

• To investigate the effect of sport-specific stress in the iron metabolism of dragon boat athletes
• To investigate the effects of sport-specific stress in the activity of pro-hepcidin and hepcidin

Study Overview

• Status: Completed
• Conditions: Anaemia
• Intervention / Treatment: Other: specific dragon boating training intervention; Other: specific dragon boat intervention

Detailed Description

This investigation evaluates the effects of sport-specific stress in iron metabolism of dragon boat athletes. Recent studies showed a significant increase in hepcidin activity under exercise (Röcker L. et al.(2005): Iron regulatory protein hepcidin is increased in female athletes after a marathon. European Journal of Applied Physiology, S. 95, 569-571)which possibly influences the iron metabolism.

In particular in this investigation the activity of pro-hepcidin and hepcidin under sport-specific stress is analysed. Therefore elite dragonboat athletes will be included to this study. Every athlete is tested once. At one exercise day from every athlete the iron metabolism especially the change of hepcidin, prohepcidin and iron before and after a specific dragonboat intervention is analysed.

• Study Type: Interventional
• Enrollment (Anticipated): 40
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• athletes performing dragon boat sport

Exclusion Criteria:

• acute clinically significant intercurrent diseases

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: Non-Randomized
• Interventional Model: Single Group Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: sports intervention male; male athletes of the german national dragon boat team	Other: specific dragon boating training intervention; male athletes of the german national dragon boat team performing three specific training units at one day
Active Comparator: sports intervention women; women athletes of the german national dragon boat team	Other: specific dragon boat intervention; women athletes of the german national dragon boat team performing two specific training units and one weight lifting test at one day

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
change from Baseline in prohepcidin after performing dragonboating	one meassurement of prohepcidin immediate before and within three hours after performing two to four specific dragonboat interventions at the same day	pre and post exercise intervention at the same day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
haematocrit	one meassurement of haematocrit immediate before and within three hours after performing two to four specific dragonboat intervention at the same day	pre and post exercise intervention at the same day
value of reticulocytes	one meassurement of reticulocytes immediate before performing two to four specific dragonboat interventions	pre exercise
value of hypochromic erythrocytes	one meassurement of hypochromic erythrocytes immediate before performing two to four specific dragonboat interventions	pre exercise
change from Baseline in serum iron after performing dragonboating	one meassurement of serum iron immediate before and within three hours after performing two to four specific dragonboat interventions at the same day	pre and post exercise intervention at the same day
value of transferrin	one meassurement of transferrin immediate before performing two to four specific dragonboat interventions	pre exercise
value of transferrin saturation	one meassurement of transferrin saturation immediate before performing two to four specific dragonboat interventions	pre exercise
value of ferritin	one meassurement of ferritin immediate before performing two to four specific dragonboat interventions	pre exercise
change from Baseline in hepcidin after performing dragonboating	one meassurement of hepcidin immediate before and within three hours after performing two to four specific dragonboat interventions at the same day	pre and post exercise intervention at the same day

Collaborators and Investigators

• Sponsor: University of Giessen
• Collaborators: MVZ für Laboratoriumsmedizin Koblenz; Deutscher Drachenboot Verband e.V.
• Investigators: Principal Investigator: Andree Hillebrecht, Dr. med., Department of sportsmedicine- University Giessen

Study record dates

Study Major Dates

• Study Start: April 1, 2011
• Primary Completion (Actual): April 1, 2012
• Study Completion (Actual): April 1, 2012

Study Registration Dates

• First Submitted: August 31, 2011
• First Submitted That Met QC Criteria: September 7, 2011
• First Posted (Estimate): September 9, 2011

Study Record Updates

• Last Update Posted (Estimate): July 24, 2012
• Last Update Submitted That Met QC Criteria: July 21, 2012
• Last Verified: July 1, 2012

More Information

Terms related to this study

• Keywords: hepcidin; anaemia; sport; iron; iron metabolism; dragon boating; sport-specific stress
• Additional Relevant MeSH Terms: Hematologic Diseases; Anemia; Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Anti-Infective Agents, Local; Anti-Infective Agents; Peripheral Nervous System Agents; Enzyme Inhibitors; Analgesics; Sensory System Agents; Anti-Inflammatory Agents, Non-Steroidal; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Antirheumatic Agents; Cyclooxygenase Inhibitors; Dermatologic Agents; Antipruritics; Salicylates; Methyl salicylate; Menthol; Camphor
• Other Study ID Numbers: Gi-02-2011