Clinico-Epidemiological Profile Of Acquired Aplastic Anemia Among Children At Assiut Governorate .

Clinico_Epidemiological Profile Of Acquired Aplastic Anemia Among Children At Assiut Governorate.

1. Assessment the clinical presentation and epidemiological profile of children with acquired aplastic anemia.
2. Determining the possible risk factors and associated conditions contributing to the development of acquired aplastic anemia.

Study Overview

• Status: Not yet recruiting
• Conditions: Acquired Aplastic Anaemia
• Intervention / Treatment: Other: observational case series study no intervention

Detailed Description

Aplastic anaemia is a term describing the common findings of pancytopenia and marrow hypoplasia from arising variety of disease states, including acquired aplastic anaemia and a variety of congenital marrow failure states(1). The global incidence of paediatric AA varies geographically, with rates of 2 to 3 cases per million per year in Europe, but higher in East Asia and certain developing regions(2) .Among Egyptian Children, inherited bone marrow failure syndromes (BMFS), including AA, constitute about 10-15%of all BMFS and up to 30% of paediatric BMFS ,with an average of 65 cases per million live births each year .Acquired AA remains the predominant from in older children and adolescent , while inherited forms are more common in younger children(3).The clinical presentation of aplastic anaemia regularly consists of symptoms associated with pancytopenia, including fatigue, pallor, bruising, bleeding, and extended susceptibility to infections(4). Identified etiologic risk factors include infections of viral origin, such as hepatitis-associated, Epstein-Barr, parvovirus, human immunodeficiency virus, varicella zoster, measles and other viruses, as well as exposure to toxic chemicals (e.g. benzene, pesticides and insecticides) and ionizing radiation (5). Over the last three decades, bone marrow transplantation (BMT) from a matched related donor (MRD) has been the treatment of choice for children with acquired AA (6) The Rationale of our study: aplastic anaemia in children is a serious ,life threatening bone marrow failure syndrome ,often resulting from immune-mediated destruction of hematopoietic stem cell triggered by factors such as viral infections, environmental toxin, or genetic predispositions and requires precise diagnosis to distinguish from inherited bone marrow failure syndromes or hypoplastic myelodysplastic syndrome to guide appropriate treatment strategies .

The Research question: What is the clinico-epidemiological profile of acquired aplastic anaemia among children at Assiut governorate.

• Study Type: Observational
• Enrollment (Estimated): 35

Contacts and Locations

• Study Contact: Name: Sara Ramadan Hassanein, Resident doctor; Phone Number: +2001018426240; Email: sararamadan25399@gmail.com
• Study Contact Backup: Name: Hamdy Mohamed Mohamed, Lecturer at familly medicine; Phone Number: +2001000882184; Email: dhamdy2003@med.aun.edu.eg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Children at 1 to 18 years old diagnosed with acquired aplastic anemia at assuit governorate from october 2020 to october 2026

Description

Inclusion Criteria:

• 1- Children aged 1-18 years old diagnosed with acquired aplastic anemia 2-Fulfillment of the diagnostic criteria for acquired AA 3-patient with complete medical records,including diagnostic ,labaratory and treatement data 4-Diagnosed or treated at assuit university children hospital and the central health insurance clinic at assuit Governorate (october 2020 to october 2026)

Exclusion Criteria:

• 1-children with congental bone marrow failure syndrome 2-patient with a history of chemotherapy or radiotherapy prior to diagnosis 2-cases with incomplete medical or insufficient medical records that prevented confirmination of diagnosis or extraction of essential study data

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Acquired Aplastic Anemia among children	Determine the clinic-epidemiological profile of acquired aplastic anemia among children at assiut governorate	from October 2020 to October 2026
determine the clinico-Epidemiological profile of acquired aplastic anemia among children at assuit governorate	To descripe and record clinical characteristic ,management,and outcomes of the included cases	from october 2020 to october 2026

Collaborators and Investigators

• Sponsor: Assiut University
• Investigators: Principal Investigator: Mostafa Mohamed Embaby, professor of pediatic, Departement of Familly medicine Assuit University

Study record dates

Study Major Dates

• Study Start (Estimated): December 1, 2025
• Primary Completion (Estimated): October 30, 2026
• Study Completion (Estimated): November 30, 2026

Study Registration Dates

• First Submitted: November 21, 2025
• First Submitted That Met QC Criteria: November 21, 2025
• First Posted (Actual): December 2, 2025

Study Record Updates

• Last Update Posted (Actual): December 2, 2025
• Last Update Submitted That Met QC Criteria: November 21, 2025
• Last Verified: November 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: Aplastic anemia in children .

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No