Evaluation of a Systematic Approach to Weaning From Mechanical Ventilation

Implantation of a Multidisciplinary Ventilator-weaning Protocol in a Intensive Care Unit of Teaching Hospital of Federal University of Uberlandia

Prolongation of mechanical ventilation poses serious personal and financial threats to healthcare consumers.

The investigators objectives are create and implement an multidisciplinary evidenced-based ventilator-weaning protocol to assess whether a systematic approach compared with the physician's judgment only decreases time spent on the ventilator, complications of mechanical ventilation and length of stay in critical care unit.

Study Overview

• Status: Completed
• Conditions: Weaning Failure; Complication of Respirator [Ventilator]
• Intervention / Treatment: Other: Multidisciplinary weaning-ventilator protocol

• Study Type: Interventional
• Enrollment (Actual): 235
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Brazil
  • Minas Gerais
    • Uberlandia, Minas Gerais, Brazil, 38400-902
      • Federal University of Uberlândia

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• remain in mechanical ventilation for more than 24 hours
• begin weaning from mechanical ventilation

Exclusion Criteria:

• admitted in the unit already in weaning from mechanical ventilation

Study Plan

How is the study designed?

Design Details

• Allocation: Non-Randomized
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Protocol-directed; Discontinuation of ventilation was based in multidisciplinary protocol.	Other: Multidisciplinary weaning-ventilator protocol; We implemented a multidisciplinary protocol for weaning from mechanical ventilation.This consist of a daily screening for readiness, performing a spontaneous breathing test, evaluation of signs of intolerance and decision on extubation.; Other Names: Weaning-ventilator protocol
No Intervention: Usual care; Discontinuation of ventilation was left entirely to the discretion of the physicians.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Mortality	length of ICU stay (days)
Duration of Weaning From Mechanical Ventilation	days
Duration of Mechanical Ventilation	days
Length of Intensive Care Unit Stay	days

Collaborators and Investigators

• Sponsor: Federal University of Uberlandia
• Investigators: Principal Investigator: Liliane Barbosa da Silva Passos, Federal University of Uberlândia; Study Chair: Thulio Marquez Cunha, Federal University of Uberlândia; Study Chair: Carlos Henrique Alves de Rezende, MD, Federal University of Uberlândia

Study record dates

Study Major Dates

• Study Start: January 1, 2011
• Primary Completion (Actual): January 1, 2012
• Study Completion (Actual): January 1, 2012

Study Registration Dates

• First Submitted: November 27, 2011
• First Submitted That Met QC Criteria: November 29, 2011
• First Posted (Estimate): November 30, 2011

Study Record Updates

• Last Update Posted (Estimate): March 4, 2013
• Last Update Submitted That Met QC Criteria: January 27, 2013
• Last Verified: January 1, 2013

More Information

Terms related to this study

• Keywords: ventilator weaning; protocol
• Other Study ID Numbers: Desmame