Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism (NMDA-Autism)

January 13, 2017 updated by: University Hospital, Tours

Autism and Glutamatergic Synapse : Research of Genetic Mutations and Identification of Clinical and Neurophysiological Markers.

Neurophysiological, Molecular and Developmental Analysis of the glutamate synapse in Autism

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Analysis about 50 genes in glutamate synapse

Study Type

Interventional

Enrollment (Actual)

497

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Brest, France, 29000
        • CHRU - Centre de Ressources Autisme (CRA)
      • Rouen, France, 76000
        • CHS du Rouvray
      • Tours, France, 37000
        • Chru - Cic
      • Tours, France, F-37000
        • CHRU - Pédopsychiatrie

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

2 years and older (Child, Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • have a Pervasive Developmental Disorder

Exclusion Criteria:

  • N/A

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Autism
Analysis of the glutamate synapse in autism
Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
Other: Relative
Analysis of the glutamate synapse in autism
Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
Other: Major control
DNA collection
Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
Other: Minor control
auditory evoked potentials
Other: Auditory evoked potentials
auditory evoked potentials

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
screening of about 50 genes encoding proteins of the NMDA receptor complex, chosen according to their chromosomal localisation located in hotspots depicted by genome-wide screens in large population of autistic patients
Time Frame: two years
two years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Tours

Investigators

  • Study Director: Frédérique BONNET-BRILHAULT, MD PHD, University François Rabelais of TOURS

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2009

Primary Completion (Actual)

January 1, 2011

Study Completion (Actual)

June 1, 2014

Study Registration Dates

First Submitted

January 15, 2013

First Submitted That Met QC Criteria

January 16, 2013

First Posted (Estimate)

January 17, 2013

Study Record Updates

Last Update Posted (Estimate)

January 16, 2017

Last Update Submitted That Met QC Criteria

January 13, 2017

Last Verified

January 1, 2017

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • AORT08-FBB/NMDA-Autism
  • 2008-A01162-53 (Other Identifier: ID RCB)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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