Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable CAD in Post MI Patients (TIGRIS)

TIGRIS: Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable Coronary Artery dISease in Post Myocardial Infarction Patients

THis study is intended to provide contemporary data on the burden of disease in patients 1 to 3 years post-MI, including a description of patient characteristics, current treatment patterns, rate of major CV events, and healthcare resource utilization in a 'real world' patient population at high atherothrombotic risk.

Study Overview

• Status: Terminated
• Conditions: Stable Coronary Artery Disease (CAD), Myocardial Infarction

Detailed Description

TIGRIS is a multinational, multi-centre, observational, prospective, longitudinal cohort study which will include stable CAD patients with history of MI 1-3 years ago and high risk of developing atherothrombotic events in a real world setting. The follow-up period is 3 years.

Patients will undergo clinical assessments and receive standard medical care as determined by the treating physician. Patients will not receive experimental intervention or experimental treatment as a consequence of their participation in the study.

• Study Type: Observational
• Enrollment (Actual): 9284

Contacts and Locations

Study Locations

• Argentina
  • Buenos Aires, Argentina
    • Research Site
  • Cordoba, Argentina
    • Research Site
  • Corrientes, Argentina
    • Research Site
  • Mendoza, Argentina
    • Research Site
  • Salta, Argentina
    • Research Site
  • Santa Fe de la Vera Cruz, Argentina
    • Research Site
• Australia
  • New South Wales
    • Coffs Harbour, New South Wales, Australia
      • Research Site
    • Concord, New South Wales, Australia
      • Research Site
    • Kogarh, New South Wales, Australia
      • Research Site
    • Liverpool, New South Wales, Australia
      • Research Site
    • Newcastele, New South Wales, Australia
      • Research Site
    • St Leonards, New South Wales, Australia
      • Research Site
    • Wollongong, New South Wales, Australia
      • Research Site
  • Queensland
    • Brisbane, Queensland, Australia
      • Research Site
    • Nambour, Queensland, Australia
      • Research Site
    • Southport, Queensland, Australia
      • Research Site
    • Woolloongabba, Queensland, Australia
      • Research Site
  • Victoria
    • Epping, Victoria, Australia
      • Research Site
    • Parkville, Victoria, Australia
      • Research Site
    • Richmond, Victoria, Australia
      • Research Site
  • Western Australia
    • Fremantle, Western Australia, Australia
      • Research Site
    • Nedlands, Western Australia, Australia
      • Research Site
• Belgium
  • Aalst, Belgium
    • Research Site
  • Bonheiden, Belgium
    • Research Site
  • Brasschaat, Belgium
    • Research Site
  • Bruxelles, Belgium
    • Research Site
  • Genk, Belgium
    • Research Site
  • Gent, Belgium
    • Research Site
  • Kortrijk, Belgium
    • Research Site
  • Oostende, Belgium
    • Research Site
  • Overpelt, Belgium
    • Research Site
  • Veurne, Belgium
    • Research Site
• Brazil
  • Mato Grosso Do Sul
    • Campo Grande, Mato Grosso Do Sul, Brazil
      • Research Site
  • Santa Cantarina
    • Blumenal, Santa Cantarina, Brazil
      • Research Site
  • Sao Paulo
    • Marilia, Sao Paulo, Brazil
      • Research Site
    • Sao Jose do Rio Preto, Sao Paulo, Brazil
      • Research Site
• Canada
  • Quebec, Canada
    • Research Site
  • New Brunswick
    • Saint John, New Brunswick, Canada
      • Research Site
  • Ontario
    • Brampton, Ontario, Canada
      • Research Site
    • Cambridge, Ontario, Canada
      • Research Site
    • Hamilton, Ontario, Canada
      • Research Site
    • London, Ontario, Canada
      • Research Site
    • Newmarket, Ontario, Canada
      • Research Site
    • North York, Ontario, Canada
      • Research Site
    • Toronto, Ontario, Canada
      • Research Site
    • Windsor, Ontario, Canada
      • Research Site
  • Quebec
    • Greenfield Park, Quebec, Canada
      • Research Site
    • Montreal, Quebec, Canada
      • Research Site
    • Saint-Jerome, Quebec, Canada
      • Research Site
    • Thetford Mines, Quebec, Canada
      • Research Site
• China
  • Beijing
    • Beijing, Beijing, China
      • Research Site
  • Chongqing
    • Chongqing, Chongqing, China
      • Research Site
  • Gansu
    • Lanzhou, Gansu, China
      • Research Site
  • Guangdong
    • Guangzhou, Guangdong, China
      • Research Site
  • Jiangsu
    • Nanjing, Jiangsu, China
      • Research Site
    • Wuxi, Jiangsu, China
      • Research Site
    • Zhenjiang, Jiangsu, China
      • Research Site
  • Jilin
    • Changchun, Jilin, China
      • Research Site
  • Liaoning
    • Jinzhou, Liaoning, China
      • Research Site
  • Shandong
    • Jinan, Shandong, China
      • Research Site
  • Shanghai
    • Shanghai, Shanghai, China
      • Research Site
  • Shanxi
    • Xian, Shanxi, China
      • Research Site
  • Shanyuan
    • Taiyuan, Shanyuan, China
      • Research Site
  • Tianjin
    • Tianjin, Tianjin, China
      • Research Site
  • Yunnan
    • Kunming, Yunnan, China
      • Research Site
• Colombia
  • Antioquia
    • Medellin, Antioquia, Colombia
      • Research Site
  • Atlantico
    • Barranquilla, Atlantico, Colombia
      • Research Site
  • Caldas
    • Cartagena, Caldas, Colombia
      • Research Site
    • Manizales, Caldas, Colombia
      • Research Site
  • Santander Dept
    • Bucaramanga, Santander Dept, Colombia
      • Research Site
  • Valle Del Cauca
    • Cali, Valle Del Cauca, Colombia
      • Research Site
• Denmark
  • Alborg, Denmark
    • Research Site
  • Haderslev, Denmark
    • Research Site
  • Hellerup, Denmark
    • Research Site
  • Kobenhavn, Denmark
    • Research Site
  • Kobenhavn NV, Denmark
    • Research Site
  • Kobenhavn S, Denmark
    • Research Site
  • Randers, Denmark
    • Research Site
  • arhus N, Denmark
    • Research Site
• Finland
  • Jyvaskyla, Finland
    • Research Site
  • Rovaniemi, Finland
    • Research Site
  • Tampere, Finland
    • Research Site
  • Turku, Finland
    • Research Site
• France
  • Abbeville, France
    • Research Site
  • Arras, France
    • Research Site
  • Boulogne-Billancourt, France
    • Research Site
  • Briis Sous Forge, France
    • Research Site
  • Corbeille Essone, France
    • Research Site
  • Dijon Cedex, France
    • Research Site
  • La Rochelle, France
    • Research Site
  • Langres, France
    • Research Site
  • Le Chesnay, France
    • Research Site
  • Le Coudray, France
    • Research Site
  • Lyon, France
    • Research Site
  • Marseille, France
    • Research Site
  • Nice Cedex 1, France
    • Research Site
  • Roubaix, France
    • Research Site
  • Salouel, France
    • Research Site
  • Toulouse, France
    • Research Site
• Germany
  • Berlin, Germany
    • Research Site
  • Bochum, Germany
    • Research Site
  • Chemnitz, Germany
    • Research Site
  • Cloppenburg, Germany
    • Research Site
  • Coburg, Germany
    • Research Site
  • Dresden, Germany
    • Research Site
  • Erfurt, Germany
    • Research Site
  • Erlangen, Germany
    • Research Site
  • Essen, Germany
    • Research Site
  • Frankfurt, Germany
    • Research Site
  • Frankfurt M, Germany
    • Research Site
  • Hamburg, Germany
    • Research Site
  • Heidelberg, Germany
    • Research Site
  • Kiel, Germany
    • Research Site
  • Koblenz, Germany
    • Research Site
  • Koln, Germany
    • Research Site
  • Leipzig, Germany
    • Research Site
  • Leverkusen, Germany
    • Research Site
  • Lubeck, Germany
    • Research Site
  • Ludwigshafen, Germany
    • Research Site
  • Mainz, Germany
    • Research Site
  • Merseburg, Germany
    • Research Site
  • Monchengladbach, Germany
    • Research Site
  • Munchen, Germany
    • Research Site
  • Potsdam, Germany
    • Research Site
  • Soltau, Germany
    • Research Site
  • Stuttgart, Germany
    • Research Site
  • Ulm, Germany
    • Research Site
• India
  • Andhra Pradesh
    • Hyderabad, Andhra Pradesh, India
      • Research Site
  • Delhi
    • New Delhi, Delhi, India
      • Research Site
  • Gujarat
    • Surat, Gujarat, India
      • Research Site
  • Karnataka
    • Bangalore, Karnataka, India
      • Research Site
  • Kerala
    • Thrisur, Kerala, India
      • Research Site
    • Trivandrum, Kerala, India
      • Research Site
  • Madhya Pradesh
    • Indore, Madhya Pradesh, India
      • Research Site
  • Maharashtra
    • Mumbai, Maharashtra, India
      • Research Site
    • Pune, Maharashtra, India
      • Research Site
  • Punjab
    • Mohali, Punjab, India
      • Research Site
  • Rajasthan
    • Jaipur, Rajasthan, India
      • Research Site
  • Tamil Nadu
    • Chennai, Tamil Nadu, India
      • Research Site
    • Madurai, Tamil Nadu, India
      • Research Site
  • Uttar Pradesh
    • Noida, Uttar Pradesh, India
      • Research Site
  • West Bengal
    • Kolkata, West Bengal, India
      • Research Site
• Italy
  • Ancona, Italy
    • Research Site
  • Bologna, Italy
    • Research Site
  • Catania, Italy
    • Research Site
  • Lagosanto FE, Italy
    • Research Site
  • Lido di Camaiore, Italy
    • Research Site
  • Massa Carrara, Italy
    • Research Site
  • Milano, Italy
    • Research Site
  • Napoli, Italy
    • Research Site
  • Nuoro, Italy
    • Research Site
  • Palermo, Italy
    • Research Site
  • Perugia, Italy
    • Research Site
  • Prato, Italy
    • Research Site
  • Sassari, Italy
    • Research Site
  • Treviso, Italy
    • Research Site
• Japan
  • Aichi
    • Toyoake-shi, Aichi, Japan
      • Research Site
  • Chiba
    • Chiba-shi, Chiba, Japan
      • Research Site
    • Kisarazu-shi, Chiba, Japan
      • Research Site
  • Ehime
    • Matsuyama-shi, Ehime, Japan
      • Research Site
  • Fukui
    • Fukui-shi, Fukui, Japan
      • Research Site
  • Fukuoka
    • Fukuoka-shi, Fukuoka, Japan
      • Research Site
    • Kurume-shi, Fukuoka, Japan
      • Research Site
  • Gunma
    • Maebashi-shi, Gunma, Japan
      • Research Site
  • Hiroshima
    • Hiroshima-shi, Hiroshima, Japan
      • Research Site
  • Hokkaido
    • Sapporo-shi, Hokkaido, Japan
      • Research Site
    • Tomakomai-shi, Hokkaido, Japan
      • Research Site
  • Hyogo
    • Amagasaki-shi, Hyogo, Japan
      • Research Site
  • Ishikawa
    • Kanazawa-shi, Ishikawa, Japan
      • Research Site
  • Iwate
    • Morioka-shi, Iwate, Japan
      • Research Site
  • Kanagawa
    • Isehara-shi, Kanagawa, Japan
      • Research Site
    • Sagamihara-shi, Kanagawa, Japan
      • Research Site
    • Yokohama-shi, Kanagawa, Japan
      • Research Site
  • Kouchi
    • Kouchi-shi, Kouchi, Japan
      • Research Site
  • Kumamoto
    • Kumamoto-shi, Kumamoto, Japan
      • Research Site
  • Miyagi
    • Sendai-shi, Miyagi, Japan
      • Research Site
  • Nara
    • Tenri-shi, Nara, Japan
      • Research Site
  • Osaka
    • Hirakata-shi, Osaka, Japan
      • Research Site
    • Osaka-shi, Osaka, Japan
      • Research Site
    • Suita-shi, Osaka, Japan
      • Research Site
  • Shiga
    • Kusatsu-shi, Shiga, Japan
      • Research Site
  • Shizuoka
    • Izunokuni-shi, Shizuoka, Japan
      • Research Site
    • Shizuoka-shi, Shizuoka, Japan
      • Research Site
  • Tokushima
    • Komatsujima-shi, Tokushima, Japan
      • Research Site
  • Tokyo
    • Bunkyo-ku, Tokyo, Japan
      • Research Site
    • Chuo-Ku, Tokyo, Japan
      • Research Site
  • Wakayama
    • Wakayama-shi, Wakayama, Japan
      • Research Site
• Korea, Republic of
  • Cheongju-si
    • Chungcheongbuk-do, Cheongju-si, Korea, Republic of
      • Research Site
  • Gangwon-do
    • Wonju-si, Gangwon-do, Korea, Republic of
      • Research Site
  • Gyeongsangnam-do
    • Jinju, Gyeongsangnam-do, Korea, Republic of
      • Research Site
  • Jeollabuk-do
    • Jeonju-si, Jeollabuk-do, Korea, Republic of
      • Research Site
  • Jung-gu
    • Daejeon, Jung-gu, Korea, Republic of
      • Research Site
  • Nam-gu
    • Daegu, Nam-gu, Korea, Republic of
      • Research Site
  • Seo-gu
    • Busan, Seo-gu, Korea, Republic of
      • Research Site
  • South Jeolla
    • Gwangju, South Jeolla, Korea, Republic of
      • Research Site
  • Sudogwon
    • Seoul, Sudogwon, Korea, Republic of
      • Research Site
• Mexico
  • Chihuahua, Mexico
    • Research Site
  • Oaxaca, Mexico
    • Research Site
  • Puebla, Mexico
    • Research Site
  • San Luis Potosi, Mexico
    • Research Site
  • Baja California
    • Tijuana, Baja California, Mexico
      • Research Site
  • Coahuila
    • Torreon, Coahuila, Mexico
      • Research Site
  • Distrito Federal
    • Ciudad de Mexico, Distrito Federal, Mexico
      • Research Site
  • Estado De Mexico
    • Toluca, Estado De Mexico, Mexico
      • Research Site
  • Jalisco
    • Guadalajara, Jalisco, Mexico
      • Research Site
  • Queretaro De Arteaga
    • Queretaro, Queretaro De Arteaga, Mexico
      • Research Site
• Netherlands
  • Amsterdam, Netherlands
    • Research Site
  • Arnhem, Netherlands
    • Research Site
  • Blaricum, Netherlands
    • Research Site
  • Delft, Netherlands
    • Research Site
  • Den Haag, Netherlands
    • Research Site
  • Doetinchem, Netherlands
    • Research Site
  • Ede, Netherlands
    • Research Site
  • Groningen, Netherlands
    • Research Site
  • Haarlem, Netherlands
    • Research Site
  • Hardenberg, Netherlands
    • Research Site
  • Heerlen, Netherlands
    • Research Site
  • Hoofddorp, Netherlands
    • Research Site
  • Hoogeveen, Netherlands
    • Research Site
  • IJssel, Netherlands
    • Research Site
  • Meppel, Netherlands
    • Research Site
  • Sittard-Geleen, Netherlands
    • Research Site
  • Zutphen, Netherlands
    • Research Site
• Norway
  • Fredrikstad, Norway
    • Research Site
  • Oslo, Norway
    • Research Site
  • Stavanger, Norway
    • Research Site
• Portugal
  • Braga, Portugal
    • Research Site
  • Canelas, Portugal
    • Research Site
  • Faro, Portugal
    • Research Site
  • Lisboa, Portugal
    • Research Site
  • Porto, Portugal
    • Research Site
  • Senhora da Hora, Portugal
    • Research Site
  • Setubal, Portugal
    • Research Site
  • Viana do Castelo, Portugal
    • Research Site
• Romania
  • Arad, Romania
    • Research Site
  • Braila, Romania
    • Research Site
  • Bucuresti, Romania
    • Research Site
  • Cluj Napoca, Romania
    • Research Site
  • Craiova, Romania
    • Research Site
  • Drobeta - Turnu Severin, Romania
    • Research Site
  • Focsani, Romania
    • Research Site
  • Pitesti, Romania
    • Research Site
  • Sibiu, Romania
    • Research Site
  • Slatina, Romania
    • Research Site
  • Timisoara, Romania
    • Research Site
• Spain
  • Alicante, Spain
    • Research Site
  • Almeria, Spain
    • Research Site
  • Granada, Spain
    • Research Site
  • Lleida, Spain
    • Research Site
  • Madrid, Spain
    • Research Site
  • Murcia, Spain
    • Research Site
  • Andalusia
    • Sevilla, Andalusia, Spain
      • Research Site
  • Balearic Islands
    • Palma de Mallorca, Balearic Islands, Spain
      • Research Site
  • Castile-La Mancha
    • Toledo, Castile-La Mancha, Spain
      • Research Site
  • Catalonia
    • Barcelona, Catalonia, Spain
      • Research Site
    • Vic, Catalonia, Spain
      • Research Site
  • Extremadura
    • Caceres, Extremadura, Spain
      • Research Site
  • Galicia
    • Santiago de Compostela, Galicia, Spain
      • Research Site
  • Granada
    • Baza, Granada, Spain
      • Research Site
• Turkey
  • Ankara, Turkey
    • Research Site
  • Aydin, Turkey
    • Research Site
  • Diyarbak?r, Turkey
    • Research Site
  • Istanbul, Turkey
    • Research Site
  • Merkez, Turkey
    • Research Site
  • Mersin, Turkey
    • Research Site
• United Kingdom
  • Airdrie, United Kingdom
    • Research Site
  • Cambridge, United Kingdom
    • Research Site
  • East Kilbride, United Kingdom
    • Research Site
  • London, United Kingdom
    • Research Site
  • Portadown, United Kingdom
    • Research Site
  • Sheffield, United Kingdom
    • Research Site
  • Taunton, United Kingdom
    • Research Site
  • Wolverhampton, United Kingdom
    • Research Site
• United States
  • Alabama
    • Huntsville, Alabama, United States
      • Research Site
  • California
    • Los Angeles, California, United States
      • Research Site
    • Santa Ana, California, United States
      • Research Site
    • Torrance, California, United States
      • Research Site
    • Ventura, California, United States
      • Research Site
  • Florida
    • Clearwater, Florida, United States
      • Research Site
    • Miami, Florida, United States
      • Research Site
    • Tallahassee, Florida, United States
      • Research Site
  • Georgia
    • Tucker, Georgia, United States
      • Research Site
  • Illinois
    • Arlington Heights, Illinois, United States
      • Research Site
    • Englewood, Illinois, United States
      • Research Site
  • Indiana
    • Lebanon, Indiana, United States
      • Research Site
  • Maine
    • Auburn, Maine, United States
      • Research Site
    • Bangor, Maine, United States
      • Research Site
  • Maryland
    • Columbia, Maryland, United States
      • Research Site
  • Michigan
    • Jackson, Michigan, United States
      • Research Site
  • Minnesota
    • Minneapolis, Minnesota, United States
      • Research Site
  • New York
    • Manhasset, New York, United States
      • Research Site
  • North Carolina
    • Chapel Hill, North Carolina, United States
      • Research Site
    • Durham, North Carolina, United States
      • Research Site
  • Ohio
    • Sandusky, Ohio, United States
      • Research Site
  • Pennsylvania
    • Abington, Pennsylvania, United States
      • Research Site
    • Doylestown, Pennsylvania, United States
      • Research Site
    • Pittsburgh, Pennsylvania, United States
      • Research Site
    • Sayre, Pennsylvania, United States
      • Research Site
  • Rhode Island
    • Providence, Rhode Island, United States
      • Research Site
  • Tennessee
    • Jackson, Tennessee, United States
      • Research Site
  • Texas
    • Houston, Texas, United States
      • Research Site
    • Plano, Texas, United States
      • Research Site
  • Vermont
    • Burlington, Vermont, United States
      • Research Site
  • Virginia
    • Falls Church, Virginia, United States
      • Research Site
    • Manassas, Virginia, United States
      • Research Site
  • Washington
    • Seattle, Washington, United States
      • Research Site
    • Spokane, Washington, United States
      • Research Site
• Venezuela
  • Carabobo
    • Valencia, Carabobo, Venezuela
      • Research Site
  • Miranda
    • Caracas, Miranda, Venezuela
      • Research Site

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Stable CAD patients aged 50 years or older with documented history of presumed spontaneous MI with their most recent MI occurring 1 to 3 years prior to enrollment and at least one additional risk factor for atherothrombotic events

Description

Inclusion Criteria:

- Stable CAD patients aged 50 years or older with documented history of presumed spontaneous MI with their most recent MI occurring 1 to 3 years prior to enrollment and have at least 1 of the following risk factors: age ≥ 65 years; diabetes mellitus requiring medication; documented history of a second prior presumed spontaneous MI (>1 year ago); documented history of angiographic evidence of multivessel coronary artery disease; chronic renal dysfunction.

Exclusion Criteria:

• Presence of serious co-morbidities in the opinion of the investigator which may limit life expectancy (<1 year)
• Current participation in a blinded randomized clinical trial.
• Presence of any condition/circumstance which in the opinion of the investigator could significantly limit the complete follow up of the patient
• Patients receiving treatment of ticagrelor beyond 12 months, or off label use of ticagrelor.

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort
Stable CAD patients aged 50 years or older; Stable CAD patients aged 50 years or older with documented history of presumed spontaneous MI with their most recent MI occurring 1 to 3 years prior to enrollment and have at least 1 additional risk factor

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
MI, unstable angina with urgent revascularization, stroke, and death for any cause	Event rates (time to first occurrence of any event from the composite of MI, unstable angina with urgent revascularization, stroke or death for any cause) in a three-year follow-up period.	in a 3-year follow-up period
Healthcare resource utilization	Healthcare resource utilization associated with the events (MI, unstable angina with urgent revascularization, stroke or death for any cause) in a three-year follow-up period.	in a 3-year follow-up period

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Ischemic events (MI, unstable angina with urgent revascularization, ischemic stroke, CV death or death with unknown reason)	To describe the rate of ischemic events (time to first occurrence of any event from the composite of MI, unstable angina with urgent revascularization, ischemic stroke, CV death or death with unknown reason) in a three-year follow-up period.	in a 3-year follow-up period
Bleeding events which require medical attention	To describe the rate of bleeding events requiring medical attention.	in a 3 year follow-up period

Collaborators and Investigators

• Sponsor: AstraZeneca
• Investigators: Study Chair: Lin Zhang, M.D., PhD, AstraZeneca GMA; Principal Investigator: David Brieger, MBBS, PhD, Concord Repatriation General Hospital

Publications and helpful links

General Publications

• Bagai A, Ali FM, Gregson J, Alexander KP, Cohen MG, Sundell KA, Simon T, Westermann D, Yasuda S, Brieger D, Goodman SG, Nicolau JC, Granger CB, Pocock S. Multimorbidity, functional impairment, and mortality in older patients stable after prior acute myocardial infarction: Insights from the TIGRIS registry. Clin Cardiol. 2022 Nov 1. doi: 10.1002/clc.23915. Online ahead of print.
• Carnicelli AP, Owen R, Pocock SJ, Brieger DB, Yasuda S, Nicolau JC, Goodman SG, Cohen MG, Simon T, Westermann D, Hedman K, Andersson Sundell K, Granger CB. Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction. Open Heart. 2021 Dec;8(2):e001726. doi: 10.1136/openhrt-2021-001726.
• Russo JJ, Yan AT, Pocock SJ, Brieger D, Owen R, Sundell KA, Bagai A, Granger CB, Cohen MG, Yasuda S, Nicolau JC, Brandrup-Wognsen G, Westermann D, Simon T, Goodman SG. Determinants of long-term dual antiplatelet therapy use in post myocardial infarction patients: Insights from the TIGRIS registry. J Cardiol. 2022 Apr;79(4):522-529. doi: 10.1016/j.jjcc.2021.10.024. Epub 2021 Nov 29.
• Pocock S, Brieger DB, Owen R, Chen J, Cohen MG, Goodman S, Granger CB, Nicolau JC, Simon T, Westermann D, Yasuda S, Hedman K, Mellstrom C, Andersson Sundell K, Grieve R. Health-related quality of life 1-3 years post-myocardial infarction: its impact on prognosis. Open Heart. 2021 Feb;8(1):e001499. doi: 10.1136/openhrt-2020-001499.
• Nicolau JC, Brieger D, Owen R, Furtado RHM, Goodman SG, Cohen MG, Simon T, Westermann D, Granger CB, Grieve R, Yasuda S, Chen J, Hedman K, Mellstrom C, Brandrup-Wognsen G, Pocock SJ. Diabetes association with self-reported health, resource utilization, and prognosis post-myocardial infarction. Clin Cardiol. 2020 Dec;43(12):1352-1361. doi: 10.1002/clc.23476. Epub 2020 Nov 4.
• Westermann D, Goodman SG, Nicolau JC, Requena G, Maguire A, Chen JY, Granger CB, Grieve R, Pocock SJ, Blankenberg S, Vega AM, Yasuda S, Simon T, Brieger D; TIGRIS Study Investigators. Rationale and design of the long-Term rIsk, clinical manaGement, and healthcare Resource utilization of stable coronary artery dISease in post-myocardial infarction patients (TIGRIS) study. Clin Cardiol. 2017 Dec;40(12):1197-1204. doi: 10.1002/clc.22837. Epub 2017 Dec 16.
• Goodman SG, Nicolau JC, Requena G, Maguire A, Blankenberg S, Chen JY, Granger CB, Grieve R, Pocock SJ, Simon T, Yasuda S, Vega AM, Brieger D; TIGRIS Study Investigators. Longer-term oral antiplatelet use in stable post-myocardial infarction patients: Insights from the long Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease (TIGRIS) observational study. Int J Cardiol. 2017 Jun 1;236:54-60. doi: 10.1016/j.ijcard.2017.02.062. Epub 2017 Feb 21.

Helpful Links

• CSR Synopsis

Study record dates

Study Major Dates

• Study Start (Actual): June 19, 2013
• Primary Completion (Actual): March 31, 2017
• Study Completion (Actual): March 31, 2017

Study Registration Dates

• First Submitted: May 29, 2013
• First Submitted That Met QC Criteria: May 31, 2013
• First Posted (Estimate): June 3, 2013

Study Record Updates

• Last Update Posted (Actual): September 4, 2018
• Last Update Submitted That Met QC Criteria: August 30, 2018
• Last Verified: August 1, 2018

More Information

Terms related to this study

• Keywords: Coronary artery disease, Myocardial infarction
• Additional Relevant MeSH Terms: Ischemia; Pathologic Processes; Necrosis; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Myocardial Infarction; Infarction; Coronary Artery Disease; Myocardial Ischemia; Coronary Disease
• Other Study ID Numbers: NIS-CMC-DUM-2013/1