Dopaminergic Function and Food Reward

May 28, 2015 updated by: Sabine Frank, University Hospital Tuebingen

The broad aim of the study is to obtain a better understanding of alterations in mesolimbic reward pathways in adiposity based on the hypothesis of a hypofunctioning reward system in obesity.

This will be achieved by integrating a functional neuroimaging (fMRI) with behavioral reward tasks and the modulation of the dopamine level by dopamine depletion.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

36

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Germany
      • Tuebingen, Germany, 72076
        • University Clinic of Tuebingen, MEG Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

21 years to 45 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Female

Sampling Method

Non-Probability Sample

Study Population

community sample

Description

Inclusion Criteria:

  • female
  • healthy

Exclusion Criteria:

  • fMRI contraindications
  • claustrophobia

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
subjecst with different BMI
Dietary supplement: Dopamine depletion vs. Balanced aminoacid drink

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Differential brain functions in the dopaminergic reward system
Time Frame: 4 hours after intake of the dopamine depletion or balanced aminoacid drink
differential brain fuctions will be measured by blood oxygen level dependent effect.
4 hours after intake of the dopamine depletion or balanced aminoacid drink

Secondary Outcome Measures

Outcome Measure
Time Frame
amino acid level changes due to dopamine depletion
Time Frame: 4 hours after intake of the dopamine depletion or balanced aminoacid drink
4 hours after intake of the dopamine depletion or balanced aminoacid drink

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital Tuebingen

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Primary Completion (Actual)

March 1, 2014

Study Registration Dates

First Submitted

July 8, 2013

First Submitted That Met QC Criteria

July 19, 2013

First Posted (Estimate)

July 24, 2013

Study Record Updates

Last Update Posted (Estimate)

May 29, 2015

Last Update Submitted That Met QC Criteria

May 28, 2015

Last Verified

May 1, 2015

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • DAD

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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