Incubation of Alcohol Craving During Abstinence

November 18, 2013 updated by: National Institute on Drug Dependence, China

The Neural Mechanisms of the Incubation of Cue-induced Craving in Alcohol Dependence

In order to determine whether the 'incubation of craving' phenomenon also occurred in alcoholics, investigators employed an experimental approach to investigate the time course of cue-induced craving in alcoholism. Eighty male participants were randomly divided into Four groups, and they were assessed at 7, 14, 30, and 60 days of abstinence for cue-induced alcohol craving . Another group including 19 patients was repeatedly tested for the cue-induced alcohol craving at the above abstinence days. Other psychological and physiological measures were administered at the four abstinence time points.

Study Overview

Status

Completed

Conditions

Detailed Description

All subjects provided written informed consent after a full explanation of the protocol design.

Study Type

Observational

Enrollment (Actual)

99

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 60 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Sampling Method

Probability Sample

Study Population

alcohol dependence

Description

Inclusion Criteria:

  • met the criteria of DSM-IV for alcohol dependence
  • aged 18-60 years,male

Exclusion Criteria:

  • current or past history of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) axis I disorders
  • with other serious physical diseases (respiratory disorders, cardiovascular disease and so on)
  • other drug abuse except for nicotine

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Only
  • Time Perspectives: Prospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
changes of alcohol craving measured with visual analogue scales
Time Frame: abstained from alcohol for 7 days, 14 days, 30 days and 60 days
abstained from alcohol for 7 days, 14 days, 30 days and 60 days

Secondary Outcome Measures

Outcome Measure
Time Frame
heart rate changes
Time Frame: 7, 14, 30 and 60 days after abstained
7, 14, 30 and 60 days after abstained
blood pressure changes in different abstinence days
Time Frame: 7, 14, 30 and 60 days after abstained
7, 14, 30 and 60 days after abstained
skin conductance changes in different abstinence days
Time Frame: 7, 14, 30 and 60 days after abstained
7, 14, 30 and 60 days after abstained
changes of Alcohol Urge Questionnaire
Time Frame: 7, 14, 30 and 60 days after abstained
7, 14, 30 and 60 days after abstained

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

National Institute on Drug Dependence, China

Collaborators

National Natural Science Foundation of China

Investigators

  • Study Director: Lin Lu, Prof., National Institute on Drug Dependence, China

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2011

Primary Completion (Actual)

March 1, 2013

Study Completion (Actual)

October 1, 2013

Study Registration Dates

First Submitted

November 8, 2013

First Submitted That Met QC Criteria

November 18, 2013

First Posted (Estimate)

November 25, 2013

Study Record Updates

Last Update Posted (Estimate)

November 25, 2013

Last Update Submitted That Met QC Criteria

November 18, 2013

Last Verified

November 1, 2013

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • nidd_peking

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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