Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction(POCD)

Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction After On-pump Cardiac Surgery

The aim of this study is to perform a whole-genome linkage analysis for identification of the susceptibility loci for POCD

Study Overview

• Status: Unknown
• Conditions: Cardiac Surgery Patients

Detailed Description

BACKGROUND: Postoperative cognitive dysfunction is probably the most frequent type of postoperative cognitive impairment. As it mainly affect the elderly population, POCD is receiving increasing attention. However, the pathophysiology of POCD remains incompletely understood. No study had elucidate why somebody are apt to suffer from POCD, but others not. In current study, we try to use GWAS technology to find out whether there is a correlation between POCD and gene specificity.

DESIGNING: 120 patients will be screened who are schedule to receive selective on-pump cardiac surgery， 5 ml blood of the patient will be collected before anesthesia induction. Investigetors will measure the cognitive function of the patients one day before surgery and 7 d after surgery and identify whether the patient suffer from POCD used in MMSE test. Randomly select 36 patients who suffer from POCD and 36 patients without POCD(control), GWAS technology will be used to screen the susceptibility gene between these two groups.

EXPECTED RESULTS ：Find out some susceptibility genes correlate to POCD.

CONCLUSIONS: The patients who are apt to suffer from POCD have some special susceptibility genes differ from normal people.

• Study Type: Observational
• Enrollment (Anticipated): 120

Contacts and Locations

Study Locations

• China
  • Shaanxi
    • Xi'an, Shaanxi, China, 710032
      • Recruiting
      • Xijing Hospital
      • Principal Investigator: Hailong Dong, MD, PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 60 years to 75 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Old patient(>60 y) who are schedule to receive of-pump cardiac surgery.

Description

Inclusion Criteria:

1. Age from 60 to 75 years old;
2. Schedule for on-pump cardiac surgery;
3. undergoing full intravenous anesthesia;
4. without hepatic, renal, pulmonary disease or full intravenous anesthesia surgery history;
5. Gave the informed consent.

Exclusion Criteria:

1. Emergency surgery;
2. A history of cerebrovascular disease;
3. The history of mental disease;
4. Long term use of sedative and antidepressant drugs;
5. Alcoholism;
6. serious vision, hearing impairment and inapprehensive language;
7. chromosomal abnormalities;
8. blood disease;
9. refused to sign the informed consent.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Experimental: Patient with POCD; Patients who suffer from POCD after surgery. The mini-mental state examination scale decline more than 1 SD of baseline after surgery.
Sham Comparator: patient without POCD; Patients who don't suffer from POCD after surgery. There is no obvious difference between pre-operation and post-operation in mini-mental state examination scale

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
single nucleotide polymorphisms(SNPs) of each patient	about 10 minutes before anesthesia induction

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
mini-mental state examination scale	the cognitive function	one day before surgery, 7 d after surgery

Collaborators and Investigators

• Sponsor: Xijing Hospital

Study record dates

Study Major Dates

• Study Start: March 1, 2013
• Primary Completion (Anticipated): September 1, 2014
• Study Completion (Anticipated): September 1, 2014

Study Registration Dates

• First Submitted: March 4, 2014
• First Submitted That Met QC Criteria: March 6, 2014
• First Posted (Estimate): March 11, 2014

Study Record Updates

• Last Update Posted (Estimate): August 15, 2014
• Last Update Submitted That Met QC Criteria: August 14, 2014
• Last Verified: August 1, 2014

More Information

Terms related to this study

• Keywords: cardiac surgery; GWAS; POCD; Susceptibility gene
• Additional Relevant MeSH Terms: Mental Disorders; Pathologic Processes; Postoperative Complications; Neurocognitive Disorders; Disease Attributes; Cognition Disorders; Cognitive Dysfunction; Postoperative Cognitive Complications; Disease Susceptibility
• Other Study ID Numbers: DONG2014POCD