Respiratory Muscles and Inspiratory Muscle Training (IMT)

April 15, 2019 updated by: Jordan Guenette, University of British Columbia

Effects of Inspiratory Muscle Training on Respiratory Muscle Mechanics and Haemodynamics in Healthy Adults

The effects of inspiratory muscle training (IMT) remain controversial. Many studies have examined the effect IMT has on exercise performance, but any changes to the body that come from IMT have yet to be looked at.

This study will look at how someone breathes can change after IMT. Understanding how IMT changes the body can help us use IMT in different treatments.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

25

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Canada
    • British Columbia
      • Vancouver, British Columbia, Canada, V6Z 1Y6
        • Centre for Heart Lung Innovation

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

19 years to 39 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Recreationally active, 'Moderate' or 'High' category on International Physical Activity Questionnaire Short form questionnaire
  • Able to read and understand English
  • Pulmonary function within normal limits

Exclusion Criteria:

  • History of or currently smoking
  • History or current symptoms of cardiopulmonary disease (including asthma and exercise induced asthma)
  • Currently participating and training in a sport at a provincial, national, or international level
  • Ulcer or tumor in the esophagus, a nasal septum deviation, or recent nasopharyngeal surgery
  • Allergies to latex or local anesthetic
  • Contraindications to exercise testing

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Inspiratory Muscle Training
Other: Inspiratory Muscle Training
6-weeks of inspiratory muscle training
Sham Comparator: Sham-Control Inspiratory Muscle Training
Inspiratory muscle training at a low intensity meant to elicit no physiological changes.
Other: Sham Inspiratory Muscle Training
A sham training procedure that is meant to elicit no physiologic changes

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Diaphragm Electromyography
Time Frame: Post Intervention - ie. immediately after 5 weeks of inspiratory muscle training

Using a multipair esophageal electrode catheter we will determine any changes to the electric activity of the diaphragm.

Diaphragm electromyography (EMG) has been expressed as %max. This unit is determined as the ratio of average EMG value (uV) divided by the maximal EMG activity (uV) generated during a maximal respiratory maneuver (inspiratory capacity during exercise).
Post Intervention - ie. immediately after 5 weeks of inspiratory muscle training

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Accessory Respiratory Muscle Activation
Time Frame: Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training

Using surface electromyography to determine the activation patterns of accessory respiratory muscles (scalene and sternocleidomastoid).

Data are expressed as %max. This value is determined by taking the average electromyography (EMG) activity divided by the maximal EMG activity generated during a maximal inspiratory maneuver (inspiratory capacity during exercise).
Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Dyspnoea
Time Frame: Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training

Using the modified Borg scale to assess changes in perceived dyspnoea after inspiratory muscle training.

The modified Borg scale is a 0-10 category ratio scale. The floor (0) of the scale is anchored subjectively to the subjects interpretation of "no breathing discomfort at all", and the ceiling (10) to represent "the most intense breathing discomfort they have experienced or could imagine experiencing".
Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training
Muscle Oxygenation
Time Frame: Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training
Using near-infrared spectroscopy to examine if there are any relative changes in concentration (∆umol/Litre) of deoxygenated hemoglobin (HHb) after training. Deoxygenated hemoglobin is used as a surrogate of oxygen extraction specific to the local vasculature of the vastus lateralis,
Post-intervention - ie. immediately after 5 weeks of inspiratory muscle training

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of British Columbia

Collaborators

Natural Sciences and Engineering Research Council, Canada

Investigators

  • Principal Investigator: Jordan A Guenette, PhD, University of British Columbia/Centre for Heart Lung Innovation

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 2014

Primary Completion (Actual)

July 1, 2016

Study Completion (Actual)

July 1, 2016

Study Registration Dates

First Submitted

September 16, 2014

First Submitted That Met QC Criteria

September 17, 2014

First Posted (Estimate)

September 18, 2014

Study Record Updates

Last Update Posted (Actual)

July 5, 2019

Last Update Submitted That Met QC Criteria

April 15, 2019

Last Verified

April 1, 2019

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • H14-00067

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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