Is Gait Speed and Sarcopenia Prognostic in Chronic Respiratory Disease?

Do Gait Speed and Markers of Sarcopenia Predict Prognosis in Patients With Chronic Respiratory Disease?

This study aims to assess usual walking speed (4-metre gait speed) and markers of sarcopenia predict mortality in patients with chronic respiratory disease.

Study Overview

• Status: Completed
• Conditions: Chronic Obstructive Pulmonary Disease and Allied Conditions

• Study Type: Observational
• Enrollment (Actual): 565

Contacts and Locations

Study Locations

• United Kingdom
  • Middlesex
    • Harefield, Middlesex, United Kingdom, UB96JH
      • Harefield Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Any patient with chronic respiratory disease. The cohort will be recruited from Harefield hospital.

Description

Inclusion Criteria:

• All patients with chronic respiratory disease who are able to complete the assessments.

Exclusion Criteria:

• Significant co-morbidities that would limit walking ability, exercise capacity or make exercise unsafe (e.g. unstable ischaemic heart disease, neuromuscular disease, severe hip/lower limb joint pain, peripheral vascular disease, lower limb amputation).
• Any patient whom the Chief Investigator feels it is unsafe to exercise (e.g. unstable cardiovascular disease).

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Number of participant deaths	1 year

Secondary Outcome Measures

Outcome Measure	Time Frame
Number of participant deaths	2 years and 5 years
Number of exacerbations as defined by a worsening of symptoms that warrant a change in medication.	1 and 2 years
Number of hospital admissions	1 and 2 years
Number of patients admitted to a nursing home	2 and 5 years
Number of hospital bed days	1 and 2 years

Collaborators and Investigators

• Sponsor: Royal Brompton & Harefield NHS Foundation Trust
• Collaborators: Medical Research Council
• Investigators: Principal Investigator: William DC Man, FRCP PhD, NIHR Respiratory Biomedical Research Unit Royal Brompton & Harefield NHS Foundation Trust

Study record dates

Study Major Dates

• Study Start (Actual): December 1, 2013
• Primary Completion (Actual): April 1, 2018
• Study Completion (Actual): April 1, 2022

Study Registration Dates

• First Submitted: May 1, 2014
• First Submitted That Met QC Criteria: October 6, 2014
• First Posted (Estimate): October 10, 2014

Study Record Updates

• Last Update Posted (Actual): November 1, 2022
• Last Update Submitted That Met QC Criteria: October 30, 2022
• Last Verified: October 1, 2022

More Information

Terms related to this study

• Keywords: Sarcopenia
• Additional Relevant MeSH Terms: Nervous System Diseases; Lung Diseases; Neurologic Manifestations; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Muscular Atrophy; Atrophy; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive; Sarcopenia; Respiration Disorders; Respiratory Tract Diseases
• Other Study ID Numbers: 2013LF003H