Diffusion Weighted Magnetic Resonance Imaging for the Characterization of Solitary Pulmonary Lesions (DWIMRICSPL)

The purpose of this study, is to investigate the value of diffusion weighted imaging on the differential diagnosis of solitary pulmonary lesions.

Study Overview

• Status: Completed
• Conditions: Thorax Cancer

Detailed Description

When a patient is diagnosed with a lung lesion, the differential diagnosis is important, since the treatment is determined by the lesion character. The goal in the evaluation of solitary pulmonary lesions is to distinguish malignant lesions from benign lesions in as non-invasive a manner as possible. As computed tomography is widely used, the diagnosis of solitary pulmonary lesions has become easier. The size, features of the edges, shape, internal structure (calcification, fat content, cavitation, etc.), density, satellite nodule, growth rate and contrast involvement of the lesion are important properties which help to distinguish benign lesions from malignant ones. However, as the distinction is not absolute at all times, other imaging methods such as positron emission tomography and magnetic resonance are preferred. The importance of this issue is the high five-year survival rate in early-diagnosed lung cancer cases.

Diffusion is the randomized microscopic motion of water molecules. It is known that diffusion is a sensitive parameter of tissue characterization at a microscopic level. Nowadays, diffusion is measured in vivo with diffusion weighted MRI and ADC measurements.

Diffusion weighted imaging has a wide use on oncologic patients for the purpose of diagnosis. In addition, it is used in the distinction of acute cerebral infarction and epidermoid or arachnoid cysts. Recently, it has also been used in the characterization of cystic or solid lesions in the thoracic cavity. In this study, the investigators aimed to evaluate the accuracy of differentiation of solitary pulmonary lesions.

• Study Type: Observational
• Enrollment (Actual): 46

Contacts and Locations

Study Locations

• Turkey
  • Edi̇rne, Turkey, 22400
    • Trakya University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 78 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Magnetic resonance imaging (MRI) was applied to a total of 46 patients between January 2011 and July 2011, who presented.

Description

Inclusion Criteria:

• All patients had a solitary pulmonary nodule or mass.

Exclusion Criteria:

-

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
On diffusion weighted images, the signal intensities of the lesions were visually compared to the SI of the thoracic spinal cord using a 5-point scale.	1 year

Collaborators and Investigators

• Sponsor: ÇAĞLAYAN ÇAKIR
• Investigators: Study Director: HAKAN GENÇHELLAÇ, MD, TURKEY,EDİRNE ,TRAKYA UNİVERSİTY HOSPİTAL

Publications and helpful links

General Publications

• Cakir C, Genchellac H, Temizoz O, Polat A, Sengul E, Duygulu G. Diffusion Weighted Magnetic Resonance Imaging for the Characterization of Solitary Pulmonary Lesions. Balkan Med J. 2015 Oct;32(4):403-9. doi: 10.5152/balkanmedj.2015.15663. Epub 2015 Oct 1.

Study record dates

Study Major Dates

• Study Start: January 1, 2011
• Primary Completion (Actual): December 1, 2011
• Study Completion (Actual): December 1, 2011

Study Registration Dates

• First Submitted: June 19, 2015
• First Submitted That Met QC Criteria: June 25, 2015
• First Posted (Estimate): June 26, 2015

Study Record Updates

• Last Update Posted (Estimate): June 26, 2015
• Last Update Submitted That Met QC Criteria: June 25, 2015
• Last Verified: June 1, 2015

More Information

Terms related to this study

• Keywords: diffusion weighted magnetic resonance imaging
• Additional Relevant MeSH Terms: Body Weight
• Other Study ID Numbers: TRAKYA22