Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects

The purpose of this study is to compare physical activity levels between patients with bronchiectasis and healthy subjects.

We hypothesize that patients with bronchiectasis will have lower levels of physical activity, since physical activity levels is affected by reduced exercise tolerance, severity of disease and other disease related symptoms and conditions.

Study Overview

• Status: Completed
• Conditions: Bronchiectasis

Detailed Description

Physical activity limitation in chronic respiratory diseases is caused by many factors including respiratory, hemodynamic, and peripheral muscle weakness. Bronchiectasis is characterized by irreversible widening of the medium-sized airways, with inflammation, chronic bacterial infection and destruction of the bronchial walls. In addition to pulmonary function worsening, extra pulmonary features such as reduced peripheral muscle endurance can be a significant physical problem which causing a decrease in physical activity levels.

Despite physical activity is considered to be essential for the management of chronic respiratory diseases, there is a lack of scientific study, which compares physical activity levels between patients with bronchiectasis and healthy subjects.

This study will assess physical activity level, exercise capacity, quality of life and peripheral muscle strength in patients with bronchiectasis compared to healthy subjects.

• Study Type: Observational
• Enrollment (Actual): 76

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey, 06100
    • Aslihan Cakmak

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

The study population will consist of patients with bronchiectasis and healthy subjects.

Description

Inclusion Criteria:

Inclusion criteria of the Bronchiectasis Group:

1. Diagnosis of bronchiectasis
2. Being 18 years of age or older
3. Able and willing to complete the informed consent process.
4. Able to walk and co-operate

Exclusion Criteria:

Exclusion criteria of Bronchiectasis Group:

1. Unstable medical condition
2. To have severe neurological, orthopedic problems or severe heart failure.

The control group will consist of healthy subjects.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number of steps on accelerometer	Participants will wear an accelerometer (physical activity monitor) for seven consecutive days.	Seven days
Energy expenditure on activity monitor	Total energy expenditure will be calculated using activity monitor for seven consecutive days	Seven days
Exercise capacity using 6-minute walk test and incremental shuttle walk test	6-minute walk test will be performed in a long, straight, enclosed corridor 30 meters in length. Patients are required to walk in their walking speed with standardized instructions. The distance walked by subjects during 6 minutes will be recorded. The incremental shuttle walk test will be performed in an enclosed corridor. Patients are required to walk back and forth, turning around two cones placed 9 meters apart making the shuttle distance 10 meters long. Patients will follow the rhythm dictated by the audio signal.	8th day (after using device)
Physical activity level using International Physical Activity Questionnaire	Instrument to obtain internationally comparable data on health related physical activity This measure assesses the types of intensity of physical activity and sitting time in daily life and estimates total physical activity in MET-min/week and time spent sitting. It comprises open-ended questions surrounding individuals' last 7-day recall of physical activity.	8th day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Shortness of breath using the Modified Medical Research Council Dyspnea Scale	Scale is used to establish functional impairment due to dyspnea attributable to respiratory disease. The scoring ranges from 0 to 4. The higher scores indicate higher perception of dyspnea.	1st day (before using device)
Quality of Life using St. George Respiratory Questionnaire	It measures the health impairment. The questionnaire consist of 50 items, 2 parts (3 components). The name of categories/domains were stated as follows: Part 1: Symptoms component (frequency&severity), Part 2: Activities that cause or are limited by breathlessness; Impact components (social functioning, psychological disturbances resulting from airways disease). The scores range from 0 to 100, with higher scores indicating more limitations.	1st day
Peripheral muscle strength test using a hand-held dynamometer	Measurement of peripheral muscle strength	8th day (after using device)
Maximal inspiratory and expiratory pressures measurement using a mouthpiece device	Measurement of respiratory muscle strength	8th day (after using device)

Collaborators and Investigators

• Sponsor: Hacettepe University
• Investigators: Principal Investigator: ASLIHAN CAKMAK, Hacettepe University

Study record dates

Study Major Dates

• Study Start (Actual): September 1, 2015
• Primary Completion (Actual): August 1, 2016
• Study Completion (Actual): August 1, 2016

Study Registration Dates

• First Submitted: September 13, 2015
• First Submitted That Met QC Criteria: September 14, 2015
• First Posted (Estimate): September 16, 2015

Study Record Updates

• Last Update Posted (Actual): September 9, 2019
• Last Update Submitted That Met QC Criteria: September 5, 2019
• Last Verified: September 1, 2019

More Information

Terms related to this study

• Keywords: Bronchiectasis; Physical activity levels
• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Bronchial Diseases; Bronchiectasis
• Other Study ID Numbers: GO 15/313