- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02856581
Management of Tobacco Treatment Intervention in Reducing Surgical Complications in Patients With Newly Diagnosed Lung Cancer Who Smoke Cigarettes
Reducing Surgical Complications in Newly Diagnosed Lung Cancer Patients Who Smoke Cigarettes
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
PRIMARY OBJECTIVES:
I. To determine if varenicline plus a behavioral intervention consisting of a brief clinician-delivered intervention and tobacco quitline follow-up, decreases postsurgical complications through 24 weeks after surgery when compared to placebo plus the behavioral intervention in lung cancer patients who undergo surgery and are motivated to stop smoking.
SECONDARY OBJECTIVES:
I. To compare changes from baseline to 12 and 24 weeks after surgery in the patient quality of life (Linear Analogue Self-Assessment [LASA]-12) domains between the intervention (varenicline) and control group (placebo).
II. To compare changes from baseline to 6, 12 and 24 weeks after surgery in the patient quality of life related domains (LASA) for the Patient Health Questionnaire (PHQ)-9 and Smoking Self Efficacy Questionnaire (SEQ)12 between the intervention and control groups.
III. To compare the proportion of patients 12 weeks and 24 weeks after surgery who endorse ("Was It Worth It") each treatment (intervention versus [vs] control groups).
IV. To compare post-operative care (as measured by length of hospital and high dependency unit stay) between the intervention and control groups.
V. To compare treatment adherence between the intervention and control groups. VI. To compare rates of smoking abstinence between the intervention and control groups as a covariate of the primary outcome only.
Study Type
Enrollment (Actual)
Phase
- Phase 3
Contacts and Locations
Study Locations
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Alaska
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Fairbanks, Alaska, United States, 99701
- Fairbanks Memorial Hospital
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Arizona
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Kingman, Arizona, United States, 86401
- Kingman Regional Medical Center
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Arkansas
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Jonesboro, Arkansas, United States, 72401
- Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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California
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Arroyo Grande, California, United States, 93420
- PCR Oncology
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Loma Linda, California, United States, 92357
- Veterans Affairs Loma Linda Healthcare System
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Rancho Mirage, California, United States, 92270
- Eisenhower Medical Center
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Saint Helena, California, United States, 94574
- Saint Helena Hospital
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Colorado
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Aurora, Colorado, United States, 80045
- University of Colorado Hospital
-
Aurora, Colorado, United States, 80012
- Rocky Mountain Cancer Centers-Aurora
-
Aurora, Colorado, United States, 80012
- The Medical Center of Aurora
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Boulder, Colorado, United States, 80301
- Boulder Community Hospital
-
Boulder, Colorado, United States, 80304
- Rocky Mountain Cancer Centers-Boulder
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Colorado Springs, Colorado, United States, 80909
- UCHealth Memorial Hospital Central
-
Colorado Springs, Colorado, United States, 80920
- Memorial Hospital North
-
Denver, Colorado, United States, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
-
Denver, Colorado, United States, 80218
- SCL Health Saint Joseph Hospital
-
Denver, Colorado, United States, 80220
- Rose Medical Center
-
Denver, Colorado, United States, 80218
- Rocky Mountain Cancer Centers-Midtown
-
Denver, Colorado, United States, 80220
- Rocky Mountain Cancer Centers-Rose
-
Denver, Colorado, United States, 80218
- Colorado Blood Cancer Institute
-
Denver, Colorado, United States, 80204
- Cancer Center of Colorado at Sloan's Lake
-
Denver, Colorado, United States, 80209
- The Women's Imaging Center
-
Denver, Colorado, United States, 80206
- National Jewish Health-Main Campus
-
Denver, Colorado, United States, 80220
- Western Surgical Care
-
Englewood, Colorado, United States, 80113
- Mountain Blue Cancer Care Center - Swedish
-
Englewood, Colorado, United States, 80113
- Swedish Medical Center
-
Golden, Colorado, United States, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, United States, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, United States, 80631
- North Colorado Medical Center
-
Lafayette, Colorado, United States, 80026
- Good Samaritan Medical Center
-
Littleton, Colorado, United States, 80120
- Rocky Mountain Cancer Centers-Littleton
-
Lone Tree, Colorado, United States, 80124
- Sky Ridge Medical Center
-
Lone Tree, Colorado, United States, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
-
Loveland, Colorado, United States, 80539
- McKee Medical Center
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Thornton, Colorado, United States, 80260
- National Jewish Health-Northern Hematology Oncology
-
Wheat Ridge, Colorado, United States, 80033
- SCL Health Lutheran Medical Center
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Connecticut
-
Middletown, Connecticut, United States, 06457
- Middlesex Hospital
-
West Haven, Connecticut, United States, 06516
- Veterans Affairs Connecticut Healthcare System-West Haven Campus
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Florida
-
Fort Lauderdale, Florida, United States, 33316
- Broward Health Medical Center
-
Gainesville, Florida, United States, 32610
- University of Florida Health Science Center - Gainesville
-
Hollywood, Florida, United States, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
-
Pembroke Pines, Florida, United States, 33028
- Memorial Hospital West
-
Vero Beach, Florida, United States, 32960
- Indian River Medical Center
-
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Georgia
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Atlanta, Georgia, United States, 30309
- Piedmont Hospital
-
Savannah, Georgia, United States, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, United States, 31405
- Summit Cancer Care-Candler
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Idaho
-
Boise, Idaho, United States, 83706
- Saint Alphonsus Cancer Care Center-Boise
-
Caldwell, Idaho, United States, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
-
Coeur d'Alene, Idaho, United States, 83814
- Kootenai Medical Center
-
Emmett, Idaho, United States, 83617
- Walter Knox Memorial Hospital
-
Meridian, Idaho, United States, 83642
- Idaho Urologic Institute-Meridian
-
Nampa, Idaho, United States, 83686
- Saint Alphonsus Medical Center-Nampa
-
Post Falls, Idaho, United States, 83854
- Kootenai Cancer Center
-
Sandpoint, Idaho, United States, 83864
- Kootenai Cancer Clinic
-
-
Illinois
-
Arlington Heights, Illinois, United States, 60005
- Northwest Community Hospital
-
Aurora, Illinois, United States, 60504
- Rush - Copley Medical Center
-
Bloomington, Illinois, United States, 61704
- Illinois CancerCare-Bloomington
-
Canton, Illinois, United States, 61520
- Illinois CancerCare-Canton
-
Carbondale, Illinois, United States, 62902
- Memorial Hospital of Carbondale
-
Carterville, Illinois, United States, 62918
- SIH Cancer Institute
-
Carthage, Illinois, United States, 62321
- Illinois CancerCare-Carthage
-
Centralia, Illinois, United States, 62801
- Centralia Oncology Clinic
-
Chicago, Illinois, United States, 60612
- University of Illinois
-
Chicago, Illinois, United States, 60612
- John H Stroger Jr Hospital of Cook County
-
Danville, Illinois, United States, 61832
- Carle on Vermilion
-
Decatur, Illinois, United States, 62526
- Decatur Memorial Hospital
-
Decatur, Illinois, United States, 62526
- Cancer Care Specialists of Illinois - Decatur
-
Dixon, Illinois, United States, 61021
- Illinois CancerCare-Dixon
-
Effingham, Illinois, United States, 62401
- Crossroads Cancer Center
-
Effingham, Illinois, United States, 62401
- Carle Physician Group-Effingham
-
Eureka, Illinois, United States, 61530
- Illinois CancerCare-Eureka
-
Galesburg, Illinois, United States, 61401
- Western Illinois Cancer Treatment Center
-
Galesburg, Illinois, United States, 61401
- Illinois CancerCare-Galesburg
-
Kewanee, Illinois, United States, 61443
- Illinois CancerCare-Kewanee Clinic
-
Macomb, Illinois, United States, 61455
- Illinois CancerCare-Macomb
-
Mattoon, Illinois, United States, 61938
- Carle Physician Group-Mattoon/Charleston
-
Maywood, Illinois, United States, 60153
- Loyola University Medical Center
-
Melrose Park, Illinois, United States, 60160
- Marjorie Weinberg Cancer Center at Loyola-Gottlieb
-
Moline, Illinois, United States, 61265
- Trinity Medical Center
-
Ottawa, Illinois, United States, 61350
- Illinois CancerCare-Ottawa Clinic
-
Pekin, Illinois, United States, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, United States, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
-
Peoria, Illinois, United States, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, United States, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, United States, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, United States, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
-
Peru, Illinois, United States, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, United States, 61354
- Valley Radiation Oncology
-
Princeton, Illinois, United States, 61356
- Illinois CancerCare-Princeton
-
Springfield, Illinois, United States, 62781
- Memorial Medical Center
-
Springfield, Illinois, United States, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, United States, 62702
- Springfield Clinic
-
Swansea, Illinois, United States, 62226
- Southwest Illinois Health Services LLP
-
Swansea, Illinois, United States, 62226
- Cancer Care Specialists of Illinois-Swansea
-
Urbana, Illinois, United States, 61801
- Carle Cancer Center
-
Urbana, Illinois, United States, 61801
- The Carle Foundation Hospital
-
Yorkville, Illinois, United States, 60560
- Rush-Copley Healthcare Center
-
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Indiana
-
Evansville, Indiana, United States, 47713
- Deaconess Clinic Downtown
-
Fort Wayne, Indiana, United States, 46805
- Parkview Hospital Randallia
-
Fort Wayne, Indiana, United States, 46845
- Parkview Regional Medical Center
-
Indianapolis, Indiana, United States, 46237
- Franciscan Health Indianapolis
-
Michigan City, Indiana, United States, 46360
- Woodland Cancer Care Center
-
Mishawaka, Indiana, United States, 46545
- Memorial Regional Cancer Center Day Road
-
Mooresville, Indiana, United States, 46158
- Franciscan Health Mooresville
-
Newburgh, Indiana, United States, 47630
- Chancellor Center for Oncology
-
Richmond, Indiana, United States, 47374
- Reid Health
-
South Bend, Indiana, United States, 46601
- Memorial Hospital of South Bend
-
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Kentucky
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Corbin, Kentucky, United States, 40701
- Baptist Health Corbin
-
Lexington, Kentucky, United States, 40503
- Baptist Health Lexington
-
Louisville, Kentucky, United States, 40207
- Baptist Health Louisville
-
Madisonville, Kentucky, United States, 42431
- Baptist Health Madisonville/Merle Mahr Cancer Center
-
Paducah, Kentucky, United States, 42003
- Baptist Health Paducah
-
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Louisiana
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Baton Rouge, Louisiana, United States, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, United States, 70816
- Medical Center of Baton Rouge
-
Baton Rouge, Louisiana, United States, 70836
- Ochsner High Grove
-
New Orleans, Louisiana, United States, 70121
- Ochsner Medical Center Jefferson
-
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Maine
-
Bangor, Maine, United States, 04401
- Eastern Maine Medical Center
-
Brewer, Maine, United States, 04412
- Lafayette Family Cancer Center-EMMC
-
-
Maryland
-
Bel Air, Maryland, United States, 21014
- UM Upper Chesapeake Medical Center
-
-
Massachusetts
-
Springfield, Massachusetts, United States, 01104
- Mercy Medical Center
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48109
- University of Michigan Comprehensive Cancer Center
-
Ann Arbor, Michigan, United States, 48106
- Saint Joseph Mercy Hospital
-
Brighton, Michigan, United States, 48114
- Saint Joseph Mercy Brighton
-
Brighton, Michigan, United States, 48114
- IHA Hematology Oncology Consultants-Brighton
-
Canton, Michigan, United States, 48188
- Saint Joseph Mercy Canton
-
Canton, Michigan, United States, 48188
- IHA Hematology Oncology Consultants-Canton
-
Caro, Michigan, United States, 48723
- Caro Cancer Center
-
Chelsea, Michigan, United States, 48118
- Saint Joseph Mercy Chelsea
-
Chelsea, Michigan, United States, 48118
- IHA Hematology Oncology Consultants-Chelsea
-
Clarkston, Michigan, United States, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, United States, 48346
- Newland Medical Associates-Clarkston
-
Dearborn, Michigan, United States, 48124
- Beaumont Hospital - Dearborn
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Detroit, Michigan, United States, 48236
- Ascension Saint John Hospital
-
East China Township, Michigan, United States, 48054
- Great Lakes Cancer Management Specialists-Doctors Park
-
Flint, Michigan, United States, 48503
- Hurley Medical Center
-
Flint, Michigan, United States, 48503
- Genesee Cancer and Blood Disease Treatment Center
-
Flint, Michigan, United States, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, United States, 48503
- Genesys Hurley Cancer Institute
-
Grosse Pointe Woods, Michigan, United States, 48236
- Academic Hematology Oncology Specialists
-
Grosse Pointe Woods, Michigan, United States, 48236
- Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
-
Grosse Pointe Woods, Michigan, United States, 48236
- Michigan Breast Specialists-Grosse Pointe Woods
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Jackson, Michigan, United States, 49201
- Allegiance Health
-
Lansing, Michigan, United States, 48912
- Sparrow Hospital
-
Livonia, Michigan, United States, 48154
- Saint Mary Mercy Hospital
-
Livonia, Michigan, United States, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, United States, 48044
- Great Lakes Cancer Management Specialists-Macomb Medical Campus
-
Macomb, Michigan, United States, 48044
- Michigan Breast Specialists-Macomb Township
-
Marlette, Michigan, United States, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Marquette, Michigan, United States, 49855
- UP Health System Marquette
-
Marquette, Michigan, United States, 49855
- UP Health System Hematology Oncology Marquette
-
Pontiac, Michigan, United States, 48341
- Saint Joseph Mercy Oakland
-
Pontiac, Michigan, United States, 48341
- 21st Century Oncology-Pontiac
-
Pontiac, Michigan, United States, 48341
- Hope Cancer Center
-
Pontiac, Michigan, United States, 48341
- Newland Medical Associates-Pontiac
-
Port Huron, Michigan, United States, 48060
- Lake Huron Medical Center
-
Port Huron, Michigan, United States, 48060
- Huron Medical Center PC
-
Rochester Hills, Michigan, United States, 48309
- Great Lakes Cancer Management Specialists-Rochester Hills
-
Saginaw, Michigan, United States, 48601
- Ascension Saint Mary's Hospital
-
Saginaw, Michigan, United States, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Sterling Heights, Michigan, United States, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, United States, 48764
- Ascension Saint Joseph Hospital
-
Warren, Michigan, United States, 48093
- Saint John Macomb-Oakland Hospital
-
Warren, Michigan, United States, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, United States, 48093
- Great Lakes Cancer Management Specialists-Macomb Professional Building
-
Warren, Michigan, United States, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, United States, 48093
- Michigan Breast Specialists-Warren
-
West Branch, Michigan, United States, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Ypsilanti, Michigan, United States, 48106
- Huron Gastroenterology PC
-
Ypsilanti, Michigan, United States, 48197
- IHA Hematology Oncology Consultants-Ann Arbor
-
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Minnesota
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Mankato, Minnesota, United States, 56001
- Mayo Clinic Health Systems-Mankato
-
Rochester, Minnesota, United States, 55905
- Mayo Clinic
-
Saint Cloud, Minnesota, United States, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Cloud, Minnesota, United States, 56303
- Saint Cloud Hospital
-
-
Mississippi
-
Columbus, Mississippi, United States, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Jackson, Mississippi, United States, 39216
- University of Mississippi Medical Center
-
New Albany, Mississippi, United States, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, United States, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Pascagoula, Mississippi, United States, 39581
- Singing River Hospital
-
Southhaven, Mississippi, United States, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Bonne Terre, Missouri, United States, 63628
- Parkland Health Center-Bonne Terre
-
Cape Girardeau, Missouri, United States, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, United States, 63703
- Southeast Cancer Center
-
Farmington, Missouri, United States, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, United States, 65109
- Capital Region Southwest Campus
-
Saint Louis, Missouri, United States, 63131
- Missouri Baptist Medical Center
-
Sainte Genevieve, Missouri, United States, 63670
- Sainte Genevieve County Memorial Hospital
-
Sullivan, Missouri, United States, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, United States, 63127
- Missouri Baptist Outpatient Center-Sunset Hills
-
-
Montana
-
Anaconda, Montana, United States, 59711
- Community Hospital of Anaconda
-
Billings, Montana, United States, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, United States, 59101
- Saint Vincent Healthcare
-
Billings, Montana, United States, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, United States, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, United States, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, United States, 59405
- Great Falls Clinic
-
Great Falls, Montana, United States, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Helena, Montana, United States, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, United States, 59901
- Kalispell Regional Medical Center
-
Missoula, Montana, United States, 59804
- Community Medical Hospital
-
-
Nebraska
-
Omaha, Nebraska, United States, 68114
- Nebraska Methodist Hospital
-
-
Nevada
-
Carson City, Nevada, United States, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, United States, 89052
- OptumCare Cancer Care at Seven Hills
-
Henderson, Nevada, United States, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, United States, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, United States, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, United States, 89074
- 21st Century Oncology-Henderson
-
Henderson, Nevada, United States, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, United States, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, United States, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, United States, 89074
- Urology Specialists of Nevada - Green Valley
-
Las Vegas, Nevada, United States, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, United States, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, United States, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, United States, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, United States, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, United States, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, United States, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, United States, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, United States, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, United States, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, United States, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, United States, 89106
- Cancer and Blood Specialists-Shadow
-
Las Vegas, Nevada, United States, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, United States, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, United States, 89121
- Cancer Therapy and Integrative Medicine
-
Las Vegas, Nevada, United States, 89128
- Cancer and Blood Specialists-Tenaya
-
Las Vegas, Nevada, United States, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, United States, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, United States, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, United States, 89109
- 21st Century Oncology
-
Las Vegas, Nevada, United States, 89128
- 21st Century Oncology-Vegas Tenaya
-
Las Vegas, Nevada, United States, 89148
- 21st Century Oncology-Fort Apache
-
Las Vegas, Nevada, United States, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, United States, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, United States, 89102
- Desert West Surgery
-
Las Vegas, Nevada, United States, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, United States, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, United States, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, United States, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, United States, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, United States, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, United States, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, United States, 89148
- Urology Specialists of Nevada - Southwest
-
Las Vegas, Nevada, United States, 89169
- University Cancer Center
-
Las Vegas, Nevada, United States, 89106
- OptumCare Cancer Care at Oakey
-
Pahrump, Nevada, United States, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, United States, 89502
- Renown Regional Medical Center
-
Reno, Nevada, United States, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, United States, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Lebanon, New Hampshire, United States, 03756
- Dartmouth Hitchcock Medical Center
-
-
New Jersey
-
Brick, New Jersey, United States, 08724
- Ocean Medical Center
-
Flemington, New Jersey, United States, 08822
- Hunterdon Medical Center
-
Hamilton, New Jersey, United States, 08690
- The Cancer Institute of New Jersey Hamilton
-
Holmdel, New Jersey, United States, 07733
- Bayshore Community Hospital
-
Manahawkin, New Jersey, United States, 08050
- Southern Ocean County Medical Center
-
Mount Holly, New Jersey, United States, 08060
- Virtua Memorial
-
Neptune, New Jersey, United States, 07753
- Jersey Shore Medical Center
-
Red Bank, New Jersey, United States, 07701
- Riverview Medical Center/Booker Cancer Center
-
Somerville, New Jersey, United States, 08876
- Robert Wood Johnson University Hospital Somerset
-
Voorhees, New Jersey, United States, 08043
- Virtua Voorhees
-
-
New York
-
Glens Falls, New York, United States, 12801
- Glens Falls Hospital
-
New York, New York, United States, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
Poughkeepsie, New York, United States, 12601
- Vassar Brothers Medical Center
-
Rochester, New York, United States, 14642
- University of Rochester
-
-
North Carolina
-
Greenville, North Carolina, United States, 27834
- East Carolina University
-
-
Ohio
-
Alliance, Ohio, United States, 44601
- Alliance Cancer Center
-
Beavercreek, Ohio, United States, 45431
- Indu and Raj Soin Medical Center
-
Boardman, Ohio, United States, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, United States, 44710
- Aultman Health Foundation
-
Centerville, Ohio, United States, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, United States, 45459
- Dayton Physicians LLC-Miami Valley South
-
Cincinnati, Ohio, United States, 45236
- Oncology Hematology Care Inc-Kenwood
-
Dayton, Ohio, United States, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, United States, 45409
- Miami Valley Hospital
-
Dayton, Ohio, United States, 45415
- Dayton Physician LLC-Miami Valley Hospital North
-
Dayton, Ohio, United States, 45415
- Miami Valley Hospital North
-
Findlay, Ohio, United States, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, United States, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, United States, 45840
- Orion Cancer Care
-
Franklin, Ohio, United States, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, United States, 45005
- Dayton Physicians LLC-Atrium
-
Greenville, Ohio, United States, 45331
- Wayne Hospital
-
Greenville, Ohio, United States, 45331
- Dayton Physicians LLC-Wayne
-
Kettering, Ohio, United States, 45429
- Kettering Medical Center
-
Kettering, Ohio, United States, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, United States, 45420
- First Dayton Cancer Care
-
Springfield, Ohio, United States, 45505
- Springfield Regional Medical Center
-
Springfield, Ohio, United States, 45504
- Springfield Regional Cancer Center
-
Troy, Ohio, United States, 45373
- Upper Valley Medical Center
-
Troy, Ohio, United States, 45373
- Dayton Physicians LLC-Upper Valley
-
Warren, Ohio, United States, 44484
- Saint Joseph Warren Hospital
-
Youngstown, Ohio, United States, 44501
- Saint Elizabeth Youngstown Hospital
-
-
Oklahoma
-
Oklahoma City, Oklahoma, United States, 73104
- University of Oklahoma Health Sciences Center
-
Tulsa, Oklahoma, United States, 74146
- Oklahoma Cancer Specialists and Research Institute-Tulsa
-
-
Oregon
-
Baker City, Oregon, United States, 97814
- Saint Alphonsus Medical Center-Baker City
-
Ontario, Oregon, United States, 97914
- Saint Alphonsus Medical Center-Ontario
-
-
Pennsylvania
-
Allentown, Pennsylvania, United States, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, United States, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Danville, Pennsylvania, United States, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, United States, 18301
- Pocono Medical Center
-
Hazleton, Pennsylvania, United States, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, United States, 18201
- Lehigh Valley Hospital-Hazleton
-
Lewisburg, Pennsylvania, United States, 17837
- Geisinger Medical Oncology-Lewisburg
-
Lewistown, Pennsylvania, United States, 17044
- Lewistown Hospital
-
Philadelphia, Pennsylvania, United States, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, United States, 19107
- Thomas Jefferson University Hospital
-
Pottsville, Pennsylvania, United States, 17901
- Geisinger Cancer Services-Pottsville
-
Scranton, Pennsylvania, United States, 18510
- Community Medical Center
-
Selinsgrove, Pennsylvania, United States, 17870
- Geisinger Medical Oncology-Selinsgrove
-
State College, Pennsylvania, United States, 16801
- Geisinger Medical Group
-
State College, Pennsylvania, United States, 16803
- Mount Nittany Medical Center
-
Wilkes-Barre, Pennsylvania, United States, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
-
South Carolina
-
Charleston, South Carolina, United States, 29401
- Ralph H Johnson VA Medical Center
-
Clinton, South Carolina, United States, 29325
- Prisma Health Cancer Institute - Laurens
-
Easley, South Carolina, United States, 29640
- Prisma Health Cancer Institute - Easley
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Faris
-
Greenville, South Carolina, United States, 29615
- Prisma Health Cancer Institute - Eastside
-
Greenville, South Carolina, United States, 29605
- Prisma Health Cancer Institute - Butternut
-
Greenville, South Carolina, United States, 29605
- Prisma Health Greenville Memorial Hospital
-
Greer, South Carolina, United States, 29650
- Prisma Health Cancer Institute - Greer
-
Seneca, South Carolina, United States, 29672
- Prisma Health Cancer Institute - Seneca
-
Spartanburg, South Carolina, United States, 29307
- Prisma Health Cancer Institute - Spartanburg
-
-
Tennessee
-
Memphis, Tennessee, United States, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
Memphis, Tennessee, United States, 38120
- Baptist Memorial Hospital for Women
-
-
Texas
-
Dallas, Texas, United States, 75246
- Baylor University Medical Center
-
Galveston, Texas, United States, 77555-0565
- University of Texas Medical Branch
-
League City, Texas, United States, 77573
- UTMB Cancer Center at Victory Lakes
-
-
Utah
-
American Fork, Utah, United States, 84003
- American Fork Hospital / Huntsman Intermountain Cancer Center
-
Cedar City, Utah, United States, 84720
- Sandra L Maxwell Cancer Center
-
Logan, Utah, United States, 84321
- Logan Regional Hospital
-
Murray, Utah, United States, 84107
- Intermountain Medical Center
-
Ogden, Utah, United States, 84403
- McKay-Dee Hospital Center
-
Provo, Utah, United States, 84604
- Utah Valley Regional Medical Center
-
Riverton, Utah, United States, 84065
- Riverton Hospital
-
Saint George, Utah, United States, 84770
- Dixie Medical Center Regional Cancer Center
-
Salt Lake City, Utah, United States, 84106
- Utah Cancer Specialists-Salt Lake City
-
Salt Lake City, Utah, United States, 84143
- LDS Hospital
-
-
Vermont
-
Berlin, Vermont, United States, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, United States, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, United States, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Charlottesville, Virginia, United States, 22908
- University of Virginia Cancer Center
-
Charlottesville, Virginia, United States, 22901
- Sentara Martha Jefferson Hospital
-
Fishersville, Virginia, United States, 22939
- Augusta Health Center for Cancer and Blood Disorders
-
Norfolk, Virginia, United States, 23507
- Sentara Norfolk General Hospital
-
-
Washington
-
Auburn, Washington, United States, 98001
- MultiCare Auburn Medical Center
-
Bainbridge Island, Washington, United States, 98110
- Virginia Mason Bainbridge Island Medical Center
-
Bellevue, Washington, United States, 98004
- Overlake Hospital Medical Center
-
Federal Way, Washington, United States, 98002
- Virginia Mason Federal Way Medical Center
-
Gig Harbor, Washington, United States, 98332
- Tacoma/Valley Radiation Oncology Centers-Gig Harbor
-
Gig Harbor, Washington, United States, 98335
- MultiCare Gig Harbor Medical Park
-
Kennewick, Washington, United States, 99336
- Northwest Cancer Clinic
-
Lynnwood, Washington, United States, 98036
- Virginia Mason Lynnwood Medical Center
-
Port Townsend, Washington, United States, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, United States, 98370
- Peninsula Cancer Center
-
Puyallup, Washington, United States, 98372
- MultiCare Good Samaritan Hospital
-
Puyallup, Washington, United States, 98372
- Tacoma/Valley Radiation Oncology Centers-Puyallup
-
Renton, Washington, United States, 98055
- Valley Medical Center
-
Seattle, Washington, United States, 98101
- Virginia Mason Medical Center
-
Spokane, Washington, United States, 99204
- Rockwood Cancer Treatment Center-DHEC-Downtown
-
Spokane, Washington, United States, 99218
- Rockwood North Cancer Treatment Center
-
Spokane Valley, Washington, United States, 99216
- Rockwood Clinic Cancer Treatment Center-Valley
-
Tacoma, Washington, United States, 98405
- Mary Bridge Children's Hospital and Health Center
-
Tacoma, Washington, United States, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, United States, 98405
- Tacoma/Valley Radiation Oncology Centers-Saint Joe's
-
Tacoma, Washington, United States, 97405
- Tacoma/Valley Radiation Oncology Centers-Jackson Hall
-
Yakima, Washington, United States, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
-
Wisconsin
-
La Crosse, Wisconsin, United States, 54601
- Mayo Clinic Health System-Franciscan Healthcare
-
Milwaukee, Wisconsin, United States, 53215
- Aurora Saint Luke's Medical Center
-
-
Wyoming
-
Cheyenne, Wyoming, United States, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, United States, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, United States, 82801
- Welch Cancer Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
- Eligible patients will have a new diagnosis of lung cancer and have sought a surgical consult relating to this diagnosis
- Surgery must be scheduled no sooner than 10 days after randomization and no more than twelve weeks after randomization
- Have smoked daily or nearly every day in the previous 6 months up to the date of surgical consult AND have smoked at least one puff in the previous 7 days
- Motivated to stop smoking, as indicated by a score of 6 or above on the Contemplation Ladder
- Within the 30 days before registration, no use of: 1) any pharmacologic treatment for smoking cessation, including bupropion or nicotine replacement therapy; 2) any nicotine delivery system (i.e., e-cigarettes and vape products); or 3) be enrolled in any formal behavioral treatment program for tobacco dependence as determined by patient report
- No allergies to and not currently using varenicline
- No suicidal thoughts as indicated by a positive (1+) response to the PHQ9
- No active untreated clinically significant psychiatric condition (psychosis, bipolar disorder, or depression)
Negative pregnancy test (serum or urine) done =< 7 days prior to registration, for women of childbearing potential only
* A female of childbearing potential is a sexually mature female who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months)
- No unstable angina, myocardial infarction, or coronary angioplasty within the past 3 months or an untreated cardiac dysrhythmia
- No history of seizures
- No unstable neurologic, hepatic, renal, cardiovascular, lymphatic, or metabolic disease
- Not currently on renal dialysis or has a history of significant renal impairment
No recent history (=< 90 days) of substance abuse (outside of tobacco) defined by National Institute on Alcohol Abuse and Alcoholism (NIAAA) as:
- If male, drinking > 14 alcoholic beverages per week for past 1 month
- If female, drinking > 7 alcoholic beverages per week for past 1 month
- Use of cocaine, heroin, club drugs (i.e., 3,4-methylenedioxymethamphetamine (MDMA)/"ecstasy"), methamphetamine, or hallucinogens (e.g., lysergic acid diethylamide [LSD]) at any time during the past 1 month
- Use of marijuana on a weekly basis for the past 1 month
- Patients must be able to complete study questionnaires in English
- No other household member or relative participating in the study
- No known history of any condition or factor judged by the investigator to preclude participation in the study or which might hinder study adherence
- Calculated creatinine clearance >= 30 mL/min * For females, use 85% of calculated creatinine clearance (CrCl) value
Study Plan
How is the study designed?
Design Details
- Primary Purpose: SUPPORTIVE_CARE
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: DOUBLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Intervention group (varenicline and behavioral intervention)
Patients receive varenicline PO QD on days 1-3 and BID on days 4-84 for 12 weeks in the absence of disease progression or unacceptable toxicity.
Patients also complete behavioral intervention consisting of no smoking message from surgical team member and how to use NCI quitline at surgical consult.
|
Given PO
Complete counseling session
|
PLACEBO_COMPARATOR: Control group (placebo and behavioral intervention)
Patients receive placebo PO QD on days 1-3 and BID on days 4-84 for 12 weeks in the absence of disease progression or unacceptable toxicity.
Patients also complete behavioral intervention consisting of no smoking message from surgical team member and how to use NCI quitline at surgical consult.
|
Given PO
Complete counseling session
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Mortality
Time Frame: Up to 30 days post-surgery
|
Number of patients that died within 30 days of surgery
|
Up to 30 days post-surgery
|
Re-hospitalization
Time Frame: Up to 30 days post-surgery
|
Number of patients re-hospitalized within 30 days of surgery
|
Up to 30 days post-surgery
|
Number of Paticipants With Incidence of Pulmonary Complications
Time Frame: Up to 24 weeks post-surgery
|
Surgical complication incidence rates at 24 weeks after surgery will be compared between the intervention vs. control groups using a Fisher's exact test.
Logistic regression models will supplement the univariate analysis, using complication incidence as the dependent variable and will include smoking status at the time of surgery as an independent variable and also adjust for age, gender, Fagerström Test for Nicotine Dependence (FTND), time between randomization and surgery, and presence of adjuvant chemotherapy and/or radiation therapy.
We will also explore the collinear relationship between arm and smoking status to see whether they can be included together in the logistic models.
|
Up to 24 weeks post-surgery
|
Number of Participants With Incidence of Intensive Care Unit Readmission
Time Frame: Up to 24 weeks post-surgery
|
Surgical complication incidence rates at 24 weeks after surgery will be compared between the intervention vs. control groups using a Fisher's exact test.
Logistic regression models will supplement the univariate analysis, using complication incidence as the dependent variable and will include smoking status at the time of surgery as an independent variable and also adjust for age, gender, FTND, time between randomization and surgery, and presence of adjuvant chemotherapy and/or radiation therapy.
A separate logistic model will be created including treatment arm instead of smoking status.
We will also explore the collinear relationship between arm and smoking status to see whether they can be included together in the logistic models.
|
Up to 24 weeks post-surgery
|
Number of Participants With Incidence of Unspecified Wound Infection
Time Frame: Up to 24 weeks post-surgery
|
Surgical complication incidence rates at 24 weeks after surgery will be compared between the intervention vs. control groups using a Fisher's exact test.
Logistic regression models will supplement the univariate analysis, using complication incidence as the dependent variable and will include smoking status at the time of surgery as an independent variable and also adjust for age, gender, FTND, time between randomization and surgery, and presence of adjuvant chemotherapy and/or radiation therapy.
A separate logistic model will be created including treatment arm instead of smoking status.
We will also explore the collinear relationship between arm and smoking status to see whether they can be included together in the logistic models.
|
Up to 24 weeks post-surgery
|
Number of Participants With Incidence of Anastomotic Failure
Time Frame: Up to 24 weeks post-surgery
|
Surgical complication incidence rates at 24 weeks after surgery will be compared between the intervention vs. control groups using a Fisher's exact test.
Logistic regression models will supplement the univariate analysis, using complication incidence as the dependent variable and will include smoking status at the time of surgery as an independent variable and also adjust for age, gender, FTND, time between randomization and surgery, and presence of adjuvant chemotherapy and/or radiation therapy.
A separate logistic model will be created including treatment arm instead of smoking status.
We will also explore the collinear relationship between arm and smoking status to see whether they can be included together in the logistic models.
|
Up to 24 weeks post-surgery
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in QOL as Measured by the LASA-12, PHQ-9, SEQ-12
Time Frame: Baseline up to 24 weeks after surgery
|
Analysis of covariance and linear mixed model repeated measures analysis will be used for each assessment domain (LASA-12, PHQ-9, SEQ12).
|
Baseline up to 24 weeks after surgery
|
Change in QOL as Measured by Was It Worth It Assessments
Time Frame: At 12 weeks after surgery
|
At 12 weeks after surgery
|
|
Change in QOL as Measured by Was It Worth It Assessments
Time Frame: At 24 weeks after surgery
|
At 24 weeks after surgery
|
|
Length of Hospital Stay
Time Frame: The time from surgery until the patient is released from the hospital
|
Logrank testing of Kaplan-Meier estimates will be used for length of hospital stay and supplemented by Cox models to control for concomitant covariates.
|
The time from surgery until the patient is released from the hospital
|
Length of High Dependency Unit Stay
Time Frame: The time from surgery until the patient is released from the hospital
|
Logrank testing of Kaplan-Meier estimates will be used for length of high dependency unit stay and supplemented by Cox models to control for concomitant covariates.
|
The time from surgery until the patient is released from the hospital
|
Expanded Complication Rate
Time Frame: Up to 1 year
|
Up to 1 year
|
|
Treatment Adherence Rates Related to Visits, Medication Compliance, Quitline Usage, and Surgeon Teachable Moment Delivery
Time Frame: Up to 12 weeks
|
Up to 12 weeks
|
|
Smoking Abstinence Rates as Measured by Self-report
Time Frame: Up to 12 weeks
|
Up to 12 weeks
|
|
Smoking Abstinence Rates as Measured by Salivary Cotinine Testing
Time Frame: Up to 12 weeks
|
Up to 12 weeks
|
Collaborators and Investigators
Investigators
- Study Chair: Ivana Croghan, PhD, MAYO
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Respiratory Tract Diseases
- Neoplasms
- Lung Diseases
- Neoplasms by Site
- Respiratory Tract Neoplasms
- Thoracic Neoplasms
- Lung Neoplasms
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Cholinergic Agents
- Nicotinic Agonists
- Cholinergic Agonists
- Varenicline
Other Study ID Numbers
- A211401
- NCI-2016-00438 (REGISTRY: NCI Clinical Trial Reporting Program)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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