Perception of Objects and Natural Scenes in People With Vision Loss (ACTIVIS) (ACTIVIS)

Evaluation of the Perception of Objects and Natural Scenes in People With Vision Loss (Loss of Central or Peripheral Vision)

The loss of central vision causes difficulty not only in reading but also in faces recognition, and in particular in the identification of facial expression, objects or spaces. These visual deficits have been mainly studied in relation with reading, which is the main complaint of these kind of patients. However, there are not enough data regarding perception of objects and spaces in this population. Then, the objectives are to study the visual-spatial abilities in individuals with vision loss, and altered cognitive processes, (2) to develop clinics tools for early detection and quantification of visual-spatial deficits and (3)to understand the capacities of normal peripheral vision in order to test the possibility of potential training for use of peripheral vision when central vision is impaired by an ophthalmic pathology.

Study Overview

• Status: Completed
• Conditions: Vision Loss
• Intervention / Treatment: Other: vision tests

• Study Type: Observational
• Enrollment (Actual): 260

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 90 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients with eye disease causing loss of central or peripheral vision

Description

Inclusion Criteria cases:

• Patients with eye disease causing loss of central or peripheral vision
• French speakers
• Age between 18 and 90 years old
• Written consent
• Health insurance

Inclusion Criteria controls:

• Sex and age matched controls (+/- 5 years)
• French speakers
• Normal visual examination with visual acuity of min 9/10

Exclusion Criteria:

• Psychiatric disease or neurological pathologies
• Communication difficulties (deafness / mutism)
• Drug treatment altering concentration
• Mental deterioration with MMS <24
• Alcoholism or addiction to drugs
• Persons under guardianship

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Patients with loss of central vision; Patients coming in ophthalmic consultation will be selected for the study. The diagnosis of this disease is based on clinical examination, and imaging of the retina.Patients with only loss of central vision will be selected.	Other: vision tests
Patients with loss of peripheral vision; Patients coming in ophthalmic consultation will be selected for the study. Patients with loss of peripheral vision will be selected on the bases of presence of tunnel vision.	Other: vision tests
Control group; Patients without loss of vision.	Other: vision tests

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Comparison of performances in visual tests between different groups according to error rate	These behavioral studies include a series of short tests of 5 to 10 minutes each (not exceeding 60 minutes with breaks and instructions) in which photos of scenes or isolated objects will be presented in central or peripheral vision using a computer screen or a panoramic screen covering a 180° field.	at inclusion
Comparison of performances in visual tests between different groups according to answer time	These behavioral studies include a series of short tests of 5 to 10 minutes each (not exceeding 60 minutes with breaks and instructions) in which photos of scenes or isolated objects will be presented in central or peripheral vision using a computer screen or a panoramic screen covering a 180° field.	at inclusion

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Estimation of the score of visual acuity by the logMAR chart		at inclusion
Measure of lesion size		at inclusion
Pearson correlation coefficient to determine the correlation between the performance parameters during visual tests (error rate and answer time) and clinical parameters (visual acuity and lesion size)	These behavioral studies include a series of short tests of 5 to 10 minutes each (not exceeding 60 minutes with breaks and instructions) in which photos of scenes or isolated objects will be presented in central or peripheral vision using a computer screen or a panoramic screen covering a 180° field.	at inclusion

Collaborators and Investigators

• Sponsor: Lille Catholic University
• Collaborators: University Hospital, Lille
• Investigators: Principal Investigator: Thi Ha Chau Tran, MD, Hospital of the Lille Catholic Institute

Study record dates

Study Major Dates

• Study Start: March 1, 2011
• Primary Completion (Actual): March 1, 2015
• Study Completion (Actual): March 1, 2015

Study Registration Dates

• First Submitted: August 2, 2016
• First Submitted That Met QC Criteria: August 8, 2016
• First Posted (Estimate): August 11, 2016

Study Record Updates

• Last Update Posted (Estimate): August 11, 2016
• Last Update Submitted That Met QC Criteria: August 8, 2016
• Last Verified: August 1, 2016

More Information

Terms related to this study

• Keywords: Vision loss; Object recognition; Space recognition
• Additional Relevant MeSH Terms: Nervous System Diseases; Eye Diseases; Neurologic Manifestations; Sensation Disorders; Blindness; Vision Disorders
• Other Study ID Numbers: RC-P009

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No