Survivor Choices for Eating and Drinking - Colorectal Cancer (SUCCEED)

Epidemiologic data suggest that a Western dietary pattern after diagnosis of colorectal cancer increases risk of disease recurrence and death. High intake of red and processed meat, dairy, refined grains, and sweets/desserts characterize a 'Western dietary pattern'. This study aims to translate the epidemiologic findings into a patient-centered, web-based dietary intervention with text messaging to inform and modify users' dietary choices. The investigators' specific aims are to: 1) Develop a web-based dietary intervention with text messaging for colorectal cancer survivors; and 2) Conduct a 12-week pilot randomized controlled trial to determine the acceptability and feasibility of the dietary intervention among 50 colorectal cancer survivors. All participants will receive standard of care print materials regarding diet following a colorectal cancer diagnosis. Participants in the intervention group will also receive access to a web-based dietary intervention with text messaging for 12 weeks. This study will generate preliminary data on the effect of the intervention on dietary choices among colorectal cancer survivors for future studies.

Study Overview

• Status: Completed
• Conditions: Rectal Cancer; Colon Cancer; ColoRectal Cancer
• Intervention / Treatment: Behavioral: Website and text messages

• Study Type: Interventional
• Enrollment (Actual): 50
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • California
    • San Francisco, California, United States, 94158
      • University of California, San Francisco

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• diagnosed with colon or rectal adenocarcinoma
• completed standard cytotoxic chemotherapy prior to enrollment, if medically indicated
• considered disease-free or have stable disease at baseline
• able to speak and read English
• access to a mobile phone with Internet and text messaging capabilities
• able to navigate websites, fill out forms on the web, communicate by email, and have regular access to the Internet

Exclusion Criteria:

Individuals who are already meeting four or more of the six target dietary behaviors will be excluded:

• ≥5 servings/day of fruits & vegetables
• ≥3 servings/day of whole grains
• ≥2 servings/week of fish
• no processed meat
• no sugar-sweetened beverages
• ≤1 alcoholic drink/d for women and ≤2 alcoholic drinks/d for men.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Intervention; Participants will be given print material on diet for cancer survivors and access to a web-based dietary intervention with text messaging for 12 weeks.	Behavioral: Website and text messages; Participants receive a personalized diet report, access to a digital health dietary intervention, and text messages for 12 weeks.
No Intervention: Control; Participants randomized to the control arm will receive print materials on diet for cancer survivors. After completion of their 12-week follow-up assessments, control participants will be given access to the web-based dietary intervention with text messaging for 12 weeks.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Adherence	Frequency of logging on to website and responding to text messages	12-weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Dietary change assessed via diet records	Change in consuming vegetables, whole grains, fish, processed meat, sugar-sweetened beverages, and alcohol	12-weeks
Quality-of-life (EORTC C30)	Change in quality-of-life	12-weeks
Colorectal cancer-specific quality-of-life (EORTC C30 CR29)	Change in colorectal cancer-specific quality-of-life	12-weeks
Change in body mass index	Change in objectively measured BMI	12-weeks
Change in waist circumference	Change in objectively measured waist circumference	12-weeks
Change in fasting blood lipids	Change in fasting blood lipids	12-weeks
Change in fasting glucose	Change in fasting glucose	12-weeks

Collaborators and Investigators

• Sponsor: University of California, San Francisco
• Investigators: Principal Investigator: Erin Van Blarigan, ScD, University of California, San Francisco

Publications and helpful links

General Publications

• Van Blarigan EL, Kenfield SA, Chan JM, Van Loon K, Paciorek A, Zhang L, Chan H, Savoie MB, Bocobo AG, Liu VN, Wong LX, Laffan A, Atreya CE, Miaskowski C, Fukuoka Y, Meyerhardt JA, Venook AP. Feasibility and Acceptability of a Web-Based Dietary Intervention with Text Messages for Colorectal Cancer: A Randomized Pilot Trial. Cancer Epidemiol Biomarkers Prev. 2020 Apr;29(4):752-760. doi: 10.1158/1055-9965.EPI-19-0840. Epub 2020 Jan 15.
• Wang L, Langlais C, Kenfield SA, Van Loon K, Laffan A, Atreya CE, Chan JM, Zhang L, Allen IE, Miaskowski C, Fukuoka Y, Meyerhardt JA, Venook AP, Van Blarigan EL. Quality of life among colorectal cancer survivors participating in a pilot randomized controlled trial of a web-based dietary intervention with text messages. Support Care Cancer. 2023 Feb 10;31(3):155. doi: 10.1007/s00520-023-07620-x.

Study record dates

Study Major Dates

• Study Start (Actual): April 10, 2017
• Primary Completion (Actual): September 2, 2018
• Study Completion (Actual): November 20, 2018

Study Registration Dates

• First Submitted: November 14, 2016
• First Submitted That Met QC Criteria: November 14, 2016
• First Posted (Estimated): November 16, 2016

Study Record Updates

• Last Update Posted (Estimated): December 17, 2025
• Last Update Submitted That Met QC Criteria: December 10, 2025
• Last Verified: December 1, 2025

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms by Site; Neoplasms; Intestinal Diseases; Gastrointestinal Neoplasms; Digestive System Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Intestinal Neoplasms; Rectal Diseases; Colonic Diseases; Rectal Neoplasms; Colorectal Neoplasms; Colonic Neoplasms
• Other Study ID Numbers: 164511; NCI-2017-01381 (Registry Identifier: NCI Clinical Trials Reporting Program (CTRP))

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No