The Effect of a Protein Hydrolysate on Muscle Strength Recovery

The Effect of a Protein Hydrolysate on Muscle Strength Recovery in Athletes

Overtraining is a real problem for (semi-)professional athletes. Overtraining is often caused by the bodies' lack of ability to recover between training. In addition, during high intensity training reactive oxygen species are formed up to 20 fold compared to resting values. This causes increased muscle tissue damage after intense exercise, which slows down recovery. Improving recovery may increase an athlete's ability to reach higher training volumes resulting in establishing a higher performance plateau.

It is known that hydrolyzed proteins have a positive effect on muscle protein synthesis due to its faster absorption rate. Therefore, it is hypothesized that a known protein hydrolysate may have positive effects on strength recovery.

Study Overview

• Status: Completed
• Conditions: Muscle Strength Recovery
• Intervention / Treatment: Dietary supplement: Placebo; Dietary supplement: Protein hydrolysate high dose; Dietary supplement: Protein hydrolysate low dose

• Study Type: Interventional
• Enrollment (Actual): 48
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Healthy individuals (based on their medical history provided during a general health questionnaire)
• Participants are amateur or (semi-) professional athletes in resistance or interval sports (engage in >6 hours of intense physical activity per week).
• Age 18 - 35
• Experience in resistance training

Exclusion Criteria:

• Use of creatine supplements and/or anabolic steroids.
• Allergy to test product/protein
• Allergy to specific protein hydrolysate
• BMI lower than 18 or higher than 30.
• Lack of technique in correctly performing a barbell squat (judged by sports physiologist).
• Recent muscle injury in legs or back less than one month before the start of the study.
• Cardiovascular complications
• Use of medication
• Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study (to be decided by the principle investigator), in the 180 days prior to the study.
• Abuse of products; alcohol (> 20 alcoholic units per week) and drugs

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo	Dietary supplement: Placebo
Experimental: Protein hydrolysate high dose	Dietary supplement: Protein hydrolysate high dose
Experimental: Protein hydrolysate low dose	Dietary supplement: Protein hydrolysate low dose

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle strength recovery	difference in peak force between the exhaustion challenge and the recovery challenge, measured with a linear encoder during a squat exercise	4 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Blood lactate buildup	in mmol/L, measured trough a finger prick after exhaustion and recovery challenge	4 weeks
Body composition	fat percentage, based on 4-point skin fold measurement	4 weeks
Exercise volume	amount of repetitions x time taken x power, measured with a linear encoder during squat exercise	4 weeks
Peak force output	measured with a linear encoder during the squat exercise	4 weeks

Collaborators and Investigators

• Sponsor: BioActor

Study record dates

Study Major Dates

• Study Start (Actual): June 6, 2016
• Primary Completion (Actual): February 9, 2017
• Study Completion (Actual): February 20, 2017

Study Registration Dates

• First Submitted: February 2, 2017
• First Submitted That Met QC Criteria: February 21, 2017
• First Posted (Actual): February 24, 2017

Study Record Updates

• Last Update Posted (Actual): March 3, 2017
• Last Update Submitted That Met QC Criteria: March 1, 2017
• Last Verified: March 1, 2017

More Information

Terms related to this study

• Other Study ID Numbers: MU-001

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED