- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03214341
Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging
Study Overview
Detailed Description
Differentiation between benign and malignant mediastinal tumors as well as characterization and grading of malignancy is essential for treatment planning as well as for prognosis .
MRI presents valuable diagnostic information in assessing the mediastinum. In addition, special applications have been developed over recent years diffusion-weighted magnetic resonance imaging is one such technique The advent of echo-planar imaging technique has rendered diffusion weighted imaging of the abdomen and thoracic cavity possible .
Quantitative assessment of the mediastinal mass is possible by calculation of apparent diffusion co-efficient value ,which is related to the proportion of extracellular and intracellular component.
The apparent diffusion co-efficient is inversely correlated with tissue cellularity. It is lower in viable tumor tissue with densely packed diffusion-hindering obstacles than in tissue with less densely packed obstacles such as tumor necrosis and benign tissue .
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Noha Mohammed Ali Attia, lecturer
- Phone Number: 00201001238435
- Email: nohamohammedali@yahoo.com
Study Contact Backup
- Name: Mostafa Thabet Hussein, professor
- Phone Number: 00201122999878
- Email: Thabet.mostafa@yahoo.com
Study Locations
-
-
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Assiut, Egypt
- Assiut University
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Any age groups
- diagnosis of mediastinal mass (by Multislice Computed Tomography).
Exclusion Criteria:
- chemotherapy radiotherapy.
- thoracic surgery.
- cystic mass .
- mass with large amount of necrosis or calcification.
- contraindication of MRI (e.g. pacemakers , claustrophobia).
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
sensitivity and specificity of magnetic resonance imaging diffusion in mediastinal masses
Time Frame: up to one month
|
up to one month
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Mostafa Thabet Hussein, professor, Assiut University
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- MRIML
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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