- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03328247
Achieving Self-directed Integrated Cancer Aftercare (ASICA) in Melanoma (ASICA)
April 27, 2021 updated by: University of Aberdeen
Achieving Self-directed Integrated Cancer Aftercare (ASICA) in Melanoma: A Randomized Patient-focused Trial of Delivering the ASICA Intervention as a Means to Earlier Detection of Recurrent and Second Primary Melanoma
The ASICA study is looking at how the UK National Health Service (NHS) might use technology in the future to more effectively support people who have been treated for melanoma.
Study Overview
Detailed Description
All patients who have been treated for melanoma are advised to regularly examine their own skin (total-skin-self-examinations; TSSE) but research has found that many people are not shown how to do this effectively.
We are investigating whether a digital app we have developed (ASICA) can help people with melanoma to use a hand-held tablet computer to do more regular and effective TSSE, and whether this would lead to earlier detection of recurrent and new primary melanomas.
The ASICA app also uses the internet to enable people to electronically communicate the findings of their TSSE to a specialist nurse.
All those who consent to take part in the study will be randomly allocated into one of two groups.
One group will use the ASICA app in addition to their normal follow-up, the other group will continue to attend their routine melanoma follow-up only.
Participants will be recruited from two UK sites - NHS Grampian and Cambridge University Hospitals.
Study Type
Interventional
Enrollment (Actual)
240
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Aberdeen, United Kingdom
- University of Aberdeen
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Cambridge, United Kingdom
- Addenbrookes Hospital
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Adult (≥18)
- Patients treated for stage 0-2C cutaneous melanoma within the preceding 24 months
Exclusion Criteria:
- Stage 3 and 4 melanoma.
- Previous local recurrence of melanoma within last 24 months.
- Patients who are unable to consent and/or complete questionnaires (e.g. due to cognitive or language issues).
- Patients who are blind or visually impaired.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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No Intervention: Control
Control group will attend their routine melanoma follow-ups
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Experimental: Intervention
The intervention group will use the ASICA app in addition to their routine follow-ups
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Participants in the intervention arm will be trained to use ASICA (in addition to completing routine follow-up) and participants within the control arm will continue to attend their usual structured melanoma follow-up only.
The hypothesis is that the ASICA intervention will increase TSSE practice in those affected by melanoma without affecting psychological well-being and lead to earlier detection of recurrent and new primary melanoma.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The impact of receiving ASICA on cancer worry
Time Frame: Up to 12 months following randomisation.
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This outcome will be measured using Melanoma Worry Scale (MWS).
The scale consists of four questions asking the patients how worried they are about getting melanoma and how this impacts their current lifestyle.
The patients choose the answers on a 5-point scale ranging from 'not at all worried' (best answer) to 'worried almost all the time' (worst answer).
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Up to 12 months following randomisation.
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The impact of receiving ASICA on anxiety and depression
Time Frame: Up to 12 months following randomisation.
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This outcome will be measured using Hospital Anxiety and Depression Scale (HADS).
HADS was devised to measure anxiety and depression in a general medical population of patients.
The questionnaire comprises seven questions for anxiety and seven questions for depression.
The patients choose the answers on a 4-point scale ranging from 'not at all' (best answer) to 'all the time' (worst answer).
Each item on the questionnaire is scored from 0-3 leading to a score range of 0 and 21 for each subscales (anxiety or depression).
For both scales, scores of less than 7 indicate non-cases, scores of 8-10 indicate mild anxiety/depression, scores of 11-14 indicate moderate anxiety/depression, and scores of 15-21 indicate severe anxiety/depression.
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Up to 12 months following randomisation.
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The impact of receiving ASICA quality of life.
Time Frame: Up to 12 months following randomisation.
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This outcome will be measured using EQ-5D-5L questionnaire.
EQ-5D-5L consists of two sections - descriptive system and a visual scale.
The descriptive system comprises of five questions about mobility, self-care, usual activities, pain/discomfort and anxiety/depression.
Each question has five possible answers ranging from: no problems, slight problems, moderate problems, severe problems and extreme problems.
The patient chooses the most appropriate statement in each of the five questions.
This decision results in a 1-digit number that expresses the level selected for that question.
The digits for the five dimensions can be combined into a 5-digit number that describes the patient's health state.
The higher the number the worse the health state is.
The visual scale records the patient's self-rated health on a vertical visual analogue scale, where the endpoints are labelled 'The worst health you can imagine' (score of 0) and 'The best health you can imagine' (score of 100).
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Up to 12 months following randomisation.
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The impact of receiving ASICA on detection rate of second primary and recurrent melanoma
Time Frame: Up to 12 months following randomisation.
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The questionnaire consists of 14 questions asking patients whether they have ever and in the past 12 month checked any part of their skin for signs of skin cancer (yes/no answer).
If so, how often (5 point scale ranging from 'zero' to 'more than six times') and which areas of the body were checked.
The patients are also asked whether they used a mirror or get help to check difficult to reach areas of their body.
The patients are also asked how confident they are about being able to check their own skin.
Patients choose the answers on a 10-point scale ranging from 'not at all confident' (worst answer) to 'highly confident' (best answer).
The final set of questions ask patients whether they have found anything concerning during their last skin check (yes/no answer) and if so what action was taken by the patient (watched it/showed it to a relative/showed it to a professional) and how quickly (immediately, in few days, in a week, in a month, other).
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Up to 12 months following randomisation.
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The impact of receiving ASICA on adherence to and self-efficacy to conduct TSSE in future
Time Frame: Up to 12 months following randomisation.
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This outcome will be measured using a questionnaire designed to determine what the patients think about examining their own skin.
The questionnaire consists of nine statements about how important it is to patients to check their skin, do they do it regularly, does it make them anxious, whether they feel confident about having their skin checked by a professional, and do they make plans regarding when and where they will have their skin checked.
For each statement, patients indicate whether they strongly disagree, disagree, agree, strongly agree, or are unsure.
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Up to 12 months following randomisation.
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The impact of receiving ASICA on patterns of UK NHS resource use
Time Frame: Up to 12 months following randomisation.
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This outcome will be measured using a questionnaire designed to determine whether patients used NHS because of their skin problems.
The set of seven questions is about any appointments within the NHS that patients may have had about their skin in the past 12 months.
Patients are asked whether they had any appointments with a medical professional (GP/nurse/other) for their skin in the past 12 months (yes/no answer), how many (free text) and at what setting (visit at the practice/visit at home/telephone).
Patients are also asked about operations or any other treatment they may have had on their skin in the past 12 months (free text).
Patients are also asked to list any prescribed medicines or non-prescribed skin products in the last 12 months and their cost (free text).
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Up to 12 months following randomisation.
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Peter Murchie, MBChB, PhD, University of Aberdeen
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Murchie P, Constable L, Hall S, Brant W, Allan J, Johnston M, Masthoff J, Lee A, Treweek S, Ayansina D, Proby C, Rahman K, Walter F, Burrows N, Durrani A, Maclennan G. The Achieving Self-directed Integrated Cancer Aftercare Intervention for Detection of Recurrent and Second Primary Melanoma in Survivors of Melanoma: Pilot Randomized Controlled Trial. JMIR Cancer. 2022 Sep 8;8(3):e37539. doi: 10.2196/37539.
- Allan JL, Johnston DW, Johnston M, Murchie P. Describing, predicting and explaining adherence to total skin self-examination (TSSE) in people with melanoma: a 12-month longitudinal study. BMJ Open. 2022 Aug 30;12(8):e056755. doi: 10.1136/bmjopen-2021-056755.
- Reilly F, Contstable L, Brant W, Rahman K, Durrani A, Burrows N, Proby C, Allan J, Johnston M, Johnston D, Walter F, Murchie P. Achieving integrated self-directed Cancer aftercare (ASICA) for melanoma: how a digital intervention to support total skin self-examination was used by people treated for cutaneous melanoma. BMC Cancer. 2021 Nov 13;21(1):1217. doi: 10.1186/s12885-021-08959-2.
- Murchie P, Masthoff J, Walter FM, Rahman K, Allan JL, Burrows N, Proby C, Lee AJ, Johnston M, Durrani A, Depasquale I, Brant B, Neilson A, Meredith F, Treweek S, Hall S, McDonald A. Achieving Self-Directed Integrated Cancer Aftercare (ASICA) in melanoma: protocol for a randomised patient-focused pilot trial of delivering the ASICA intervention as a means to earlier detection of recurrent and second primary melanoma. Trials. 2019 Jun 3;20(1):318. doi: 10.1186/s13063-019-3453-x.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 12, 2018
Primary Completion (Actual)
March 31, 2020
Study Completion (Actual)
March 31, 2020
Study Registration Dates
First Submitted
October 23, 2017
First Submitted That Met QC Criteria
October 26, 2017
First Posted (Actual)
November 1, 2017
Study Record Updates
Last Update Posted (Actual)
April 28, 2021
Last Update Submitted That Met QC Criteria
April 27, 2021
Last Verified
April 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2-028-17
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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