Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

June 4, 2026 updated by: Merck Sharp & Dohme LLC

A Multicenter, Open-label, Phase 3 Study to Evaluate the Long-term Safety and Efficacy in Participants Who Are Currently on Treatment or in Follow-up in Studies That Include Pembrolizumab

The purpose of this study is to evaluate the long-term safety and efficacy of pembrolizumab (MK-3475) in participants from previous Merck pembrolizumab-based parent studies who transition into this extension study.

This study will consist of three phases: 1) First Course Phase, 2) Survival Follow-up Phase or 3) Second Course Phase. Each participant will transition to this extension study in one of the following three phases, depending on the study phase they were in at the completion of the parent study. Participants who were in the First Course Phase of study treatment with pembrolizumab or lenvatinib in their parent study will enter the First Course Phase of this study and complete up to 35 doses or more every 3 weeks (Q3W) or 17 doses or more every 6 weeks (Q6W) of study treatment with pembrolizumab or a pembrolizumab-based combination or lenvatinib according to arm assignment. Participants who were in the Follow-up Phase in the parent study (post-treatment or Survival Follow-up Phase) will enter the Survival Follow-up Phase of this study. Participants who were in the Second Course Phase in their parent study will enter Second Course Phase of this study and complete up to 17 doses Q3W or 8 doses Q6W of study treatment with pembrolizumab or a pembrolizumab-based combination according to arm assignment.

Any participant originating from a parent trial where crossover to pembrolizumab was permitted upon disease progression may be eligible for 35 doses as Q3W or 17 doses Q6W of pembrolizumab (approximately 2 years), if they progress while on the control arm and pembrolizumab is approved for the indication in the country where the potential eligible crossover participant is being evaluated.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

3500

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Argentina
      • Buenos Aires, Argentina, C1118AAT
        • Recruiting
        • Hospital Aleman-Oncology ( Site 1351)
        • Contact:
          • Study Coordinator
          • Phone Number: 541148277000
      • Córdoba, Argentina, X5016KEH
        • Completed
        • Hospital Privado Universitario de Córdoba ( Site 1354)
      • Córdoba, Argentina, X5004SHP
        • Recruiting
        • Clínica Universitaria Reina Fabiola ( Site 1376)
        • Contact:
          • Study Coordinator
          • Phone Number: +5435196778868
      • Córdoba, Argentina, X5008AAC
        • Recruiting
        • Centro Medico Privado CEMAIC ( Site 1371)
        • Contact:
          • Study Coordinator
          • Phone Number: +5493513976568
      • La Rioja, Argentina, F5300COE
        • Recruiting
        • Fundación CORI para la Investigación y Prevención del Cáncer ( Site 1358)
        • Contact:
          • Study Coordinator
          • Phone Number: +54-380-443-6443
      • San Juan, Argentina, J5400EBB
        • Recruiting
        • Instituto San Marcos ( Site 1366)
        • Contact:
          • Study Coordinator
          • Phone Number: (0264) 4222935
      • San Miguel de Tucumán, Argentina, T4000IAK
        • Recruiting
        • Centro Medico San Roque-Oncology ( Site 1352)
        • Contact:
          • Study Coordinator
          • Phone Number: 5493815000953
      • Santiago del Estero, Argentina, G4200AWD
        • Recruiting
        • Centro Oncologico Norte. ( Site 1370)
        • Contact:
          • Study Coordinator
          • Phone Number: +543854754816
    • Buenos Aires
      • Berazategui, Buenos Aires, Argentina, B1884BBF
        • Recruiting
        • Centro de Oncología e Investigación de Buenos Aires ( Site 1357)
        • Contact:
          • Study Coordinator
          • Phone Number: 541142563156
      • Buenos Aires., Buenos Aires, Argentina, C1431FWO
        • Recruiting
        • Centro de Educación Médica e Investigaciones clínicas "Dr. Norberto Quirno" (CEMIC) ( Site 1368)
        • Contact:
          • Study Coordinator
          • Phone Number: +54-911-36115955
      • CABA, Buenos Aires, Argentina, C1093AAS
        • Recruiting
        • Fundacion Favaloro ( Site 1367)
        • Contact:
          • Study Coordinator
          • Phone Number: (54-11) 4378-1200
      • CABA, Buenos Aires, Argentina, C1426ECQ
        • Recruiting
        • Derma Internacional SA ( Site 1372)
        • Contact:
          • Study Coordinator
          • Phone Number: 01168192023
      • Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ANZ
        • Recruiting
        • Instituto Alexander Fleming ( Site 1364)
        • Contact:
          • Study Coordinator
          • Phone Number: +54-911-36115955
      • Ciudad de Buenos Aires, Buenos Aires, Argentina, C1012AAR
        • Active, not recruiting
        • IDIM - Instituto de Investigaciones Metabólicas ( Site 1362)
      • Mar del Plata, Buenos Aires, Argentina, B7600FYZ
        • Recruiting
        • Instituto de Investigaciones Clínicas Mar del Plata ( Site 1363)
        • Contact:
          • Study Coordinator
          • Phone Number: +54-911-36115955
    • Córdoba Province
      • Río Cuarto, Córdoba Province, Argentina, X5800
        • Recruiting
        • Instituto Médico Río Cuarto ( Site 1375)
        • Contact:
          • Study Coordinator
          • Phone Number: +5493585628491
    • Río Negro Province
      • Viedma, Río Negro Province, Argentina, R8500ACE
        • Recruiting
        • Clinica Viedma ( Site 1353)
        • Contact:
          • Study Coordinator
          • Phone Number: +542920432720
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, S2000CEJ
        • Recruiting
        • Fundacion Estudios Clinicos ( Site 1369)
        • Contact:
          • Study Coordinator
          • Phone Number: +543412384171
      • Rosario, Santa Fe Province, Argentina, S2000KZE
        • Recruiting
        • Instituto de Oncologia de Rosario ( Site 1350)
        • Contact:
          • Study Coordinator
          • Phone Number: 5493415778394
      • Rosario, Santa Fe Province, Argentina, S2002KDS
        • Recruiting
        • Hospital Provincial del Centenario ( Site 1359)
        • Contact:
          • Study Coordinator
          • Phone Number: 0341 430-7185
      • Rosario, Santa Fe Province, Argentina, S2000DSV
        • Recruiting
        • Sanatorio Parque ( Site 1355)
        • Contact:
          • Study Coordinator
          • Phone Number: 543414268409
  • Australia
    • New South Wales
      • Camperdown, New South Wales, Australia, 2050
        • Recruiting
        • Chris OBrien Lifehouse ( Site 3003)
        • Contact:
          • Study Coordinator
          • Phone Number: +61285140144
      • Camperdown, New South Wales, Australia, 2050
        • Completed
        • Royal Prince Alfred Hospital-A.W. Morrow Gastroenterology and Liver Centre ( Site 3016)
      • Liverpool, New South Wales, Australia, 2170
        • Recruiting
        • Liverpool Hospital-Medical Oncology ( Site 3021)
        • Contact:
          • Study Coordinator
          • Phone Number: +61287389000
      • Macquarie University, New South Wales, Australia, 2109
        • Recruiting
        • Macquarie University ( Site 3010)
        • Contact:
          • Study Coordinator
          • Phone Number: +61298123635
      • North Sydney, New South Wales, Australia, 2060
        • Recruiting
        • Mater Hospital Sydney ( Site 3007)
        • Contact:
          • Study Coordinator
          • Phone Number: +61419128168
      • Orange, New South Wales, Australia, 2800
        • Recruiting
        • Orange Hospital-Clinical Trials Unit ( Site 3027)
        • Contact:
          • Study Coordinator
          • Phone Number: 61263693000
      • Port Macquarie, New South Wales, Australia, 2444
        • Recruiting
        • Port Macquarie - Mid North Coast Cancer Institute-Medical Oncology ( Site 3020)
        • Contact:
          • Study Coordinator
          • Phone Number: 0439 345 715
      • St Leonards, New South Wales, Australia, 2065
        • Recruiting
        • Royal North Shore Hospital-Medical Oncology Clinical Trials ( Site 3025)
        • Contact:
          • Study Coordinator
          • Phone Number: +61294631172
      • Waratah, New South Wales, Australia, 2298
        • Recruiting
        • Calvary Mater Newcastle ( Site 3005)
        • Contact:
          • Study Coordinator
          • Phone Number: +61240143699
      • Westmead, New South Wales, Australia, 2145
        • Recruiting
        • Westmead Hospital ( Site 3000)
        • Contact:
          • Study Coordinator
          • Phone Number: +61298459553
      • Wollstonecraft, New South Wales, Australia, 2065
        • Recruiting
        • Melanoma Institute Australia ( Site 3001)
        • Contact:
          • Study Coordinator
          • Phone Number: +61299117321
    • Queensland
      • Brisbane, Queensland, Australia, 4101
        • Completed
        • Mater Misericordiae Limited-Medical Oncology ( Site 3019)
      • Brisbane, Queensland, Australia, 4120
        • Completed
        • Gallipoli Medical Research Ltd ( Site 3011)
      • Herston, Queensland, Australia, 4029
        • Recruiting
        • Royal Brisbane and Women's Hospital ( Site 3009)
        • Contact:
          • Study Coordinator
          • Phone Number: +61736468111
      • Southport, Queensland, Australia, 4215
        • Recruiting
        • Tasman Oncology Research Pty Ltd ( Site 3012)
        • Contact:
          • Study Coordinator
          • Phone Number: +61756132480
      • Southport, Queensland, Australia, 4215
        • Recruiting
        • Gold Coast University Hospital ( Site 3028)
        • Contact:
          • Study Coordinator
          • Phone Number: +611300744284
      • Sunshine Coast, Queensland, Australia, 4575
        • Active, not recruiting
        • Sunshine Coast University Private Hospital-Coastal Cancer Care ( Site 3032)
      • Townsville, Queensland, Australia, 4814
        • Recruiting
        • The Townsville Hospital ( Site 3017)
        • Contact:
          • Study Coordinator
          • Phone Number: +61744331111
      • Woolloongabba, Queensland, Australia, 4102
        • Recruiting
        • Princess Alexandra Hospital ( Site 3002)
        • Contact:
          • Study Coordinator
          • Phone Number: +61731766577
    • South Australia
      • Adelaide, South Australia, Australia, 5000
        • Recruiting
        • Royal Adelaide Hospital ( Site 3014)
        • Contact:
          • Study Coordinator
          • Phone Number: +61870740000
      • Woodville, South Australia, Australia, 5011
        • Recruiting
        • The Queen Elizabeth Hospital ( Site 3026)
        • Contact:
          • Study Coordinator
          • Phone Number: +61 8 82227096
    • Victoria
      • Clayton, Victoria, Australia, 3168
        • Recruiting
        • Monash Health ( Site 3015)
        • Contact:
          • Study Coordinator
          • Phone Number: +61438780439
      • Heidelberg, Victoria, Australia, 3084
        • Recruiting
        • Austin Health-Austin Hospital ( Site 3004)
        • Contact:
          • Study Coordinator
          • Phone Number: +61385598872
      • Melbourne, Victoria, Australia, 3065
        • Recruiting
        • St Vincent's Hospital-Oncology Clinical Trials ( Site 3018)
        • Contact:
          • Study Coordinator
          • Phone Number: 61392313167
      • Melbourne, Victoria, Australia, 3000
        • Recruiting
        • Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 3008)
        • Contact:
          • Study Coordinator
          • Phone Number: +61396563642
      • St Albans, Victoria, Australia, 3021
        • Recruiting
        • Western Health-Sunshine & Footscray Hospitals ( Site 3023)
        • Contact:
          • Study Coordinator
          • Phone Number: 61383451333
      • Wendouree, Victoria, Australia, 3355
        • Recruiting
        • Ballarat Oncology & Haematology Services ( Site 3022)
        • Contact:
          • Study Coordinator
          • Phone Number: 61353398000
    • Western Australia
      • Murdock, Western Australia, Australia, 6150
        • Recruiting
        • Fiona Stanley Hospital ( Site 3029)
        • Contact:
          • Study Coordinator
          • Phone Number: 61861526712
      • Nedlands, Western Australia, Australia, 6009
        • Recruiting
        • Sir Charles Gairdner Hospital ( Site 3006)
        • Contact:
          • Study Coordinator
          • Phone Number: +61864573333
      • Subiaco, Western Australia, Australia, 6008
        • Recruiting
        • St John of God Subiaco Hospital ( Site 3013)
        • Contact:
          • Study Coordinator
          • Phone Number: +61893826111
  • Austria
      • Salzburg, Austria, 5020
        • Completed
        • Uniklinikum Salzburg ( Site 2956)
      • Vienna, Austria, 1090
        • Completed
        • Medizinische Universität Wien ( Site 2953)
      • Vienna, Austria, 1210
        • Recruiting
        • Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 2954)
        • Contact:
          • Study Coordinator
          • Phone Number: +431277003855
    • Styria
      • Graz, Styria, Austria, 8036
        • Recruiting
        • Medical University of Graz ( Site 2952)
        • Contact:
          • Study Coordinator
          • Phone Number: +4331638580321
    • Tyrol
      • Innsbruck, Tyrol, Austria, 6020
        • Recruiting
        • Medizinische Universitaet Innsbruck ( Site 2951)
        • Contact:
          • Study Coordinator
          • Phone Number: +4351250422971
    • Upper Austria
      • Linz, Upper Austria, Austria, 4020
        • Recruiting
        • Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 2957)
        • Contact:
          • Study Coordinator
          • Phone Number: +4373276764226
      • Linz, Upper Austria, Austria, 4021
        • Completed
        • Kepler Universitätsklinikum ( Site 2955)
  • Belgium
      • Namur, Belgium, 5530
        • Active, not recruiting
        • Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant-Godinne - Site Godi ( Site 2909)
    • Antwerpen
      • Mechelen, Antwerpen, Belgium, 2800
        • Active, not recruiting
        • AZ Sint-Maarten ( Site 2904)
    • Bruxelles-Capitale, Region de
      • Anderlecht, Bruxelles-Capitale, Region de, Belgium, 1070
        • Active, not recruiting
        • Institut Jules Bordet ( Site 2903)
      • Brussels, Bruxelles-Capitale, Region de, Belgium, 1070
        • Completed
        • Cliniques Universitaires de Bruxelles - CUB - Hopital Erasme ( Site 2905)
      • Brussels, Bruxelles-Capitale, Region de, Belgium, 1200
        • Active, not recruiting
        • Cliniques universitaires Saint-Luc-Medical Oncology ( Site 2911)
      • Brussels, Bruxelles-Capitale, Region de, Belgium, 1090
        • Active, not recruiting
        • UZ Brussel ( Site 2900)
    • Oost-Vlaanderen
      • Ghent, Oost-Vlaanderen, Belgium, 9000
        • Active, not recruiting
        • AZ Maria Middelares ( Site 2908)
    • Vlaams-Brabant
      • Leuven, Vlaams-Brabant, Belgium, 3000
        • Recruiting
        • UZ Leuven - Campus Gasthuisberg ( Site 2906)
        • Contact:
          • Study Coordinator
          • Phone Number: +3216344218
      • Leuven, Vlaams-Brabant, Belgium, 3000
        • Completed
        • UZ Leuven Gasthuisberg, Gynaecologie-Verloskunde ( Site 2907)
      • Leuven, Vlaams-Brabant, Belgium, 3000
        • Active, not recruiting
        • UZ Leuven ( Site 2901)
  • Brazil
      • Rio de Janeiro, Brazil, 22775-001
        • Recruiting
        • Instituto de de Educação, pesquisa e Gestão em Saúde ( Site 1014)
        • Contact:
          • Study Coordinator
          • Phone Number: +552135092115
      • Rio de Janeiro, Brazil, 20230-130
        • Recruiting
        • Instituto Nacional de Câncer José Alencar Gomes da Silva - INCA ( Site 1020)
        • Contact:
          • Study Coordinator
          • Phone Number: +552132076585
      • São Paulo, Brazil, 01246-000
        • Recruiting
        • Instituto do Cancer do Estado de Sao Paulo - ICESP ( Site 1001)
        • Contact:
          • Study Coordinator
          • Phone Number: +551138932645
      • São Paulo, Brazil, 01321-001
        • Recruiting
        • BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 1030)
        • Contact:
          • Study Coordinator
          • Phone Number: +551135056675
      • São Paulo, Brazil, 01509-010
        • Recruiting
        • A. C. Camargo Cancer Center ( Site 1002)
        • Contact:
          • Study Coordinator
          • Phone Number: 551121895000
      • São Paulo, Brazil, 01321-001
        • Recruiting
        • Hospital Paulistano ( Site 1033)
        • Contact:
          • Study Coordinator
          • Phone Number: +551131411083
      • São Paulo, Brazil, 04014-012
        • Recruiting
        • Núcleo de Pesquisa Clínica da Rede São Camilo ( Site 1018)
        • Contact:
          • Study Coordinator
          • Phone Number: 55 11 4450-0363
    • Ceará
      • Fortaleza, Ceará, Brazil, 60135-237
        • Recruiting
        • Hospital São Carlos-Oncocentro Ce ( Site 1029)
        • Contact:
          • Study Coordinator
          • Phone Number: +558532865934
      • Fortaleza, Ceará, Brazil, 60336-232
        • Recruiting
        • CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA-Pesquisa Clínica ( Site 1024)
        • Contact:
          • Study Coordinator
          • Phone Number: +55 85 32865934
      • Fortaleza, Ceará, Brazil, 60430235
        • Recruiting
        • Centro de Pesquisa Clínica do Instituto do Câncer do Ceará ( Site 1016)
        • Contact:
          • Study Coordinator
          • Phone Number: +5585999547790
    • Paraná
      • Curitiba, Paraná, Brazil, 81520-060
        • Active, not recruiting
        • Hospital Erasto Gaertner ( Site 1036)
    • Rio Grande do Sul
      • Bento Gonçalves, Rio Grande do Sul, Brazil, 95700-000
        • Recruiting
        • Hospital Tacchini ( Site 1040)
        • Contact:
          • Study Coordinator
          • Phone Number: +555434554333
      • Ijuí, Rio Grande do Sul, Brazil, 98700-000
        • Recruiting
        • ONCOSITE - Centro de Pesquisa Clinica em Oncologia ( Site 1008)
        • Contact:
          • Study Coordinator
          • Phone Number: +555531950504
      • Passo Fundo, Rio Grande do Sul, Brazil, 99010-260
        • Recruiting
        • Hospital de Clínicas de Passo Fundo ( Site 1025)
        • Contact:
          • Study Coordinator
          • Phone Number: +555421034130
      • Pelotas, Rio Grande do Sul, Brazil, 96020-080
        • Recruiting
        • Lacks - Oncologia E Hematologia ( Site 1026)
        • Contact:
          • Study Coordinator
          • Phone Number: +555330285068
      • Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
        • Recruiting
        • Hospital de Clinicas de Porto Alegre ( Site 1000)
        • Contact:
          • Study Coordinator
          • Phone Number: +555133598619
      • Porto Alegre, Rio Grande do Sul, Brazil, 90610-000
        • Recruiting
        • Hospital São Lucas da PUCRS-Centro de Pesquisa em Oncologia ( Site 1006)
        • Contact:
          • Study Coordinator
          • Phone Number: 555133203000
      • Porto Alegre, Rio Grande do Sul, Brazil, 91350-200
        • Recruiting
        • Hospital Nossa Senhora da Conceição ( Site 1011)
        • Contact:
          • Study Coordinator
          • Phone Number: +555135160954
      • Porto Alegree, Rio Grande do Sul, Brazil, 90050-170
        • Active, not recruiting
        • Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 1035)
      • Santa Maria, Rio Grande do Sul, Brazil, 97015-372
        • Recruiting
        • Clinica Viver ( Site 1021)
        • Contact:
          • Study Coordinator
          • Phone Number: +55 55 30267720
      • Ssanta Cruz Do Sul, Rio Grande do Sul, Brazil, 96810-102
        • Recruiting
        • Instituto de Oncologia Saint Gallen ( Site 1039)
        • Contact:
          • Study Coordinator
          • Phone Number: +5551991898942
    • Santa Catarina
      • Florianópolis, Santa Catarina, Brazil, 88034-000
        • Recruiting
        • CEPON ( Site 1012)
        • Contact:
          • Study Coordinator
          • Phone Number: 5548984320757
      • Florianópolis, Santa Catarina, Brazil, 88020-210
        • Active, not recruiting
        • CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 1034)
      • Itajaí, Santa Catarina, Brazil, 88301-220
        • Active, not recruiting
        • Centro de Novos Tratamentos Itajai - Clinica de Neoplasias Litoral ( Site 1041)
    • São Paulo
      • Barretos, São Paulo, Brazil, 14784400
        • Recruiting
        • Fundação Pio XII - Hospital de Câncer de Barretos ( Site 1010)
        • Contact:
          • Study Coordinator
          • Phone Number: +551733216637
      • Jaú, São Paulo, Brazil, 17210-080
        • Recruiting
        • Hospital Amaral Carvalho ( Site 1023)
        • Contact:
          • Study Coordinator
          • Phone Number: +551436021397
      • São José do Rio Preto, São Paulo, Brazil, 15090000
        • Recruiting
        • Fundação Faculdade Regional de Medicina de São José do Rio Preto-Centro Integrado de Pesquisa ( Site 1003)
        • Contact:
          • Study Coordinator
          • Phone Number: 551732015054
      • São Paulo, São Paulo, Brazil, 01317-001
        • Recruiting
        • Clínica de Pesquisa e Centro de Estudos em Ginecologia Oncológica e Mamária LTDA ( Site 1017)
        • Contact:
          • Study Coordinator
          • Phone Number: 5511991931500
  • Canada
    • Alberta
      • Calgary, Alberta, Canada, T2N 5G2
        • Recruiting
        • Arthur J.E. Child Comprehensive Cancer Centre ( Site 2815)
        • Contact:
          • Study Coordinator
          • Phone Number: (587) 231-6204
      • Edmonton, Alberta, Canada, T6G 1Z2
        • Recruiting
        • Cross Cancer Institute ( Site 2804)
        • Contact:
          • Study Coordinator
          • Phone Number: 7804328248
    • Manitoba
      • Winnipeg, Manitoba, Canada, R3E 0V9
        • Recruiting
        • CancerCare Manitoba ( Site 2814)
        • Contact:
          • Study Coordinator
          • Phone Number: 204-787-2197
    • Ontario
      • Hamilton, Ontario, Canada, L8V 5C2
        • Completed
        • Hamilton Health Sciences-Juravinski Cancer Centre ( Site 2801)
      • Kingston, Ontario, Canada, K7L 2V7
        • Recruiting
        • Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 2808)
        • Contact:
          • Study Coordinator
          • Phone Number: 6135496666
      • London, Ontario, Canada, N6A 5W9
        • Active, not recruiting
        • London Health Sciences Centre ( Site 2806)
      • Ottawa, Ontario, Canada, K1H 8L6
        • Recruiting
        • The Ottawa Hospital - General Campus ( Site 2813)
        • Contact:
          • Study Coordinator
          • Phone Number: 613-737-7700x71985
      • Toronto, Ontario, Canada, M4N 3M5
        • Recruiting
        • Sunnybrook Research Institute ( Site 2802)
        • Contact:
          • Study Coordinator
          • Phone Number: 4164804616
      • Toronto, Ontario, Canada, M5G 2C4
        • Recruiting
        • Princess Margaret Cancer Centre ( Site 2803)
        • Contact:
          • Study Coordinator
          • Phone Number: 4169462000
      • Toronto, Ontario, Canada, M5G 1X5
        • Recruiting
        • Mount Sinai Hospital ( Site 2811)
        • Contact:
          • Study Coordinator
          • Phone Number: 416-586-5117
    • Quebec
      • Greenfield Park, Quebec, Canada, J4V 2H1
        • Recruiting
        • Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre-Oncology ( Site 2809)
        • Contact:
          • Study Coordinator
          • Phone Number: 4504665000
      • Laval, Quebec, Canada, H7M 3L9
        • Recruiting
        • Centre Intégré de Santé et de Services Sociaux (CISSS) de La-Centre intégré de cancérologie de Lava ( Site 2810)
        • Contact:
          • Study Coordinator
          • Phone Number: 450-668-1010x23671
      • Montreal, Quebec, Canada, H2X 3E4
        • Recruiting
        • Centre Hospitalier de l Universite de Montreal - CHUM ( Site 2807)
        • Contact:
          • Study Coordinator
          • Phone Number: 5144127512
      • Montreal, Quebec, Canada, H3T 1E2
        • Recruiting
        • Jewish General Hospital ( Site 2800)
        • Contact:
          • Study Coordinator
          • Phone Number: 5143408222
      • Montreal, Quebec, Canada, H4A 3J1
        • Recruiting
        • McGill University Health Centre ( Site 2818)
        • Contact:
          • Study Coordinator
          • Phone Number: 5149341934
      • Montreal, Quebec, Canada, H3T 1M5
        • Recruiting
        • St. Marys Hospital Center ( Site 2820)
        • Contact:
          • Study Coordinator
          • Phone Number: 514-345-3511x3378
      • Québec, Quebec, Canada, G1J 1Z4
        • Recruiting
        • Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 2805)
        • Contact:
          • Study Coordinator
          • Phone Number: 4185254444
      • Sherbrooke, Quebec, Canada, J1H 5H4
        • Recruiting
        • Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer ( Site 2812)
        • Contact:
          • Study Coordinator
          • Phone Number: 8193461110X12848
      • Trois-Rivières, Quebec, Canada, G8Z 3R9
        • Recruiting
        • Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 2816)
        • Contact:
          • Study Coordinator
          • Phone Number: 8196973333x63238
  • Chile
      • Antofagasta, Chile, 1263521
        • Recruiting
        • Bradford Hill Norte ( Site 2761)
        • Contact:
          • Study Coordinator
          • Phone Number: +56974944605
    • Araucania
      • Temuco, Araucania, Chile, 4800827
        • Recruiting
        • James Lind Centro de Investigacion del Cancer ( Site 2757)
        • Contact:
          • Study Coordinator
          • Phone Number: +56956083262
      • Temuco, Araucania, Chile, 4810148
        • Recruiting
        • CIDO SpA ( Site 2765)
        • Contact:
          • Study Coordinator
          • Phone Number: +56452657374
    • Biobio
      • Concepción, Biobio, Chile, 4070196
        • Recruiting
        • Biocenter ( Site 2763)
        • Contact:
          • Study Coordinator
          • Phone Number: +56412858421
    • Coquimbo Region
      • La Serena, Coquimbo Region, Chile, 1720430
        • Recruiting
        • IC La Serena Research ( Site 2766)
        • Contact:
          • Study Coordinator
          • Phone Number: +56958646664
    • Maule Region
      • Talca, Maule Region, Chile, 3465584
        • Recruiting
        • UNIVERSIDAD CATÓLICA DEL MAULE ( Site 2768)
        • Contact:
          • Study Coordinator
          • Phone Number: +56712635600
    • Region M. de Santiago
      • Santiago, Region M. de Santiago, Chile, 7500713
        • Completed
        • Orlandi Oncologia-Oncology ( Site 2752)
      • Santiago, Region M. de Santiago, Chile, 7500921
        • Recruiting
        • Fundacion Arturo Lopez Perez FALP ( Site 2750)
        • Contact:
          • Study Coordinator
          • Phone Number: +56992108354
      • Santiago, Region M. de Santiago, Chile, 7500994
        • Recruiting
        • Oncovida ( Site 2759)
        • Contact:
          • Study Coordinator
          • Phone Number: 56225992945
      • Santiago, Region M. de Santiago, Chile, 8330024
        • Recruiting
        • Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 2751)
        • Contact:
          • Study Coordinator
          • Phone Number: +56963413803
      • Santiago, Region M. de Santiago, Chile, 8380455
        • Recruiting
        • Instituto Nacional del Cancer-CR Investigación ( Site 2753)
        • Contact:
          • Study Coordinator
          • Phone Number: +56 2575 7100
      • Santiago, Region M. de Santiago, Chile, 8420383
        • Recruiting
        • Bradfordhill-Clinical Area ( Site 2756)
        • Contact:
          • Study Coordinator
          • Phone Number: +56229490970
      • Santiago, Region M. de Santiago, Chile, 7580206
        • Recruiting
        • Clínica Inmunocel ( Site 2762)
        • Contact:
          • Study Coordinator
          • Phone Number: +56997890202
      • Santiago, Region M. de Santiago, Chile, 7500653
        • Recruiting
        • Centro de Estudios Clínicos SAGA ( Site 2767)
        • Contact:
          • Study Coordinator
          • Phone Number: +562223592703
    • Valparaiso
      • Viña del Mar, Valparaiso, Chile, 2540488
        • Recruiting
        • Centro de Investigaciones ( Site 2755)
        • Contact:
          • Study Coordinator
          • Phone Number: +56323245375
      • Viña del Mar, Valparaiso, Chile, 2520598
        • Recruiting
        • ONCOCENTRO APYS-ACEREY ( Site 2758)
        • Contact:
          • Study Coordinator
          • Phone Number: +56323320850
  • China
    • Anhui
      • Hefei, Anhui, China, 230001
        • Recruiting
        • Anhui Provincial Hospital-Cancer Chemotherapy Department ( Site 3480)
        • Contact:
          • Study Coordinator
          • Phone Number: 13805695536
      • Hefei, Anhui, China, 230036
        • Recruiting
        • Anhui Provincil Hospital South District-Respiratory Medicine Dept ( Site 3487)
        • Contact:
          • Study Coordinator
          • Phone Number: 18963789187
    • Beijing Municipality
      • Beijing, Beijing Municipality, China, 100035
        • Recruiting
        • Beijing Cancer Hospital ( Site 3451)
        • Contact:
          • Study Coordinator
          • Phone Number: 010-88121122
      • Beijing, Beijing Municipality, China, 100071
        • Recruiting
        • The Fifth Medical Center Of The Chinese PLA General Hospital (South) ( Site 3465)
        • Contact:
          • Study Coordinator
          • Phone Number: 861066947161
      • Beijing, Beijing Municipality, China, 100142
        • Recruiting
        • Beijing Cancer Hospital ( Site 3499)
        • Contact:
          • Study Coordinator
          • Phone Number: +861088196100
      • Beijing, Beijing Municipality, China, 100142
        • Recruiting
        • Beijing Cancer Hospital ( Site 3500)
        • Contact:
          • Study Coordinator
          • Phone Number: +861088197746
      • Beijing, Beijing Municipality, China, 100142
        • Recruiting
        • Beijing Cancer hospital-Thoracic Cancer Department A ( Site 3454)
        • Contact:
          • Study Coordinator
          • Phone Number: 010-88121122
      • Beijing, Beijing Municipality, China, 100730
        • Recruiting
        • Chinese Academy of medical science, Peking Union Medical College Hospital(Dongdan) ( Site 3466)
        • Contact:
          • Study Coordinator
          • Phone Number: (010)69158883
    • Chongqing Municipality
      • Chongqing, Chongqing Municipality, China, 400042
        • Recruiting
        • Army Medical Center of People's Liberation Army-Oncology Department ( Site 3477)
        • Contact:
          • Study Coordinator
          • Phone Number: 13908338998
    • Fujian
      • Fuzhou, Fujian, China, 350014
        • Recruiting
        • Fujian Provincial Cancer Hospital ( Site 3461)
        • Contact:
          • Study Coordinator
          • Phone Number: +8659187487329
      • Xiamen, Fujian, China, 361003
        • Recruiting
        • The First Affiliated Hospital of Xiamen University ( Site 3514)
        • Contact:
          • Study Coordinator
          • Phone Number: 0592-2139767
    • Guangdong
      • Guanghzou, Guangdong, China, 510515
        • Recruiting
        • Southern medical university Nangfang Hospital ( Site 3490)
        • Contact:
          • Study Coordinator
          • Phone Number: 020-61641888
      • Guangzhou, Guangdong, China, 510030
        • Recruiting
        • SUN YAT-SEN UNIVERSITY CANCER CENTRE-Internal Medicine ( Site 3452)
        • Contact:
          • Study Coordinator
          • Phone Number: +862087343535
      • Guangzhou, Guangdong, China, 510060
        • Recruiting
        • Sun Yat-sen University Cancer Center-melanoma ( Site 3482)
        • Contact:
          • Study Coordinator
          • Phone Number: +8659187487329
      • Guangzhou, Guangdong, China, 510080
        • Recruiting
        • Guangdong Provincial People's Hospital-Cancer Center ( Site 3462)
        • Contact:
          • Study Coordinator
          • Phone Number: +8602083827812
      • Guangzhou, Guangdong, China, 510080
        • Recruiting
        • The First Affiliated Hospital, Sun Yat-sen University-pneumology department ( Site 3459)
        • Contact:
          • Study Coordinator
          • Phone Number: +862087333133
      • Guangzhou, Guangdong, China, 510000
        • Recruiting
        • The Sixth Affiliated Hospital of Sun Yat-sen University ( Site 3491)
        • Contact:
          • Study Coordinator
          • Phone Number: 020 3825 4110
      • Guangzhou, Guangdong, China, 510120
        • Recruiting
        • The First Affiliated Hospital of Guangzhou Medical University-thoracic surgery department ( Site 3460)
        • Contact:
          • Study Coordinator
          • Phone Number: +862083062755
      • Guangzhou, Guangdong, China, 510515
        • Recruiting
        • Nanfang Hospital of Southern Medical University ( Site 3509)
        • Contact:
          • Study Coordinator
          • Phone Number: 020-62786847
    • Guizhou
      • Guiyang, Guizhou, China, 550008
        • Recruiting
        • The Affiliated Cancer Hospital of Guizhou Medical University ( Site 3498)
        • Contact:
          • Study Coordinator
          • Phone Number: 0851-86812999
    • Hebei
      • Shijiazhuang, Hebei, China, 050011
        • Active, not recruiting
        • Fourth Hospital of Hebei Medical University ( Site 3520)
    • Heilongjiang
      • Harbin, Heilongjiang, China, 150081
        • Recruiting
        • Harbin Medical University Cancer Hospital-Harbin Medical University Cancer Hospital ( Site 3475)
        • Contact:
          • Study Coordinator
          • Phone Number: 0451-86298000
      • Harbin, Heilongjiang, China, 150081
        • Recruiting
        • Harbin Medical University Cancer Hospital ( Site 3506)
        • Contact:
          • Study Coordinator
          • Phone Number: +8613945095085
    • Henan
      • Zhengzhou, Henan, China, 450008
        • Recruiting
        • Henan Cancer Hospital ( Site 3488)
        • Contact:
          • Study Coordinator
          • Phone Number: 0371-65587588
    • Hubei
      • Wuhan, Hubei, China, 430022
        • Recruiting
        • Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 3492)
        • Contact:
          • Study Coordinator
          • Phone Number: 027 8572 6754
      • Wuhan, Hubei, China, 430000
        • Completed
        • Tongji Hospital Tongji Medical,Science & Technology-oncology ( Site 3476)
    • Hunan
      • Changsha, Hunan, China, 410013
        • Recruiting
        • Hunan Cancer Hospital ( Site 3485)
        • Contact:
          • Study Coordinator
          • Phone Number: 0731-88651900
      • Changsha, Hunan, China, 410008
        • Active, not recruiting
        • Xiangya Hospital Central South University-Respiratory ( Site 3479)
      • Changsha, Hunan, China, 410008
        • Recruiting
        • Xiangya Hospital Central South University-Gynecology ( Site 3497)
        • Contact:
          • Study Coordinator
          • Phone Number: +86073189753999
      • Changsha, Hunan, China, 410013
        • Recruiting
        • Hunan Cancer Hospital ( Site 3501)
        • Contact:
          • Study Coordinator
          • Phone Number: 0731-88651900
      • Changsha, Hunan, China, 410008
        • Recruiting
        • Xiangya Hospital Central South University ( Site 3508)
        • Contact:
          • Study Coordinator
          • Phone Number: 0731-89753999
    • Jiangsu
      • Nanjing, Jiangsu, China, 210009
        • Recruiting
        • Jiangsu Cancer Hospital-Medical Oncotherapy ( Site 3469)
        • Contact:
          • Study Coordinator
          • Phone Number: 8613901581264
      • Yancheng, Jiangsu, China, 224005
        • Recruiting
        • Yancheng First People s Hospital ( Site 3504)
        • Contact:
          • Study Coordinator
          • Phone Number: 0515-66696800
      • Yangzhou, Jiangsu, China, 225000
        • Recruiting
        • Northern Jiangsu People's Hospital-General Surgery Department ( Site 3474)
        • Contact:
          • Study Coordinator
          • Phone Number: 13813194298
    • Jiangxi
      • Nanchang, Jiangxi, China, 30006
        • Recruiting
        • The First Affiliated Hospital of Nanchang University ( Site 3513)
        • Contact:
          • Study Coordinator
          • Phone Number: 0791-88695051
    • Jilin
      • Changchun, Jilin, China, 130021
        • Recruiting
        • The First Hospital of Jilin University-Oncology ( Site 3464)
        • Contact:
          • Study Coordinator
          • Phone Number: 0431-88782222
      • Changchun, Jilin, China, 132000
        • Recruiting
        • Jilin Province Tumor Hospital ( Site 3484)
        • Contact:
          • Study Coordinator
          • Phone Number: 0431-80596607
    • Shaanxi
      • Xi'an, Shaanxi, China, 710038
        • Recruiting
        • Tangdu Hospital of Fourth Military Medical University of Chi-department of radiotherapy ( Site 3455)
        • Contact:
          • Study Coordinator
          • Phone Number: 029-84777777
    • Shandong
      • Jinan, Shandong, China, 250117
        • Recruiting
        • Shandong Cancer Hospital ( Site 3517)
        • Contact:
          • Study Coordinator
          • Phone Number: +86053167626073
      • Linyi, Shandong, China, 276000
        • Recruiting
        • LinYi Cancer Hospital ( Site 3511)
        • Contact:
          • Study Coordinator
          • Phone Number: 0539-8121800
    • Shanghai Municipality
      • Shanghai, Shanghai Municipality, China, 200032
        • Recruiting
        • Fudan University Shanghai Cancer Center ( Site 3467)
        • Contact:
          • Study Coordinator
          • Phone Number: +86 13636382225
      • Shanghai, Shanghai Municipality, China, 200032
        • Recruiting
        • Zhongshan Hospital of Fudan University ( Site 3503)
        • Contact:
          • Study Coordinator
          • Phone Number: 021-64041990
      • Shanghai, Shanghai Municipality, China, 200090
        • Recruiting
        • Obstetrics & Gynecology Hospital of Fudan University ( Site 3494)
        • Contact:
          • Study Coordinator
          • Phone Number: 021-33189900
      • Shanghai, Shanghai Municipality, China, 200433
        • Recruiting
        • Shanghai Pulmonary Hospital ( Site 3470)
        • Contact:
          • Study Coordinator
          • Phone Number: 8613817918714
    • Shanxi
      • XiAn, Shanxi, China, 710061
        • Recruiting
        • The First Affiliated Hospital of Xi an Jiaotong University ( Site 3489)
        • Contact:
          • Study Coordinator
          • Phone Number: 029-58324600
    • Sichuan
      • Chengdu, Sichuan, China, 610042
        • Recruiting
        • Sichuan Cancer hospital. ( Site 3515)
        • Contact:
          • Study Coordinator
          • Phone Number: +862885420305
      • Chengdu, Sichuan, China, 610041
        • Active, not recruiting
        • West China Hospital Sichuan University-respiratory ( Site 3473)
      • Yibin, Sichuan, China, 644000
        • Recruiting
        • The Second People's Hospital of Yibin ( Site 3516)
        • Contact:
          • Study Coordinator
          • Phone Number: 0831-2381106
    • Tianjin Municipality
      • Tianjin, Tianjin Municipality, China, 300060
        • Recruiting
        • Tianjin Medical University Cancer Institute and Hospital ( Site 3456)
        • Contact:
          • Study Coordinator
          • Phone Number: 022-23109106
    • Xinjiang
      • Ürümqi, Xinjiang, China, 830000
        • Recruiting
        • Xinjiang Medical University Cancer Hospital - Urumqi-galactophore department ( Site 3486)
        • Contact:
          • Study Coordinator
          • Phone Number: 0991-7968088
      • Ürümqi, Xinjiang, China, 841100
        • Recruiting
        • The Affiliated Cancer Hospital of Xinjiang Medical University ( Site 3502)
        • Contact:
          • Study Coordinator
          • Phone Number: 0991-7968088
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310002
        • Recruiting
        • Hangzhou Cancer Hospital-Medical Oncology ( Site 3468)
        • Contact:
          • Study Coordinator
          • Phone Number: 13735430109
      • Hangzhou, Zhejiang, China, 310022
        • Recruiting
        • Zhejiang Cancer Hospital ( Site 3481)
        • Contact:
          • Study Coordinator
          • Phone Number: 13588832760
      • Hangzhou, Zhejiang, China, 310001
        • Recruiting
        • Women s Hospital School of Medicine Zhejiang University ( Site 3493)
        • Contact:
          • Study Coordinator
          • Phone Number: 0571-89992071
      • Hangzhou, Zhejiang, China, 310016
        • Recruiting
        • Sir Run Run Shaw Hospital ( Site 3505)
        • Contact:
          • Study Coordinator
          • Phone Number: 0571-86090073
      • Hangzhou, Zhejiang, China, 310003
        • Recruiting
        • The First Affiliated Hospital of Zhejiang University ( Site 3518)
        • Contact:
          • Study Coordinator
          • Phone Number: 057187236560
      • Hangzhou, Zhejiang, China, 310022
        • Recruiting
        • Zhejiang Cancer Hospital ( Site 3495)
        • Contact:
          • Study Coordinator
          • Phone Number: +86 13750851650
  • Colombia
    • Antioquia
      • Medellín, Antioquia, Colombia, 050030
        • Recruiting
        • Fundacion Colombiana de Cancerología Clinica Vida ( Site 2707)
        • Contact:
          • Study Coordinator
          • Phone Number: +57 3134336816
      • Medellín, Antioquia, Colombia, 050024
        • Recruiting
        • Instituto de Cancerología-Oncology ( Site 2702)
        • Contact:
          • Study Coordinator
          • Phone Number: 574 3409393 ext 5329
    • Atlántico
      • Barranquilla, Atlántico, Colombia, 080020
        • Recruiting
        • Clinica de la Costa S.A.S. ( Site 2705)
        • Contact:
          • Study Coordinator
          • Phone Number: +57 6053369999x229
    • Bogota D.C.
      • Bogotá, Bogota D.C., Colombia, 110221
        • Recruiting
        • Administradora Country S.A. ( Site 2701)
        • Contact:
          • Study Coordinator
          • Phone Number: +573174236866
    • Cesar Department
      • Valledupar, Cesar Department, Colombia, 200001
        • Recruiting
        • Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 2704)
        • Contact:
          • Study Coordinator
          • Phone Number: 573015371818
    • Cundinamarca
      • Bogota, Cundinamarca, Colombia, 111151
        • Recruiting
        • Instituto Nacional De Cancerologia-Oncología Clínica ( Site 2706)
        • Contact:
          • Study Coordinator
          • Phone Number: +576014320160
    • Departamento de Córdoba
      • Montería, Departamento de Córdoba, Colombia, 230002
        • Recruiting
        • IMAT S.A.S ( Site 2703)
        • Contact:
          • Study Coordinator
          • Phone Number: +573135342052
    • Risaralda Department
      • Pereira, Risaralda Department, Colombia, 660001
        • Recruiting
        • Oncologos del Occidente ( Site 2709)
        • Contact:
          • Study Coordinator
          • Phone Number: +573114746650
    • Valle del Cauca Department
      • Cali, Valle del Cauca Department, Colombia, 760032
        • Recruiting
        • Fundación Valle del Lili ( Site 2700)
        • Contact:
          • Study Coordinator
          • Phone Number: +576023319090Ext7760
      • Cali, Valle del Cauca Department, Colombia, 760042
        • Recruiting
        • Clínica Imbanaco S.A.S ( Site 2708)
        • Contact:
          • Study Coordinator
          • Phone Number: +576023851000
  • Costa Rica
      • San José, Costa Rica, 10103
        • Recruiting
        • CIMCA ( Site 3900)
        • Contact:
          • Study Coordinator
          • Phone Number: +50683893636
    • Provincia de San José
      • Santa Ana, Provincia de San José, Costa Rica, 10903
        • Active, not recruiting
        • Hospital Metropolitano - Sede Lindora ( Site 3901)
  • Czechia
      • Olomouc, Czechia, 779 00
        • Recruiting
        • Fakultni nemocnice Olomouc ( Site 0701)
        • Contact:
          • Study Coordinator
          • Phone Number: +420588441671
      • Prague, Czechia, 150 06
        • Active, not recruiting
        • Fakultni nemocnice v Motole ( Site 0700)
    • Brno-mesto
      • Brno, Brno-mesto, Czechia, 656 53
        • Recruiting
        • Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0703)
        • Contact:
          • Study Coordinator
          • Phone Number: +420543132216
    • Olomouc Region
      • Olomouc, Olomouc Region, Czechia, 779 00
        • Recruiting
        • Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0704)
        • Contact:
          • Study Coordinator
          • Phone Number: +420 588 444 288
    • Praha 4
      • Prague, Praha 4, Czechia, 140 59
        • Recruiting
        • Fakultni Thomayerova nemocnice-Onkologicka klinika 1. LF UK ( Site 0702)
        • Contact:
          • Study Coordinator
          • Phone Number: +420261082531
    • Praha 5
      • Prague, Praha 5, Czechia, 150 06
        • Active, not recruiting
        • Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0705)
  • Denmark
    • Region Syddanmark
      • Odense, Region Syddanmark, Denmark, 5000
        • Active, not recruiting
        • Odense Universitetshospital ( Site 0650)
      • Vejle, Region Syddanmark, Denmark, 7100
        • Recruiting
        • Vejle Sygehus ( Site 0653)
        • Contact:
          • Study Coordinator
          • Phone Number: +45 79405000
  • Estonia
    • Tartu
      • Tartu, Tartu, Estonia, 50406
        • Recruiting
        • Tartu University Hospital-Radiotherapy and oncology ( Site 3800)
        • Contact:
          • Study Coordinator
          • Phone Number: +3727319049
  • Finland
    • Pirkanmaa
      • Tampere, Pirkanmaa, Finland, 33520
        • Suspended
        • Tampere University Hospital [Tampere Finland] ( Site 0600)
    • Southwest Finland
      • Turku, Southwest Finland, Finland, 20520
        • Suspended
        • Turku University Hospital ( Site 0601)
  • France
      • Paris, France, 75006
        • Recruiting
        • Hopital Cochin ( Site 2509)
        • Contact:
          • Study Coordinator
          • Phone Number: +33158411781
      • Paris, France, 75010
        • Recruiting
        • Hopital Saint Louis ( Site 2510)
        • Contact:
          • Study Coordinator
          • Phone Number: +33142494949
      • Paris, France, 75012
        • Recruiting
        • CHU Hopital Saint Antoine ( Site 2517)
        • Contact:
          • Study Coordinator
          • Phone Number: +33171970387
      • Paris, France, 75020
        • Recruiting
        • Hôpital Tenon ( Site 2530)
        • Contact:
          • Study Coordinator
          • Phone Number: +33156016531
      • Paris, France, 75020
        • Recruiting
        • Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 2545)
        • Contact:
          • Study Coordinator
          • Phone Number: +33 1 44 74 11 53
    • Alpes-Maritimes
      • Nice, Alpes-Maritimes, France, 06200
        • Recruiting
        • Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Dermatology Department ( Site 2539)
        • Contact:
          • Study Coordinator
          • Phone Number: +33492036667
    • Alsace
      • Strasbourg, Alsace, France, 67091
        • Recruiting
        • Nouvel Hôpital Civil (NHC) ( Site 2529)
        • Contact:
          • Study Coordinator
          • Phone Number: +33369550905
    • Aquitaine
      • Pessac, Aquitaine, France, 33600
        • Completed
        • CHU Bordeaux Haut-Leveque ( Site 2534)
    • Auvergne
      • Lyon, Auvergne, France, 69373
        • Recruiting
        • Centre Hopitalar Leon-Berard ( Site 2519)
        • Contact:
          • Study Coordinator
          • Phone Number: +33478782654
    • Auvergne-Rhône-Alpes
      • Pierre-Bénite, Auvergne-Rhône-Alpes, France, 69495
        • Recruiting
        • CH Lyon Sud Hospices Civils de Lyon ( Site 2521)
        • Contact:
          • Study Coordinator
          • Phone Number: +33478861679
    • Bouches-du-Rhone
      • Marseille, Bouches-du-Rhone, France, 13015
        • Recruiting
        • Hopital Nord ( Site 2516)
        • Contact:
          • Study Coordinator
          • Phone Number: +33491965901
      • Marseille, Bouches-du-Rhone, France, 13385
        • Recruiting
        • CHU La Timone ( Site 2508)
        • Contact:
          • Study Coordinator
          • Phone Number: +33491388801
      • Marseille, Bouches-du-Rhone, France, 13273
        • Recruiting
        • Hôpital Privé Clairval ( Site 2549)
        • Contact:
          • Study Coordinator
          • Phone Number: +33496196234
    • Calvados
      • Caen, Calvados, France, 14076
        • Recruiting
        • Centre Francois Baclesse ( Site 2558)
        • Contact:
          • Study Coordinator
          • Phone Number: +33231455015
    • Cote-d Or
      • Dijon, Cote-d Or, France, 21079
        • Recruiting
        • Centre Georges François Leclerc-Centre de recherche clinique ( Site 2536)
        • Contact:
          • Study Coordinator
          • Phone Number: +33380737751
    • Doubs
      • Besançon, Doubs, France, 25000
        • Recruiting
        • CHU-Jean Minjoz ( Site 2550)
        • Contact:
          • Study Coordinator
          • Phone Number: +33381479999
      • Besançon, Doubs, France, 25030
        • Completed
        • CHU Jean Minjoz ( Site 2520)
    • Finistere
      • Brest, Finistere, France, 29200
        • Recruiting
        • CHRU Brest - Hopital Cavale Blanche ( Site 2504)
        • Contact:
          • Study Coordinator
          • Phone Number: +33298223578
    • Gironde
      • Bordeaux, Gironde, France, 33076
        • Recruiting
        • Institut Bergonie ( Site 2502)
        • Contact:
          • Study Coordinator
          • Phone Number: +33556333333
    • Haute-Garonne
      • Toulouse, Haute-Garonne, France, 31059
        • Recruiting
        • CHU Toulouse - Hopital Rangueil ( Site 2518)
        • Contact:
          • Study Coordinator
          • Phone Number: +33561322142
      • Toulouse, Haute-Garonne, France, 31059
        • Recruiting
        • Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE ( Site 2560)
        • Contact:
          • Study Coordinator
          • Phone Number: +33531156191
      • Toulouse, Haute-Garonne, France, 31400
        • Active, not recruiting
        • CHU de Toulouse - Hopital Larrey-service de pneumologie ( Site 2526)
    • Haute-Savoie
      • Epagny Metz Tessy, Haute-Savoie, France, 74730
        • Recruiting
        • Centre Hospitalier Annecy Genevois ( Site 2554)
        • Contact:
          • Study Coordinator
          • Phone Number: +33450636863
    • Hauts-de-France
      • Lille, Hauts-de-France, France, 59020
        • Recruiting
        • Centre Oscar Lambret ( Site 2551)
        • Contact:
          • Study Coordinator
          • Phone Number: +33320295959
    • Hauts-de-Seine
      • Boulogne, Hauts-de-Seine, France, 92104
        • Recruiting
        • Ambroise Pare Hopital ( Site 2503)
        • Contact:
          • Study Coordinator
          • Phone Number: +33149095673
      • Suresnes, Hauts-de-Seine, France, 92150
        • Recruiting
        • Hôpital Foch ( Site 2543)
        • Contact:
          • Study Coordinator
          • Phone Number: +33146252078
    • Herault
      • Montpellier, Herault, France, 34295
        • Recruiting
        • CHU Montpellier. ( Site 2556)
        • Contact:
          • Study Coordinator
          • Phone Number: +33467336933
    • Ille-et-Vilaine
      • Rennes, Ille-et-Vilaine, France, 35042
        • Recruiting
        • Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 2525)
        • Contact:
          • Study Coordinator
          • Phone Number: 33299253196
    • Indre-et-Loire
      • Chambray-lès-Tours, Indre-et-Loire, France, 37170
        • Completed
        • Hopital Trousseau ( Site 2512)
      • Tours, Indre-et-Loire, France, 37044
        • Recruiting
        • C.H.U. de Tours - Hopital Bretonneau ( Site 2515)
        • Contact:
          • Study Coordinator
          • Phone Number: +33247474747
    • Loire-Atlantique
      • Saint-Herblain, Loire-Atlantique, France, 44800
        • Recruiting
        • Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes-lung oncology ( Site 2546)
        • Contact:
          • Study Coordinator
          • Phone Number: +33240083333
      • Saint-Herblain, Loire-Atlantique, France, 44805
        • Recruiting
        • Institut de Cancérologie de l'Ouest-Oncologie Médicale ( Site 2522)
        • Contact:
          • Study Coordinator
          • Phone Number: +33240679900
    • Lorraine
      • Vandœuvre-lès-Nancy, Lorraine, France, 54519
        • Recruiting
        • Institut de Cancérologie de Lorraine Alexis Vautrin ( Site 2532)
        • Contact:
          • Study Coordinator
          • Phone Number: +33383598461
    • Nord
      • Lille, Nord, France, 59037
        • Recruiting
        • CHRU Lille Hospital Claude Huriez ( Site 2506)
        • Contact:
          • Study Coordinator
          • Phone Number: +33320444193
    • Puy-de-Dome
      • Clermont-Ferrand, Puy-de-Dome, France, 63003
        • Recruiting
        • Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne-ONCOLOGY ( Site 2542)
        • Contact:
          • Study Coordinator
          • Phone Number: +33473278137
    • Pyrenees-Atlantiques
      • Pau, Pyrenees-Atlantiques, France, 64000
        • Recruiting
        • Centre Hospitalier de Pau ( Site 2563)
        • Contact:
          • Study Coordinator
          • Phone Number: +33559924723
    • Rhone
      • Pierre-Bénite, Rhone, France, 35033
        • Recruiting
        • C.H.U. Pontchaillou ( Site 2511)
        • Contact:
          • Study Coordinator
          • Phone Number: +33299289795
    • Sarthe
      • Le Mans, Sarthe, France, 72000
        • Recruiting
        • Centre Hospitalier du Mans-Pneumologie ( Site 2527)
        • Contact:
          • Study Coordinator
          • Phone Number: +33243432764
    • Seine-Maritime
      • Rouen, Seine-Maritime, France, 76038
        • Recruiting
        • Centre Henri Becquerel ( Site 2547)
        • Contact:
          • Study Coordinator
          • Phone Number: +33232082222
    • Seine-Saint-Denis
      • Bobigny, Seine-Saint-Denis, France, 93000
        • Recruiting
        • Hôpital Avicenne-Dermatologie ( Site 2538)
        • Contact:
          • Study Coordinator
          • Phone Number: +331 48 95 55 55
    • Somme
      • Amiens, Somme, France, 80000
        • Recruiting
        • Clinique de L'Europe ( Site 2548)
        • Contact:
          • Study Coordinator
          • Phone Number: +33360125235
    • Val-de-Marne
      • Créteil, Val-de-Marne, France, 94010
        • Recruiting
        • HENRI MONDOR HOSPITAL ( Site 2561)
        • Contact:
          • Study Coordinator
          • Phone Number: +330149814182
      • Créteil, Val-de-Marne, France, 94010
        • Recruiting
        • Centre Hospitalier Intercommunal de Créteil ( Site 2514)
        • Contact:
          • Study Coordinator
          • Phone Number: +33157022101
      • Villejuif, Val-de-Marne, France, 94800
        • Recruiting
        • Hôpital Universitaire Paul Brousse ( Site 2541)
        • Contact:
          • Study Coordinator
          • Phone Number: +33145596540
    • Vaucluse
      • Avignon, Vaucluse, France, 84918
        • Recruiting
        • Institut Sainte Catherine ( Site 2557)
        • Contact:
          • Study Coordinator
          • Phone Number: +33490276397
    • Vienne
      • Poitiers, Vienne, France, 86021
        • Recruiting
        • Centre Hospitalier Universitaire de Poitiers-Dermatologie ( Site 2544)
        • Contact:
          • Study Coordinator
          • Phone Number: 0549444444
    • Île-de-France Region
      • Clichy, Île-de-France Region, France, 92110
        • Recruiting
        • Hôpital Beaujon ( Site 2524)
        • Contact:
          • Study Coordinator
          • Phone Number: +33140875614
      • Paris, Île-de-France Region, France, 75014
        • Recruiting
        • Groupe hospitalier Paris saint Joseph-Service de Pneumologie-Allergologie -Oncologie Thoracique ( Site 2533)
        • Contact:
          • Study Coordinator
          • Phone Number: +33144123752
      • Villejuif, Île-de-France Region, France, 94800
        • Recruiting
        • Institut Gustave Roussy ( Site 2513)
        • Contact:
          • Study Coordinator
          • Phone Number: +33142114210
  • Germany
      • Berlin, Germany, 14165
        • Completed
        • Helios Klinikum Emil von Behring Berlin-Zehlendorf-Lungenklinik Heckeshorn ( Site 2418)
      • Berlin, Germany, 12203
        • Recruiting
        • Charite Universitätsmedizin Berlin Campus Benjamin Franklin ( Site 2424)
        • Contact:
          • Study Coordinator
          • Phone Number: +4930 450513514
      • Hamburg, Germany, 20249
        • Completed
        • Facharztzentrum Eppendorf ( Site 2415)
    • Baden-Wurttemberg
      • Tübingen, Baden-Wurttemberg, Germany, 72076
        • Completed
        • Universitaetsklinikum Tuebingen ( Site 2405)
    • Bavaria
      • Erlangen, Bavaria, Germany, 91054
        • Completed
        • Universitätsklinikum Erlangen ( Site 2408)
      • Munich, Bavaria, Germany, 80337
        • Completed
        • Universitaetsklinik Muenchen ( Site 2406)
    • Hesse
      • Frankfurt am Main, Hesse, Germany, 60488
        • Completed
        • Krankenhaus Nordwest ( Site 2409)
    • Lower Saxony
      • Buxtehude, Lower Saxony, Germany, 21614
        • Completed
        • Elbe Klinikum Buxtehude ( Site 2400)
      • Hanover, Lower Saxony, Germany, 30625
        • Completed
        • Medizinische Hochschule Hannover ( Site 2402)
    • North Rhine-Westphalia
      • Essen, North Rhine-Westphalia, Germany, 45147
        • Completed
        • Universitaetsklinikum Essen ( Site 2404)
    • Saarland
      • Homburg, Saarland, Germany, 66424
        • Completed
        • Universitaetsklinikum des Saarlandes-Klinik für Innere Medizin V-Pneumologie, Allergologie, Beatmun ( Site 2411)
    • Saxony
      • Dresden, Saxony, Germany, 01307
        • Completed
        • Universitatsklinikum Carl Gustav Carus ( Site 2407)
    • Schleswig-Holstein
      • Großhansdorf, Schleswig-Holstein, Germany, 22927
        • Completed
        • LungenClinic Grosshansdorf GmbH ( Site 2412)
    • Thuringia
      • Gera, Thuringia, Germany, 07548
        • Completed
        • SRH Wald-Klinikum Gera GmbH ( Site 2403)
  • Greece
      • Thessaloniki, Greece, 570 01
        • Recruiting
        • European Interbalkan Medical Center ( Site 1855)
        • Contact:
          • Study Coordinator
          • Phone Number: 0030 2310400213
    • Attica
      • Athens, Attica, Greece, 115 27
        • Recruiting
        • General Hospital of Athens "Laiko"-Hematology Department ( Site 1851)
        • Contact:
          • Study Coordinator
          • Phone Number: 0030 2136060981
      • Athens, Attica, Greece, 115 27
        • Completed
        • Sotiria Regional Chest Diseases Hospital of Athens ( Site 1850)
      • Athens, Attica, Greece, 161 21
        • Recruiting
        • Andreas Syggros Hospital ( Site 1853)
        • Contact:
          • Study Coordinator
          • Phone Number: 0030 2107210839
  • Guatemala
      • Guatemala City, Guatemala, 01009
        • Recruiting
        • MEDI-K ( Site 3403)
        • Contact:
          • Study Coordinator
          • Phone Number: +5022291-2323
      • Guatemala City, Guatemala, 01010
        • Recruiting
        • Oncomedica ( Site 3401)
        • Contact:
          • Study Coordinator
          • Phone Number: +50222781269
      • Guatemala City, Guatemala, 01015
        • Recruiting
        • Grupo Medico Angeles ( Site 3402)
        • Contact:
          • Study Coordinator
          • Phone Number: +50223857572
      • Guatemala City, Guatemala, 01010
        • Recruiting
        • CELAN,S.A ( Site 3405)
        • Contact:
          • Study Coordinator
          • Phone Number: +5022783107
  • Hong Kong
      • Hksar, Hong Kong
        • Recruiting
        • Queen Mary Hospital ( Site 1902)
        • Contact:
          • Study Coordinator
          • Phone Number: 8522255435
      • Hksar, Hong Kong
        • Completed
        • Queen Mary Hospital-Department of Medicine (Respiratory) ( Site 1900)
      • Hong Kong, Hong Kong
        • Recruiting
        • Princess Margaret Hospital ( Site 1903)
        • Contact:
          • Study Coordinator
          • Phone Number: +852 2990 1111
  • Hungary
      • Budapest, Hungary, 1088
        • Recruiting
        • Semmelweis University-Belgyógyászati és Hematológiai Klinika ( Site 1406)
        • Contact:
          • Study Coordinator
          • Phone Number: +36202051965
      • Budapest, Hungary, 1121
        • Recruiting
        • Orszagos Koranyi Pulmonologiai Intezet ( Site 1403)
        • Contact:
          • Study Coordinator
          • Phone Number: +36302005233
      • Budapest, Hungary, 1145
        • Recruiting
        • Uzsoki Utcai Kórház-Onkoradiológiai Osztály ( Site 1413)
        • Contact:
          • Study Coordinator
          • Phone Number: +36 1 467 3700
      • Debrecen, Hungary, 4032
        • Recruiting
        • Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 1412)
        • Contact:
          • Study Coordinator
          • Phone Number: +36 52 512 701
      • Debrecen, Hungary, 4032
        • Recruiting
        • Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Haematologia) ( Site 1415)
        • Contact:
          • Study Coordinator
          • Phone Number: +36 52 255 196
      • Kaposvár, Hungary, 7400
        • Recruiting
        • Somogy Megyei Kaposi Mor Oktato Korhaz ( Site 1402)
        • Contact:
          • Study Coordinator
          • Phone Number: +36304805269
      • Zalaegerszeg, Hungary, 8900
        • Recruiting
        • Zala Megyei Szent Rafael Korhaz ( Site 1400)
        • Contact:
          • Study Coordinator
          • Phone Number: +3692501527
    • Bekes County
      • Gyula, Bekes County, Hungary, 5700
        • Recruiting
        • Békés Megyei Központi Kórház Pándy Kálmán Tagkórház-Megyei Onkológiai Centrum ( Site 1405)
        • Contact:
          • Study Coordinator
          • Phone Number: +3666526526
    • Borsod-Abauj Zemplen county
      • Miskolc, Borsod-Abauj Zemplen county, Hungary, 3526
        • Recruiting
        • Borsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Oktatókórház ( Site 1409)
        • Contact:
          • Study Coordinator
          • Phone Number: +36304719966
    • Bács-Kiskun county
      • Kecskemét, Bács-Kiskun county, Hungary, 6000
        • Recruiting
        • Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 1419)
        • Contact:
          • Study Coordinator
          • Phone Number: +3676519853
    • Fejér
      • Székesfehérvár, Fejér, Hungary, 8000
        • Recruiting
        • Fejér Megyei Szent György Egyetemi Oktató Kórház-l.Pulmonologia ( Site 1407)
        • Contact:
          • Study Coordinator
          • Phone Number: +36309513053
    • Győr-Moson-Sopron
      • Győr, Győr-Moson-Sopron, Hungary, 9024
        • Recruiting
        • Petz Aladar Egyetemi Oktato Korhaz-Pulmonológia (Dr. Szalai Zsuzsanna) ( Site 1408)
        • Contact:
          • Study Coordinator
          • Phone Number: +3696507900
    • Heves County
      • Gyöngyös, Heves County, Hungary, 3233
        • Recruiting
        • Mátrai Gyógyintézet ( Site 1417)
        • Contact:
          • Study Coordinator
          • Phone Number: +36203929250
    • Jász-Nagykun-Szolnok
      • Szolnok, Jász-Nagykun-Szolnok, Hungary, 5000
        • Recruiting
        • Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 1401)
        • Contact:
          • Study Coordinator
          • Phone Number: +36209323256
    • Pest County
      • Budapest, Pest County, Hungary, 1122
        • Recruiting
        • Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 1411)
        • Contact:
          • Study Coordinator
          • Phone Number: +36122486003162
      • Törökbálint, Pest County, Hungary, 2045
        • Recruiting
        • Reformatus Pulmonologiai Centrum ( Site 1418)
        • Contact:
          • Study Coordinator
          • Phone Number: +3623511580
    • Vas County
      • Szombathely, Vas County, Hungary, 9700
        • Recruiting
        • Markusovszky Egyetemi Oktatokorhaz-Onkológiai Osztály ( Site 1410)
        • Contact:
          • Study Coordinator
          • Phone Number: +36204714153
    • Veszprém megye
      • Farkasgyepű, Veszprém megye, Hungary, 8582
        • Completed
        • Farkasgyepui Tudogyogyintezet-Pulmonologia ( Site 1414)
  • Ireland
      • Dublin, Ireland, Dublin 8
        • Recruiting
        • St. James s Hospital ( Site 1801)
        • Contact:
          • Study Coordinator
          • Phone Number: +35314103000
      • Dublin, Ireland, D24 NR0A
        • Recruiting
        • Tallaght University Hospital ( Site 1803)
        • Contact:
          • Study Coordinator
          • Phone Number: +35314144209
    • Leinster
      • Dublin, Leinster, Ireland, DO7R2DWY
        • Recruiting
        • Mater Misercordiae University Hospital ( Site 1800)
        • Contact:
          • Study Coordinator
          • Phone Number: +353 1 803 2000
  • Israel
      • Afula, Israel, 1834111
        • Recruiting
        • Emek Medical Center ( Site 2072)
        • Contact:
          • Study Coordinator
          • Phone Number: 9724649572
      • Haifa, Israel, 3109601
        • Recruiting
        • Rambam Health Care Campus-Oncology Division ( Site 2053)
        • Contact:
          • Study Coordinator
          • Phone Number: +97247773811
      • Haifa, Israel, 3339419
        • Active, not recruiting
        • Bnai Zion Medical Center ( Site 2060)
      • Jerusalem, Israel, 9112001
        • Recruiting
        • Hadassah Ein Kerem Medical Center ( Site 2051)
        • Contact:
          • Study Coordinator
          • Phone Number: +97226776781
      • Jerusalem, Israel, 9103102
        • Recruiting
        • Shaare Zedek Medical Center ( Site 2068)
        • Contact:
          • Study Coordinator
          • Phone Number: +97226555999
      • Petah Tikva, Israel, 49100
        • Recruiting
        • Rabin Medical Center ( Site 2059)
        • Contact:
          • Study Coordinator
          • Phone Number: +97239378076
      • Ramat Gan, Israel, 5262000
        • Recruiting
        • Chaim Sheba Medical Center ( Site 2055)
        • Contact:
          • Study Coordinator
          • Phone Number: +97235307096
      • Ramat Gan, Israel, 5224213
        • Recruiting
        • Chaim Sheba Medical Center. ( Site 2052)
        • Contact:
          • Study Coordinator
          • Phone Number: +97235302243
      • Ramat Gan, Israel, 5265601
        • Recruiting
        • Sheba Medical Center ( Site 2065)
        • Contact:
          • Study Coordinator
          • Phone Number: +97235303030
      • Ramat Gan, Israel, 5265601
        • Active, not recruiting
        • Sheba Medical Center ( Site 2062)
      • Safed, Israel, 1311001
        • Completed
        • ZIV Medical Center-Hematology Institute ( Site 2061)
      • Tel Aviv, Israel, 6423906
        • Recruiting
        • Sourasky Medical Center ( Site 2054)
        • Contact:
          • Study Coordinator
          • Phone Number: +97236973082
      • Ẕerifin, Israel, 6093000
        • Completed
        • Shamir Medical Center Assaf Harofeh ( Site 2058)
  • Italy
      • Bergamo, Italy, 24127
        • Recruiting
        • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-UOC Oncologia ( Site 1967)
        • Contact:
          • Study Coordinator
          • Phone Number: +390352673694
      • Bergamo, Italy, 24125
        • Completed
        • Humanitas Gavazzeni ( Site 1954)
      • Brescia, Italy, 25123
        • Completed
        • Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 1972)
      • Genova, Italy, 16132
        • Active, not recruiting
        • IRCCS A.O.U. San Martino - IST ( Site 1961)
      • Milan, Italy, 20132
        • Recruiting
        • Ospedale San Raffaele. ( Site 1979)
        • Contact:
          • Study Coordinator
          • Phone Number: 02 26438003
      • Milan, Italy, 20141
        • Recruiting
        • Istituto Europeo di Oncologia ( Site 1952)
        • Contact:
          • Study Coordinator
          • Phone Number: +390294372161
      • Naples, Italy, 80131
        • Active, not recruiting
        • Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1955)
      • Parma, Italy, 43126
        • Recruiting
        • Azienda Ospedaliero Universitaria di Parma-UO Oncologia Medica ( Site 1964)
        • Contact:
          • Study Coordinator
          • Phone Number: 390521702682
      • Pavia, Italy, 27100
        • Recruiting
        • Fondazione IRCCS Policlinico San Matteo ( Site 1982)
        • Contact:
          • Study Coordinator
          • Phone Number: 0382.502511
      • Roma, Italy, 00168
        • Recruiting
        • Policlinico Universitario Agostino Gemelli ( Site 1965)
        • Contact:
          • Study Coordinator
          • Phone Number: +390630155878
      • Roma, Italy, 00152
        • Active, not recruiting
        • Azienda Ospedaliera San Camillo Forlanini ( Site 1958)
      • Siena, Italy, 53100
        • Recruiting
        • ospedale le scotte-U.O.C. Immunoterapia Oncologica ( Site 1969)
        • Contact:
          • Study Coordinator
          • Phone Number: +390577586335
      • Terni, Italy, 05100
        • Active, not recruiting
        • Azienda Ospedaliera Santa Maria ( Site 1962)
      • Torino, Italy, 10126
        • Completed
        • Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 1974)
    • Emilia-Romagna
      • Bologna, Emilia-Romagna, Italy, 40138
        • Recruiting
        • IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1978)
        • Contact:
          • Study Coordinator
          • Phone Number: +39 0512144548
    • Lazio
      • Rome, Lazio, Italy, 00144
        • Recruiting
        • Istittuto Nazionale dei Tumori Regina Elena IRCCS - IFO ( Site 1963)
        • Contact:
          • Study Coordinator
          • Phone Number: +390652665637
      • Rome, Lazio, Italy, 00168
        • Recruiting
        • Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1975)
        • Contact:
          • Study Coordinator
          • Phone Number: +39 06 3015 5202
    • Lombardy
      • Milan, Lombardy, Italy, 20133
        • Recruiting
        • Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1977)
        • Contact:
          • Study Coordinator
          • Phone Number: 0223903650
      • Monza, Lombardy, Italy, 20900
        • Recruiting
        • Azienda Ospedaliera San Gerardo ( Site 1980)
        • Contact:
          • Study Coordinator
          • Phone Number: 039.233.4514
    • Milano
      • Rozzano, Milano, Italy, 20089
        • Recruiting
        • Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1968)
        • Contact:
          • Study Coordinator
          • Phone Number: 390282244080
    • Pordenone
      • Aviano, Pordenone, Italy, 33081
        • Active, not recruiting
        • IRCCS CRO Aviano, Hematology/Oncology ( Site 1957)
    • Sicily
      • Catania, Sicily, Italy, 95126
        • Completed
        • Ospedale Cannizzaro ( Site 1981)
    • Torino
      • Candiolo, Torino, Italy, 10060
        • Recruiting
        • Istituto di Candiolo - IRCCS ( Site 1960)
        • Contact:
          • Study Coordinator
          • Phone Number: 390119933628
      • Orbassano, Torino, Italy, 10143
        • Active, not recruiting
        • Ospedale San Luigi Gonzaga ( Site 1956)
    • Umbria
      • Perugia, Umbria, Italy, 06132
        • Active, not recruiting
        • AO Santa Maria della Misericordia-Oncology Department ( Site 1971)
    • Veneto
      • Padova, Veneto, Italy, 35128
        • Recruiting
        • Istituto Oncologico Veneto IRCCS ( Site 1976)
        • Contact:
          • Study Coordinator
          • Phone Number: +39 049 8215931
  • Japan
      • Chiba, Japan, 260-8717
        • Recruiting
        • Chiba Cancer Center ( Site 3117)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-43-264-5431
      • Fukuoka, Japan, 810-8563
        • Completed
        • National Hospital Organization Kyushu Medical Center ( Site 3136)
      • Fukuoka, Japan, 811-1395
        • Completed
        • National Hospital Organization Kyushu Cancer Center ( Site 3169)
      • Fukuoka, Japan, 812-8582
        • Completed
        • Kyushu University Hospital ( Site 3143)
      • Fukuoka, Japan, 812-8582
        • Completed
        • Kyushu University Hospital ( Site 3185)
      • Gifu, Japan, 501-1112
        • Completed
        • Gifu University Hospital ( Site 3161)
      • Hiroshima, Japan, 730-8518
        • Completed
        • Hiroshima City Hiroshima Citizens Hospital ( Site 3119)
      • Hiroshima, Japan, 734-8551
        • Completed
        • Hiroshima University Hospital ( Site 3154)
      • Kochi, Japan, 781-8555
        • Completed
        • Kochi Health Sciences Center ( Site 3145)
      • Kumamoto, Japan, 860-8556
        • Completed
        • Kumamoto University Hospital ( Site 3179)
      • Kyoto, Japan, 606-8507
        • Completed
        • Kyoto University Hospital ( Site 3181)
      • Niigata, Japan, 951-8520
        • Recruiting
        • Niigata University Medical & Dental Hospital ( Site 3174)
        • Contact:
          • Study Coordinator
          • Phone Number: +81252236161
      • Okayama, Japan, 700-8558
        • Recruiting
        • Okayama University Hospital ( Site 3107)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-86-223-7151
      • Osaka, Japan, 540-0006
        • Recruiting
        • National Hospital Organization Osaka National Hospital ( Site 3162)
        • Contact:
          • Study Coordinator
          • Phone Number: +81669421331
      • Osaka, Japan, 541-8567
        • Recruiting
        • Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 3129)
        • Contact:
          • Study Coordinator
          • Phone Number: +81669451181
      • Osaka, Japan, 534-0021
        • Completed
        • Osaka City General Hospital ( Site 3125)
      • Osaka, Japan, 558-8558
        • Completed
        • Osaka General Medical Center ( Site 3184)
      • Tokyo, Japan, 104-0045
        • Recruiting
        • National Cancer Center Hospital ( Site 3130)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3542-2511
      • Tokyo, Japan, 113-8677
        • Recruiting
        • Tokyo Metropolitan Komagome Hospital ( Site 3133)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3823-2101
      • Tokyo, Japan, 160-8582
        • Recruiting
        • Keio University Hospital ( Site 3127)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3353-1211
      • Tokyo, Japan, 173-8606
        • Completed
        • Teikyo University Hospital ( Site 3104)
      • Tokyo, Japan, 105-8471
        • Recruiting
        • The Jikei University Hospital ( Site 3156)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3433-1111
      • Tokyo, Japan, 135-8550
        • Recruiting
        • Cancer Institute Hospital of JFCR ( Site 3108)
        • Contact:
          • Study Coordinator
          • Phone Number: +81335200111
      • Tokyo, Japan, 104-8560
        • Completed
        • St.Luke's International Hospital ( Site 3120)
      • Tokyo, Japan, 113-8603
        • Completed
        • Nippon Medical School Hospital ( Site 3139)
      • Toyama, Japan, 930-8550
        • Completed
        • Toyama Prefectural Central Hospital ( Site 3183)
      • Wakayama, Japan, 641-8510
        • Recruiting
        • Wakayama Medical University Hospital ( Site 3124)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-73-447-2300
    • Aichi-ken
      • Nagoya, Aichi-ken, Japan, 460-0001
        • Recruiting
        • National Hospital Organization Nagoya Medical Center ( Site 3109)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-52-951-1111
      • Nagoya, Aichi-ken, Japan, 464-8681
        • Recruiting
        • Aichi Cancer Center ( Site 3101)
        • Contact:
          • Study Coordinator
          • Phone Number: +81527626111
      • Nagoya, Aichi-ken, Japan, 466-8560
        • Recruiting
        • Nagoya University Hospital ( Site 3151)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-52-741-2111
    • Chiba
      • Kashiwa, Chiba, Japan, 2778577
        • Recruiting
        • National Cancer Center Hospital East ( Site 3121)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-4-7133-1111
    • Ehime
      • Matsuyama, Ehime, Japan, 791-0280
        • Completed
        • National Hospital Organization Shikoku Cancer Center ( Site 3116)
      • Tōon, Ehime, Japan, 791-0295
        • Recruiting
        • Ehime University Hospital ( Site 3158)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-89-960-5910
    • Fukuoka
      • Kurume, Fukuoka, Japan, 830-0011
        • Recruiting
        • Kurume University Hospital ( Site 3105)
        • Contact:
          • Study Coordinator
          • Phone Number: +81942353311
    • Hokkaido
      • Sapporo, Hokkaido, Japan, 060-8543
        • Recruiting
        • Sapporo Medical University Hospital ( Site 3113)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-11-611-2111
      • Sapporo, Hokkaido, Japan, 003-0804
        • Completed
        • National Hospital Organization Hokkaido Cancer Center ( Site 3160)
      • Sapporo, Hokkaido, Japan, 060-0033
        • Completed
        • Sapporo Kosei General Hospital ( Site 3172)
      • Sapporo, Hokkaido, Japan, 060-8648
        • Completed
        • Hokkaido University Hospital ( Site 3165)
    • Hyōgo
      • Akashi, Hyōgo, Japan, 673-8558
        • Recruiting
        • Hyogo Cancer Center ( Site 3131)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-78-929-1151
      • Himeji, Hyōgo, Japan, 670-8520
        • Recruiting
        • National Hospital Organization Himeji Medical Center ( Site 3111)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-79-225-3211
      • Kobe, Hyōgo, Japan, 650-0047
        • Completed
        • Kobe City Medical Center General Hospital ( Site 3144)
      • Nishinomiya, Hyōgo, Japan, 663-8501
        • Recruiting
        • Hyogo Medical University Hospital ( Site 3100)
        • Contact:
          • Study Coordinator
          • Phone Number: +81798456111
    • Ibaraki
      • Kasama, Ibaraki, Japan, 309-1793
        • Recruiting
        • Ibaraki Prefectural Central Hospital ( Site 3180)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-296-78-0021
      • Tsukuba, Ibaraki, Japan, 305-8576
        • Recruiting
        • University of Tsukuba Hospital ( Site 3176)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-29-853-3900
    • Ishikawa-ken
      • Kanazawa, Ishikawa-ken, Japan, 920-8641
        • Recruiting
        • Kanazawa University Hospital ( Site 3140)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-76-265-2000
    • Iwate
      • Shiwa-gun, Iwate, Japan, 028-3695
        • Completed
        • Iwate Medical University Hospital ( Site 3157)
    • Kagawa-ken
      • Kita, Kagawa-ken, Japan, 761-0701
        • Completed
        • Kagawa University Hospital ( Site 3171)
    • Kanagawa
      • Kawasaki, Kanagawa, Japan, 211-8533
        • Recruiting
        • Nippon Medical School Musashi Kosugi Hospital ( Site 3178)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-44-733-5181
      • Kawasaki, Kanagawa, Japan, 216-8511
        • Completed
        • St. Marianna University Hospital ( Site 3182)
      • Sagamihara, Kanagawa, Japan, 252-0375
        • Recruiting
        • Kitasato University Hospital ( Site 3142)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-42-778-8111
      • Yokohama, Kanagawa, Japan, 241-8515
        • Recruiting
        • Kanagawa Cancer Center ( Site 3137)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-45-520-2222
      • Yokohama, Kanagawa, Japan, 236-0004
        • Completed
        • Yokohama City University Hospital ( Site 3163)
      • Yokosuka, Kanagawa, Japan, 238-8558
        • Completed
        • Yokosuka Kyosai Hospital ( Site 3150)
    • Miyagi
      • Natori-shi, Miyagi, Japan, 981-1293
        • Completed
        • Miyagi Cancer Center ( Site 3122)
      • Sendai, Miyagi, Japan, 981-0914
        • Recruiting
        • Sendai Kousei Hospital ( Site 3115)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-22-222-6181
      • Sendai, Miyagi, Japan, 980-8574
        • Recruiting
        • Tohoku University Hospital ( Site 3175)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-22-717-7000
    • Nara
      • Kashihara, Nara, Japan, 634-8522
        • Completed
        • Nara Medical University Hospital ( Site 3110)
    • Niigata
      • Niigata, Niigata, Japan, 951-8566
        • Completed
        • Niigata Cancer Center Hospital ( Site 3173)
    • Okayama-ken
      • Kurashiki, Okayama-ken, Japan, 710-8602
        • Completed
        • Kurashiki Central Hospital ( Site 3132)
    • Okinawa
      • Ginowan, Okinawa, Japan, 901-2725
        • Recruiting
        • University of the Ryukyus Hospital ( Site 3155)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-98-894-1301
    • Osaka
      • Habikino, Osaka, Japan, 583-8588
        • Completed
        • Osaka Habikino Medical Center ( Site 3138)
      • Hirakata, Osaka, Japan, 573-1191
        • Recruiting
        • Kansai Medical University Hospital ( Site 3126)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-72-804-0101
      • Sakai, Osaka, Japan, 591-8025
        • Recruiting
        • Osaka Rosai Hospital ( Site 3148)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-72-252-3561
      • Sakai, Osaka, Japan, 590-0197
        • Recruiting
        • Kindai University Hospital ( Site 3102)
        • Contact:
          • Study Coordinator
          • Phone Number: +81723660221
      • Sakai, Osaka, Japan, 590-0197
        • Completed
        • Kindai University Hospital ( Site 3166)
      • Sakai, Osaka, Japan, 590-0197
        • Completed
        • Kindai University Hospital ( Site 3135)
      • Suita, Osaka, Japan, 565-0871
        • Completed
        • The University of Osaka Hospital ( Site 3168)
      • Takatsuki, Osaka, Japan, 569-8686
        • Recruiting
        • Osaka Medical and Pharmaceutical University Hospital ( Site 3187)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-72-683-1221
      • Takatsuki, Osaka, Japan, 569-8686
        • Completed
        • Osaka Medical and Pharmaceutical University Hospital ( Site 3167)
    • Saitama
      • Hidaka, Saitama, Japan, 350-1298
        • Recruiting
        • Saitama Medical University International Medical Center ( Site 3118)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-42-984-4111
      • Kitaadachi-gun, Saitama, Japan, 362-0806
        • Recruiting
        • Saitama Prefectural Cancer Center ( Site 3112)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-48-722-1111
      • Koshigaya, Saitama, Japan, 3438555
        • Completed
        • Dokkyo Medical University Saitama Medical Center ( Site 3152)
      • Tokorozawa, Saitama, Japan, 359-8513
        • Recruiting
        • National Defense Medical College Hospital ( Site 3177)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-4-2995-1682
    • Shizuoka
      • Nakatogari, Shizuoka, Japan, 411-8777
        • Recruiting
        • Shizuoka Cancer Center ( Site 3128)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-55-989-5222
    • Tochigi
      • Shimotsuke, Tochigi, Japan, 329-0498
        • Completed
        • Jichi Medical University Hospital ( Site 3141)
    • Tokyo
      • Bunkyō, Tokyo, Japan, 113-8519
        • Completed
        • Institute of Science Tokyo Hospital ( Site 3149)
      • Koto, Tokyo, Japan, 135-8550
        • Recruiting
        • Cancer Institute Hospital of JFCR ( Site 3146)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3520-0111
      • Koto, Tokyo, Japan, 135-8550
        • Recruiting
        • Cancer Institute Hospital of JFCR ( Site 3164)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3520-0111
      • Minato, Tokyo, Japan, 105-8470
        • Recruiting
        • Toranomon Hospital ( Site 3189)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3588-1111
      • Minato-ku, Tokyo, Japan, 105-8470
        • Recruiting
        • Toranomon Hospital ( Site 3134)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3588-1111
      • Minato-ku, Tokyo, Japan, 105-8470
        • Completed
        • Toranomon Hospital ( Site 3153)
      • Mitaka, Tokyo, Japan, 181-8611
        • Recruiting
        • Kyorin University Hospital ( Site 3103)
        • Contact:
          • Study Coordinator
          • Phone Number: +81422475511
      • Mitaka-shi, Tokyo, Japan, 181-8611
        • Completed
        • Kyorin University Hospital ( Site 3147)
      • Shinagawa, Tokyo, Japan, 142-8666
        • Recruiting
        • Showa Medical University Hospital ( Site 3188)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3784-8000
      • Shinjuku-ku, Tokyo, Japan, 160-0023
        • Completed
        • Tokyo Medical University Hospital ( Site 3170)
    • Yamaguchi
      • Ube, Yamaguchi, Japan, 755-0241
        • Completed
        • National Hospital Organization Yamaguchi Ube Medical Center ( Site 3123)
      • Ube, Yamaguchi, Japan, 755-8505
        • Completed
        • Yamaguchi University Hospital ( Site 3114)
  • Latvia
      • Liepāja, Latvia, LV-3414
        • Recruiting
        • Liepjas reionl slimnca ( Site 3851)
        • Contact:
          • Study Coordinator
          • Phone Number: +371 26351999
      • Riga, Latvia, LV1079
        • Recruiting
        • RIGA EAST UNIVERSITY HOSPITAL ,Oncology Centre of Latvia-Out-patient and Day patient facility of Ch ( Site 3850)
        • Contact:
          • Study Coordinator
          • Phone Number: +37126594570
  • Lithuania
      • Vilnius, Lithuania, 08460
        • Recruiting
        • Vilniaus Universiteto Ligonine Santaros Klinikos ( Site 3300)
        • Contact:
          • Study Coordinator
          • Phone Number: +37068388052
      • Vilnius, Lithuania, LT-08406
        • Recruiting
        • Vilnius University Hospital Santaros Clinics Affiliate - National Cancer Center ( Site 3301)
        • Contact:
          • Study Coordinator
          • Phone Number: +37061129056
    • Klaipedos Miestas
      • Klaipėda, Klaipedos Miestas, Lithuania, 92288
        • Completed
        • Klaipeda University Hospital-Oncology chemotherapy ( Site 3302)
  • Malaysia
      • Kuala Lumpur, Malaysia, 59100
        • Recruiting
        • University Malaya Medical Centre ( Site 0626)
        • Contact:
          • Study Coordinator
          • Phone Number: +60379492120
      • Kuala Lumpur, Malaysia, 59100
        • Completed
        • Pantai Hospital Kuala Lumpur ( Site 0628)
    • Pahang
      • Kuantan, Pahang, Malaysia, 25100
        • Recruiting
        • Hospital Tengku Ampuan Afzan ( Site 0627)
        • Contact:
          • Study Coordinator
          • Phone Number: +6095706400
    • Pulau Pinang
      • George Town, Pulau Pinang, Malaysia, 10050
        • Recruiting
        • Gleneagles Penang ( Site 0625)
        • Contact:
          • Study Coordinator
          • Phone Number: +6042229189
      • George Town, Pulau Pinang, Malaysia, 10990
        • Recruiting
        • Hospital Pulau Pinang ( Site 0629)
        • Contact:
          • Study Coordinator
          • Phone Number: +6042225333
    • Putrajaya
      • Putrajaya - Wilayah Persekutuan, Putrajaya, Malaysia, 62250
        • Recruiting
        • Institut Kanser Negara - National Cancer Institute ( Site 0630)
        • Contact:
          • Study Coordinator
          • Phone Number: +60123304499
  • Mexico
      • Chihuahua City, Mexico, 31123
        • Recruiting
        • Unidad de Mastologia Avanzada de Chihuahua S.A de C.V ( Site 1109)
        • Contact:
          • Study Coordinator
          • Phone Number: 52 6143458712
      • Mexico City, Mexico, 03810
        • Recruiting
        • Oncare Viaducto Napoles ( Site 1107)
        • Contact:
          • Study Coordinator
          • Phone Number: +52 55 2909-1366
      • Querétaro, Mexico, 76000
        • Active, not recruiting
        • Cuidados Oncologicos. ( Site 1118)
    • Baja California Sur
      • La Paz, Baja California Sur, Mexico, 23040
        • Recruiting
        • Investigación Oncofarmacéutica-Investigación clínica ( Site 1114)
        • Contact:
          • Study Coordinator
          • Phone Number: 52 6121297171
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44630
        • Recruiting
        • Centro de Inmuno Oncología de Occidente SA de CV ( Site 1115)
        • Contact:
          • Study Coordinator
          • Phone Number: +523332592394
    • Mexico City
      • Mexico City, Mexico City, Mexico, 14080
        • Recruiting
        • INSTITUTO NACIONAL DE CANCEROLOGIA ( Site 1102)
        • Contact:
          • Study Coordinator
          • Phone Number: +52 55 1315-0894
      • Mexico City, Mexico City, Mexico, 06700
        • Recruiting
        • Arke Estudios Clinicos ( Site 1117)
        • Contact:
          • Study Coordinator
          • Phone Number: 55 55115833
    • Nuevo León
      • Monterrey, Nuevo León, Mexico, 64623
        • Recruiting
        • Avix Investigación Clinica, S.C.-Oncology ( Site 1104)
        • Contact:
          • Study Coordinator
          • Phone Number: 8181431112
      • Monterrey, Nuevo León, Mexico, 66460
        • Recruiting
        • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Hematologia and Oncologia ( Site 1113)
        • Contact:
          • Study Coordinator
          • Phone Number: 52 8183338111
      • Monterrey, Nuevo León, Mexico, 64710
        • Active, not recruiting
        • I Can Oncology Center SA de CV ( Site 1116)
      • San Pedro Garza García, Nuevo León, Mexico, 66269
        • Recruiting
        • Centro de Urologa Avanzada del Noreste ( Site 1110)
        • Contact:
          • Study Coordinator
          • Phone Number: 52 8183631717
    • Oaxaca
      • Oaxaca City, Oaxaca, Mexico, 68000
        • Recruiting
        • Oaxaca Site Management Organization ( Site 1106)
        • Contact:
          • Study Coordinator
          • Phone Number: +52 951 229-0849
    • Tamaulipas
      • Ciudad Madero, Tamaulipas, Mexico, 89440
        • Recruiting
        • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C. ( Site 1119)
        • Contact:
          • Study Coordinator
          • Phone Number: +528331260055
    • Yucatán
      • Mérida, Yucatán, Mexico, 97070
        • Completed
        • Medical Care and Research SA de CV ( Site 1103)
  • Netherlands
      • Groningen, Netherlands, 9713GZ
        • Recruiting
        • Universitair Medisch Centrum Groningen ( Site 1550)
        • Contact:
          • Study Coordinator
          • Phone Number: +31503616161
    • Gelderland
      • Nijmegen, Gelderland, Netherlands, 6525 GA
        • Recruiting
        • Radboud University Medical Center ( Site 1554)
        • Contact:
          • Study Coordinator
          • Phone Number: +31243610353
    • North Holland
      • Amsterdam, North Holland, Netherlands, 1066 CX
        • Recruiting
        • Antoni van Leeuwenhoek Ziekenhuis ( Site 1551)
        • Contact:
          • Study Coordinator
          • Phone Number: +31205129111
      • Amsterdam, North Holland, Netherlands, 1081 HV
        • Recruiting
        • Amsterdam UMC, locatie VUmc ( Site 1555)
        • Contact:
          • Study Coordinator
          • Phone Number: +310204444321
    • South Holland
      • Rotterdam, South Holland, Netherlands, 3015 GD
        • Completed
        • Erasmus MC ( Site 1553)
  • New Zealand
      • Auckland, New Zealand, 1023
        • Recruiting
        • Auckland City Hospital ( Site 1503)
        • Contact:
          • Study Coordinator
          • Phone Number: +6493670000
      • Wellington, New Zealand, 6021
        • Recruiting
        • Capital & Coast District Health Board - Wellington Hospital ( Site 1501)
        • Contact:
          • Study Coordinator
          • Phone Number: +6449186109
    • Canterbury
      • Christchurch, Canterbury, New Zealand, 8011
        • Recruiting
        • Canterbury Regional Cancer & Blood Service ( Site 1500)
        • Contact:
          • Study Coordinator
          • Phone Number: +6433640020
    • Manawatu-Wanganui
      • Palmerston North, Manawatu-Wanganui, New Zealand, 4442
        • Recruiting
        • Palmerston North Hospital, MidCentral DHB ( Site 1504)
        • Contact:
          • Study Coordinator
          • Phone Number: +6463507486
    • Waikato Region
      • Hamilton, Waikato Region, New Zealand, 3204
        • Recruiting
        • Waikato Hospital ( Site 1502)
        • Contact:
          • Study Coordinator
          • Phone Number: +6478398899
  • Norway
      • Oslo, Norway, 0379
        • Recruiting
        • Oslo Universitetssykehus Radiumhospitalet ( Site 1450)
        • Contact:
          • Study Coordinator
          • Phone Number: +4722934809
      • Oslo, Norway, 0379
        • Recruiting
        • Oslo universitetssykehus, Radiumhospitalet ( Site 1452)
        • Contact:
          • Study Coordinator
          • Phone Number: +47 23026600
    • Vestfold
      • Bergen, Vestfold, Norway, 5021
        • Recruiting
        • Helse Bergen Haukeland universitetssykehus ( Site 1451)
        • Contact:
          • Study Coordinator
          • Phone Number: +4755974200
  • Peru
      • Lima, Peru, 15036
        • Recruiting
        • IPOR Instituto Peruano de Oncología & Radioterapia ( Site 0678)
        • Contact:
          • Study Coordinator
          • Phone Number: +51012241598 Ext 121
      • Lima, Peru, 15038
        • Recruiting
        • INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 0681)
        • Contact:
          • Study Coordinator
          • Phone Number: +51012016500 Ext3009
      • Lima, Peru, 15102
        • Completed
        • Hospital Cayetano Heredia-Oncology ( Site 0675)
  • Philippines
    • National Capital Region
      • Makati City, National Capital Region, Philippines, 1229
        • Recruiting
        • Makati Medical Center ( Site 1702)
        • Contact:
          • Study Coordinator
          • Phone Number: 639178990272
      • Quezon City, National Capital Region, Philippines, 1102
        • Recruiting
        • St. Luke s Medical Center ( Site 1700)
        • Contact:
          • Study Coordinator
          • Phone Number: +639175431178
      • Quezon City, National Capital Region, Philippines, 1100
        • Completed
        • Lung Center of the Philippines ( Site 1705)
  • Poland
    • Greater Poland Voivodeship
      • Konin, Greater Poland Voivodeship, Poland, 62-500
        • Recruiting
        • Przychodnia Lekarska KOMED ( Site 1603)
        • Contact:
          • Study Coordinator
          • Phone Number: 48632428009
      • Poznan, Greater Poland Voivodeship, Poland, 60-693
        • Recruiting
        • Med-Polonia Sp. z o. o. ( Site 1605)
        • Contact:
          • Study Coordinator
          • Phone Number: 505758992
      • Poznan, Greater Poland Voivodeship, Poland, 61-848
        • Recruiting
        • Szpital Kliniczny im. Przemienienia Panskiego Uniwersytetu Medycznego im. K. Marcinkowskiego w Pozna ( Site 1601)
        • Contact:
          • Study Coordinator
          • Phone Number: +48618549014
      • Poznan, Greater Poland Voivodeship, Poland, 61-866
        • Recruiting
        • Wielkopolskie Centrum Onkologii im.M.Sklodowskiej-Curie ( Site 1619)
        • Contact:
          • Study Coordinator
          • Phone Number: +48 61 88 50 738
      • Poznan, Greater Poland Voivodeship, Poland, 60-569
        • Recruiting
        • Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 1607)
        • Contact:
          • Study Coordinator
          • Phone Number: 48618549038
    • Kuyavian-Pomeranian Voivodeship
      • Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-796
        • Recruiting
        • Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1612)
        • Contact:
          • Study Coordinator
          • Phone Number: +48523743589
    • Lesser Poland Voivodeship
      • Krakow, Lesser Poland Voivodeship, Poland, 31-115
        • Recruiting
        • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Oddzial w Krakowie ( Site 1608)
        • Contact:
          • Study Coordinator
          • Phone Number: +48126348245
      • Krakow, Lesser Poland Voivodeship, Poland, 31-826
        • Recruiting
        • Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 1618)
        • Contact:
          • Study Coordinator
          • Phone Number: +48 126468000
    • Masovian Voivodeship
      • Warsaw, Masovian Voivodeship, Poland, 01-748
        • Recruiting
        • Luxmed Onkologia sp. z o. o. ( Site 1621)
        • Contact:
          • Study Coordinator
          • Phone Number: +48224698363
      • Warsaw, Masovian Voivodeship, Poland, 02-781
        • Recruiting
        • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 1604)
        • Contact:
          • Study Coordinator
          • Phone Number: 48225463066
      • Warsaw, Masovian Voivodeship, Poland, 04-141
        • Recruiting
        • Wojskowy Instytut Medyczny-Klinika Onkologii ( Site 1606)
        • Contact:
          • Study Coordinator
          • Phone Number: +48226817235
    • Opole Voivodeship
      • Opole, Opole Voivodeship, Poland, 45-061
        • Recruiting
        • Opolskie Centrum Onkologii w Opolu im. prof. Tadeusza Kosza-Klinika Onkologii z Odcinkiem Dziennym ( Site 1616)
        • Contact:
          • Study Coordinator
          • Phone Number: +48774416084
    • Podlaskie Voivodeship
      • Bialystok, Podlaskie Voivodeship, Poland, 15-027
        • Recruiting
        • Bialostockie Centrum Onkologii ( Site 1610)
        • Contact:
          • Study Coordinator
          • Phone Number: +48692267220
    • Pomeranian Voivodeship
      • Gdansk, Pomeranian Voivodeship, Poland, 80-214
        • Recruiting
        • Uniwersyteckie Centrum Kliniczne-Klinika Chirurgii Onkologicznej, Transplantacyjnej i Ogólnej ( Site 1622)
        • Contact:
          • Study Coordinator
          • Phone Number: 58 584 44 66
      • Gdynia, Pomeranian Voivodeship, Poland, 81-519
        • Recruiting
        • Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 1625)
        • Contact:
          • Study Coordinator
          • Phone Number: +48583419348
    • Silesian Voivodeship
      • Gliwice, Silesian Voivodeship, Poland, 44-102
        • Recruiting
        • Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 1620)
        • Contact:
          • Study Coordinator
          • Phone Number: 32 278 97 94
      • Racibórz, Silesian Voivodeship, Poland, 47-400
        • Recruiting
        • Szpital Rejonowy im. dr. J. Rostka w Raciborzu ( Site 1624)
        • Contact:
          • Study Coordinator
          • Phone Number: +48327555006
    • Warmian-Masurian Voivodeship
      • Olsztyn, Warmian-Masurian Voivodeship, Poland, 10-357
        • Recruiting
        • Warminsko-Mazurskie Centrum Chorob Pluc w Olsztynie ( Site 1623)
        • Contact:
          • Study Coordinator
          • Phone Number: +48895322978
    • West Pomeranian Voivodeship
      • Koszalin, West Pomeranian Voivodeship, Poland, 75-581
        • Recruiting
        • Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie ( Site 1614)
        • Contact:
          • Study Coordinator
          • Phone Number: +48502204953
    • Łódź Voivodeship
      • Brzeziny, Łódź Voivodeship, Poland, 95-060
        • Completed
        • Powiatowe Centrum Zdrowia w Brzezinach Sp. z o. o. Oddział Dziennej Chemioterapii ( Site 1611)
      • Lodz, Łódź Voivodeship, Poland, 93-338
        • Recruiting
        • Instytut Centrum Zdrowia Matki Polki-Klinika Onkologii ( Site 1609)
        • Contact:
          • Study Coordinator
          • Phone Number: +48422711000
  • Portugal
      • Lisbon, Portugal, 1769-001
        • Active, not recruiting
        • Unidade Local de Saude de Santa Maria - Hospital Pulido Valente ( Site 1750)
      • Porto, Portugal, 4200-319
        • Completed
        • Centro Hospitalar de Sao Joao - Hospital de Sao Joao ( Site 1752)
      • Porto, Portugal, 4200-072
        • Active, not recruiting
        • Instituto Português de Oncologia do Porto Francisco Gentil, EPE-Oncologia Médica ( Site 1753)
    • Lisbon District
      • Lisbon, Lisbon District, Portugal, 1400-038
        • Active, not recruiting
        • Champalimaud Foundation ( Site 1751)
  • Puerto Rico
      • Ponce, Puerto Rico, 00717
        • Completed
        • Ad-Vance Medical Research-Research ( Site 1151)
      • San Juan, Puerto Rico, 00935
        • Completed
        • UPR Comprehensive Cancer Center ( Site 1150)
      • San Juan, Puerto Rico, 00927
        • Completed
        • FDI Clinical Research ( Site 1152)
  • Romania
      • Cluj-Napoca, Romania, 400015
        • Recruiting
        • Institutul Oncologic "Prof. Dr. Ioan Chiricuta" ( Site 3551)
        • Contact:
          • Study Coordinator
          • Phone Number: +0264 598 362
      • Suceava, Romania, 720237
        • Recruiting
        • Spitalul Județean Sfântul Ioan cel Nou Suceava-Oncology ( Site 3550)
        • Contact:
          • Study Coordinator
          • Phone Number: +40722423653
    • Bucharest
      • Bucharest, Bucharest, Romania, 013823
        • Recruiting
        • MEMORIAL HEALTHCARE INTERNATIONAL S.R.L ( Site 3553)
        • Contact:
          • Study Coordinator
          • Phone Number: +40319393
    • Cluj
      • Cluj-Napoca, Cluj, Romania, 400015
        • Recruiting
        • Cardiomed SRL Cluj-Napoca ( Site 3555)
        • Contact:
          • Study Coordinator
          • Phone Number: +40264406600
    • Dolj
      • Craiova, Dolj, Romania, 200347
        • Recruiting
        • Centrul de Oncologie "Sfântul Nectarie" ( Site 3552)
        • Contact:
          • Study Coordinator
          • Phone Number: +40731604432
    • Timiș County
      • Timișoara, Timiș County, Romania, 300239
        • Recruiting
        • Cabinet Medical Oncomed ( Site 3554)
        • Contact:
          • Study Coordinator
          • Phone Number: +40356460996
  • Russia
    • Altayskiy Kray
      • Barnaul, Altayskiy Kray, Russia, 656045
        • Active, not recruiting
        • Altai Regional Clinical Oncology Center ( Site 1229)
    • Baskortostan, Respublika
      • Ufa, Baskortostan, Respublika, Russia, 450054
        • Active, not recruiting
        • GBUZ Republican Clinical Oncological Dispensary-Antitumor drug therapy department ( Site 1250)
      • Ufa, Baskortostan, Respublika, Russia, 450054
        • Active, not recruiting
        • Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1204)
      • Ufa, Baskortostan, Respublika, Russia, 450083
        • Active, not recruiting
        • Bashkir State Medical University ( Site 1221)
    • Belgorod Oblast
      • Belgorod, Belgorod Oblast, Russia, 308010
        • Active, not recruiting
        • Belgorod Oncology Dispensary ( Site 1213)
    • Chelyabinsk Oblast
      • Chelyabinsk, Chelyabinsk Oblast, Russia, 454080
        • Active, not recruiting
        • LLC Medical Centre "Lotos" ( Site 1253)
    • Ivanovo Oblast
      • Ivanovo, Ivanovo Oblast, Russia, 153040
        • Active, not recruiting
        • Regional Budgetary Healthcare Institution 'Ivanovo Regional Oncology Dispensary'-Urology ( Site 1219)
    • Krasnodarskiy Kray
      • Sochi, Krasnodarskiy Kray, Russia, 354057
        • Active, not recruiting
        • Oncological Dispensary #2 of Ministry of Health of Krasnodar region ( Site 1244)
    • Leningradskaya Oblast'
      • Saint-Petersburg, Leningradskaya Oblast', Russia, 194291
        • Active, not recruiting
        • GBUZ LOKB-Oncology department #1 ( Site 1222)
      • Saint-Petersburg, Leningradskaya Oblast', Russia, 194291
        • Active, not recruiting
        • GBUZ LOKB ( Site 1218)
    • Mordoviya, Respublika
      • Saransk, Mordoviya, Respublika, Russia, 430005
        • Completed
        • Ogarev Mordovia State University ( Site 1206)
    • Moscow
      • Moscow, Moscow, Russia, 105203
        • Active, not recruiting
        • The National Medico-Surgical Center N.I. Pirogov ( Site 1225)
      • Moscow, Moscow, Russia, 115478
        • Completed
        • N.N. Blokhin NMRCO ( Site 1209)
      • Moscow, Moscow, Russia, 115682
        • Recruiting
        • FSBI-FRCC of Special Types Med. Care and Technologies FMBA of Russia ( Site 1234)
        • Contact:
          • Study Coordinator
          • Phone Number: +79161359600
      • Moscow, Moscow, Russia, 125284
        • Completed
        • P. A. Hertsen Moscow Oncology Research Center ( Site 1214)
      • Moscow, Moscow, Russia, 125284
        • Recruiting
        • P. A. Hertsen Moscow Oncology Research Center ( Site 1247)
        • Contact:
          • Study Coordinator
          • Phone Number: 79037971178
      • Moscow, Moscow, Russia, 119991
        • Active, not recruiting
        • First Moscow State Medical University n.a. I.M.Sechenov ( Site 1245)
      • Moscow, Moscow, Russia, 115478
        • Active, not recruiting
        • Russian Oncological Research Center n.a. N.N.Blokhin of MoH ( Site 1201)
      • Moscow, Moscow, Russia, 117485
        • Active, not recruiting
        • Russian Scientific Center of Roentgenoradiology ( Site 1215)
      • Moscow, Moscow, Russia, 125367
        • Active, not recruiting
        • FSAI Treatment and Rehabilitation Centre of the MoH and SD of RF ( Site 1208)
    • Nizhny Novgorod Oblast
      • Nizhny Novgorod, Nizhny Novgorod Oblast, Russia, 603074
        • Recruiting
        • Volga District Medical Center Federal Medical and Biological Agency ( Site 1242)
        • Contact:
          • Study Coordinator
          • Phone Number: +79519068094
    • Sankt-Peterburg
      • Saint Petersburg, Sankt-Peterburg, Russia, 197022
        • Completed
        • EuroCityClinic ( Site 1230)
      • Saint Petersburg, Sankt-Peterburg, Russia, 197758
        • Recruiting
        • National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 1210)
        • Contact:
          • Study Coordinator
          • Phone Number: +89219464788
      • Saint Petersburg, Sankt-Peterburg, Russia, 191024
        • Active, not recruiting
        • Russian Scientific Research Institute of Hematology and Blood Transfusion-Hematology ( Site 1224)
      • Saint Petersburg, Sankt-Peterburg, Russia, 197022
        • Active, not recruiting
        • First Pavlov State Medical University of Saint Petersburg ( Site 1232)
      • Saint Petersburg, Sankt-Peterburg, Russia, 197758
        • Active, not recruiting
        • N.N.Petrov Research Institute of Oncology-Department of Preclinical and Clinical Research ( Site 1211)
      • Saint Petersburg, Sankt-Peterburg, Russia, 197758
        • Active, not recruiting
        • Clinical Research Center of specialized types medical care-Oncology ( Site 1205)
      • Saint Petersburg, Sankt-Peterburg, Russia, 194017
        • Active, not recruiting
        • St. Petersburg Clinical Hospital of Russian Academy Of Sciences ( Site 1235)
      • Saint Petersburg, Sankt-Peterburg, Russia, 197341
        • Active, not recruiting
        • Almazov National Medical Research Centre ( Site 1233)
      • Saint Petersburg, Sankt-Peterburg, Russia, 198255
        • Active, not recruiting
        • City Clinical Oncology Center ( Site 1237)
    • Stavropol Kray
      • Pyatigorsk, Stavropol Kray, Russia, 357502
        • Completed
        • GBUZ SK Pyatigorsk Interdistrict Oncology dispensary ( Site 1223)
    • Tatarstan, Respublika
      • Kazan', Tatarstan, Respublika, Russia, 420029
        • Recruiting
        • Republican Clinical Oncology Dispensary ( Site 1228)
        • Contact:
          • Study Coordinator
          • Phone Number: +79172662851
      • Kazan', Tatarstan, Respublika, Russia, 420029
        • Active, not recruiting
        • Republican Clinical Oncology Dispensary of Tatarstan MoH named after professor M.Z. Sigal ( Site 1203)
    • Tomsk Oblast
      • Tomsk, Tomsk Oblast, Russia, 634028
        • Active, not recruiting
        • Tomsk Scientific Research Institute of Oncology ( Site 1227)
    • Tyumen Oblast
      • Tyumen, Tyumen Oblast, Russia, 625000
        • Active, not recruiting
        • SAIH of the Tyumen region, Multidisciplinary Clinical Medical Center "Medical town" ( Site 1220)
    • Udmurtiya Republic
      • Izhevsk, Udmurtiya Republic, Russia, 426009
        • Completed
        • Udmurtian Republican Clinical Oncology Center ( Site 1212)
    • Yaroslavl Oblast
      • Yaroslavl, Yaroslavl Oblast, Russia, 150054
        • Active, not recruiting
        • Yaroslavl Regional SBIH Clinical Oncology Hospital ( Site 1243)
  • Singapore
    • Central Singapore
      • Singapore, Central Singapore, Singapore, 168583
        • Recruiting
        • National Cancer Centre Singapore ( Site 2200)
        • Contact:
          • Study Coordinator
          • Phone Number: +6564368000
    • South West
      • Singapore, South West, Singapore, 119074
        • Recruiting
        • National University Hospital-Haematology -Oncology Research Group ( Site 2201)
        • Contact:
          • Study Coordinator
          • Phone Number: +6567726825
  • South Africa
    • Gauteng
      • Johannesburg, Gauteng, South Africa, 2193
        • Recruiting
        • WCR Office ( Site 2002)
        • Contact:
          • Study Coordinator
          • Phone Number: +27113390600
      • Pretoria, Gauteng, South Africa, 0181
        • Recruiting
        • LIFE GROENKLOOF-Mary Potter Cancer Centre ( Site 2005)
        • Contact:
          • Study Coordinator
          • Phone Number: +27123466701
      • Pretoria, Gauteng, South Africa, 0040
        • Recruiting
        • Wilgers Oncology Centre ( Site 2006)
        • Contact:
          • Study Coordinator
          • Phone Number: +27128072744
      • Sandton, Gauteng, South Africa, 2196
        • Recruiting
        • Sandton Oncology Medical Group (Pty) Ltd-Research ( Site 2004)
        • Contact:
          • Study Coordinator
          • Phone Number: +27118830900
    • KwaZulu-Natal
      • Durban, KwaZulu-Natal, South Africa, 4091
        • Recruiting
        • The Oncology Centre ( Site 2000)
        • Contact:
          • Study Coordinator
          • Phone Number: +27312088666
    • Western Cape
      • Cape Town, Western Cape, South Africa, 7570
        • Recruiting
        • Cape Town Oncology Trials ( Site 2007)
        • Contact:
          • Study Coordinator
          • Phone Number: +27219443832
      • George, Western Cape, South Africa, 6520
        • Recruiting
        • GVI Oncology ( Site 2008)
        • Contact:
          • Study Coordinator
          • Phone Number: +448840806
  • South Korea
      • Seoul, South Korea, 02841
        • Recruiting
        • Korea University Anam Hospital ( Site 0956)
        • Contact:
          • Study Coordinator
          • Phone Number: 8229205114
      • Seoul, South Korea, 03080
        • Recruiting
        • Seoul National University Hospital ( Site 0953)
        • Contact:
          • Study Coordinator
          • Phone Number: +82220720850
      • Seoul, South Korea, 03722
        • Recruiting
        • Severance Hospital ( Site 0954)
        • Contact:
          • Study Coordinator
          • Phone Number: +82222288130
      • Seoul, South Korea, 03722
        • Recruiting
        • Severance Hospital, Yonsei University Health System ( Site 0962)
        • Contact:
          • Study Coordinator
          • Phone Number: +82-2-2228-4190
      • Seoul, South Korea, 06351
        • Recruiting
        • Samsung Medical Center ( Site 0950)
        • Contact:
          • Study Coordinator
          • Phone Number: 82234103438
      • Seoul, South Korea, 08308
        • Recruiting
        • Korea University Guro Hospital ( Site 0963)
        • Contact:
          • Study Coordinator
          • Phone Number: +82 2-862-6453
      • Seoul, South Korea, 06351
        • Recruiting
        • Samsung Medical Center ( Site 0970)
        • Contact:
          • Study Coordinator
          • Phone Number: +821020154932
      • Seoul, South Korea, 06351
        • Recruiting
        • Samsung Medical Center ( Site 0971)
        • Contact:
          • Study Coordinator
          • Phone Number: +82234106250
      • Seoul, South Korea, 06591
        • Completed
        • The Catholic Univ. of Korea Seoul St. Mary's Hospital ( Site 0972)
    • Incheon
      • Inceon, Incheon, South Korea, 21565
        • Completed
        • Gachon University Gil Medical Center ( Site 0967)
    • Jeonranamdo
      • Hwasun, Jeonranamdo, South Korea, 58128
        • Recruiting
        • Chonnam National University Hwasun Hospital-Hemato-Oncology ( Site 0959)
        • Contact:
          • Study Coordinator
          • Phone Number: +82-61-379-7634
    • Kyonggi-do
      • Goyang-si, Kyonggi-do, South Korea, 10408
        • Recruiting
        • National Cancer Center ( Site 0955)
        • Contact:
          • Study Coordinator
          • Phone Number: +82-31-920-1210
      • Seongnam-si, Kyonggi-do, South Korea, 13496
        • Recruiting
        • CHA Bundang Medical Center CHA University ( Site 0957)
        • Contact:
          • Study Coordinator
          • Phone Number: +82317805000
      • Seongnam-si, Kyonggi-do, South Korea, 13620
        • Recruiting
        • Seoul National University Bundang Hospital ( Site 0951)
        • Contact:
          • Study Coordinator
          • Phone Number: +82215883369
      • Suwon, Kyonggi-do, South Korea, 16247
        • Recruiting
        • The Catholic University Of Korea St. Vincent's Hospital ( Site 0968)
        • Contact:
          • Study Coordinator
          • Phone Number: +82312498153
      • Suwon, Kyonggi-do, South Korea, 16499
        • Recruiting
        • Ajou University Hospital ( Site 0969)
        • Contact:
          • Study Coordinator
          • Phone Number: +82312195142
    • North Chungcheong
      • Cheongju-si, North Chungcheong, South Korea, 28644
        • Recruiting
        • Chungbuk National University Hospital ( Site 0961)
        • Contact:
          • Study Coordinator
          • Phone Number: +82-43-269-6015
    • Seoul
      • Gangnam-gu, Seoul, South Korea, 06273
        • Completed
        • Gangnam Severance Hospital, Yonsei University Health System ( Site 0966)
      • Songpagu, Seoul, South Korea, 05505
        • Recruiting
        • Asan Medical Center ( Site 0952)
        • Contact:
          • Study Coordinator
          • Phone Number: +82216887575
    • Taegu-Kwangyokshi
      • Daegu, Taegu-Kwangyokshi, South Korea, 42601
        • Recruiting
        • Keimyung University Dongsan Hospital CRC room 1 ( Site 0960)
        • Contact:
          • Study Coordinator
          • Phone Number: +82-53-250-7518
      • Deagu, Taegu-Kwangyokshi, South Korea, 41404
        • Recruiting
        • Kyungpook National University Chilgok Hospital ( Site 0964)
        • Contact:
          • Study Coordinator
          • Phone Number: +82-53-200-2623
    • Taejon-Kwangyokshi
      • Daejeon, Taejon-Kwangyokshi, South Korea, 35015
        • Recruiting
        • Chungnam national university hospital-Department of Internal Medicine ( Site 0958)
        • Contact:
          • Study Coordinator
          • Phone Number: +82-42-280-8369
  • Spain
      • Alicante, Spain, 03010
        • Recruiting
        • Hospital General Universitario de Alicante-Oncologia ( Site 0881)
        • Contact:
          • Study Coordinator
          • Phone Number: +34965933513
      • Barcelona, Spain, 08003
        • Recruiting
        • Parc de Salut Mar - Hospital del Mar-Oncologia ( Site 0873)
        • Contact:
          • Study Coordinator
          • Phone Number: +34932483860
      • Barcelona, Spain, 08035
        • Recruiting
        • H.U. Vall de Hebron ( Site 0850)
        • Contact:
          • Study Coordinator
          • Phone Number: +34934894158
      • Barcelona, Spain, 08035
        • Recruiting
        • Hospital Vall d´Hebron Skin Cancer & Woman cancer therapeutic area ( Site 0887)
        • Contact:
          • Study Coordinator
          • Phone Number: +34 93 274 60 00
      • Barcelona, Spain, 08035
        • Recruiting
        • Vall d´Hebron Gastric & Esophageal & Colorectal cancer therapeutic area ( Site 0889)
        • Contact:
          • Study Coordinator
          • Phone Number: +34 93 274 60 00
      • Barcelona, Spain, 08035
        • Recruiting
        • Vall d´Hebron Prostatic & Renal & Bladder cancer therapeutic area ( Site 0888)
        • Contact:
          • Study Coordinator
          • Phone Number: +34 93 274 60 00
      • Córdoba, Spain, 14004
        • Recruiting
        • Hospital Universitario Reina Sofia ( Site 0885)
        • Contact:
          • Study Coordinator
          • Phone Number: +34 957011456
      • Jaén, Spain, 23007
        • Recruiting
        • Complejo Hospitalario de Jaén-Servicio de Oncología Médica ( Site 0879)
        • Contact:
          • Study Coordinator
          • Phone Number: +34953220306
      • Madrid, Spain, 28027
        • Recruiting
        • Clinica Universitaria de Navarra ( Site 0855)
        • Contact:
          • Study Coordinator
          • Phone Number: +34948255400
      • Madrid, Spain, 28040
        • Recruiting
        • Hospital Clinico San Carlos ( Site 0857)
        • Contact:
          • Study Coordinator
          • Phone Number: +34913303000ext7768
      • Madrid, Spain, 28040
        • Recruiting
        • Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 0871)
        • Contact:
          • Study Coordinator
          • Phone Number: +34 91 550 48 00
      • Madrid, Spain, 28041
        • Recruiting
        • Hospital General Universitario 12 de Octubre ( Site 0856)
        • Contact:
          • Study Coordinator
          • Phone Number: +34914692313
      • Madrid, Spain, 28046
        • Recruiting
        • Hospital Universitario La Paz ( Site 0853)
        • Contact:
          • Study Coordinator
          • Phone Number: +34912071138
      • Madrid, Spain, 28009
        • Recruiting
        • Hospital Universitario Gregorio Maranon ( Site 0864)
        • Contact:
          • Study Coordinator
          • Phone Number: +34914269393
      • Madrid, Spain, 28050
        • Recruiting
        • Centro Integral Oncologico Clara Campal-Hospital HM Universitario Sanchinarro-START Madrid, ( Site 0869)
        • Contact:
          • Study Coordinator
          • Phone Number: +34917567825
      • Málaga, Spain, 29010
        • Recruiting
        • Hospital Universitario Virgen de la Victoria ( Site 0878)
        • Contact:
          • Study Coordinator
          • Phone Number: +34951032508
      • Seville, Spain, 41009
        • Recruiting
        • Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 0880)
        • Contact:
          • Study Coordinator
          • Phone Number: +34 671560092
      • Seville, Spain, 41013
        • Recruiting
        • HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 0872)
        • Contact:
          • Study Coordinator
          • Phone Number: +34915504800
      • Seville, Spain, 41014
        • Recruiting
        • Hospital Universitario Virgen de Valme-Departamento de Oncologia ( Site 0882)
        • Contact:
          • Study Coordinator
          • Phone Number: 34 955015273
      • Zaragoza, Spain, 50009
        • Recruiting
        • Hospital Clinico Universitario Lozano Blesa ( Site 0859)
        • Contact:
          • Study Coordinator
          • Phone Number: +34976765746
    • Balearic Islands
      • Palma, Balearic Islands, Spain, 07120
        • Active, not recruiting
        • Hospital Universitari Son Espases-Oncologia ( Site 0883)
      • Palma de Mallorca, Balearic Islands, Spain, 07198
        • Completed
        • Hospital Son Llatzer ( Site 0886)
    • Barcelona
      • L'Hospitalet de Llobregat, Barcelona, Spain, 08907
        • Recruiting
        • Instituto Catalan de Oncologia ICO - Hospital Duran i Reynals ( Site 0860)
        • Contact:
          • Study Coordinator
          • Phone Number: +34932607744
    • Basque Country
      • San Sebastian- Donostia, Basque Country, Spain, 20014
        • Recruiting
        • Hospital Universitario de Donostia ( Site 0890)
        • Contact:
          • Study Coordinator
          • Phone Number: +34943328338
    • Cantabria
      • Santander, Cantabria, Spain, 39008
        • Recruiting
        • H. Marques de Valdecilla ( Site 0865)
        • Contact:
          • Study Coordinator
          • Phone Number: +34942202525
    • Catalonia
      • Badalona, Catalonia, Spain, 08916
        • Recruiting
        • Institut Catala d Oncologia Hospital Germans Trias i Pujol ( Site 0851)
        • Contact:
          • Study Coordinator
          • Phone Number: +34934978925
      • Barcelona, Catalonia, Spain, 08036
        • Recruiting
        • Hospital Clinic de Barcelona ( Site 0852)
        • Contact:
          • Study Coordinator
          • Phone Number: +34932275402
      • Barcelona, Catalonia, Spain, 08041
        • Completed
        • Hospital de la Santa Creu i Sant Pau-Oncología Médica ( Site 0862)
    • La Coruna
      • Santiago de Compostela, La Coruna, Spain, 15706
        • Recruiting
        • CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 0876)
        • Contact:
          • Study Coordinator
          • Phone Number: +34981950511
    • Las Palmas
      • Las Palmas de Gran Canaria, Las Palmas, Spain, 35001
        • Recruiting
        • Hospital Universitario Insular de Gran Canaria ( Site 0867)
        • Contact:
          • Study Coordinator
          • Phone Number: +34961452191
    • Madrid
      • Majadahonda, Madrid, Spain, 28222
        • Recruiting
        • Hospital Universitario Puerta de Hierro-Majadahonda ( Site 0861)
        • Contact:
          • Study Coordinator
          • Phone Number: +34911917759
      • Pozuelo de Alarcón, Madrid, Spain, 28223
        • Completed
        • Hospital Universitario Quiron Madrid ( Site 0868)
    • Madrid, Comunidad de
      • Madrid, Madrid, Comunidad de, Spain, 28034
        • Recruiting
        • Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 0877)
        • Contact:
          • Study Coordinator
          • Phone Number: +34913368263
    • Malaga
      • Málaga, Malaga, Spain, 29010
        • Recruiting
        • H.R.U Malaga - Hospital General ( Site 0884)
        • Contact:
          • Study Coordinator
          • Phone Number: +34 951308130
    • Principality of Asturias
      • Oviedo, Principality of Asturias, Spain, 33011
        • Recruiting
        • Hospital Universitario Central de Asturias-Medical Oncology ( Site 0870)
        • Contact:
          • Study Coordinator
          • Phone Number: 34 985108000 x36582
    • Tarragona
      • Reus, Tarragona, Spain, 43204
        • Recruiting
        • Hospital Universitari Sant Joan de Reus-Oncology ( Site 0874)
        • Contact:
          • Study Coordinator
          • Phone Number: +34977310300
    • Valencia
      • Valencia, Valencia, Spain, 46026
        • Recruiting
        • Hospital Universitari i Politecnic La Fe ( Site 0875)
        • Contact:
          • Study Coordinator
          • Phone Number: +34961245877
    • Valenciana, Comunitat
      • Valencia, Valenciana, Comunitat, Spain, 46009
        • Recruiting
        • Instituto Valenciano de Oncologia - IVO ( Site 0863)
        • Contact:
          • Study Coordinator
          • Phone Number: +34961114605
      • Valencia, Valenciana, Comunitat, Spain, 46010
        • Recruiting
        • Hospital Clinico de Valencia ( Site 0858)
        • Contact:
          • Study Coordinator
          • Phone Number: +34961973583
      • Valencia, Valenciana, Comunitat, Spain, 46014
        • Recruiting
        • Hospital General Universitario de Valencia ( Site 0854)
        • Contact:
          • Study Coordinator
          • Phone Number: 34963131800x437635
      • Valencia, Valenciana, Comunitat, Spain, 46015
        • Completed
        • Hospital Arnau de Vilanova ( Site 0866)
  • Sweden
    • Stockholm County
      • Stockholm, Stockholm County, Sweden, 171 76
        • Recruiting
        • Karolinska Universitetssjukhuset Solna ( Site 0802)
        • Contact:
          • Study Coordinator
          • Phone Number: +46851770000
    • Uppsala County
      • Uppsala, Uppsala County, Sweden, 751 85
        • Recruiting
        • Blod och Tumorssjukdomar. Akademiska sjukhuset ( Site 0801)
        • Contact:
          • Study Coordinator
          • Phone Number: +46186110000
    • Västerbotten County
      • Umeå, Västerbotten County, Sweden, 901 85
        • Active, not recruiting
        • Norrlands Universitetssjukhus ( Site 0800)
    • Västra Götaland County
      • Gothenburg, Västra Götaland County, Sweden, 413 45
        • Recruiting
        • Sahlgrenska Universitetssjukhuset-Department of Oncology CTU Clinical Trial Unit ( Site 0803)
        • Contact:
          • Study Coordinator
          • Phone Number: +46313421000
  • Switzerland
    • Canton of Basel-City
      • Basel, Canton of Basel-City, Switzerland, 4031
        • Active, not recruiting
        • University Hospital Basel ( Site 0752)
    • Canton of Geneva
      • Geneva, Canton of Geneva, Switzerland, 1211
        • Active, not recruiting
        • Hôpitaux Universitaires de Genève (HUG) ( Site 0753)
    • Canton of Zurich
      • Zürich-Flughafen, Canton of Zurich, Switzerland, 8058
        • Active, not recruiting
        • Universitaetsspital Zuerich ( Site 0750)
  • Taiwan
      • Changhua, Taiwan, 50006
        • Recruiting
        • Changhua Christian Hospital ( Site 3210)
        • Contact:
          • Study Coordinator
          • Phone Number: +88647238595
      • Hsinchu, Taiwan, 300195
        • Recruiting
        • National Taiwan University Hospital - Hsinchu branch ( Site 3208)
        • Contact:
          • Study Coordinator
          • Phone Number: +88635326151
      • Kaohsiung City, Taiwan, 83301
        • Recruiting
        • Kaohsiung Chang Gung Memorial Hospital ( Site 3203)
        • Contact:
          • Study Coordinator
          • Phone Number: +886975056230
      • Taichung, Taiwan, 40447
        • Recruiting
        • China Medical University Hospital ( Site 3204)
        • Contact:
          • Study Coordinator
          • Phone Number: +886975681629
      • Taichung, Taiwan, 40705
        • Recruiting
        • Taichung Veterans General Hospital ( Site 3209)
        • Contact:
          • Study Coordinator
          • Phone Number: +886423592525x3219
      • Tainan, Taiwan, 70457
        • Recruiting
        • National Cheng Kung University Hospital ( Site 3201)
        • Contact:
          • Study Coordinator
          • Phone Number: 886-6-235-3535x5401
      • Taipei, Taiwan, 10048
        • Recruiting
        • National Taiwan University Hospital ( Site 3200)
        • Contact:
          • Study Coordinator
          • Phone Number: +8862232123456
      • Taipei, Taiwan, 11217
        • Recruiting
        • Taipei Veterans General Hospital ( Site 3202)
        • Contact:
          • Study Coordinator
          • Phone Number: +886228712121
      • Taipei, Taiwan, 10449
        • Recruiting
        • Mackay Memorial Hospital ( Site 3205)
        • Contact:
          • Study Coordinator
          • Phone Number: +886225433535
      • Taipei, Taiwan, 112
        • Recruiting
        • Koo Foundation Sun Yat-Sen Cancer Center-Gynecology, Obstetrics, and women's health ( Site 3207)
        • Contact:
          • Study Coordinator
          • Phone Number: +886228970011x1686
      • Taipei, Taiwan, 110
        • Recruiting
        • Taipei Medical University Hospital ( Site 3211)
        • Contact:
          • Study Coordinator
          • Phone Number: +886227372181
      • Taoyuan, Taiwan, 33305
        • Recruiting
        • Chang Gung Medical Foundation-Linkou Branch ( Site 3206)
        • Contact:
          • Study Coordinator
          • Phone Number: +88633281200x8468
  • Thailand
    • Bangkok
      • Bangkok, Bangkok, Thailand, 10400
        • Recruiting
        • Ramathibodi Hospital. ( Site 2364)
        • Contact:
          • Study Coordinator
          • Phone Number: +6622011671
      • Bangkoknoi, Bangkok, Thailand, 10700
        • Recruiting
        • Faculty of Medicine Siriraj Hospital ( Site 2365)
        • Contact:
          • Study Coordinator
          • Phone Number: +6624194488
      • Pathumwan, Bangkok, Thailand, 10330
        • Recruiting
        • Chulalongkorn University ( Site 2363)
        • Contact:
          • Study Coordinator
          • Phone Number: +6622516704
    • Changwat Khon Kaen
      • Muang, Changwat Khon Kaen, Thailand, 40002
        • Active, not recruiting
        • Faculty of Medicine - Khon Kaen University ( Site 2366)
    • Changwat Songkhla
      • Hat Yai, Changwat Songkhla, Thailand, 90110
        • Recruiting
        • Songklanagarind Hospital ( Site 2367)
        • Contact:
          • Study Coordinator
          • Phone Number: +6674451469
  • Turkey (Türkiye)
      • Adana, Turkey (Türkiye), 01130
        • Recruiting
        • Acibadem Adana Hospital-Pediatric Hematology-Oncology ( Site 1312)
        • Contact:
          • Study Coordinator
          • Phone Number: +905349179166
      • Adana, Turkey (Türkiye), 01250
        • Recruiting
        • Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1307)
        • Contact:
          • Study Coordinator
          • Phone Number: +903223272727
      • Adana, Turkey (Türkiye), 01370
        • Recruiting
        • Adana Sehir Egitim ve Arastirma Hastanesi ( Site 1324)
        • Contact:
          • Study Coordinator
          • Phone Number: +90 322 455 90 00
      • Ankara, Turkey (Türkiye), 06100
        • Recruiting
        • Ankara University Hospital Cebeci ( Site 1306)
        • Contact:
          • Study Coordinator
          • Phone Number: +903125957115
      • Ankara, Turkey (Türkiye), 06230
        • Recruiting
        • Hacettepe Universitesi-oncology hospital ( Site 1304)
        • Contact:
          • Study Coordinator
          • Phone Number: +905334318506
      • Ankara, Turkey (Türkiye), 06560
        • Recruiting
        • Gazi University Health Research and Application Center Gazi Hospital ( Site 1325)
        • Contact:
          • Study Coordinator
          • Phone Number: 03122026970
      • Ankara, Turkey (Türkiye), 06800
        • Recruiting
        • Ankara City Hospital-Medical Oncology ( Site 1311)
        • Contact:
          • Study Coordinator
          • Phone Number: +905551737206
      • Ankara, Turkey (Türkiye), 34180
        • Recruiting
        • Baskent Universitesi Ankara Hastanesi ( Site 1303)
        • Contact:
          • Study Coordinator
          • Phone Number: 905333414050
      • Ankara, Turkey (Türkiye), 06620
        • Recruiting
        • Ankara University Health Practice and Research Hospitals ( Site 1331)
        • Contact:
          • Study Coordinator
          • Phone Number: 00903124663550
      • Ankara, Turkey (Türkiye), 06680
        • Recruiting
        • Liv Hospital Ankara ( Site 1330)
        • Contact:
          • Study Coordinator
          • Phone Number: 444 6 623
      • Antalya, Turkey (Türkiye), 07059
        • Recruiting
        • Akdeniz Universitesi Hastanesi-Medical Onkology ( Site 1318)
        • Contact:
          • Study Coordinator
          • Phone Number: 90 (242) 249 60 00
      • Antalya, Turkey (Türkiye), 07090
        • Recruiting
        • Memorial Antalya Hospital-Oncology ( Site 1315)
        • Contact:
          • Study Coordinator
          • Phone Number: +902423146666
      • Edirne, Turkey (Türkiye), 22030
        • Recruiting
        • Trakya Universitesi Tip Fakultesi ( Site 1301)
        • Contact:
          • Study Coordinator
          • Phone Number: +902842360910
      • Erzurum, Turkey (Türkiye), 25240
        • Recruiting
        • Atatürk Üniversitesi ( Site 1333)
        • Contact:
          • Study Coordinator
          • Phone Number: +90 442 344 66 66
      • Istanbul, Turkey (Türkiye), 34093
        • Recruiting
        • Bezmialem Vakf Üniversitesi-Oncology ( Site 1308)
        • Contact:
          • Study Coordinator
          • Phone Number: 444 0 600
      • Istanbul, Turkey (Türkiye), 34457
        • Recruiting
        • Acıbadem Maslak Hastanesi-Medical Oncology ( Site 1321)
        • Contact:
          • Study Coordinator
          • Phone Number: +902123045713
      • Istanbul, Turkey (Türkiye), 34668
        • Recruiting
        • Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1302)
        • Contact:
          • Study Coordinator
          • Phone Number: +902124143434
      • Istanbul, Turkey (Türkiye), 34722
        • Recruiting
        • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1316)
        • Contact:
          • Study Coordinator
          • Phone Number: +905063509061
      • Istanbul, Turkey (Türkiye), 34899
        • Recruiting
        • Marmara Universitesi Pendik Egitim Arastirma Hastanesi-Medical Oncology ( Site 1305)
        • Contact:
          • Study Coordinator
          • Phone Number: +905323702473
      • Istanbul, Turkey (Türkiye), 34214
        • Recruiting
        • Medipol Mega Universite Hastanesi ( Site 1326)
        • Contact:
          • Study Coordinator
          • Phone Number: +90212447244
      • Istanbul, Turkey (Türkiye), 34766
        • Recruiting
        • Umraniye Training and Research Hospital ( Site 1329)
        • Contact:
          • Study Coordinator
          • Phone Number: 0216 632 1818
      • Istanbul, Turkey (Türkiye), 34303
        • Completed
        • Acibadem Universitesi Atakent Hastanesi ( Site 1319)
      • Istanbul, Turkey (Türkiye), 34093
        • Active, not recruiting
        • Istanbul University Capa Campus ( Site 1314)
      • Izmir, Turkey (Türkiye), 35040
        • Recruiting
        • Ege Universitesi Tip Fakultesi Hastanesi ( Site 1300)
        • Contact:
          • Study Coordinator
          • Phone Number: 905337360674
      • Izmir, Turkey (Türkiye), 35577
        • Active, not recruiting
        • I.E.U. Medical Point Hastanesi-Oncology ( Site 1310)
      • Kocaeli, Turkey (Türkiye), 41380
        • Recruiting
        • Kocaeli Üniversitesi ( Site 1313)
        • Contact:
          • Study Coordinator
          • Phone Number: +902623037575
      • Malatya, Turkey (Türkiye), 44280
        • Recruiting
        • Inonu Universitesi ( Site 1309)
        • Contact:
          • Study Coordinator
          • Phone Number: +905385003562
      • Sakarya, Turkey (Türkiye), 54100
        • Recruiting
        • Sakarya University School of Medicine ( Site 1332)
        • Contact:
          • Study Coordinator
          • Phone Number: +0902648884000
      • Samsun, Turkey (Türkiye), 55200
        • Recruiting
        • Samsun Medical Park Hastanesi ( Site 1328)
        • Contact:
          • Study Coordinator
          • Phone Number: +9 0 362 311 40 40
    • Istanbul
      • Üsküdar /Istanbul, Istanbul, Turkey (Türkiye)
        • Active, not recruiting
        • Acibadem Altunizade Hospital-Oncology ( Site 1317)
    • İzmir
      • Balçova, İzmir, Turkey (Türkiye), 35340
        • Recruiting
        • Dokuz Eylul Universitesi Hastanesi ( Site 1323)
        • Contact:
          • Study Coordinator
          • Phone Number: +902324129898
  • Ukraine
    • Cherkasy Oblast
      • Cherkasy, Cherkasy Oblast, Ukraine, 18009
        • Active, not recruiting
        • COMMUNAL NONPROFIT ENTERPRISE CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 3671)
    • Dnipropetrovsk Oblast
      • Dnipro, Dnipropetrovsk Oblast, Ukraine, 49102
        • Active, not recruiting
        • Municipal Non-profit Enterprise "City Clinical Hospital #4" of Dnipro City Council ( Site 3650)
      • Dnipro, Dnipropetrovsk Oblast, Ukraine, 49005
        • Active, not recruiting
        • ME І.І. Mechnykov Dnipro Regional Clinical Hospital ( Site 3668)
      • Kryvyi Rih, Dnipropetrovsk Oblast, Ukraine, 50048
        • Active, not recruiting
        • MI Kryvyi Rih Oncology Dispensary of Dnipropetrovsk Regional-Chemotherapy department ( Site 3657)
    • Ivano-Frankivsk Oblast
      • Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine, 76018
        • Recruiting
        • Communal Non-Commercial Enterprise "Prykarpatski Clinical Oncological Center" of Ivano-Frankivsk Reg ( Site 3663)
        • Contact:
          • Study Coordinator
          • Phone Number: +380502094000
    • Kharkiv Oblast
      • Kharkiv, Kharkiv Oblast, Ukraine, 61070
        • Active, not recruiting
        • MNPE Regional Center of Oncology ( Site 3665)
      • Kharlkiv, Kharkiv Oblast, Ukraine, 61024
        • Active, not recruiting
        • SO"Grigoriev Inst for Med Radiolgy and Oncology of NAMS of Ukraine" ( Site 3666)
    • Khmelnytskyi Oblast
      • Khmelnytskyi, Khmelnytskyi Oblast, Ukraine, 29009
        • Recruiting
        • MNE "Khmelnytskyi regional antitumor center" ( Site 3675)
        • Contact:
          • Study Coordinator
          • Phone Number: +380382656137
    • Kirovohrad Oblast
      • Kropyvnytskyi, Kirovohrad Oblast, Ukraine, 25006
        • Active, not recruiting
        • Private Enterprise Private Manufacturing Company Acinus-Medical and Diagnostic Centre ( Site 3656)
    • Kyivska Oblast
      • Khodosovka, Kyivska Oblast, Ukraine, 08173
        • Recruiting
        • Asklepion Medical Center ( Site 3667)
        • Contact:
          • Study Coordinator
          • Phone Number: 0503481865
      • Kyiv, Kyivska Oblast, Ukraine, 03022
        • Recruiting
        • National Cancer Institute-Department of Minimally Invasive and Endoscopic Surgery, Interventional R ( Site 3658)
        • Contact:
          • Study Coordinator
          • Phone Number: +380509095151
      • Kyiv, Kyivska Oblast, Ukraine, 03115
        • Active, not recruiting
        • Municipal non-profit enterprise "Kyiv City Clinical Oncology Center" of executive body of Kyiv City ( Site 3651)
      • Kyiv, Kyivska Oblast, Ukraine, 03039
        • Active, not recruiting
        • LLC Clinic Verum Expert ( Site 3669)
    • Lviv Oblast
      • Lviv, Lviv Oblast, Ukraine, 79031
        • Active, not recruiting
        • Municipal institution of Lviv regional council Lviv Oncology-Chemotherapy ( Site 3653)
    • Odesa Oblast
      • Odesa, Odesa Oblast, Ukraine, 65055
        • Active, not recruiting
        • Odessa Regional Oncology Center ( Site 3655)
    • Sumska Oblast
      • Sumy, Sumska Oblast, Ukraine, 40022
        • Active, not recruiting
        • Sumy regional clinical oncological dispensary-Oncothoracic department ( Site 3661)
    • Vinnytsia Oblast
      • Vinnytsia, Vinnytsia Oblast, Ukraine, 21029
        • Active, not recruiting
        • Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council" ( Site 3662)
    • Zakarpattia Oblast
      • Uzhhorod, Zakarpattia Oblast, Ukraine, 88000
        • Active, not recruiting
        • Transcarpathian Regional Clinical Oncology Center-Chemotherapy dept. ( Site 3652)
      • Uzhhorod, Zakarpattia Oblast, Ukraine, 88000
        • Recruiting
        • Uzhhorod City Multidisciplinary Clinical Hospital ( Site 3672)
        • Contact:
          • Study Coordinator
          • Phone Number: +380312647211
    • Zaporizhzhia Oblast
      • Zaporizhzhia, Zaporizhzhia Oblast, Ukraine, 69600
        • Completed
        • Municipal non-profit enterprise "Zaporizhzhia regional clinical hospital" of Zaporizhzhia regional c ( Site 3664)
    • Zhytomyr Oblast
      • Zhytomyr, Zhytomyr Oblast, Ukraine, 10002
        • Active, not recruiting
        • Zhytomyr Regional Oncology Center ( Site 3670)
  • United Kingdom
      • Coventry, United Kingdom, CV2 2DX
        • Recruiting
        • University Hospital Coventry & Warwickshire ( Site 0524)
        • Contact:
          • Study Coordinator
          • Phone Number: +442476967485
      • Leeds, United Kingdom, LS9 7TF
        • Recruiting
        • St James University Hospital ( Site 0509)
        • Contact:
          • Study Coordinator
          • Phone Number: +441132068320
      • Sutton, United Kingdom, SM2 5PT
        • Recruiting
        • The Royal Marsden NHS Foundation Trust. ( Site 0513)
        • Contact:
          • Study Coordinator
          • Phone Number: +4402073528171
      • Wolverhampton, United Kingdom, WV10 0QP
        • Recruiting
        • New Cross Hospital-Department of Oncology ( Site 0517)
        • Contact:
          • Study Coordinator
          • Phone Number: +441902307999
    • Aberdeen City
      • Aberdeen, Aberdeen City, United Kingdom, AB25 2ZN
        • Recruiting
        • Aberdeen Royal Infirmary-Department of Oncology ( Site 0521)
        • Contact:
          • Study Coordinator
          • Phone Number: +44345 456 6000
    • Cambridgeshire
      • Cambridge, Cambridgeshire, United Kingdom, CB2 2QQ
        • Recruiting
        • Addenbrookes Hospital ( Site 0522)
        • Contact:
          • Study Coordinator
          • Phone Number: 01223 216083
    • Edinburgh, City of
      • Edinburgh, Edinburgh, City of, United Kingdom, EH4 2XU
        • Recruiting
        • Western General Hospital ( Site 0502)
        • Contact:
          • Study Coordinator
          • Phone Number: +441315371000
    • England
      • Manchester, England, United Kingdom, M20 4BX
        • Recruiting
        • The Christie ( Site 0516)
        • Contact:
          • Study Coordinator
          • Phone Number: 01614463000
      • Sheffield, England, United Kingdom, S10 2SJ
        • Recruiting
        • Weston Park Hospital ( Site 0519)
        • Contact:
          • Study Coordinator
          • Phone Number: 0114 2265000
    • Essex
      • Broomfield, Essex, United Kingdom, CM1 7ET
        • Completed
        • Mid Essex Hospitals Service Trust. Broomfield Hospital ( Site 0503)
    • Glasgow City
      • Glasgow, Glasgow City, United Kingdom, G12 0YN
        • Recruiting
        • The Beatson West of Scotland Cancer Centre ( Site 0506)
        • Contact:
          • Study Coordinator
          • Phone Number: +441413017073
    • Lancashire
      • Preston, Lancashire, United Kingdom, PR2 9HT
        • Recruiting
        • Royal Preston Hospital ( Site 0518)
        • Contact:
          • Study Coordinator
          • Phone Number: 01772 524656
    • London, City of
      • London, London, City of, United Kingdom, EC1A 7BE
        • Recruiting
        • Barts Health NHS Trust ( Site 0512)
        • Contact:
          • Study Coordinator
          • Phone Number: +442034657108
      • London, London, City of, United Kingdom, NW1 2PG
        • Recruiting
        • University College London Hospital-Cancer Clinical Trials Unit ( Site 0520)
        • Contact:
          • Study Coordinator
          • Phone Number: 07943 094 762
      • London, London, City of, United Kingdom, NW3 2QG
        • Active, not recruiting
        • Royal Free Hospital ( Site 0507)
      • London, London, City of, United Kingdom, SW3 6JJ
        • Recruiting
        • Royal Marsden Hospital ( Site 0505)
        • Contact:
          • Study Coordinator
          • Phone Number: +442078082132
      • London, London, City of, United Kingdom, W1G 6AD
        • Active, not recruiting
        • Sarah Cannon Research UK ( Site 0504)
    • Northern Ireland
      • Belfast, Northern Ireland, United Kingdom, BT9 7AB
        • Completed
        • Belfast City Hospital ( Site 0508)
    • Nottinghamshire
      • Nottingham, Nottinghamshire, United Kingdom, NG5 1PB
        • Recruiting
        • Nottingham University Hospitals NHS Trust ( Site 0510)
        • Contact:
          • Study Coordinator
          • Phone Number: +44115 9691169
  • United States
    • Arizona
      • Tucson, Arizona, United States, 85719
        • Recruiting
        • Arizona Cancer Center at UMC North ( Site 0018)
        • Contact:
          • Study Coordinator
          • Phone Number: 520-694-1053
    • California
      • Bakersfield, California, United States, 93309
        • Recruiting
        • Comprehensive Blood & Cancer Center [Bakersfield, CA] ( Site 0054)
        • Contact:
          • Study Coordinator
          • Phone Number: 661-322-2206
      • Fresno, California, United States, 93720
        • Active, not recruiting
        • California Cancer Associates for Research & Excellence ( Site 0016)
      • Fullerton, California, United States, 92835
        • Completed
        • Providence Medical Foundation ( Site 0087)
      • Los Angeles, California, United States, 90025
        • Active, not recruiting
        • The Angeles Clinic and Research Institute ( Site 0005)
      • Los Angeles, California, United States, 90095
        • Recruiting
        • UCLA Hematology/Oncology - Westwood (Building 100) ( Site 0009)
        • Contact:
          • Study Coordinator
          • Phone Number: 310-794-6913
      • Orange, California, United States, 92868
        • Active, not recruiting
        • University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0076)
      • Palo Alto, California, United States, 94304
        • Recruiting
        • Stanford Cancer Center ( Site 0086)
        • Contact:
          • Study Coordinator
          • Phone Number: 650-721-7489
      • San Francisco, California, United States, 94158
        • Recruiting
        • UCSF Helen Diller Family Comprehensive Cancer Center ( Site 0004)
        • Contact:
          • Study Coordinator
          • Phone Number: 415-514-6382
      • Santa Monica, California, United States, 90404
        • Recruiting
        • Providence Saint John's Health Center ( Site 0059)
        • Contact:
          • Study Coordinator
          • Phone Number: 310-449-5244
    • Colorado
      • Aurora, Colorado, United States, 80045
        • Recruiting
        • University of Colorado Cancer Center ( Site 0021)
        • Contact:
          • Study Coordinator
          • Phone Number: 720-848-7135
    • Connecticut
      • New Haven, Connecticut, United States, 06511
        • Active, not recruiting
        • Yale Cancer Center ( Site 0014)
    • District of Columbia
      • Washington D.C., District of Columbia, United States, 20007
        • Active, not recruiting
        • Georgetown University Medical Center ( Site 0023)
    • Florida
      • Fort Lauderdale, Florida, United States, 33308
        • Recruiting
        • Holy Cross Hospital, Michael & Dianne Bienes Comp Cancer Ctr ( Site 0022)
        • Contact:
          • Study Coordinator
          • Phone Number: 954-776-3036
      • Jacksonville, Florida, United States, 32207
        • Active, not recruiting
        • Baptist MD Anderson Cancer Center ( Site 0083)
      • Miami Beach, Florida, United States, 33140
        • Recruiting
        • Mount Sinai Medical Center Comprehensive Cancer Center ( Site 0031)
        • Contact:
          • Study Coordinator
          • Phone Number: 305-674-2625
      • Tampa, Florida, United States, 33612
        • Completed
        • Moffitt Cancer Center ( Site 0011)
    • Georgia
      • Atlanta, Georgia, United States, 30322
        • Completed
        • Emory School of Medicine ( Site 0013)
      • Augusta, Georgia, United States, 30912
        • Recruiting
        • Augusta University ( Site 0077)
        • Contact:
          • Study Coordinator
          • Phone Number: 706-721-5557
      • Marietta, Georgia, United States, 30060
        • Recruiting
        • Northwest Georgia Oncology Centers PC ( Site 0061)
        • Contact:
          • Study Coordinator
          • Phone Number: 770-281-5124
    • Hawaii
      • Honolulu, Hawaii, United States, 96813
        • Recruiting
        • Kaiser Permanente Moanalua Medical Center ( Site 0063)
        • Contact:
          • Study Coordinator
          • Phone Number: 808-284-0257
    • Illinois
      • Chicago, Illinois, United States, 60637
        • Recruiting
        • The University of Chicago ( Site 0020)
        • Contact:
          • Study Coordinator
          • Phone Number: 773-834-7961
    • Iowa
      • Iowa City, Iowa, United States, 52242
        • Recruiting
        • University of Iowa Hospital and Clinics ( Site 0026)
        • Contact:
          • Study Coordinator
          • Phone Number: 319-356-1228
    • Kentucky
      • Louisville, Kentucky, United States, 40202
        • Recruiting
        • James Graham Brown Cancer Center ( Site 0058)
        • Contact:
          • Study Coordinator
          • Phone Number: 502-562-4673
      • Paducah, Kentucky, United States, 42003
        • Recruiting
        • Mercy Health-Paducah Cancer Center ( Site 0084)
        • Contact:
          • Study Coordinator
          • Phone Number: 270-441-4343
    • Louisiana
      • Covington, Louisiana, United States, 70433
        • Recruiting
        • Women's Cancer Care ( Site 0088)
        • Contact:
          • Study Coordinator
          • Phone Number: 985-317-6005
    • Maryland
      • Baltimore, Maryland, United States, 21237
        • Recruiting
        • MedStar Franklin Square Medical Center ( Site 0046)
        • Contact:
          • Study Coordinator
          • Phone Number: 443-777-7364
      • Baltimore, Maryland, United States, 21287
        • Recruiting
        • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 0056)
        • Contact:
          • Study Coordinator
          • Phone Number: 410-955-5222
      • Columbia, Maryland, United States, 21044
        • Recruiting
        • Maryland Oncology Hematology (MOH) ( Site 8000)
        • Contact:
          • Study Coordinator
          • Phone Number: 410-964-2212
    • Massachusetts
      • Boston, Massachusetts, United States, 02114
        • Active, not recruiting
        • Massachusetts General Hospital ( Site 0041)
      • Boston, Massachusetts, United States, 02215
        • Active, not recruiting
        • Dana-Farber Cancer Institute ( Site 0006)
    • Michigan
      • Detroit, Michigan, United States, 48201
        • Recruiting
        • Karmanos Cancer Institute ( Site 0047)
        • Contact:
          • Study Coordinator
          • Phone Number: 800-527-6266
    • Minnesota
      • Rochester, Minnesota, United States, 55905
        • Recruiting
        • Mayo Clinic in Rochester, Minnesota ( Site 0002)
        • Contact:
          • Study Coordinator
          • Phone Number: 507-538-6739
    • Nevada
      • Las Vegas, Nevada, United States, 89169
        • Recruiting
        • Comprehensive Cancer Centers of Nevada ( Site 0043)
        • Contact:
          • Study Coordinator
          • Phone Number: 702-952-3400
    • New Jersey
      • Hackensack, New Jersey, United States, 07601
        • Active, not recruiting
        • John Theurer Cancer Center at Hackensack University Medical Center ( Site 0038)
      • New Brunswick, New Jersey, United States, 08901
        • Recruiting
        • Cancer Institute of New Jersey ( Site 0025)
        • Contact:
          • Study Coordinator
          • Phone Number: 917-991-4174
    • New York
      • New York, New York, United States, 10016
        • Recruiting
        • Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0032)
        • Contact:
          • Study Coordinator
          • Phone Number: 212-731-5431
      • New York, New York, United States, 10065
        • Active, not recruiting
        • Memorial Sloan Kettering Cancer Center ( Site 0012)
      • White Plains, New York, United States, 10601
        • Recruiting
        • White Plains Hospital-Center for Cancer Care ( Site 0069)
        • Contact:
          • Study Coordinator
          • Phone Number: 914-849-7630
    • North Carolina
      • Cary, North Carolina, United States, 27518
        • Recruiting
        • WakeMed Cancer Care - Waverly Hematology & Medical Oncology ( Site 0074)
        • Contact:
          • Study Coordinator
          • Phone Number: 919-235-2873
      • Chapel Hill, North Carolina, United States, 27514
        • Recruiting
        • University of North Carolina at Chapel Hill ( Site 0040)
        • Contact:
          • Study Coordinator
          • Phone Number: 919-843-7713
      • Charlotte, North Carolina, United States, 28204
        • Active, not recruiting
        • Levine Cancer Institute ( Site 0034)
      • Durham, North Carolina, United States, 27710
        • Recruiting
        • Duke Cancer Center ( Site 0028)
        • Contact:
          • Study Coordinator
          • Phone Number: 919-668-3771
    • North Dakota
      • Fargo, North Dakota, United States, 58102
        • Completed
        • Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0065)
    • Ohio
      • Cleveland, Ohio, United States, 44106
        • Completed
        • University Hospitals ( Site 0044)
    • Oklahoma
      • Tulsa, Oklahoma, United States, 74146
        • Recruiting
        • Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0082)
        • Contact:
          • Study Coordinator
          • Phone Number: 918-505-3200
    • Oregon
      • Portland, Oregon, United States, 97225
        • Completed
        • Providence Portland Medical Center ( Site 0051)
    • Pennsylvania
      • Bethlehem, Pennsylvania, United States, 18015
        • Recruiting
        • St. Luke's University Health Network ( Site 0017)
        • Contact:
          • Study Coordinator
          • Phone Number: 484-503-4153
      • Philadelphia, Pennsylvania, United States, 19104
        • Recruiting
        • University of Pennsylvania ( Site 0010)
        • Contact:
          • Study Coordinator
          • Phone Number: 215-662-7908
      • Philadelphia, Pennsylvania, United States, 19111
        • Recruiting
        • Fox Chase Cancer Center ( Site 0042)
        • Contact:
          • Study Coordinator
          • Phone Number: 215-214-4297
      • Pittsburgh, Pennsylvania, United States, 15232
        • Recruiting
        • UPMC Hillman Cancer Center ( Site 0008)
        • Contact:
          • Study Coordinator
          • Phone Number: 412-623-3272
    • South Carolina
      • Greenville, South Carolina, United States, 29607
        • Recruiting
        • Saint Francis Health System ( Site 0089)
        • Contact:
          • Study Coordinator
          • Phone Number: 864-603-6300
    • South Dakota
      • Sioux Falls, South Dakota, United States, 57104
        • Completed
        • Sanford Cancer Center ( Site 0066)
    • Tennessee
      • Germantown, Tennessee, United States, 38138
        • Completed
        • West Cancer Center and Research Institute ( Site 0055)
      • Nashville, Tennessee, United States, 37204
        • Recruiting
        • Vanderbilt Health One Hundred Oaks Diagnostic ( Site 0060)
        • Contact:
          • Study Coordinator
          • Phone Number: 615-936-6726
      • Nashville, Tennessee, United States, 37232
        • Recruiting
        • Vanderbilt Ingram Cancer Center ( Site 0015)
        • Contact:
          • Study Coordinator
          • Phone Number: 615-936-6726
    • Texas
      • Austin, Texas, United States, 78745
        • Recruiting
        • Texas Oncology - Central/South Texas ( Site 8001)
        • Contact:
          • Study Coordinator
          • Phone Number: 512-447-2202
      • Dallas, Texas, United States, 75246
        • Recruiting
        • Texas Oncology-Baylor Sammons Cancer Center ( Site 0062)
        • Contact:
          • Study Coordinator
          • Phone Number: 214-370-1000
      • Houston, Texas, United States, 77030
        • Recruiting
        • University of Texas MD Anderson Cancer Center ( Site 0007)
        • Contact:
          • Study Coordinator
          • Phone Number: 713-792-2921
      • San Antonio, Texas, United States, 78229
        • Recruiting
        • South Texas Accelerated Research Therapeutics, LLC (START) ( Site 0001)
        • Contact:
          • Study Coordinator
          • Phone Number: 210-593-5265
    • Virginia
      • Charlottesville, Virginia, United States, 22908
        • Recruiting
        • University of Virginia Health System ( Site 0035)
        • Contact:
          • Study Coordinator
          • Phone Number: 434-243-6303
      • Midlothian, Virginia, United States, 23114
        • Completed
        • Bon Secours St. Francis Medical Center-Oncology Research ( Site 0075)
      • Richmond, Virginia, United States, 23219
        • Recruiting
        • VCU Health Adult Outpatient Pavillion ( Site 0080)
        • Contact:
          • Study Coordinator
          • Phone Number: 804-628-6430
      • Roanoke, Virginia, United States, 24014
        • Recruiting
        • Blue Ridge Cancer Care ( Site 0067)
        • Contact:
          • Study Coordinator
          • Phone Number: 540-491-2244
    • Washington
      • Seattle, Washington, United States, 98109
        • Recruiting
        • Fred Hutchinson Cancer Center ( Site 0024)
        • Contact:
          • Study Coordinator
          • Phone Number: 206-606-8245
  • Vietnam
    • Hanoi
      • Hanoi, Hanoi, Vietnam, 100000
        • Recruiting
        • National Lung Hospital ( Site 3781)
        • Contact:
          • Study Coordinator
          • Phone Number: +84 967 941 616
      • Hanoi, Hanoi, Vietnam, 100000
        • Active, not recruiting
        • Hanoi Oncology Hospital ( Site 3780)
      • Hanoi, Hanoi, Vietnam, 100000
        • Active, not recruiting
        • K Hospital - National Cancer Hospital ( Site 3783)

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Treated on the parent pembrolizumab studies established by the Sponsor as MK-3475-587 ready.
  • Currently receiving pembrolizumab, pembrolizumab based combinations or lenvatinib from parent studies or in a follow-up phase.

Additional eligibility criteria for participants who enter Second Course Phase once they are enrolled on MK-3475-587:

  • Has not received any anticancer systemic treatment since the last dose of pembrolizumab or a pembrolizumab-based combination in First Course Phase.
  • Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
  • Demonstrates adequate organ function.
  • Have resolution of any toxic effect(s) of First Course Phase trial treatment with pembrolizumab or a pembrolizumab-based combination to Grade 1 or less (except alopecia) before trial treatment in Second Course Phase is started. If participant received major surgery or radiation therapy of >30 Gray (Gy), they must have recovered from the toxicity and/or complications of the intervention.
  • A female participant is eligible to enroll if she is not pregnant, not breastfeeding, and ≥1 of the following conditions applies: A woman of childbearing potential (WOCBP) who agrees to use contraception during the study treatment period and for ≥120 days (corresponding to time needed to eliminate any study combination treatment(s) plus 30 days (a menstruation cycle) for study treatments with risk of genotoxicity.

Additional eligibility criteria for participants who enter dosing with Lenvatinib:

  • Adequately controlled blood pressure (BP) to <150/90 mmHg, with or without antihypertensive medications.
  • For male agrees to be abstinent from penile-vaginal intercourse OR agrees to use a highly effective contraceptive method while receiving study drug and for 7 days after the last dose of lenvatinib.
  • Is female and not pregnant/breastfeeding and at least one of the following applies during the study and for ≥4 days after: is not a woman of childbearing potential (WOCBP), is a WOCBP and uses highly effective contraception (low user dependency method OR a user dependent hormonal method in combination with a barrier method) or is a WOCBP who is abstinent from heterosexual intercourse.

Exclusion Criteria:

-There are no exclusion criteria to participate in MK-3475-587.

Participants are excluded from entering Second Course trial treatment once they are enrolled on MK-3475-587 if any of the following criteria applies:

  • Has severe hypersensitivity (≥ Grade 3) to pembrolizumab and/or any of its excipients.
  • Has received a live vaccine within 30 days prior to the first dose of Second Course Phase trial treatment.
  • Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to the Cycle 1 Day 1 of Second Course Phase.
  • Has a known additional malignancy that is progressing or requires active treatment. Exceptions include early stage cancers (carcinoma in situ or Stage 1) treated with curative intent, melanoma (non-ulcerated, thin primary), basal cell carcinoma of the skin, squamous cell carcinoma of the skin, in situ cervical cancer, or in situ breast cancer that has undergone potentially curative therapy.
  • Has known active central nervous system metastases and/or carcinomatous meningitis.
  • Has an active autoimmune disease that has required systemic treatment in the past 2 years (i.e., use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed.
  • Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis. Note: Participants that experienced pneumonitis during First Course that did not meet the criteria for permanent discontinuation are eligible.
  • Non-small cell lung cancer (NSCLC) participants only: Has interstitial lung disease.
  • Has an active infection requiring systemic therapy.
  • Has a known history of human immunodeficiency virus (HIV) infection.
  • Has a known history of or is positive for hepatitis B or hepatitis C. For parent studies where inclusion of participants with hepatitis was permitted, MK-3475-587 will follow the parent study eligibility criteria for hepatitis.
  • Is pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with the Second Course Phase eligibility Visit through 120 days after the last dose of study treatment.
  • Has severe cardiovascular disease, i.e., arrhythmias, requiring chronic treatment, congestive heart failure (New York Heart Association Class III or IV) or symptomatic ischemic heart disease.
  • Has hepatic decompensation (Child-Pugh score >6 [class B and C]).
  • Has uncontrolled thyroid dysfunction.
  • Has uncontrolled diabetes mellitus.
  • Has had an allogeneic tissue/solid organ transplant.
  • Has a known history of active tuberculosis (TB; Bacillus tuberculosis).

Additional exclusion criteria for participants who enter dosing with Lenvatinib:

  • Has had major surgery within 3 weeks prior to first dose of study intervention(s).
  • Has preexisting ≥Grade 3 gastrointestinal or non-gastrointestinal fistula.
  • Has urine protein ≥1 g/24 hours.
  • Has LVEF below the institutional (or local laboratory) normal range, as determined by multigated acquisition scan (MUGA) or echocardiogram (ECHO).
  • Has radiographic evidence of encasement or invasion of a major blood vessel, or of intratumoral cavitation.
  • Prolongation of QT intervals corrected for heart rate using Fridericia's (cube root) correction (QTcF) interval to >480 ms.
  • Has clinically significant cardiovascular disease within 12 months from first dose of study intervention, including New York Heart Association Class III or IV congestive heart failure, unstable angina, myocardial infarction, cerebral vascular accident, or cardiac arrhythmia associated with hemodynamic instability.
  • Gastrointestinal malabsorption or any other condition that might affect the absorption of lenvatinib.
  • Active hemoptysis (bright red blood of at least 0.5 teaspoon) within 3 weeks prior to the first dose of study drug.
  • Has a history of any contraindication or has a severe hypersensitivity to any components of lenvatinib.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Pembrolizumab 200 mg
Participants receive pembrolizumab 200 mg via intravenous (IV) infusion on Day 1 of each 3-week cycle for up to 35 administrations or more for First Course participants and up to 17 administrations for Second Course participants.
Drug: Pembrolizumab
200 or 400 mg IV infusion
Other Names:
  • MK-3475
  • KEYTRUDA®
Experimental: Pembrolizumab 400 mg
Participants receive pembrolizumab 400 mg via intravenous (IV) infusion on Day 1 of each 6-week cycle for up to 17 administrations or more for First Course participants and up to 8 administrations for Second Course participants.
Drug: Pembrolizumab
200 or 400 mg IV infusion
Other Names:
  • MK-3475
  • KEYTRUDA®
Experimental: Pembrolizumab 200 mg + SOC: Per Parent Study)
Participants receive pembrolizumab 200 mg via IV infusion on Day 1 of each 3-week cycle PLUS standard of care (SOC) treatment (or per parent study if there is no SOC) for up to 35 administrations or more for First Course participants and up to 17 administrations for Second Course participants. Participants receiving a pembrolizumab-based combination treatment will receive the dose regimen of the combination drug(s) which is recommended per SOC or was used in the parent study protocol if there is no SOC recommendation.
Drug: Pembrolizumab
200 or 400 mg IV infusion
Other Names:
  • MK-3475
  • KEYTRUDA®
Drug: Standard of Care (SOC)
IV infusion or oral tablets
Experimental: Pembrolizumab 400 mg + SOC (Per Parent Study)
Participants receive pembrolizumab 400 mg via IV infusion on Day 1 of each 6-week cycle PLUS SOC treatment (or per parent study if there is no SOC) for up to 17 administrations or more for First Course participants and up to 8 administrations for Second Course participants. Participants receiving a pembrolizumab-based combination treatment will receive the dose regimen of the combination drug(s) which is recommended per SOC or was used in the parent study protocol if there is no SOC recommendation.
Drug: Pembrolizumab
200 or 400 mg IV infusion
Other Names:
  • MK-3475
  • KEYTRUDA®
Drug: Standard of Care (SOC)
IV infusion or oral tablets
Active Comparator: SOC (Per Parent Study)
Participants receive the dose matched non-pembrolizumab SOC treatment (e.g. chemotherapy) they were receiving as per parent study protocol.
Drug: Standard of Care (SOC)
IV infusion or oral tablets
Experimental: Lenvatinib 20 mg
Participants with body weight (BW)>60kg receive Lenvatinib 20mg orally once daily on a 21 or 42 day cycle. It is taken 0-4 hours after completion of pembrolizumabd administration in the clinic on cycle 1 day 1(C1D1), C2D1, C3D1, etc. Taken at home on all other days.
Drug: Lenvatinib
Oral capsules
Experimental: Lenvatinib 24 mg
Participants with body weight (BW)>60 kg receive Lenvatinib 24 mg orally once daily on a 21 or 42 day cycle. It is taken 0-4 hours after completion of pembrolizumabd administration in the clinic on cycle 1 day 1(C1D1), C2D1, C3D1, etc. Taken at home on all other days.
Drug: Lenvatinib
Oral capsules
Experimental: Lenvatinib 12 mg
Participants with body weight (BW)>60 kg receive Lenvatinib 12 mg orally once daily on a 21 or 42 day cycle. It is taken 0-4 hours after completion of pembrolizumabd administration in the clinic on cycle 1 day 1(C1D1), C2D1, C3D1, etc. Taken at home on all other days.
Drug: Lenvatinib
Oral capsules
Experimental: Lenvatinib 8 mg
Participants with body weight (BW)<60 kg receive Lenvatinib 8 mg orally once daily on a 21 or 42 day cycle. It is taken 0-4 hours after completion of pembrolizumabd administration in the clinic on cycle 1 day 1(C1D1), C2D1, C3D1, etc. Taken at home on all other days.
Drug: Lenvatinib
Oral capsules
Experimental: Lenvatinib 2mg
Participants with body weight (BW)<60 kg receive Lenvatinib 2 mg orally once daily on a 21 or 42 day cycle. It is taken 0-4 hours after completion of pembrolizumab administration in the clinic on cycle 1 day 1(C1D1), C2D1, C3D1, etc. Taken at home on all other days.
Drug: Lenvatinib
Oral capsules
Experimental: Olaparib 300mg
Participants receive Olaparib 300 mg orally twice daily (BID) until disease progression or toxicity prohibits its administration.
Drug: Olaparib
300mg or 250mg or 100mg oral tablers
Other Names:
  • Lynparza
Experimental: Olaparib 250mg
Participants receive Olaparib 250 mg orally twice daily (BID) until disease progression or toxicity prohibits its administration.
Drug: Olaparib
300mg or 250mg or 100mg oral tablers
Other Names:
  • Lynparza
Experimental: Olaparib 100mg
Participants receive Olaparib 100 mg orally twice daily (BID) until disease progression or toxicity prohibits its administration.
Drug: Olaparib
300mg or 250mg or 100mg oral tablers
Other Names:
  • Lynparza
Experimental: MK-4280 800mg
Participants receive MK-4280 800mg as IV infusion every 3 weeks (Q3W) and may continue study therapy until study treatment completion or may transition to pembrolizumab to complete their treatment.
Drug: MK-4280
IV Infusion
Other Names:
  • Favezelimab
Experimental: MK-4280A
Participants receive MK-4280A (800mg favezelimab + 200mg pembrolizumab) as IV infusion every 3 weeks (Q3W) and may continue study therapy until study treatment completion or may transition to pembrolizumab to complete their treatment.
Biological: MK-4280A
800mg favezelimab + 200mg pembrolizumab IV Infusion
Experimental: Pembrolizumab (+) Berahyaluronidase alfa 395 mg
Participants receive 395 mg of a fixed-dose formulation of pembrolizumab and berahyaluronidase alfa via subcutaneous (SC) administration on Day 1 of each 3-week cycle for up to 35 administrations.
Biological: Pembrolizumab (+) Berahyaluronidase alfa
395 mg or 790 mg SC administration
Other Names:
  • MK-3475A
Experimental: Pembrolizumab (+) Berahyaluronidase alfa 790 mg
Participants receive 790 mg of a fixed-dose formulation of pembrolizumab and berahyaluronidase alfa via SC administration on Day 1 of each 6-week cycle for up to 35 administrations.
Biological: Pembrolizumab (+) Berahyaluronidase alfa
395 mg or 790 mg SC administration
Other Names:
  • MK-3475A

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Overall Survival (OS)
Time Frame: Up to approximately 10 years
OS is defined as the time from randomization or start of study treatment for non-randomized participants (on the parent study) to death due to any cause. Participants without documented death at the time of analysis will be censored at the date of the last known to be alive.
Up to approximately 10 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Number of Participants Who Experience Serious Adverse Events (SAEs)
Time Frame: Up to approximately 42 months (Up to 90 days after last dose of study treatment)
A SAE is defined as any untoward medical occurrence that, at any dose: Results in death, Is life-threatening, Requires inpatient hospitalization or prolongation of existing hospitalization, Results in persistent or significant disability/incapacity or Is a congenital anomaly/birth defect. The number of participants who experience a SAE in this study will be presented.
Up to approximately 42 months (Up to 90 days after last dose of study treatment)
Number of Participants Who Experience Adverse Events of Special Interest (AEOSI)
Time Frame: Up to approximately 40 months (Up to 30 days after last dose of study treatment)
AEOSI for this study include selected preferred terms from Medical Dictionary for Regulatory Activities (MedDRA) version 20.1 for the following higher-level terms: Pneumonitis, Colitis, Hepatitis, Nephritis, Adrenal Insufficiency, Hypophysitis, Hyperthyroidism, Hypothyroidism, Thyroiditis, Type 1 Diabetes Mellitus, Severe Skin Reactions Including Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN): or If grade 3 or higher, Uveitis, Pancreatitis, Myositis, Guillain-Barre Syndrome, Myocarditis, Encephalitis, Sarcoidosis, Infusion Reactions and Myasthenic Syndrome. The number of participants who experience an AEOSI in this study will be presented.
Up to approximately 40 months (Up to 30 days after last dose of study treatment)
Number of Participants Who Experience Events of Clinical Interest (ECI)
Time Frame: Up to approximately 40 months (Up to 30 days after last dose of study treatment)
ECIs for this study include: 1) An overdose of Sponsor's product, that is not associated with clinical symptoms or abnormal laboratory results or 2) An elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) lab value that is ≥3X the upper limit of normal (ULN) and an elevated total bilirubin lab value that is ≥2X ULN and, at the same time, an alkaline phosphatase lab value that is <2X ULN, as determined by way of protocol-specified laboratory testing or unscheduled laboratory testing. The number of participants who experience an ECI in this study will be presented.
Up to approximately 40 months (Up to 30 days after last dose of study treatment)
Number of Participants Who Discontinue Study Treatment Due to an AE
Time Frame: Up to approximately 39 months
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of study intervention, whether or not considered related to the study intervention. An AE can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease (new or exacerbated) temporally associated with the use of a study intervention. The number of participants who discontinue study treatment due to an AE will be presented.
Up to approximately 39 months
Number of Participants Who Experience Clinically Significant Adverse Events (CSAE)
Time Frame: Up to approximately 40 months (Up to 30 days after last dose of study treatment)
CSAE are AEs associated with lenvatinib treatment and include selected preferred terms from the lenvatinib CSAE preferred term list document. The number of participants who experience an CSAE in this study will be presented.
Up to approximately 40 months (Up to 30 days after last dose of study treatment)
Modified Progression Free Survival (PFS) Per Evaluation Criteria Used in the Parent Trial
Time Frame: Up to approximately 10 years
Modified PFS is defined as the time from randomization or start of study treatment for nonrandomized participants (on the parent study or this study) to the first documented disease progression per the evaluation criteria used in the parent study based on investigator assessment or death due to any cause, whichever occurs first. The censoring rule is modified that participants without modified PFS events at the time of the analysis will be censored at the date of last known to be alive.
Up to approximately 10 years
Modified Event Free Survival (EFS) Per Evaluation Criteria Used in the Parent Trial
Time Frame: Up to approximately 10 years
Modified EFS is defined as the time from randomization to disease progression that precludes surgery, local or distant recurrence, or death due to any cause, whichever occurs first. The censoring rule is modified that participants without documented modified EFS events at the time of the analysis will be censored at the date of last known to be alive.
Up to approximately 10 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Merck Sharp & Dohme LLC

Investigators

  • Study Director: Medical Director, Merck Sharp & Dohme LLC

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 21, 2018

Primary Completion (Estimated)

August 4, 2043

Study Completion (Estimated)

August 4, 2043

Study Registration Dates

First Submitted

March 29, 2018

First Submitted That Met QC Criteria

March 29, 2018

First Posted (Actual)

April 3, 2018

Study Record Updates

Last Update Posted (Actual)

June 5, 2026

Last Update Submitted That Met QC Criteria

June 4, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 3475-587
  • MK-3475-587 (Other Identifier: MSD)
  • KEYNOTE-587 (Other Identifier: MSD)
  • 195006 (Registry Identifier: JAPIC-CTI)
  • PHRR210209-002881 (Registry Identifier: PHRR)
  • 2017-004417-42 (EudraCT Number)
  • jRCT2080224921 (Other Identifier: jRCT)
  • 2022-501254-10-00 (Registry Identifier: EU CT)
  • U1111-1274-2274 (Registry Identifier: UTN)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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