- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03525054
Semantic and Syntactic Computerized Analysis of Free Speech (ASESID)
Study Overview
Status
Detailed Description
Different scales allow identification of patients at ultra-high-risk to develop psychosis. The current challenge is to identify a predictive marker of transition to schizophrenia. Language disorders, which reflect psyche, could be one of these markers. Computerized speech analysis techniques such as Latent Semantic Analysis (LSA) have already proven their reliability in schizophrenia. These techniques reveal subtle speech disorganization that would be predictive of a clinical transition of ultra-high-risk psychotic patients. A combination of semantic and syntactic analysis could accurately predict the psychotic transition. The aim of our longitudinal multicenter cohort study is to validate this predicitve model in french language as well as identifying specific linguistic markers of the psychotic transition.
The initial report including the CAARMS is completed with an audio recording from the initial medical interview. The recording will be transcribed and analyzed by computer following the method of lemmatization and vectorial analysis (LSA). An analysis of the grammatical function (number of words, rate of the various grammatical functions) will also be performed. This first analysis will emerge linguistic markers correlated to transition to psychosis that we will use to construct a predictive model for transition to schizophrenia.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Michel WALTER
- Phone Number: 02-98-01-51-57
- Email: michel.walter@chu-brest.fr
Study Contact Backup
- Name: Christophe LEMEY
- Email: christophe.lemey@chu-brest.fr
Study Locations
-
-
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Brest, France, 29609
- Recruiting
- CHRU de Brest
-
Contact:
- Michel WALTER
- Email: michel.walter@chu-brest.fr
-
Caen, France
- Not yet recruiting
- Meunier Sophie
-
Contact:
- Sophie Meunier
-
Paris, France, 750144
- Recruiting
- CH de SAINT ANNE
-
Contact:
- Marie-Odile KREBS
- Email: mo.krebs@ch-saint-anne.fr
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Major and/or minor from 15 to 30 years old
- Who alleged a suicidal gesture or idea or behavior that has repercussions in their emotional, social or professional life
- If patients receive neuroleptic treatment that impairs cognitive abilities, a one-week wash-out period will be scheduled prior to assessment.
Exclusion Criteria:
- History of psychosis
- Risk of self-harm or violence not compatible with outpatient treatment
- QI<70 (WAIS)
- Neurological disorder or major health problem
- Impossibility to interrupt neuroleptic treatment for one week
- Refusal to participate
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Transition to schizophrenia
Time Frame: 2 years
|
Determined from the CAARMS scale (COMPREHENSIVE ASSESSMENT OF AT RISK MENTAL STATES)
|
2 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Identification of patients at "ultra high risk " for developing schizophrenia
Time Frame: Day 0
|
Determined from the CAARMS scale ( COMPREHENSIVE ASSESSMENT OF AT RISK MENTAL STATES)
|
Day 0
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- ASESID (29BRC17.0198)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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