- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03613701
Relationship Between Endothelial Progenitor Cells and Revascularization Effect of Moyamoya Disease (REPCREMMD)
Study Overview
Status
Conditions
Detailed Description
Objective: Detect the expression of endothelial progenitor cells and endothelial cells from peripheral blood of patients with moyamoya disease, and to assess the relationship between clinical characteristics.
Design: A single center study, and planned to enroll 120 patients. The present study was to detect the quantities of EPC from peripheral blood in Moyamoya disease by flow cytometry, and to identify the relationship of endothelial progeIlitor cells and effect of the revascularization on Moyamoya disease. The present study also use cerebral ischemia animal model foe intervention experiment, to explore whether EPC can promote vascular remodeling effect of ischemic cerebrovascular disease, and to provide new thought for the treatment of chronic cerebrovascular disorder.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Lian Duan, Chief
- Phone Number: 0086-10-66947156
- Email: keyan307@163.com
Study Locations
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Beijing
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Beijing, Beijing, China, 100071
- Recruiting
- The 307th Hospital of Military Chinese People's Liberation Army
-
Contact:
- Lian Duan, Chief
- Phone Number: 0086-10-66947156
- Email: keyan307@163.com
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Health volunteers' inclusion criteria:
- Age between 18-60;
- Male or female;
Exclusion criteria:
Exclude the volunteers with history of cerebrovascular disease and heart disease.
Description
Inclusion Criteria:
- Whole-brain vessels angiography or magnetic resonance arteriography (MRA) has the following manifestations: stenosis or occlusion of terminal internal carotid artery or the anterior cerebral artery and/or initiating middle cerebral artery; In the arterial phase, the abnormal smokey vascular net near the occlusive or stenosis lesion can be seen.
- For patients with stable stroke, there was no acute or subacute cerebral infarction or cerebral hemorrhage, and at least 3 months before the last cerebral infarction or cerebral hemorrhage events.
Exclusion Criteria:
- Exclude atherosclerosis, autoimmune diseases, meningitis, intracranial tumors, multiple neurofibromatosis, Down syndrome, craniocerebral trauma, radiation injury, and other underlying diseases that may cause smoke.
- Acute or subacute cerebral infarction or cerebral hemorrhage were excluded.
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
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Moyamoya disease patients
Moyamoya disease patients/Healthy volunteers
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Expression of endothelial progenitor cells and endothelial cells in peripheral blood
Time Frame: 2017.9-2018.8
|
Expression of endothelial progenitor cells and endothelial cells in peripheral
|
2017.9-2018.8
|
Collaborators and Investigators
Investigators
- Study Chair: Lian Duan, Chief, The 307th Hospital of Military Chinese People's Liberation Army
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 8157113
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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