Autonomical and Hemodynamic Repercussions on Excentric Resistance in Different Intensities With Blood Flow Restriction

Autonomical and Hemodynamic Repercussions on Excentric Resistance in Different Intensities Associated With Blood Flow Restriction: a Randomized Clinical Trial

Introduction: Studies on resistance training (RT) associated with blood flow restriction (BFR) have emerged as an alternative method of gaining strength and hypertrophy; however, the cardiovascular and autonomic repercussion of BFR at different intensities is unknown. Thus, it becomes relevant to investigate this type of training in post-exercise. Objective: investigate and compare autonomic and hemodynamic responses of acute eccentric RT with different intensities associated or not to BFR in healthy youngsters. Method: This is a randomized clinical trial including 60 healthy men aged 18-35 years, divided into four groups according to exercise intensity and BFR: 80% without BFR, 40% without BFR, 80% with BFR and 40% with BFR. Exercise intensity will be determined by the peak of excentric torque on the dinamometer isokinetic method and by the BFR, as being 40% of the intensity required for the complete examination of the blood flow evaluated by Doppler. Participants will do an eccentric femoral quadriceps muscle exercise session on the isokinetic dynamometer according to the previously randomized group. For recovery analyzes, the recovery heart rate (HRR) in the 1st (HRR1) and 2nd (HRR2) minute, rMSSD of 30 seconds, the hemodynamic parameters (heart rate, systolic and diastolic blood pressure, respiratory rate, peripheral oxygen saturation and rate pressure product) and heart rate variability (HRV) indices analyzed in the time domain (mean HR, rMSSD and SDNN), frequency domain (LF and HF [nu and ms2]) and Poincaré plot (SD1 and SD2). The analysis will be occur on baseline, immediately e after the excentric exercise and in the post exercise period for 60 minutes. Descriptive statistics method and comparison of HRV indices and hemodynamic parameters between moments and groups will be performed with the aid of the analysis of variance technique for the repetitive measures model without the schema of two sets of tests to follow . The level of significance will be p <0.05.

Study Overview

• Status: Completed
• Conditions: Exercise
• Intervention / Treatment: Other: eccentric exercise with blood flow restriction

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Brazil
  • SP
    • Presidente Prudente, SP, Brazil, 19050-050
      • Leonardo Kesrouani Lemos

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• male sex;
• healthy;
• aged between 18 and 35 years

Exclusion Criteria:

• smokers;
• alcoholics;
• use drugs that influenced cardiac autonomic activity;
• cardiovascular, metabolic or endocrine diseases.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: High intensity eccentric training; high intensity (80% isometric peak) eccentric training of the knee extensors in the isokinetic will be performed during 6 weeks, 3 times a week.	Other: eccentric exercise with blood flow restriction; High/low intensity eccentric training group (80% and 40% of isometric peak torque) with or not blood flow restriction.
Experimental: High intensity eccentric training with blood flow restriction; high intensity (80% isometric peak) eccentric training of the knee extensors in the isokinetic associated with a pressure cuff placed in the proximal thigh (40% of absolute occlusion pressure) will be performed during 6 weeks, 3 times a week.	Other: eccentric exercise with blood flow restriction; High/low intensity eccentric training group (80% and 40% of isometric peak torque) with or not blood flow restriction.
Experimental: Low intensity eccentric training; A low intensity (40% isometric peak) eccentric training of the knee extensors in the isokinetic will be performed during 6 weeks, 3 times a week.	Other: eccentric exercise with blood flow restriction; High/low intensity eccentric training group (80% and 40% of isometric peak torque) with or not blood flow restriction.
Experimental: Low intensity eccentric training with blood flow restriction; A low intensity (40% isometric peak) eccentric training of the knee extensors in the isokinetic associated with a pressure cuff placed in the proximal thigh (40% of absolute occlusion pressure)will be performed during 6 weeks, 3 times a week.	Other: eccentric exercise with blood flow restriction; High/low intensity eccentric training group (80% and 40% of isometric peak torque) with or not blood flow restriction.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
heart rate variability indices in the time domain	mean HR, rMSSD and SDNN in ms	Change from baseline at 3rd week and 6rd week
heart rate variability indices analyzed in the Poincaré plot	SD1 and SD2 in ms	Change from baseline at 3rd week and 6rd week
heart rate variability indices in the frequency domain	LF and HF in nu and ms2	Change from baseline at 3rd week and 6rd week
vagal reentry	rMSSD of 30 seconds in ms	Change from 1 day at 10 day and 18 day
heart rate recovery	the recovery heart rate (HRR) in the 1st (HRR1) and 2st (HRR2) minute [bpm]	Change from 1 day at 10 day and 18 day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
hemodynamic parameter	heart rate [bpm]	through study completion, an average of 6 weeks
hemodynamic parameter	systolic and diastolic blood pressure [mmHg]	through study completion, an average of 6 weeks
hemodynamic parameter	respiratory rate [irpm]	through study completion, an average of 6 weeks
hemodynamic parameter	peripheral oxygen saturation [%]	through study completion, an average of 6 weeks

Collaborators and Investigators

• Sponsor: Paulista University
• Investigators: Principal Investigator: Franciele M Vanderlei, PhD, Paulista State University

Study record dates

Study Major Dates

• Study Start (Actual): March 11, 2019
• Primary Completion (Actual): October 17, 2019
• Study Completion (Actual): December 22, 2020

Study Registration Dates

• First Submitted: April 30, 2019
• First Submitted That Met QC Criteria: May 6, 2019
• First Posted (Actual): May 8, 2019

Study Record Updates

• Last Update Posted (Actual): March 9, 2021
• Last Update Submitted That Met QC Criteria: March 8, 2021
• Last Verified: March 1, 2021

More Information

Terms related to this study

• Keywords: autonomic nervous system; heart rate; resistance training; vascular occlusion; hemodynamics, cardiovascular system; recovery of physiological function
• Other Study ID Numbers: U1111-1232-0808

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No