Effects of Blood Flow Restriction During Eccentric Resistance Exercise

Effects of Blood Flow Restriction During Multiple-joint Eccentric Resistance Training on Muscle Morphology and Function of the Lower Body

The purpose of this study is to compare the muscle strength and muscle soreness effects experienced following short term (acute) eccentric exercise with and without blood flow restriction (BFR) performed at low - moderate training intensities.

Study Overview

• Status: Not yet recruiting
• Conditions: Blood Flow Restriction
• Intervention / Treatment: Device: Eccentric exercise / Eccentric exercise with blood flow restriction

• Study Type: Interventional
• Enrollment (Anticipated): 45
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Brennan J Thompson, PhD; Phone Number: 435-797-5785; Email: brennan.thompson@usu.edu
• Study Contact Backup: Name: Sara Harper, PhD; Phone Number: 435-797-1376; Email: sara.harper@usu.edu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 28 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Exclusion Criteria:

• lower body surgery or injury in the last 12 months
• have any neuromuscular disease
• height >76 inches tall
• height <54 inches tall
• eccentric strength greater than 725 pounds
• pregnant or plan to be pregnant in the duration of the protocol
• don't do resistance exercise at least once per week
• perform intense cardio or strength training >4 days per week
• Present with any other significant comorbid conditions that would impair the ability to participate in the exercise-based testing

Inclusion criteria:

• 18 - 30 years old
• strength train lower body 1-3 times per week

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Eccentric exercise; Only multi-joint eccentric exercise	Device: Eccentric exercise / Eccentric exercise with blood flow restriction; Individuals will be randomized to receive eccentric exercise only, or eccentric exercise with blood flow restriction.
Experimental: Eccentric training with blood flow restriction; Multi-joint eccentric exercise with blood flow restriction	Device: Eccentric exercise / Eccentric exercise with blood flow restriction; Individuals will be randomized to receive eccentric exercise only, or eccentric exercise with blood flow restriction.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
visual analog scale (soreness)	soreness	Baseline (pretest)
visual analog scale (soreness)	soreness	immediately post exercise
visual analog scale (soreness)	soreness	24 hours post exercise
visual analog scale (soreness)	soreness	48 hours post exercise
visual analog scale (soreness)	soreness	72 hours post exercise
force algometer (soreness)	soreness	Baseline (pretest)
force algometer (soreness)	soreness	immediately post exercise
force algometer (soreness)	soreness	24 hours post exercise
force algometer (soreness)	soreness	48 hours post exercise
force algometer (soreness)	soreness	72 hours post exercise

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Eccentric muscle strength	muscle strength will be assessed on the Eccentron.	Baseline (pretest)
Eccentric muscle strength	muscle strength will be assessed on the Eccentron.	immediately post exercise
Eccentric muscle strength	muscle strength will be assessed on the Eccentron.	24 hours post exercise
Eccentric muscle strength	muscle strength will be assessed on the Eccentron.	48 hours post exercise
Eccentric muscle strength	muscle strength will be assessed on the Eccentron.	72 hours post exercise
Single-leg hop	3 single-leg hops per limb	Baseline (pretest)
Single-leg hop	3 single-leg hops per limb	immediately post exercise
Single-leg hop	3 single-leg hops per limb	24 hours post exercise
Single-leg hop	3 single-leg hops per limb	48 hours post exercise
Single-leg hop	3 single-leg hops per limb	72 hours post exercise

Collaborators and Investigators

• Sponsor: Utah State University
• Investigators: Principal Investigator: Brennan Thompson, PhD, Utah State University

Study record dates

Study Major Dates

• Study Start (Anticipated): June 1, 2023
• Primary Completion (Anticipated): December 1, 2023
• Study Completion (Anticipated): March 1, 2024

Study Registration Dates

• First Submitted: October 13, 2022
• First Submitted That Met QC Criteria: November 3, 2022
• First Posted (Actual): November 7, 2022

Study Record Updates

• Last Update Posted (Actual): November 7, 2022
• Last Update Submitted That Met QC Criteria: November 3, 2022
• Last Verified: November 1, 2022

More Information

Terms related to this study

• Other Study ID Numbers: 12042a

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Undecided

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No