Eccentric Resistance Training With Blood Flow Restriction on Muscle Function

Effects of Blood Flow Restriction During Multiple-joint Eccentric Resistance Training on Muscle Morphology and Function of the Lower Body.

The study will determine the effects of adding blood flow restriction to eccentric training to assess whether this increases the improvements of muscle strength and size.

Study Overview

• Status: Withdrawn
• Conditions: Blood Flow Restriction
• Intervention / Treatment: Other: Exercise; Other: Eccentric plus blood-flow restriction

Detailed Description

Subjects will be randomly assigned to two groups: an eccentric only resistance training group or an eccentric training plus blood flow restriction group. Subjects will train at a moderately low intensity on a multiple-joint eccentric device. Those in the blood flow restriction will wear blood flow restriction cuffs on their upper thighs to reduce blood flow during the brief protocol. The training session will occur twice per week and will last ~5 minutes, including a one minute warm up, a one minute cool down and a three minute workout phase. The training program will last 7 weeks. Testing will be conducted at baseline (following a one session familiarization), 4 weeks and after the end of the 7 week training period. Assessments will focus on muscle strength, function, and morphology (size).

• Study Type: Interventional
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Utah
    • Logan, Utah, United States, 84322
      • Utah State Universtiy

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• 18-30 years of age
• currently engaged in some form of resistance training between 1-3 times per week
• must have been training aerobically, but no more than 3 hours a week for the past six months

Exclusion Criteria:

• Must not have had any surgery of the lower limbs within the past 1 year period
• Must not have any neuromuscular disorder (e.g., Muscular dystrophy etc.)
• < 76 inches tall (in order to fit on the training machine)
• Maximal strength of < 725 lbs for the eccentric training device
• If any of the subjects are pregnant or plan to be pregnant in the duration of the protocol.

For those randomized to the BFR group, if any of the subject's thighs are too large for the BFR cuffs (greater than 68 cm).

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Eccentric only training; This is the experimental control; where this group will be used as the standard active comparison condition.	Other: Exercise; The interventions are a form or exercise, specifically resistance exercise.
Experimental: Eccentric plus blood-flow restriction; This is the experimental condition involving the eccentric resistance training with blood flow restriction.	Other: Eccentric plus blood-flow restriction; Eccentric plus blood-flow restriction

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Eccentron maximal muscle strength	Eccentric muscle strength will be assessed via Eccentron (BTE Technologies, Inc., USA), an seated isokinetic dynamometer.	7 weeks
Local muscle hypertrophy	Muscle size changes of the quadriceps muscle measured an ultrasound device (GE NextGen LOGIQ, Tampa, Florida, USA).	7 weeks
Muscle mass	dual energy x-ray absorptiometry device (DEXA) the Hologic Horizon W Dual X-ray absorptiometry (Hologic Canada ULC, Mississauga, ON, Canada) will be used to assess appendicular (lower body) mean mass.	7 weeks
Muscle function	Vertical jump height will assess 3 maximal countermovement attempts on a jump mat (Just Jump Technologies, Huntsville, AL, USA) that measures jump height based on flight time.	7 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle soreness	local muscle soreness will be assessed throughout the duration of the intervention period using a Wagner force algometer.	7 weeks

Collaborators and Investigators

• Sponsor: Utah State University
• Investigators: Principal Investigator: Brennan J Thompson, PhD, Utah State Univeristy

Study record dates

Study Major Dates

• Study Start (Estimated): March 30, 2024
• Primary Completion (Estimated): June 1, 2025
• Study Completion (Estimated): December 1, 2025

Study Registration Dates

• First Submitted: July 20, 2021
• First Submitted That Met QC Criteria: July 24, 2021
• First Posted (Actual): July 27, 2021

Study Record Updates

• Last Update Posted (Estimated): December 7, 2023
• Last Update Submitted That Met QC Criteria: November 30, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Keywords: resistance training; muscle hypertrophy; muscle function; eccentric training; quadriceps; eccentric strength; vertical jump; muscle quality
• Other Study ID Numbers: 12042b

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No