An Extension Study for Treatment of Moderately to Severely Active Ulcerative Colitis (ELEVATE UC OLE)

April 2, 2024 updated by: Pfizer

An Open-Label Extension Study of Etrasimod in Subjects With Moderately to Severely Active Ulcerative Colitis

The purpose of this open-label extension (OLE) study is to evaluate the safety and efficacy of etrasimod in participants with moderately to severely active ulcerative colitis (UC) who previously received double-blind treatment (either etrasimod 2 mg per day or placebo) during participation in one of the qualified Phase 3 or Phase 2 double-blind, placebo-controlled parent studies including but not limited to: (APD334-301 [NCT03945188] or APD334-302 [NCT03996369] or APD334-210 [NCT04607837]).

Study Overview

Status

Recruiting

Conditions

Ulcerative Colitis

Intervention / Treatment

Drug: Etrasimod

Study Type

Interventional

Enrollment (Estimated)

912

Phase

Phase 3

Expanded Access

Available outside the clinical trial. See expanded access record.

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Pfizer CT.gov Call Center
Phone Number: 1-800-718-1021
Email: ClinicalTrials.gov_Inquiries@pfizer.com

Study Locations

Argentina
- Tucuman
  - San Miguel de Tucuman, Tucuman, Argentina, 4000
    - Active, not recruiting
    - Centro Oftalmologico Lischinsky (Optical Coherence Tomography, Ophtalmoscopy)
  - San Miguel de Tucuman, Tucuman, Argentina, 4000
    - Active, not recruiting
    - Instituto de Patologias Respitatorias (Pulmonary Function Test)
  - San Miguel de Tucuman, Tucuman, Argentina, 4000
    - Active, not recruiting
    - Sanatorio 9 de Julio S.A. (Endoscopy)
  - San Miguel de Tucuman, Tucuman, Argentina, 4000
    - Active, not recruiting
    - Sanatorio 9 de Julio S.A. (Exam Rooms)
- Tucumán
  - San Miguel de Tucuman, Tucumán, Argentina, 4000
    - Active, not recruiting
    - Centro de lnvestigation C.I .C.E. 9 de Julio
Australia
- New South Wales
  - Liverpool, New South Wales, Australia, 2170
    - Active, not recruiting
    - Liverpool Hospital
  - Sydney, New South Wales, Australia, 2200
    - Not yet recruiting
    - Bankstown-Lidcombe Hospital
- Queensland
  - Birtinya, Queensland, Australia, 4575
    - Active, not recruiting
    - Queensland Respiratory Services
  - Birtinya, Queensland, Australia, 4575
    - Active, not recruiting
    - Sunshine Coast University Private Hospital
  - Buderim, Queensland, Australia, 4556
    - Active, not recruiting
    - Dr Mark De Wet
  - Mackay, Queensland, Australia, 4740
    - Recruiting
    - Coral Sea Clinical Research Institute Pty.Ltd
  - Mackay, Queensland, Australia, 4740
    - Recruiting
    - Dr Shiran DeSilva Respiratory Clinic
  - Mackay, Queensland, Australia, 4740
    - Recruiting
    - Mackay Discount Drug Store
  - Mackay, Queensland, Australia, 4740
    - Recruiting
    - Mater Misericordiae Hospital
  - Mackay, Queensland, Australia, 4740
    - Recruiting
    - Queensland X-Ray
  - Mackay, Queensland, Australia, 4740
    - Recruiting
    - Vision Eye Institute Mackay
  - Maroochydore, Queensland, Australia, 4558
    - Active, not recruiting
    - Coastal Digestive Helath Pty. Ltd
- Victoria
  - Heidelberg, Victoria, Australia, 3084
    - Active, not recruiting
    - Austin Health
  - Melbourne, Victoria, Australia, 3004
    - Active, not recruiting
    - The Alfred Hospital
  - Parkville, Victoria, Australia, 3050
    - Not yet recruiting
    - The Royal Melbourne Hospital
Austria
- - Vienna, Austria, 1090
    - Active, not recruiting
    - Department of Internal Medicine III, Clinical Division of Gastroenterology and Hepatology
Belarus
- - Gomel, Belarus, 246027
    - Recruiting
    - Institution "Gomel Regional Specialized Clinical Hospital"
  - Gomel, Belarus, 246029
    - Recruiting
    - Institution "Gomel Regional Clinical Hospital
  - Grodno, Belarus, 230023
    - Recruiting
    - Foreign Medical and Pharmaceutical Unitary Enterprise "Medical Center" Novoe Zrenie"
  - Grodno, Belarus, 230026
    - Recruiting
    - Health Care Institution "City Clinical Hospital #4 Grodno"
  - Grodno, Belarus, 230030
    - Recruiting
    - Healthcare Institution "Grodno University Hospital"
  - Minsk, Belarus, 220096
    - Active, not recruiting
    - Health care Institution "10th City Clinical Hospital"
  - Vitebsk, Belarus, 210009
    - Recruiting
    - Educational Establishment "Vitebsk State Medical University"
  - Vitebsk, Belarus, 210037
    - Active, not recruiting
    - Health Care Institution "Vitebsk Regional Clinical Hospital"
  - Vitebsk, Belarus, 210037
    - Recruiting
    - Health Care Institution "Vitebsk Regional Clinical Hospital"
  - Vitebsk, Belarus, 210604
    - Recruiting
    - Healthcare Institution: Vitebsk Regional Clinical Specialized Center
Belgium
- - Ghent, Belgium, 9000
    - Active, not recruiting
    - Hospital AZ Sint-Lucas
  - Roeselare, Belgium, 8800
    - Active, not recruiting
    - AZ Delta campus Brugsesteenweg
  - Roeselare, Belgium, 8800
    - Active, not recruiting
    - AZ Delta
Bulgaria
- - Ruse, Bulgaria, 7002
    - Active, not recruiting
    - "UMHAT "Kanev"" AD, Ruse
  - Sliven, Bulgaria, 8800
    - Active, not recruiting
    - Diagnostic-Consultative Center I - Sliven, EOOD
  - Sofia, Bulgaria, 1407
    - Active, not recruiting
    - Acibadem City Clinic University Hospital EOOD
  - Sofia, Bulgaria, 1527
    - Active, not recruiting
    - UMHAT "Tsaritsa Yoanna - ISUL" EAD
  - Sofia, Bulgaria, 1407
    - Active, not recruiting
    - Acibadem City Clinic Tokuda Hospital Ead
  - Sofia, Bulgaria, 1431
    - Active, not recruiting
    - UMHAT "Sv. Ivan Rilski" EAD'
  - Sofia, Bulgaria, 1431
    - Active, not recruiting
    - "DCC Alexandrovska", EOOD
  - Sofia, Bulgaria, 1606
    - Active, not recruiting
    - "University multiprofile hospital for active treatment and emergency medicine N.I. Pirogov"EAD
  - Sofia, Bulgaria, 1680
    - Active, not recruiting
    - Diagnostic Consultation Center CONVEX EOOD
  - Veliko Tarnovo, Bulgaria, 5000
    - Recruiting
    - Medical Centre MEDICA Plus OOD
Canada
- Ontario
  - Toronto, Ontario, Canada, M5G 1X5
    - Active, not recruiting
    - Mount Sinai Hospital
- Quebec
  - Montreal, Quebec, Canada, H3G 1A4
    - Not yet recruiting
    - Montreal General Hospital
Chile
- Los Rios
  - Valdivia, Los Rios, Chile
    - Active, not recruiting
    - Clinical Research Chile
Croatia
- - Zadar, Croatia, 23000
    - Active, not recruiting
    - General Hospital Zadar
  - Zagreb, Croatia, 10000
    - Active, not recruiting
    - University Hospital Center Zagreb
Czechia
- - Boskovice, Czechia, 680 01
    - Active, not recruiting
    - Gastroenterologicka ambulance, Nemocnice Boskovice
  - Brno, Czechia, 656 91
    - Active, not recruiting
    - Fakultni nemocnice u svate Anny v Brne
  - Horazdovice, Czechia, 341 01
    - Active, not recruiting
    - MUDr. Jaroslava Skalova
  - Hradec Kralove, Czechia, 500 12
    - Active, not recruiting
    - Hepato-Gastroenterologie HK, s.r.o.
  - Hradec Kralove, Czechia, 500 12
    - Active, not recruiting
    - VISUS, spol.s.r.o.(OCT/ophtalmoscopy)
  - Klatovy, Czechia, 339 01
    - Active, not recruiting
    - Gastro Jeka,s.r.o
  - Klatovy, Czechia, 339 01
    - Active, not recruiting
    - Klatovska nemocnice, a.s.
  - Olomouc, Czechia, 779 00
    - Active, not recruiting
    - Amulance alergologie a klinicke imunologie - MUDr. Pavlina Kazinotova, s.r.o.
  - Olomouc, Czechia, 779 00
    - Active, not recruiting
    - Endoskopicke pracoviste, Interni oddeleni
  - Olomouc, Czechia, 779 00
    - Active, not recruiting
    - Gastroenterologicka ordinace, MUDr. Pavla Skalova s.r.o., MUDr. Frantisek Sincl s.r.o.
  - Olomouc, Czechia, 779 00
    - Active, not recruiting
    - Gastroenterologie, MUDr. David Pridal
  - Olomouc, Czechia, 779 00
    - Active, not recruiting
    - Ocni ordinace Olomouc (OCT/ophtalmoscopy)
  - Olomouc, Czechia, 779 00
    - Active, not recruiting
    - PreventaMed s.r.o.
  - Ostrava-Poruba, Czechia, 708 52
    - Recruiting
    - Fakultni nemocnice Ostrava
  - Praha 5, Czechia, 150 00
    - Active, not recruiting
    - Axon Clinical, s.r.o.
  - Praha 7, Czechia, 170 00
    - Active, not recruiting
    - Ocni centrum Praha,a.s.(OCT/ophtalmoscopy)
  - Praha 8, Czechia, 180 81
    - Active, not recruiting
    - Nemocnice Na Bulovce
  - Praha 9, Czechia, 190 00
    - Active, not recruiting
    - ISCARE a.s.
  - Praha 9, Czechia, 190 00
    - Active, not recruiting
    - Prvni plicni ambulance,s.r.o (PFT/DLCO)
  - Prerov, Czechia, 750 02
    - Recruiting
    - Gastroenterologicka ambulance, MUDr. Marcela Vyslouzilova
  - Prerov, Czechia, 750 02
    - Active, not recruiting
    - Gastroenterologicka ambulance, MUDr. Marcela Vyslouzilova
  - Prerov, Czechia, 750 02
    - Active, not recruiting
    - Gastroenterologie, MUDr. Michal Konecny, Ph.D., s.r.o.
  - Prostejov, Czechia, 796 01
    - Active, not recruiting
    - Privatni gastroenterologicka ambulance s.r.o., MUDr. Zdenek Vlk
  - Slany, Czechia, 274 01
    - Active, not recruiting
    - Nemocnice Slany
  - Vsetin, Czechia, 755 01
    - Active, not recruiting
    - GASTRO-NELL s.r.o., MUDr. Vladimir Vaculin
Denmark
- - Aalborg, Denmark, 9000
    - Active, not recruiting
    - Aalborg University Hospital, department of medical gastroenterology,
  - Herlev, Denmark, 2730
    - Active, not recruiting
    - Herlev Hospital, Stomach, -Bowel and Liver disease, Clinic 1
Estonia
- - Tallinn, Estonia, 13419
    - Active, not recruiting
    - North Estonia Medical Centre Foundation
  - Tallinn, Estonia, 10617
    - Active, not recruiting
    - West Tallinn Central Hospital
  - Tallinn, Estonia, 10117
    - Active, not recruiting
    - OU Innomedica
  - Tallinn, Estonia, 10120
    - Active, not recruiting
    - OCT: Eye Clinic Dr. Krista Turman
  - Tallinn, Estonia, 10138
    - Active, not recruiting
    - DLCO: East Tallinn Central Hospital
  - Tallinn, Estonia, 13149
    - Active, not recruiting
    - Endoscopy: North Estonia Medical Centre Foundation
France
- - AMIENS Cedex 1, France, 80054
    - Active, not recruiting
    - CHU Amiens Picardie
  - AMIENS Cedex 1, France, 80054
    - Active, not recruiting
    - Endoscopy: CHU Amiens-Picardie
  - AMIENS Cedex 1, France, 80054
    - Active, not recruiting
    - Pulmonary examination: CHU Amiens-Picardie
  - AMIENS Cedex 1, France, 80054
    - Active, not recruiting
    - Tomography: CHU Amiens-Picardie
  - Clermont-Ferrand, France, 63000
    - Not yet recruiting
    - CHU Clermont Ferrand - Hopital Gabriel Montpied
  - Grenoble Cedex 9, France, 38043
    - Active, not recruiting
    - Endoscopy: CHU Grenoble Alpes- Hopital Michallon
  - Grenoble Cedex 9, France, 38043
    - Active, not recruiting
    - Pulmonary examination: CHU Grenoble Alpes - Hopital Michallon
  - Grenoble Cedex 9, France, 38043
    - Active, not recruiting
    - Tomography: CHU Grenoble Alpes - Hopital Michallon
  - Grenoble cedex 9, France, 38043
    - Active, not recruiting
    - CHU Grenoble Alpes -Hopital Michallon
  - Lille, France, 59037
    - Not yet recruiting
    - CHU de Lille - Hopital Claude Huriez
  - Lille Cedex, France, 59037
    - Not yet recruiting
    - CHU de Lille - Hopital Claude Huriez
  - Montpellier cedex 5, France, 34295
    - Active, not recruiting
    - CHU Montpellier Hopital Saint-Eloi
  - Montpellier cedex 5, France, 34295
    - Active, not recruiting
    - Endoscopy: Hopital Saint-Eloi
  - Montpellier cedex 5, France, 34295
    - Active, not recruiting
    - Pulmonary examination: Hopital Arnaud de Villeneuve
  - Montpellier cedex 5, France, 34295
    - Active, not recruiting
    - Tomography: Hopital Gui de Chauliac
  - NICE cedex 03, France, 06202
    - Active, not recruiting
    - CHU de Nice - Hopital de l'Archet 2
  - NICE cedex 03, France, 06202
    - Active, not recruiting
    - Endoscopy: CHU de Nice - Hopital de I'Archet 2
  - NICE cedex 03, France, 06202
    - Active, not recruiting
    - Pulmonary examination: CHU de Nice - Hopital de I'Archet 2
  - NICE cedex 03, France, 06202
    - Active, not recruiting
    - Tomography: CHU de Nice - Hopital de I'Archet 2
  - Nantes, France, 44093
    - Recruiting
    - Chu Hotel Dieu
  - Nantes, France, 44093
    - Recruiting
    - Endoscopy: CHU Hotel Dieu
  - Nantes, France, 44093
    - Recruiting
    - Pulmonary examination: CHU Hotel Dieu
  - Nantes, France, 44093
    - Recruiting
    - Tomography: CHU Hotel Dieu
  - Rennes Cedex 09, France, 35033
    - Not yet recruiting
    - CHU Rennes - Hopital Pontchaillou
  - Toulouse Cedex, France, 31059
    - Active, not recruiting
    - Endoscopy: CHU RANGUEIL
  - Toulouse Cedex, France, 31059
    - Active, not recruiting
    - Pulmonary examination: CHU RANGUEIL
  - Toulouse Cedex, France, 31059
    - Active, not recruiting
    - Tomography: CHU RANGUEIL
  - Toulouse Cedex 09, France, 31059
    - Active, not recruiting
    - CHU de Toulouse-Hopital Rangueil
Georgia
- - Tbilisi, Georgia, 0131
    - Recruiting
    - LLC Vivamedi
  - Tbilisi, Georgia, 0159
    - Recruiting
    - LTD Institute of Clinical Cardiology
  - Tbilisi, Georgia, 0160
    - Recruiting
    - LTD Aversi Clinic
  - Tbilisi, Georgia, 0160
    - Recruiting
    - JSC Infectious Diseases, AIDS and Clinical Immunology Research Center
  - Tbilisi, Georgia, 0112
    - Recruiting
    - Israeli-Georgian Medical Research Clinic Helsicore, LTD
  - Tbilisi, Georgia, 0112
    - Recruiting
    - LLC Todua Clinic
  - Tbilisi, Georgia, 0159
    - Recruiting
    - Medical Center CITO LTD
  - Tbilisi, Georgia, 0160
    - Recruiting
    - Aversi Clinic, LTD
  - Tbilisi, Georgia, 0160
    - Recruiting
    - LTD Academician Nikoloz Kipshidze Central University Clinic
  - Tbilisi, Georgia, 0172
    - Recruiting
    - Malkhaz Katsiashvili Multiprofile Emergency Medicine Center, LTD
Germany
- - Berlin, Germany, 10117
    - Active, not recruiting
    - Charite Universitaetsmedizin Berlin - Campus Charite Mitte Medizinische Klinik m. S. Hepatologie
  - Berlin, Germany, 14163
    - Active, not recruiting
    - Dr. med Zacharias A. R.Sherif
  - Berlin, Germany, 14163
    - Active, not recruiting
    - Krankenhaus Waldfriede e. V. Studienambulanz lnnere Medizin
  - Bonn-Duisdorf, Germany, 53123
    - Active, not recruiting
    - Schwerpunktpraxis Bonn
  - Dusseldorf, Germany, 40489
    - Not yet recruiting
    - Florence-Nightingale-Krankenhaus
  - Kiel, Germany, 24105
    - Not yet recruiting
    - Universitaetsklinikum Schleswig-Holstein
  - Neuss, Germany, 41462
    - Active, not recruiting
    - Johanna-Etienne-Krankenhaus
  - Neuss, Germany, 41462
    - Active, not recruiting
    - OCT address: AOZNeuss Dr. Kersten
  - Remscheid, Germany, 42859
    - Active, not recruiting
    - Praxis Dr. Jorgensen
Hungary
- - Budapest, Hungary, 1136
    - Recruiting
    - Pannonia Maganorvosi Centrum
  - Budapest, Hungary, 1062
    - Recruiting
    - Pulmonary function tests: Vasutegeszsegugyi Nonprofit Kozhasznu Kft.
  - Budapest, Hungary, 1068
    - Recruiting
    - Ophthalmology tests: Magyar Honvedseg Egeszsegugyi Kozpont
  - Budapest, Hungary, 1088
    - Recruiting
    - Semmelweis Egyetem, Belgyogyaszati es Hematologiai Klinika
  - Budapest, Hungary, 1133
    - Active, not recruiting
    - Ophthalmology tests: Budapest Retina lntezet
  - Veszprem, Hungary, 8200
    - Active, not recruiting
    - Ophthalmology tests: RETINASZERVIZ Kft.
- Bekes
  - Gyula, Bekes, Hungary, 5600
    - Active, not recruiting
    - "Bekes Megyei Kozponti Korhaz Dr. Rethy Pal Tagkorhaz, 4. Belgyogyaszat es 2. Gasztroenterologia"
  - Gyula, Bekes, Hungary, 5700
    - Active, not recruiting
    - Ophthalmology tests:Bekes Megyei Kozponti Korhaz, Pady Kalman Tagkorhaz, Szemeszeti Osztaly
- Csongrad
  - Szeged, Csongrad, Hungary, 6725
    - Not yet recruiting
    - Ophthalmology tests:Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ,Szemészeti Kli
  - Szeged, Csongrad, Hungary, 6725
    - Not yet recruiting
    - Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I .Belgyogyaszati Klinika
- Fejer
  - Szekesfehervar, Fejer, Hungary, 8000
    - Active, not recruiting
    - Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
- Hajdu-bihar
  - Debrecen, Hajdu-bihar, Hungary, 4032
    - Not yet recruiting
    - Debreceni Egyetem, Belgyogyaszati Klinika, Gasztroenterologiai Osztaly
- Heves
  - Gyongyos, Heves, Hungary, 3200
    - Active, not recruiting
    - Bugat Pal Korhaz
- Komarom-esztergom
  - Tatabanya, Komarom-esztergom, Hungary, 2800
    - Active, not recruiting
    - DLCO and ophthalmology tests: Szent Borbala Korhaz
- Tolna
  - Szekszard, Tolna, Hungary, 7100
    - Active, not recruiting
    - Clinfan Szolgaltato Kft.
  - Szekszard, Tolna, Hungary, 7100
    - Active, not recruiting
    - Ophthalmology tests: Tolna Megyei Balassa Janos Korhaz
- Veszprem
  - Ajka, Veszprem, Hungary, 8400
    - Active, not recruiting
    - Endoscopy: Magyar Imre Korhaz
  - Balatonfured, Veszprem, Hungary, 8230
    - Active, not recruiting
    - DRC Gyogyszervizsgalo Kozpont Kft.
  - Tapolca, Veszprem, Hungary, 8300
    - Active, not recruiting
    - Pulmonary function tests, endoscopy: Deak Jeno Korhaz
India
- - Nagpur, India, 440009
    - Active, not recruiting
    - Government Medical College & Super Speciality Hospital
- Gujarat
  - Surat, Gujarat, India, 395002
    - Active, not recruiting
    - Surat Institute of Digestive Sciences
- Haryana
  - Gurgaon, Haryana, India, 122002
    - Active, not recruiting
    - Fortis Memorial Research Institute
- Maharashtra
  - Nagpur, Maharashtra, India, 440010
    - Active, not recruiting
    - Midas Multispeciality Hospital Pvt. Ltd
  - Nagpur, Maharashtra, India, 440010
    - Active, not recruiting
    - OCT- Drushti Eye clinic and squint centre
  - Nagpur, Maharashtra, India, 440010
    - Active, not recruiting
    - PFT and Endoscopy- Midas Multispeciality Hospital Pvt. Ltd
  - Pune, Maharashtra, India, 411001
    - Active, not recruiting
    - Grant Medical Foundation Ruby Hall Clinic
- Rajasthan
  - Jaipur, Rajasthan, India, 302001
    - Active, not recruiting
    - S.R.Kalla Memorial Gastro & General Hospital
- Uttar Pradesh
  - Kanpur, Uttar Pradesh, India, 208002
    - Active, not recruiting
    - Post Graduate Department Of Medicine
Israel
- - Haifa, Israel, 3104802, POB 4940
    - Active, not recruiting
    - Bnai Zion Medical Center
  - Holon, Israel, 5810001
    - Not yet recruiting
    - Edith Wolfson Medical Center
  - Jerusalem, Israel, 9103102
    - Active, not recruiting
    - Shaare Zedek Medical Center
  - Naharya, Israel, 2210001
    - Active, not recruiting
    - Galilee Medical Center
  - Petah Tikva, Israel, 4941492
    - Active, not recruiting
    - Rabin Medical Center
  - Ramat Gan, Israel, 5262000
    - Active, not recruiting
    - The Chaim Sheba Medical Center
  - Rehovot, Israel, 7661041
    - Active, not recruiting
    - Kaplan Medical Center
Italy
- - Catania, Italy, 829-95100
    - Active, not recruiting
    - Azienda Ospedaliera Ospedale Cannizzaro
  - Milan, Italy, 20132
    - Recruiting
    - IRCCS Ospedale San Raffaele UO di Gastroenterologia e Endoscopia Digestiva
  - Roma, Italy, 00157
    - Active, not recruiting
    - U.O.C. Gastroenterologia ed Endoscopia Digestiva
- Bari
  - Castellana Grotte, Bari, Italy, 70013
    - Active, not recruiting
    - I.R.C.C.S "Saverio De Bellis", Gastroenterologia II
- Calabria
  - Catanzaro, Calabria, Italy, 88100
    - Active, not recruiting
    - A.O. Mater Domini
- Lazio
  - Roma, Lazio, Italy, 00168
    - Active, not recruiting
    - Policlinico Universitario Agostino Gemelli IRCCS -CEMAD -UOC di Medicina lnterna e Gastroenterologia
- Lombardia
  - Brescia, Lombardia, Italy, 25123
    - Active, not recruiting
    - Spedali Civili di Brescia, U.O. Gastroenterologia
  - Milano, Lombardia, Italy, 20132
    - Active, not recruiting
    - IRCCS Ospedale San Raffaele, Oculistica
- MI
  - Milano, MI, Italy, 20132
    - Recruiting
    - Ospedale San Raffaele
- Milan
  - Milano, Milan, Italy, 20132
    - Recruiting
    - IRCCS Ospedale San Raffaele, Unita di Gastroenterologia
  - Rho, Milan, Italy, 20017
    - Active, not recruiting
    - ASST Rhodense - U.O.C. di Gastroenterologia ed Endoscopia Digestiva
- Milano
  - San Donato Milanese, Milano, Italy, 20097
    - Active, not recruiting
    - I.R.C.C.S Policlinico San Donato
- Other
  - Garbagnate Milanese, Other, Italy, 20024
    - Active, not recruiting
    - Pneumology Unit - ASST Rhodense
- Reggio Emilia
  - Modena, Reggio Emilia, Italy, 41124
    - Active, not recruiting
    - A.O.U. Policlinico di Modena
- Toscana
  - Firenze, Toscana, Italy, 50134
    - Active, not recruiting
    - Azienda Ospedaliero Universitaria Careggi, U.O. Gastroenterologia 2
- VR
  - Negrar(vr), VR, Italy, 37024
    - Active, not recruiting
    - Ospedale Sacro Cuore Don Calabria
- Veneto
  - Vicenza, Veneto, Italy, 36100
    - Not yet recruiting
    - Ospedale San Bortolo di Vicenza
Japan
- - Fukuoka, Japan, 810-0001
    - Recruiting
    - Saiseikai Fukuoka General Hospital
  - Fukushima, Japan, 960-1295
    - Active, not recruiting
    - Fukushima Medical University Hospital
  - Hirakata-city, Japan, 573-1191
    - Active, not recruiting
    - Kansai Medical University Hospital
  - Kagoshima, Japan, 890-8520
    - Not yet recruiting
    - Kagoshima University Hospital
  - Kyoto, Japan, 602-8566
    - Recruiting
    - University Hospital Kyoto Prefectural University of Medicine
  - Osaka, Japan, 545-8586
    - Not yet recruiting
    - Osaka Metropolitan University Hospital
  - Osaka, Japan, 540-0006
    - Active, not recruiting
    - NHO Osaka National Hospital
- Aichi
  - Nagakute, Aichi, Japan, 480-1195
    - Recruiting
    - Aichi Medical University Hospital
  - Nagoya, Aichi, Japan, 467-8602
    - Not yet recruiting
    - Nagoya City University Hospital
  - Toyoake-City, Aichi, Japan, 470-1192
    - Not yet recruiting
    - Fujita Health University Hospital
  - Toyohashi-shi, Aichi, Japan, 441-8570
    - Active, not recruiting
    - Toyohashi Municipal Hospital
- Aichi-ken
  - Nagoya-shi, Aichi-ken, Japan, 457-8511
    - Active, not recruiting
    - Kojunkai Daido Clinic
- Aixhi-ken
  - Nagoya-shi, Aixhi-ken, Japan, 457-8511
    - Active, not recruiting
    - Kojunkai Daido Hospital
- Aomori
  - Hirosaki-shi, Aomori, Japan, 036-8545
    - Not yet recruiting
    - NHO Hirosaki National Hospital
- Aomori KEN
  - Hirosaki-shi, Aomori KEN, Japan, 036-8563
    - Not yet recruiting
    - Hirosaki University Hospital
- Chiba
  - Kashiwa-shi, Chiba, Japan, 277-0871
    - Active, not recruiting
    - Tsujinaka Hospital Kashiwanoha
  - Nagareyama-shi, Chiba, Japan, 270-0116
    - Active, not recruiting
    - Ishii Eye Clinic
  - Sakura, Chiba, Japan, 285-8741
    - Not yet recruiting
    - Toho University Sakura Medical Center
  - Sakura, Chiba, Japan, 285-8741
    - Active, not recruiting
    - Toho University Sakura Medical Center
- Ehime
  - Matsuyama-shi, Ehime, Japan, 791-8026
    - Not yet recruiting
    - Saiseikai Matsuyama Hospital
  - Toon, Ehime, Japan, 791-0295
    - Not yet recruiting
    - Ehime University Hospital
- Fukuoka
  - Fukuoka-shi, Fukuoka, Japan, 814-0180
    - Active, not recruiting
    - Fukuoka University Hospital
  - Kasuga, Fukuoka, Japan, 816-0864
    - Active, not recruiting
    - Fukuoka Tokushukai Hospital Laboratory
  - Kasuga-shi, Fukuoka, Japan, 816-0863
    - Active, not recruiting
    - Takimoto Eye Clinic(OCT)
  - Kitakyushu, Fukuoka, Japan, 806-8501
    - Active, not recruiting
    - Japan Community Health care Organization Kyushu Hospital
  - Kitakyushu-shi, Fukuoka, Japan, 802-8561
    - Recruiting
    - Kitakyushu Municipal Medical Center
  - Kurume, Fukuoka, Japan, 830-8543
    - Active, not recruiting
    - Our Lady of the Snow St. Mary's Hospital
  - Kurume-shi, Fukuoka, Japan, 830-0011
    - Recruiting
    - Kurume University Hospital
  - Kutakyushu-shi, Fukuoka, Japan, 802-8555
    - Recruiting
    - Kokura Memorial Hospital
  - Onga-gun, Fukuoka, Japan, 807-0051
    - Active, not recruiting
    - Fukuoka Shinmizumaki Hospital
- Gifu
  - Gifu-shi, Gifu, Japan, 501-1194
    - Active, not recruiting
    - Gifu University Hospital
- Gunma
  - Ota-shi, Gunma, Japan, 373-8585
    - Active, not recruiting
    - SUBARU Health Insurance Society Ota Memorial Hospital
- Hiroshima
  - Fukuyama, Hiroshima, Japan, 720-8520
    - Active, not recruiting
    - National Hospital Organization Fukuyama Medical Center
  - Hiroshima-shi, Hiroshima, Japan, 734-8551
    - Active, not recruiting
    - Hiroshima University Hospital
- Hokkaido
  - Asahikawa-shi, Hokkaido, Japan, 070-8610
    - Active, not recruiting
    - Asahikawa City Hospital
  - Sapporo-shi, Hokkaido, Japan, 060-0033
    - Not yet recruiting
    - Sapporo-Kosei General Hospital
  - Sapporo-shi, Hokkaido, Japan, 004-0041
    - Active, not recruiting
    - Tokushukai Sapporo Tokushukai Hospital
- Ibaraki
  - Higashiibaraki-gun, Ibaraki, Japan, 311-3193
    - Active, not recruiting
    - NHO Mito Medical Center
  - Hitachi-shi, Ibaraki, Japan, 317-0077
    - Not yet recruiting
    - Hitachi Ltd. Hitachi General Hospital
  - Koga-shi, Ibaraki, Japan, 306-0232
    - Not yet recruiting
    - Yuai Memorial Hospital
  - Toride-shi, Ibaraki, Japan, 302-0014
    - Active, not recruiting
    - Matsumoto Eye Clinic
  - Tsuchiura-shi, Ibaraki, Japan, 300-0028
    - Not yet recruiting
    - Tsuchiura Kyodo General Hospital
- Ishikawa
  - Kanazawa-shi, Ishikawa, Japan, 920-8650
    - Active, not recruiting
    - NHO Kanazawa Medical Center
- Iwate
  - Morioka-shi, Iwate, Japan, 020-8505
    - Active, not recruiting
    - Iwate Medical University Uchimaru Medical Center
- Kagawa
  - Takainatsu-shi, Kagawa, Japan, 760-8557
    - Active, not recruiting
    - Kagawa Prefectural Central Hospital
  - Takamatsu-shi, Kagawa, Japan, 760-0017
    - Active, not recruiting
    - Takamatsu Red Cross Hospital
- Kagoshima
  - Kagoshima-shi, Kagoshima, Japan, 892-0846
    - Active, not recruiting
    - Sameshima Hospital
  - Kagoshima-shi, Kagoshima, Japan, 892-0824
    - Active, not recruiting
    - Jiaikai Idzuro Imamura Hospital
  - Kagoshima-shi, Kagoshima, Japan, 890-0062
    - Active, not recruiting
    - Kagoshima Kouseiren Hospital
  - Kagoshima-shi, Kagoshima, Japan, 890-0062
    - Active, not recruiting
    - JA- Kagoshima Koseiren Hospital (PET/DLCO)
  - Kagoshima-shi, Kagoshima, Japan, 892-0813
    - Active, not recruiting
    - Clinical Pathology Laboratory (Diagnostick center)
  - Kagoshima-shi, Kagoshima, Japan, 892-0825
    - Active, not recruiting
    - Sameshima Eye Clinic (OCT)
- Kanagawa
  - Sagamihara, Kanagawa, Japan, 252-5188
    - Active, not recruiting
    - Sagamihara Kyodo Hospital
  - Yokohama, Kanagawa, Japan, 245-8575
    - Not yet recruiting
    - National Hospital Organization Yokohama Medical Center
  - Yokohama-shi, Kanagawa, Japan, 234-0054
    - Active, not recruiting
    - Social Welfare Organization Imperial Gift Foundation,Inc.Saiseikai Yokohamashi Nanbu Hospital
- Kumamoto
  - Kumamoto-shi, Kumamoto, Japan, 861-8520
    - Active, not recruiting
    - Japanese Red Cross Kumamoto Hospital
- Kyoto
  - Kyoto-shi, Kyoto, Japan, 602-8566
    - Active, not recruiting
    - University Hospital Kyoto Prefectural University of Medicine
  - Kyoto-shi, Kyoto, Japan, 612-8555
    - Active, not recruiting
    - National Hospital Organization Kyoto Medical Center
- MIE
  - Tsu-shi, MIE, Japan, 514-8507
    - Active, not recruiting
    - Mie University Hospital
  - Yokkaichi-shi, MIE, Japan, 510-8561
    - Active, not recruiting
    - Mie Prefectural General Medical Center
- Miyagi
  - Sendai-shi, Miyagi, Japan, 980-8574
    - Recruiting
    - Tohoku University Hospital
  - Sendai-shi, Miyagi, Japan, 981-8563
    - Active, not recruiting
    - JOHAS Tohoku Rosai Hospital
  - Sendai-shi, Miyagi, Japan, 982-8502
    - Active, not recruiting
    - Sendai City Hospital
- Niigata
  - Nagaoka-shi, Niigata, Japan, 940-2085
    - Active, not recruiting
    - Nagaoka Red Cross Hospital
- Osaka
  - Kawachinagano, Osaka, Japan, 586-8521
    - Not yet recruiting
    - NHO Osaka Minami Medical Center
  - Kishiwada-shi, Osaka, Japan, 596-0042
    - Not yet recruiting
    - Medical Corporation Tokushukai Kishiwada Tokushukai Hospital
  - Osaka-shi, Osaka, Japan, 553-0003
    - Active, not recruiting
    - Japan Community Health care Organization Osaka Hospital
  - Takatsuki-City, Osaka, Japan, 569-8686
    - Not yet recruiting
    - Osaka Medical and Pharmaceutical University Hospital
- Saga
  - Saga-chi, Saga, Japan, 849-8501
    - Active, not recruiting
    - Saga University Hospital
- Saitama
  - Iruma-gun, Saitama, Japan, 350-0495
    - Not yet recruiting
    - Saitama Medical University Hospital
  - Saitama-shi, Saitama, Japan, 330-0074
    - Recruiting
    - Japan Community Health care Organization Saitama Medical Center
- Shiga
  - Otsu, Shiga, Japan, 520-2192
    - Not yet recruiting
    - Shiga University of Medical Science Hospital
- Shizuoka
  - Hamamatsu-shi, Shizuoka, Japan, 431-3192
    - Active, not recruiting
    - Hamamatsu University Hospital
  - Hamamatsu-shi, Shizuoka, Japan, 432-8061
    - Active, not recruiting
    - Matsuda Hospital
- Tokyo
  - Bunkyo-ku, Tokyo, Japan, 113-8519
    - Recruiting
    - Tokyo Medical And Dental University Hospital
  - Chuo-ku, Tokyo, Japan, 104-8560
    - Active, not recruiting
    - St. Luke's International Hospital
  - Hachioji, Tokyo, Japan, 192-0032
    - Recruiting
    - Tokai university hachioji hospital
  - Itabashi-ku, Tokyo, Japan, 173-8606
    - Active, not recruiting
    - Teikyo University Hospital
  - Kodaira-shi, Tokyo, Japan, 187-8510
    - Active, not recruiting
    - Showa General Hospital
  - Minato-ku, Tokyo, Japan, 108-8642
    - Active, not recruiting
    - Kitasato University Kitasato Institute Hospital
  - Shinjuku-ku, Tokyo, Japan, 169-0073
    - Active, not recruiting
    - JCHO Tokyo Yamate Medical Center
- Wakayama
  - Wakayama-shi, Wakayama, Japan, 641-8510
    - Active, not recruiting
    - Wakayama Medical University Hospital
- Yamanashi
  - Kofu-shi, Yamanashi, Japan, 400-8056
    - Active, not recruiting
    - Yamanashi Prefectural Central Hospital
Korea, Republic of
- - Busan, Korea, Republic of, 49201
    - Active, not recruiting
    - Dong-A University Hospital
  - Busan, Korea, Republic of, 49201
    - Active, not recruiting
    - Endoscopy Facility in Dong-A University Hospital
  - Busan, Korea, Republic of, 49201
    - Active, not recruiting
    - OCT Facility in Dong-A University Hospital
  - Busan, Korea, Republic of, 49201
    - Active, not recruiting
    - PFT Facility in Dong-A University Hospital
  - Daegu, Korea, Republic of, 41404
    - Active, not recruiting
    - Kyungpook National University Chilgok Hospital
  - Daegu, Korea, Republic of, 41944
    - Active, not recruiting
    - Kyungpook National University Hospital
  - Daegu, Korea, Republic of, 41404
    - Active, not recruiting
    - Endoscopy Facility in Kyungpook National University Chilgok Hospital
  - Daegu, Korea, Republic of, 41404
    - Active, not recruiting
    - OCT Facility in Kyungpook National University Chilgok Hospital
  - Daegu, Korea, Republic of, 41404
    - Active, not recruiting
    - PFT Facility in Kyungpook National University Chilgok Hospital
  - Daegu, Korea, Republic of, 41944
    - Active, not recruiting
    - Endoscopy Facility in kyungpook National University Hospital
  - Daegu, Korea, Republic of, 41944
    - Active, not recruiting
    - OCT Facility in Kyungpook National University Hospital
  - Daegu, Korea, Republic of, 41944
    - Active, not recruiting
    - PFT Facility in Kyungpook National University Hospital
  - Seoul, Korea, Republic of, 03722
    - Not yet recruiting
    - Severance Hospital
- Gangwon-do
  - Wonju-si, Gangwon-do, Korea, Republic of, 26426
    - Active, not recruiting
    - PFT Facility in Yonsei University Wonju Severance Christian Hospital
  - Wonju-si, Gangwon-do, Korea, Republic of, 26426
    - Active, not recruiting
    - Yonsei University Wonju Severance Christian Hospital
- Gangwon-du
  - Wonju-si, Gangwon-du, Korea, Republic of, 26426
    - Active, not recruiting
    - Endoscopy Facility in Yonsei University Wonju Severance Christian Hospital
  - Wonju-si, Gangwon-du, Korea, Republic of, 26426
    - Active, not recruiting
    - OCT Facility in Yonsei University Wonju Severance Christian Hospital
- Gyeonggi-do
  - Suwon-si, Gyeonggi-do, Korea, Republic of, 16247
    - Active, not recruiting
    - Endoscopy Facility in The Catholic University of Korea, St. Vincent's Hospital
  - Suwon-si, Gyeonggi-do, Korea, Republic of, 16247
    - Active, not recruiting
    - OCT Facility in The Catholic University of Korea, St. Vincent's Hospital
  - Suwon-si, Gyeonggi-do, Korea, Republic of, 16247
    - Active, not recruiting
    - PFT Facility in The Catholic University of Korea, St. Vincent's Hospital
  - Suwon-si, Gyeonggi-do, Korea, Republic of, 16427
    - Active, not recruiting
    - The Catholic University of Korea, St. Vincent's Hospital
Latvia
- - Riga, Latvia, LV-1002
    - Active, not recruiting
    - P. Stradins Clinical University Hospital, Gastroenterology, Hepatology and Nutrition Therapy Center
Lebanon
- - Beirut, Lebanon
    - Active, not recruiting
    - American University of Beirut Medical Center
Lithuania
- - Panevezys, Lithuania, LT-35144
    - Recruiting
    - Consultancy Polyclinic of Republican Panevezys Hospital
  - Panevezys, Lithuania, LT-35144
    - Recruiting
    - Republican Panevezys Hospital
  - Vilnius, Lithuania, LT-08661
    - Recruiting
    - Vilnius University Hospital Santaros Klinikos
  - Vilnius, Lithuania, 08406
    - Recruiting
    - UAB "Inlita", Santaros Clinical Trials Centre
  - Vilnius, Lithuania, 08661
    - Recruiting
    - Vilnius University Hospital Santaros Klinikos
  - Vilnius, Lithuania, 08234
    - Recruiting
    - UAB "Northway", Medical and Surgical Centre
Mexico
- - Chihuahua, Mexico, 31203
    - Active, not recruiting
    - Scientia, Investigacion Clinica S.C.
  - Veracruz, Mexico, 91900
    - Active, not recruiting
    - FAICIC S. de R.L. de C.V.
- Guanajuato
  - Irapuato, Guanajuato, Mexico, 36650
    - Active, not recruiting
    - Invesclinic MX
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44130
    - Active, not recruiting
    - Centro de lnvestigacion Medico Biologica y Terapia Avanzada S.C.
- Nuevo LEON
  - Monterrey, Nuevo LEON, Mexico, 64660
    - Active, not recruiting
    - Servicios Medicos y de lnvestigacion Clinica Inspirepharma S. de R.L. de C.V.
Moldova, Republic of
- - Chisinau, Moldova, Republic of, 2025
    - Active, not recruiting
    - IMSP Spitalul Clinic Republican "Timofei Mosneaga"
  - Chisinau, Moldova, Republic of, 2025
    - Active, not recruiting
    - ISMP Spitalul Clinic Republican "Timofei Mosneaga", RTL SM
Poland
- - Bedzin, Poland, 42-500
    - Active, not recruiting
    - Centrum Dentystyczno-Lekarskie PROMEDICA Joanna Markiewicz
  - Bialystok, Poland, 15-044
    - Active, not recruiting
    - Centrum Medycyny Oddechowej, Mroz Spolka Jawna (PFT, DLCO)
  - Bialystok, Poland, 15-322
    - Active, not recruiting
    - Gastromed Kralisz, Romatowski, Stachurska sp.j.
  - Bialystok, Poland, 15-453
    - Active, not recruiting
    - LSSP Eskulap (OCT, Ophthalmoscopy)
  - Bystra, Poland, 43-360
    - Active, not recruiting
    - Centrum Pulmonologii i Torakochirurgii w Bystrej (DLCO)
  - Dabrowa Gomicza, Poland, 41-300
    - Active, not recruiting
    - Poliklinika Dabrowska PRINN(PFT,colonoscopy)
  - Dzierzoniow, Poland, 58-200
    - Active, not recruiting
    - Centrum Okulistyczne Sudety (OCT)
  - Gdansk, Poland, 80-402
    - Active, not recruiting
    - Dobry Wzrok (OCT)
  - Gdynia, Poland, 81-366
    - Active, not recruiting
    - Poradnia Pulmonologiczna
  - Jelenia Gora, Poland, 58-500
    - Active, not recruiting
    - Karkonoskie Centrum Badan Klinicznych - Lexmedica Spolka z ograniczona odpowiedzialnoscia
  - Jelenia Gora, Poland, 58-506
    - Active, not recruiting
    - PROMED Centrum Medyczne (OCT, ophthalmoscopy)
  - Katowice, Poland, 40-156
    - Active, not recruiting
    - Clinical Medical Research sp. z o.o. (OCT. ophthalmoscopy)
  - Lodz, Poland, 91-347
    - Active, not recruiting
    - Wojewodzki Szpital Specjalistyczny im.dr. WI. Bieganskiego (endoscopy)
  - Lodz, Poland, 93-513
    - Active, not recruiting
    - Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi
  - Lodz, Poland, 90-752
    - Active, not recruiting
    - IP Clinic Sp. z o.o.
  - Lodz, Poland, 92-213
    - Active, not recruiting
    - Centralny Szpital Kliniczny UM w Lodzi (PFT)
  - Lodz, Poland, 92-551
    - Active, not recruiting
    - Salve Health Care Sp. z o.o (OCT, Endoscopy, Ophtalmoscopy)
  - Lodz, Poland, 90-644
    - Active, not recruiting
    - Amicare Sp. z o.o. Sp.k.
  - Lodz, Poland, 91-053
    - Active, not recruiting
    - Centra Medyczne 'MEDYCEUSZ" (OCT, PFT, DLCO, Ophthalmoscopy)
  - Nowy Targ, Poland, 34-400
    - Active, not recruiting
    - Allmedica Badania Kliniczne Sp. z o.o. Sp. k.
  - Nowy Targ, Poland, 34-400
    - Active, not recruiting
    - ALLMEDICA spolka z o.o (OCT/ophthalmoscopy)
  - Oswiecim, Poland, 32-600
    - Active, not recruiting
    - MEDICOME- Oswiecimskie Centrum Medyczne (OCT)
  - Oswiecim, Poland, 32-600
    - Active, not recruiting
    - Medicome Sp. z o.o.
  - Poznan, Poland, 60-538
    - Recruiting
    - Ocuservice (OCT, ophtalmoscopy)
  - Poznan, Poland, 60-569
    - Recruiting
    - Wielkopolskie Centrum Pulmonologii i Torakochirurgii (PFT)
  - Poznan, Poland, 60-681
    - Recruiting
    - NSZOZ Termedica (colonoscopy)
  - Poznan, Poland, 61-144
    - Recruiting
    - Szpital Sw. Wojciecha (colonoscopy)
  - Poznan, Poland, 61-144
    - Recruiting
    - Szpital Sw. Wojciecha (Endoscopy)
  - Poznan, Poland, 10160-681
    - Recruiting
    - Centrum Medyezne Grunwald
  - Poznan, Poland, 60-369
    - Active, not recruiting
    - Centrum Medyezne Grunwald
  - Rzeszow, Poland, 35-241
    - Active, not recruiting
    - Podkarpackie Centrum Chorob Pluc w Rzeszowie (DLCO)
  - Rzeszow, Poland, 35-326
    - Active, not recruiting
    - Centrum Medyczne Medyk
  - Sopot, Poland, 81-756
    - Active, not recruiting
    - ENDOSKOPIA Sp. z o.o.
  - Strzegom, Poland, 58-150
    - Active, not recruiting
    - Strzegomskie Centrum Medyczno - Diagnostyczne (Endoscopy)
  - Swidnica, Poland, 58-100
    - Active, not recruiting
    - DC-MED Sp. z o.o.
  - Swidnica, Poland, 58-100
    - Active, not recruiting
    - SP ZOZ w Swidnicy, Regionalny Szpital Specjalistyczny, Poradnia Gruzlicy i Chorob Pluc (Spirometry)
  - Szczecin, Poland, 71-434
    - Active, not recruiting
    - Twoja Przychodnia-Szczecinskie Centrum Medyczne
  - Szczecin, Poland, 70-233
    - Active, not recruiting
    - Spoldzielnia Pracy Lekarzy Medicus (OCT, ophtalmoscopy)
  - Warszawa, Poland, 00-635
    - Recruiting
    - Centrum Zdrowia MDM
  - Warszawa, Poland, 00-631
    - Recruiting
    - Centrum Zdrowia MDM (OCT,opthalmoscopy)
  - Warszawa, Poland, 01-138
    - Recruiting
    - Instytut Gruzlicy i Chorob Pluc(DLCO)
  - Warszawa, Poland, 02-507
    - Active, not recruiting
    - Centralny Szpital Kliniczny MSWiA w Warszawie Klinika Chorob Wewnetrznych i Gastroenterologii
  - Warszawa, Poland, 02-507
    - Active, not recruiting
    - Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych Administracji
  - Warszawa, Poland, 00-189
    - Recruiting
    - Centrum Zdrowia MDM
  - Wroclaw, Poland, 52-416
    - Active, not recruiting
    - Centrum Medyczne OPOROW
  - Wroclaw, Poland, 53-661
    - Active, not recruiting
    - Endomed
  - Wroclaw, Poland, 50-220
    - Active, not recruiting
    - Emc Instytut Medyczny Sa Przychodnia Przy Ul.Lowieckiej (Pft)
  - Wroclaw, Poland, 53-030
    - Active, not recruiting
    - Perfect Vision (Oct)
  - Wroclaw, Poland, 53-162
    - Active, not recruiting
    - Osrodek Okulistyczny Okolek (Oct, Ophtalmoscopy)
  - Wroclaw, Poland, 53-429
    - Active, not recruiting
    - Dolnoslaskie Centrum Chorob Pluc We Wroclawiu
  - Wroclaw, Poland, 54-144
    - Active, not recruiting
    - EuroMediCare Szpital Specjalistyczny z Przychodnia we Wroclawiu
  - Zakopane, Poland, 34-500
    - Active, not recruiting
    - Szpital Specjalistyczny Chorob Pluc "Odrodzenie" im. Klary Jelskiej (DLCO, PFT)
- Wielkopolskie
  - Poznan, Wielkopolskie, Poland, 60-681
    - Active, not recruiting
    - NSZOZ Termedica
  - Poznan, Wielkopolskie, Poland, 60-681
    - Active, not recruiting
    - NSZOZ Termedica - Centrum Badan Klinicznych
Portugal
- - Coimbra, Portugal, 3000-075
    - Active, not recruiting
    - Centro Hospitalar e Universitario de Coimbra, E.P.E.
  - Guimaraes, Portugal, 4835-044
    - Active, not recruiting
    - Hospital Senhora da Oliveira Guimaraes, E.P.E
  - Porto, Portugal, 4200-319
    - Active, not recruiting
    - Centro Hospitalar Universitario de Sao Joao, E.P.E
  - Vila Nova de Gaia, Portugal, 4434-502
    - Active, not recruiting
    - Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE
- Porto
  - Vila Nova de Gaia, Porto, Portugal, 4434-502
    - Active, not recruiting
    - Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE
Romania
- - Bucuresti, Romania, 020125
    - Active, not recruiting
    - Spitalul Clinic Colentina
  - Cluj-Napoca, Romania, 400006
    - Active, not recruiting
    - Spitalul Clinic Judetean de Urgenta Cluj-Napoca
  - Cluj-Napoca, Romania, 400371
    - Active, not recruiting
    - Spitalul Clinic de Pneumoftiziologie Leon Daniello Cluj-Napoca
- Bihor
  - Oradea, Bihor, Romania, 410469
    - Active, not recruiting
    - SC Pelican lmpex SRL
- Cluj
  - Cluj-Napoca, Cluj, Romania, 400501
    - Active, not recruiting
    - Oculens Med S.R.L.
- District 1
  - Bucharest, District 1, Romania, 013812
    - Active, not recruiting
    - Monza Oncology Hospital. Gastroenterology Department
- District 2
  - Bucharest, District 2, Romania, 020125
    - Active, not recruiting
    - Colentina Clinical Hospital
- Sector 1
  - Bucuresti, Sector 1, Romania, 014461
    - Active, not recruiting
    - S.C. Euroclinic Hospital S.A.
Russian Federation
- - Irkutsk, Russian Federation, 664049
    - Active, not recruiting
    - Irkutsk State Medical Academy of Postgraduate Education
  - Irkutsk, Russian Federation, 664049
    - Active, not recruiting
    - Professional Education" of MoH of RF
  - Izhevsk, Russian Federation, 426061
    - Active, not recruiting
    - LLC "Alliance Biomedical -Ural Group"
  - Kemerovo, Russian Federation, 650066
    - Active, not recruiting
    - SAIH "Kemerovo Regional Clinical Hospital"
  - Nizhniy Novgorod, Russian Federation, 603126
    - Active, not recruiting
    - State Budgetary Healthcare Instit. of Nizhniy Novgorod region
  - Novosibirsk, Russian Federation, 630005
    - Active, not recruiting
    - LLC "SibNovoMed"
  - Novosibirsk, Russian Federation, 630007
    - Active, not recruiting
    - LLC "Novosibirsk GastroCenter"
  - Novosibirsk, Russian Federation, 630084
    - Active, not recruiting
    - State Budgetary Healthcare Institution of Novosibirsk region "City clinical hospital # 12"
  - Novosibirsk, Russian Federation, 63009
    - Active, not recruiting
    - Medical center "AVITSENNA"
  - Omsk, Russian Federation, 644024
    - Active, not recruiting
    - Clinicodiagnostic center "Ultramcd"
  - Penza, Russian Federation, 440026
    - Active, not recruiting
    - State Budgetary Healthcare Institution "Penza Region Clinical Hospital n.a. N.N. Burdenko"
  - Saint Petersburg, Russian Federation, 195279
    - Active, not recruiting
    - LLC "Medi com" (SM-Clinic)
  - Saint-Petersburg, Russian Federation, 194104
    - Active, not recruiting
    - Spb SBIH "City Mariinskaya Hospital"
  - Samara, Russian Federation, 443001
    - Active, not recruiting
    - Private Educational Institution of Higher Education "Medical University "Reaviz", Multifield Clinic
  - Samara, Russian Federation, 443093
    - Active, not recruiting
    - LLC Medical company "Hepatologist"
  - Smolensk, Russian Federation, 214031
    - Not yet recruiting
    - LLC "Uromed"
  - St. Petersburg, Russian Federation, 197110
    - Active, not recruiting
    - LLC "Gastroenterological centre Expert"
  - St. Petersburg, Russian Federation, 191015
    - Active, not recruiting
    - Federal State Budgetary Ed. Inst. of Higher Education "North-Western Medical University n.a. I.I.
  - St. Petersburg, Russian Federation, 195067
    - Active, not recruiting
    - Federal state Budgetary Ed. Inst. of Higher Education "North-Western Medical University n.a.
  - St. Petersburg, Russian Federation, 197022
    - Active, not recruiting
    - FSBEI of Higher Education "First Saint Petersburg State Medical University n.a. I.P. Pavlov"
  - St.Petersburg, Russian Federation, 197706
    - Active, not recruiting
    - St.Petersburg State Budgetary Healthcare Institution "City Hospital #40 of Kurortnyi region"
  - Stavropol, Russian Federation, 355017
    - Active, not recruiting
    - Autonomous Noncommercial Medical Organizations "Stavropol Regional Clinical Diagnostic Centre''
  - Stavropol, Russian Federation, 355032
    - Active, not recruiting
    - Autonomous Noncommercial Medical Organizations " Stavropol Regional Clinical Diagnostic Centre ''
  - Stavropol, Russian Federation, 355044
    - Active, not recruiting
    - City Polyclinic #9
  - Yaroslavl, Russian Federation, 150030
    - Active, not recruiting
    - State Healthcare Institution of Yaroslavl Region "Clinical Hospital No 2"
- Altayskiy Region
  - Barnaul, Altayskiy Region, Russian Federation, 656043
    - Active, not recruiting
    - LLC "Multidisciplinary Medical Clinic "Anturium"
- Samara Region
  - Samara, Samara Region, Russian Federation, 443063
    - Active, not recruiting
    - LLC Medical company "Hepatologist"
- Stavropol Region
  - Pyatigorsk, Stavropol Region, Russian Federation, 357000
    - Active, not recruiting
    - LLC "Polyclinic of ultrasonography 4D"
Serbia
- - Belgrade, Serbia, 11000
    - Active, not recruiting
    - Clinical Center Zvezdara
  - Belgrade, Serbia, 11000
    - Active, not recruiting
    - Clinical Center " Dr Dragisa Misovic-Dedinje"
  - Sremska Mitrovica, Serbia, 22000
    - Active, not recruiting
    - General Hospital Sremska Mitrovica
Slovakia
- - Banska Bystrica, Slovakia, 97517
    - Active, not recruiting
    - Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica, II. Interna klinika SZU
  - Bardejov, Slovakia, 085 01
    - Active, not recruiting
    - DEJA. s.r.o .. Oftalmologicka ambulancia
  - Bardejov, Slovakia, 08501
    - Active, not recruiting
    - ALIAN. s.r.o .. Ambulancia vnutorneho lekarstva
  - Kosice, Slovakia, 04011
    - Active, not recruiting
    - 3F, s.r.o., Oftalmologicka ambulancia
  - Levice, Slovakia, 934 01
    - Active, not recruiting
    - OCULOSANUS, s.r.o., Oftalmologicka ambulancia
  - Lipany, Slovakia, 053 04
    - Active, not recruiting
    - MUDr. Michal Popovec, s.r.o., Oftalmologicka ambulancia
  - Nitra, Slovakia, 94901
    - Active, not recruiting
    - KM Management, spol. s r.o .. Gastroenterologicke a hepatologicke centrum
  - Nitra, Slovakia, 950 01
    - Active, not recruiting
    - Fakultna nemocnica Nitra, Oftalmologicka ambulancia
  - Nitra, Slovakia, 950 01
    - Active, not recruiting
    - Fakultna nemocnica Nitra, Pneumologicka ambulancia
  - Nitra, Slovakia, 950 01
    - Active, not recruiting
    - Fakultná nemocnica Nitra
  - Presov, Slovakia, 080 01
    - Active, not recruiting
    - GASTRO I., s.r.o. Gastroenterologicka ambulancia
  - Presov, Slovakia, 080 01
    - Active, not recruiting
    - PULMO, s.r.o., Plucna ambulancia
  - Sahy, Slovakia, 936 01
    - Active, not recruiting
    - Accout Center, s.r.o., Gastroenterologicka ambulancia
  - Sahy, Slovakia, 936 01
    - Active, not recruiting
    - COR, s.r.o., Pneumologicko-ftizeologicka ambulancia
  - Vranov nad Toplou, Slovakia, 093 01
    - Active, not recruiting
    - ENDOMED. s.r.o., Gastroenterologicka ambulancia
  - Vranov nad Toplou, Slovakia, 093 01
    - Active, not recruiting
    - PULMOX spol. s r.o., Pneumologicko-ftizeologicka ambulancia
South Africa
- - Centurion, South Africa, 1692
    - Active, not recruiting
    - Dr Fritz Potgieter, Midstream Medi Clinic
- Gauteng
  - Centurion, Gauteng, South Africa, 0157
    - Active, not recruiting
    - Johese Clinical Research:Unitas
  - Centurion, Gauteng, South Africa, 0157
    - Active, not recruiting
    - Unitas Hospital
  - Centurion, Gauteng, South Africa, 1692
    - Active, not recruiting
    - Johese Clinical Research: Midstream
- Western CAPE
  - Cape Town, Western CAPE, South Africa, 7708
    - Active, not recruiting
    - Dr John Philip Wright
Spain
- - Alicante, Spain, 03010
    - Active, not recruiting
    - Hospital General Universitario de Alicante
  - Madrid, Spain, 28046
    - Active, not recruiting
    - Hospital Universitario La Paz
Thailand
- Bangkok
  - Bangkoknoi, Bangkok, Thailand, 10700
    - Active, not recruiting
    - Siriraj Hospital, Mahidol University
  - Pathumwan, Bangkok, Thailand, 10330
    - Active, not recruiting
    - Chulalongkorn University, King Chulalongkorn Memorial Hospital
Turkey
- - Ankara, Turkey, 06500
    - Active, not recruiting
    - Gazi University Medical Faculty
  - Ankara, Turkey, 06100
    - Active, not recruiting
    - Hacettepe University Medical Faculty
  - Antalya, Turkey, 07030
    - Active, not recruiting
    - Saglik Bilimleri Universitesi Antalya Egitim ve Arastirma Hastanesi
  - Bursa, Turkey, 16059
    - Active, not recruiting
    - Uludag University Medical Faculty
  - Kocaeli, Turkey, 41380
    - Active, not recruiting
    - Kocaeli University Medical Faculty
Ukraine
- - Dnipro, Ukraine, 49005
    - Active, not recruiting
    - Communal Institution I.I. Mechnykov Dnipropetrovsk Regional Clinical Hospital, Department of
  - Ivano-Frankivsk, Ukraine, 76000
    - Active, not recruiting
    - Clinical Diagnostical Center "Simedgroup"
  - Ivano-Frankivsk, Ukraine, 76000
    - Active, not recruiting
    - Communal Non-commercial Enterprise Regional Clinical Hospital of lvano-Frankivsk Regional Council,
  - Ivano-Frankivsk, Ukraine, 76018
    - Active, not recruiting
    - Regional Clin Hospital, Dep ofGastroenterology, State Higher Educational Institution Ivano-Frankivsk
  - Kharkiv, Ukraine, 61022
    - Active, not recruiting
    - Llc "Ldts-Skaymed"
  - Kharkiv, Ukraine, 61037
    - Active, not recruiting
    - Communal Noncommercial Enterprise Prof. O.O.Shalimov City Clinical Hospital #2 of Kharkiv City
  - Kharkiv, Ukraine, 61045
    - Active, not recruiting
    - Llc Medical Center Oftalmika
  - Kharkiv, Ukraine, 61024
    - Active, not recruiting
    - LLC "EyeQClinic"
  - Kharkiv, Ukraine, 61018
    - Active, not recruiting
    - Municipal Health Care "Kharkiv City Hospital Ambulance and Emergency Medical care named alter prof.
  - Kharkiv, Ukraine, 61124
    - Active, not recruiting
    - Communal Noncommercial Enterprise City Clinical Hospital # 13 of Kharkiv City Council,
  - Kherson, Ukraine, 73000
    - Active, not recruiting
    - Communal Noncommercial Enterprise Ye.Ye. Karabelesh Kherson City
  - Kherson, Ukraine, 73003
    - Active, not recruiting
    - LLC "Diagnostic center"
  - Kyiv, Ukraine, 02091
    - Active, not recruiting
    - Kyiv City Clinical Hosptial #1, Department of Therappy #2
  - Lviv, Ukraine, 79059
    - Active, not recruiting
    - Communal Noncommercial Enterprise Lviv Clinical Emergency Hospital, 1st Department of Therapy
  - Odesa, Ukraine, 65025
    - Active, not recruiting
    - Communal Institution Odesa Regional Clinical Hospital, Regional Center of Gastroenterology,
  - Odesa, Ukraine, 65025
    - Active, not recruiting
    - LLC GLB Clinik
  - Uzhgorod, Ukraine, 88000
    - Active, not recruiting
    - Andrii Novak Transcarpathian Regional Clinical Hospital, Department of Gastroenterology
  - Uzhgorod, Ukraine, 88000
    - Active, not recruiting
    - LLC "Transcarpathian Center Zoru"
  - Vinnytsia, Ukraine, 21009
    - Active, not recruiting
    - Medical Clinical Investigational Center of Med Center LLC Health Clinic, Unit of Gastroenterology,
  - Vinnytsia, Ukraine, 21018
    - Active, not recruiting
    - Communal Nonprofit Enterprise M.I.Pyrogov Vinnytsia Regional Clinical Hospital of Vinnytsia Regional
  - Vinnytsia, Ukraine, 21018
    - Active, not recruiting
    - National Medical University, Dep of Surgery, Vinnytsia M.I.Pyrogov National Medical University,
  - Vinnytsia, Ukraine, 21029
    - Active, not recruiting
    - Scientific and Research Institute of Invalid Rehabilitation (Educational and Scientific Treatment
United Kingdom
- - London, United Kingdom, SE1 9RT
    - Active, not recruiting
    - Guy'S and St Thomas' Nhs Foundation Trust
  - London, United Kingdom, E11 1NR
    - Active, not recruiting
    - Barts Health Nhs Trust - Whipps Cross University Hospital
- Somerset
  - Yeovil, Somerset, United Kingdom, BA21 4AT
    - Active, not recruiting
    - Yeovil District Hospital NHS Foundation Trust
United States
- Alabama
  - Dothan, Alabama, United States, 36305
    - Recruiting
    - Flowers Hospital (PFT Location)
  - Dothan, Alabama, United States, 36301
    - Active, not recruiting
    - Center for Digestive Health (Colonoscopy Location)
  - Dothan, Alabama, United States, 36301
    - Active, not recruiting
    - Digestive Health Specialists (IP Address)
  - Dothan, Alabama, United States, 36301
    - Active, not recruiting
    - Dothan Eyecare-Dr. Brent McKinley (OCT Location)
  - Dothan, Alabama, United States, 36301
    - Active, not recruiting
    - Pulmonary Associates (Secondary PFT Location)
- Arizona
  - Sun City, Arizona, United States, 85351
    - Not yet recruiting
    - GI Alliance
- California
  - Beverly Hills, California, United States, 90210
    - Not yet recruiting
    - Brighton Surgical Center (endoscopy center - Nicholas Karyotakis - endoscopist)
  - Irvine, California, United States, 92697
    - Not yet recruiting
    - Center for Clinical Research (CCR)
  - Irvine, California, United States, 92697
    - Not yet recruiting
    - UCI Gavin Herbert Eye Institute
  - Irvine, California, United States, 92697
    - Not yet recruiting
    - UCI Gottschalk Medical Plaza
  - La Jolla, California, United States, 92037
    - Not yet recruiting
    - Koman Family Outpatient Pavilion (ENDO)
  - La Jolla, California, United States, 92037
    - Not yet recruiting
    - Perlman Medical Offices (IBD Clinic)
  - La Jolla, California, United States, 92037
    - Not yet recruiting
    - UCSD Clinical and Translational Research Institute (Research Clinic)
  - La Jolla, California, United States, 92037
    - Not yet recruiting
    - UCSD Health System ( ENDO and PFT)
  - La Jolla, California, United States, 92037
    - Not yet recruiting
    - UCSD lnvestigational Drug Service Pharmacy (Pharmacy Only)
  - La Jolla, California, United States, 92093
    - Not yet recruiting
    - Shiley Eye Institute (OCT)
  - Lake Elsinore, California, United States, 92532
    - Active, not recruiting
    - Inland Pulmonary Specialists [PFT Only]
  - Lancaster, California, United States, 93534
    - Active, not recruiting
    - A V Pediatrics,Allergy and Family Medicine
  - Lancaster, California, United States, 93534
    - Active, not recruiting
    - Advanced Endoscopy and Pain Center(Colonoscopy)
  - Lancaster, California, United States, 93534
    - Active, not recruiting
    - Antelope Valley Eye Care(Ophthalmologist)
  - Lancaster, California, United States, 93534
    - Active, not recruiting
    - Jatinder S.Pruthi,MD FACG CPI
  - Lancaster, California, United States, 93534
    - Active, not recruiting
    - Om Research LLC
  - Lancaster, California, United States, 93534
    - Active, not recruiting
    - Renaissance Imaging Center(Chest X-Ray only)
  - Los Angeles, California, United States, 90067
    - Not yet recruiting
    - Advanced Vision Care (OCT)
  - Los Angeles, California, United States, 90067
    - Not yet recruiting
    - Gastrointestinal Biosciences Clinical Trials, LLC
  - Murrieta, California, United States, 92563
    - Active, not recruiting
    - United Medical Doctors
  - Murrieta, California, United States, 92562
    - Active, not recruiting
    - United Surgery Center Murrieta [Endoscopy Only]
  - Orange, California, United States, 92697
    - Not yet recruiting
    - CCR-ICTS Center for Innovative Patient Care
  - Orange, California, United States, 92868
    - Not yet recruiting
    - UCI Health Eye Care Services (Ophthalmoscopy and OCTs)
  - Orange, California, United States, 92868
    - Not yet recruiting
    - UCI Health H. H. Chao Comprehensive Digestive Disease Center
  - Orange, California, United States, 92868
    - Not yet recruiting
    - UCI Investigational Drug Services (IDSP - Pharmacy)
  - Orange, California, United States, 92868
    - Not yet recruiting
    - UCI Irvine Medical Center - Pulmonology Services - PFTs
  - Palmdale, California, United States, 93551
    - Active, not recruiting
    - Advanced Imaging (Chest X-Ray)
  - Temecula, California, United States, 92591
    - Active, not recruiting
    - California Eye Professionals [OCT Only]
  - Temecula, California, United States, 92592
    - Active, not recruiting
    - United Surgery Center Temecula [Endoscopy Only]
- Colorado
  - Colorado Springs, Colorado, United States, 80903
    - Active, not recruiting
    - Front Range Endoscopy Center
  - Colorado Springs, Colorado, United States, 80920
    - Active, not recruiting
    - Peak Gastroenterology Associates
  - Englewood, Colorado, United States, 80113
    - Not yet recruiting
    - Swedish Medical Center
- Connecticut
  - New Haven, Connecticut, United States, 06510
    - Not yet recruiting
    - Yale School of Medicine
- Florida
  - Clearwater, Florida, United States, 33756
    - Active, not recruiting
    - Bay Area Chest Physicians, P.A.,-(Pulmonary Function Test)
  - Clearwater, Florida, United States, 33761
    - Active, not recruiting
    - Northwood Vision- Optical Coherence Tomography (OCT)
  - Clearwater, Florida, United States, 33762
    - Active, not recruiting
    - Gastro Florida-(Regulatory & Administrative Duties)
  - Clearwater, Florida, United States, 33765
    - Active, not recruiting
    - West Coast Endoscopy Center (Endoscopy Procedures)
  - Clearwater, Florida, United States, 33756
    - Active, not recruiting
    - West Coast Endoscopy Center (Endoscopy Facility)
  - Clearwater, Florida, United States, 33761
    - Active, not recruiting
    - MACULA CENTER Dana M. Deupree, M.D., F.A.C.S (OCT)
  - Clearwater, Florida, United States, 33761
    - Active, not recruiting
    - Northwood Vision-Optical Coherence Tomography-(OCT)
  - Clearwater, Florida, United States, 33761
    - Active, not recruiting
    - Safety Harbor Surgery (Endoscopy Facility)
  - Clearwater, Florida, United States, 33762
    - Active, not recruiting
    - Gastro Florida (Administrative & Regulatory Duties)
  - Coral Gables, Florida, United States, 33134
    - Not yet recruiting
    - Beraja Medical Institute (OCT)
  - Largo, Florida, United States, 33771
    - Active, not recruiting
    - Dr Lee Shettle
  - Largo, Florida, United States, 33771
    - Active, not recruiting
    - Florida Center for Gastroenterology
  - Largo, Florida, United States, 33771
    - Active, not recruiting
    - Tampa Bay Regional Surgery Center
  - Miami, Florida, United States, 33134
    - Not yet recruiting
    - Endoscopy Center (For Endoscopy procedure)
  - Miami, Florida, United States, 33156
    - Not yet recruiting
    - Research Associates of South Florida, LLC(IP address)
  - Miami, Florida, United States, 33157
    - Not yet recruiting
    - Kendall Endoscopy and Surgery Center
  - Miami, Florida, United States, 33173
    - Not yet recruiting
    - Juan Barrio, MD (PFT)
  - Miami, Florida, United States, 33176
    - Not yet recruiting
    - Clarineyecare
  - Naples, Florida, United States, 34102
    - Not yet recruiting
    - Gastroenterology Group of Naples
  - Naples, Florida, United States, 34102
    - Not yet recruiting
    - Gulfshore Endoscopy Center
  - Naples, Florida, United States, 34103
    - Not yet recruiting
    - Retina Consultants of Southwest Florida, PA "OCT"
  - Naples, Florida, United States, 34109
    - Not yet recruiting
    - Lisette Delgado Sanchez, MD "PFT"
  - New Smyrna Beach, Florida, United States, 32168
    - Active, not recruiting
    - NSB Research
  - Palmetto Bay, Florida, United States, 33157
    - Not yet recruiting
    - IMIC Inc .
  - Palmetto Bay, Florida, United States, 33157
    - Not yet recruiting
    - IMIC Inc.
  - Port Orange, Florida, United States, 32127
    - Not yet recruiting
    - Advanced Medical Research Center
  - South Miami, Florida, United States, 33143
    - Not yet recruiting
    - Larkin Community Hospital (For endoscopy procedure)
  - Sun City Center, Florida, United States, 33573
    - Active, not recruiting
    - Absolute Surgical Specialists - Craig Amshel, MD
  - Tampa, Florida, United States, 33603
    - Active, not recruiting
    - Tampa Bay Endoscopy Center (ENDO Only)
  - Tampa, Florida, United States, 33606
    - Active, not recruiting
    - Lab - Processing / Storage
  - Tampa, Florida, United States, 33606
    - Active, not recruiting
    - University of South Florida "Administrative Office"
  - Tampa, Florida, United States, 33606
    - Active, not recruiting
    - USF Health South Tampa Center for Advanced Healthcare
  - Tampa, Florida, United States, 33607
    - Active, not recruiting
    - Pulmonary and Sleep of Tampa Bay (PFT Only)
  - Tampa, Florida, United States, 33612
    - Active, not recruiting
    - USF Health Morsani Center For Advanced Healthcare
  - Tampa, Florida, United States, 33614
    - Active, not recruiting
    - Guardian Angel Research Center, INC
  - Tampa, Florida, United States, 33614
    - Active, not recruiting
    - Perez Eye Center (OCT only)
  - Tampa, Florida, United States, 33609
    - Active, not recruiting
    - GCP Clinical Research,LLC
  - Tampa, Florida, United States, 33609
    - Active, not recruiting
    - LoCicero Medical Group (PFT Procedure Only)
  - Tampa, Florida, United States, 33609
    - Active, not recruiting
    - Newsome Eye Specialist (OCT Procedures Only)
  - Tampa, Florida, United States, 33609
    - Active, not recruiting
    - South Tampa Surgery Center
  - Zephyrhills, Florida, United States, 33542
    - Active, not recruiting
    - Florida Medical Clinic, LLC (Endoscopy)
  - Zephyrhills, Florida, United States, 33542
    - Active, not recruiting
    - Florida Medical Clinic, LLC (OCT)
  - Zephyrhills, Florida, United States, 33542
    - Active, not recruiting
    - Florida Medical Clinic, LLC (PFT)
  - Zephyrhills, Florida, United States, 33542
    - Active, not recruiting
    - Florida Medical Clinic, LLC
- Georgia
  - Atlanta, Georgia, United States, 30328
    - Active, not recruiting
    - Thomas Eye Group Corporate (OCT)
  - Atlanta, Georgia, United States, 30342
    - Active, not recruiting
    - Pulmonary Critical Care of Atlanta (PFT)
  - Atlanta, Georgia, United States, 30342
    - Active, not recruiting
    - Atlanta Gastroenterology Associates (endoscopy only)
  - Atlanta, Georgia, United States, 30342
    - Active, not recruiting
    - Atlanta Gastroenterology Associates(IP only)
  - Atlanta, Georgia, United States, 30342
    - Active, not recruiting
    - Atlanta Pulmonary Group ( PFT only)
  - Sandy Springs, Georgia, United States, 30328
    - Active, not recruiting
    - Thomas Eye Group (OCT only)
- Illinois
  - Gurnee, Illinois, United States, 60031
    - Recruiting
    - Illinois Gastroenterology Group-Gurnee (Patients Seen; IP Delivered)
  - Gurnee, Illinois, United States, 60031
    - Recruiting
    - Medical Eye Services LTD (Ophthalmoscopy with OCT)
  - Lake Bluff, Illinois, United States, 60044
    - Recruiting
    - North Shore Endoscopy Center (Endoscopy)
  - Libertyville, Illinois, United States, 60048
    - Recruiting
    - Libertyville Imaging Center (Diagnostic Imaging)
- Louisiana
  - Baton Rouge, Louisiana, United States, 70808
    - Active, not recruiting
    - Eye Medical Center (OCT location)
  - Baton Rouge, Louisiana, United States, 70808
    - Active, not recruiting
    - Our Lady of the Lake (PFT location)
  - Baton Rouge, Louisiana, United States, 70809
    - Active, not recruiting
    - Baton Rouge LA Endoscopy
- Maryland
  - Chevy Chase, Maryland, United States, 20815
    - Active, not recruiting
    - Chevy Chase Endoscopy Center (Endoscopy Facility Only)
  - Chevy Chase, Maryland, United States, 20815
    - Active, not recruiting
    - Chevy Chase Pulmonary Associate (PFT Only)
  - Chevy Chase, Maryland, United States, 20815
    - Active, not recruiting
    - Retina Group Of Washington (OCT Only)
  - Columbia, Maryland, United States, 21045
    - Not yet recruiting
    - Gastro Center of Maryland
- Missouri
  - Creve Coeur, Missouri, United States, 63141
    - Active, not recruiting
    - Barnes-Jewish West County Hospital (Additional Endoscopy Location)
  - Saint Louis, Missouri, United States, 63110
    - Active, not recruiting
    - Washington University School of Medicine
  - Saint Louis, Missouri, United States, 63110
    - Active, not recruiting
    - Barnes-Jewish Hospital
  - Saint Louis, Missouri, United States, 63108
    - Active, not recruiting
    - Washington University School of Medicine
- Nevada
  - Las Vegas, Nevada, United States, 89113
    - Terminated
    - Durango Surgical Center
  - Las Vegas, Nevada, United States, 89148
    - Terminated
    - Abrams Eye Institute (OCT)
  - Las Vegas, Nevada, United States, 89148
    - Terminated
    - Lung Center of Nevada
- New Hampshire
  - Lebanon, New Hampshire, United States, 03756
    - Not yet recruiting
    - Dartmouth-Hitchcock Medical Center
- North Carolina
  - Durham, North Carolina, United States, 27710
    - Active, not recruiting
    - Duke University Medical Center
  - Durham, North Carolina, United States, 27704
    - Active, not recruiting
    - Duke Medical Plaza North Duke Street
  - Durham, North Carolina, United States, 27705
    - Active, not recruiting
    - Duke Eye Center (OCT only)
  - Durham, North Carolina, United States, 27710
    - Active, not recruiting
    - Investigational Drug Services (Pharmacy)
  - Raleigh, North Carolina, United States, 27617
    - Active, not recruiting
    - Brier Creek Medical Pavilion
- Ohio
  - Beachwood, Ohio, United States, 44122
    - Active, not recruiting
    - Retina Associates of Cleveland, Inc. (OCT only)
  - Cincinnati, Ohio, United States, 45219
    - Active, not recruiting
    - UC Health Hoxworth (OCT only)
  - Cincinnati, Ohio, United States, 45219
    - Active, not recruiting
    - UC Health Physicians Office
  - Cincinnati, Ohio, United States, 45219
    - Active, not recruiting
    - University of Cincinnati Medical Center (PFT and Endoscopy location)
  - Cincinnati, Ohio, United States, 45229
    - Active, not recruiting
    - UC Health (Pulmonary Function Testing)
  - Cincinnati, Ohio, United States, 45267
    - Active, not recruiting
    - University of Cincinnati Medical Center Department of Pharmacy Services
  - Mentor, Ohio, United States, 44060
    - Active, not recruiting
    - Great Lakes Gastroenterology Research, LLC
  - Mentor, Ohio, United States, 44060
    - Active, not recruiting
    - The Endoscopy Center of Lake County
  - Willoughby, Ohio, United States, 44094
    - Active, not recruiting
    - Lake Pulmonary Associates (PFT only)
- Oklahoma
  - Oklahoma City, Oklahoma, United States, 73112
    - Terminated
    - Digestive Disease Specialists, Inc. Endoscopy Lab
  - Oklahoma City, Oklahoma, United States, 73112
    - Terminated
    - Pulmonary Physicians of Oklahoma
  - Oklahoma City, Oklahoma, United States, 73112
    - Terminated
    - Retina Center of Oklahoma
- Pennsylvania
  - Camp Hill, Pennsylvania, United States, 17011
    - Active, not recruiting
    - Great Lakes Medical Research, LLC
  - Camp Hill, Pennsylvania, United States, 17011
    - Active, not recruiting
    - West Shore Endoscopy Center
  - Harrisburg, Pennsylvania, United States, 17102
    - Active, not recruiting
    - Pulmonary and Critical Care Medicine Associates (PFT only)
  - Harrisburg, Pennsylvania, United States, 17110
    - Active, not recruiting
    - Farrell Ophthalmology (OCT only)
  - Harrisburg, Pennsylvania, United States, 17110
    - Active, not recruiting
    - Great Lakes Medical Research, LLC
- Texas
  - Arlington, Texas, United States, 76012
    - Active, not recruiting
    - Cross Timbers Surgery Center(Proctosigmoidoscopy)
  - Arlington, Texas, United States, 76012
    - Active, not recruiting
    - Envision Imaging(Chest X-Ray)
  - Arlington, Texas, United States, 76012
    - Active, not recruiting
    - Texas Clinical Research Institute
  - Arlington, Texas, United States, 76012
    - Active, not recruiting
    - Texas Pulmonary and Critical Care Associates(Pulmonary Function Test)
  - Arlington, Texas, United States, 76012
    - Active, not recruiting
    - Texas Retina Associates(Ophthalmoscopy)
  - Baytown, Texas, United States, 77521
    - Terminated
    - Inquest Clinical Research
  - Dallas, Texas, United States, 75205
    - Active, not recruiting
    - Dallas Endoscopy Center (Endoscopy)
  - Fort Worth, Texas, United States, 76104
    - Not yet recruiting
    - GI Alliance
  - Houston, Texas, United States, 77004
    - Terminated
    - Plaza Medical Center
  - Houston, Texas, United States, 77029
    - Terminated
    - East Houston Physicians Group
  - Houston, Texas, United States, 77401
    - Terminated
    - Cross Eye Center (Optical Coherence Tomography)
  - Houston, Texas, United States, 77030
    - Active, not recruiting
    - Alkek Eye Center Jamail Specialty Care Center (OCT)
  - Houston, Texas, United States, 77030
    - Active, not recruiting
    - Baylor College of Medicine- Baylor Medical Center
  - Houston, Texas, United States, 77030
    - Active, not recruiting
    - Baylor College of Medicine-Baylor Medical Center ( IP Storage)
  - Houston, Texas, United States, 77030
    - Active, not recruiting
    - Baylor College of Medicine-Baylor Medical Center (Chest X-ray location)
  - Houston, Texas, United States, 77030
    - Active, not recruiting
    - Baylor St.Luke's Medical Center Endoscopy-Mc Nair Campus (Endoscopy Location)
  - Keller, Texas, United States, 76248
    - Active, not recruiting
    - Lonestar Endoscopy(Endoscopy Location)
  - New Braunfels, Texas, United States, 78130
    - Active, not recruiting
    - Christus Santa Rosa Physicians Ambulatory Surgery Center New Braunfels (Endoscopy)
  - New Braunfels, Texas, United States, 78130
    - Active, not recruiting
    - Tyrus Schroeder (PFT)
  - San Marcos, Texas, United States, 78666
    - Active, not recruiting
    - Central Texas Eye Center (OCT)
  - San Marcos, Texas, United States, 78666
    - Active, not recruiting
    - Christus Santa Rosa Physicians Ambulatory Surgery Center San Marcos (Endoscopy)
  - Southlake, Texas, United States, 76092
    - Active, not recruiting
    - Lonestar Endoscopy (Endoscopy Location)
  - Tyler, Texas, United States, 75701-8355
    - Active, not recruiting
    - Heaton Eye Associates (OCT only)
  - Tyler, Texas, United States, 75701
    - Active, not recruiting
    - Christus Trinity Mother Frances Endosopy Center ( endoscopies only)
  - Tyler, Texas, United States, 75701
    - Active, not recruiting
    - Tyler Open MRI (x-ray only)
  - Tyler, Texas, United States, 75701
    - Active, not recruiting
    - Tyler Research Institute, LLC
  - Tyler, Texas, United States, 75701
    - Active, not recruiting
    - UT Health East Texas Physicians (pulmonary functions only)
  - Victoria, Texas, United States, 77904
    - Active, not recruiting
    - Citizens Healthplex
  - Victoria, Texas, United States, 77904
    - Active, not recruiting
    - Surgery Center
  - Victoria, Texas, United States, 77904
    - Active, not recruiting
    - Victoria Eye Center
  - Victoria, Texas, United States, 77904
    - Active, not recruiting
    - Victoria Gastroenterology
- Utah
  - Salt Lake City, Utah, United States, 84132
    - Not yet recruiting
    - University of Utah School of Medicine
- Virginia
  - Forest, Virginia, United States, 24551
    - Active, not recruiting
    - Harman Eye Center (OCT only)
  - Lynchburg, Virginia, United States, 24501
    - Active, not recruiting
    - Lynchburg Pulmonary Associates, Inc. (PFT only)
  - Lynchburg, Virginia, United States, 24502
    - Active, not recruiting
    - Blue Ridge Medical Research
- Washington
  - Seattle, Washington, United States, 98122
    - Active, not recruiting
    - Swedish Medical Center
- Wisconsin
  - Milwaukee, Wisconsin, United States, 53226
    - Active, not recruiting
    - Froedtert Memorial Lutheran Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

16 years to 80 years (Child, Adult, Older Adult)

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Must have met the eligibility criteria and have been enrolled in the qualified Phase 2 or 3 parent studies listed below or other qualified region-specific studies and meet the following additional criteria:
1. Participants previously enrolled in Study APD334-301 (NCT03945188) or APD334-210 (NCT04607837) must have completed the Week 12 visit and have been assessed to have active UC that has not improved or has worsened from baseline or completed the Week 52 visit
2. Participants previously enrolled in APD334-302 (NCT03996369) must have completed the Week 12 visit

Exclusion Criteria:

If Investigator considers the participant to be unsuitable for any reason to participate in the Open-Label Extension study
Experienced an adverse event that led to discontinuation from parent study

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: N/A
Interventional Model: Single Group Assignment
Masking: None (Open Label)

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Etrasimod 2 mg	Drug: Etrasimod Etrasimod 2 mg tablet by mouth, once daily up to approximately 8 years or until marketing authorization is obtained in the participant's country, whichever comes first Other Names: APD334

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Number and Severity of Safety Measures Time Frame: Up to approximately 8 years	Safety as assessed by the evaluation of adverse events	Up to approximately 8 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Proportion of Participants Achieving Clinical Remission Assessed by Mayo Component Sub-scores Time Frame: Week 52 and Week 104		Week 52 and Week 104
Proportion of Participants Achieving Clinical Remission at Weeks 52 and 104 Among Participants Achieving Clinical Remission at Study Entry Time Frame: Week 52 and Week 104		Week 52 and Week 104
Change From Baseline in the Total Mayo Score Time Frame: Baseline, Week 52, and Week 104	The total Mayo score is a tool designed to measure disease activity for ulcerative colitis. Scoring ranges from 0 to 12 points and consists of 4 components (endoscopic score, rectal bleeding, stool frequency, and physicians global assessment), each graded 0 to 3 (0 = normal, 1 = mild, 2 = moderate, 3 = severe) with higher score indicating more severe disease.	Baseline, Week 52, and Week 104
Proportion of Participants Achieving Endoscopic Improvement Assessed by Mayo Component Sub-scores Time Frame: Week 52 and Week 104		Week 52 and Week 104
Proportion of Participants Achieving Clinical Response Assessed by Mayo Component Sub-scores Time Frame: Week 52 and Week 104		Week 52 and Week 104
Change From Baseline in Partial Mayo Score Time Frame: Baseline, Week 52, Week 104, Week 156, Week 208 and Week 260	The partial Mayo score is a tool designed to measure disease activity for ulcerative colitis. Scoring ranges from 0 to 9 points and consists of 3 non-invasive components (rectal bleeding, stool frequency, and physicians global assessment), each graded 0 to 3 (0 = normal, 1 = mild, 2 = moderate, 3 = severe) with higher score indicating more severe disease.	Baseline, Week 52, Week 104, Week 156, Week 208 and Week 260

Other Outcome Measures

Outcome Measure	Time Frame
Percentage of Participants With Histologic Improvement Assessed by the Geboes, Robarts, and Nancy Histopathology Scores Time Frame: Week 52 and Week 104	Week 52 and Week 104
Percentage of Participants With Histologic Remission Assessed by the Geboes, Robarts, and Nancy Histopathology Scores Time Frame: Week 52 and Week 104	Week 52 and Week 104
Time to Loss of Response Assessed by Mayo Component Sub-scores Time Frame: Up to Week 260	Up to Week 260
Proportion of Participants Achieving Improvement in Extraintestinal Manifestations (EIMs) in Participants With EIMs at Baseline Time Frame: Baseline, Week 12, Week 52, Week 104, Week 156, Week 208, and Week 260	Baseline, Week 12, Week 52, Week 104, Week 156, Week 208, and Week 260

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Pfizer

Collaborators

Arena is a wholly owned subsidiary of Pfizer

Investigators

Study Director: Pfizer CT.gov Call Center, Pfizer

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

To obtain contact information for a study center near you, click here.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 5, 2019

Primary Completion (Estimated)

July 21, 2026

Study Completion (Estimated)

July 21, 2026

Study Registration Dates

First Submitted

May 13, 2019

First Submitted That Met QC Criteria

May 13, 2019

First Posted (Actual)

May 15, 2019

Study Record Updates

Last Update Posted (Actual)

April 4, 2024

Last Update Submitted That Met QC Criteria

April 2, 2024

Last Verified

April 1, 2024

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

APD334-303
C5041012 (Other Identifier: Alias Study Number)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Estimated)

Phase

Expanded Access

Contacts and Locations

Study Contact

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Other Outcome Measures

Outcome Measure

Time Frame

Collaborators and Investigators

Sponsor

Collaborators

Investigators

Publications and helpful links

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Estimated)

Study Completion (Estimated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Ulcerative Colitis

Clinical Trials on Etrasimod

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