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En utvidelsesstudie for behandling av moderat til alvorlig aktiv ulcerøs kolitt (ELEVATE UC OLE)

8. juli 2026 oppdatert av: Pfizer

En åpen utvidelsesstudie av Etrasimod hos personer med moderat til alvorlig aktiv ulcerøs kolitt

Hensikten med denne åpne utvidelsesstudien (OLE) er å evaluere sikkerheten og effekten av etrasimod hos deltakere med moderat til alvorlig aktiv ulcerøs kolitt (UC) som tidligere har mottatt dobbeltblind behandling (enten etrasimod 2 mg per dag eller placebo) under deltakelse i en av de kvalifiserte fase 3- eller fase 2-dobbelblindede, placebokontrollerte foreldrestudiene inkludert, men ikke begrenset til: (APD334-301 [NCT03945188] eller APD334-302 [NCT03996369] eller APD334-260 [NCT334-260] [NCT3077]).

Studieoversikt

Status

Aktiv, ikke rekrutterende

Forhold

Intervensjon / Behandling

Studietype

Intervensjonell

Registrering (Faktiske)

896

Fase

  • Fase 3

Utvidet tilgang

Tilgjengelig utenfor den kliniske utprøvingen. Se utvidet tilgangspost.

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Argentina
    • Tucumán Province
      • San Miguel de Tucumán, Tucumán Province, Argentina, 4000
        • Centro de lnvestigation C.I .C.E. 9 de Julio
  • Australia
      • Birtinya, Australia, 4575
        • Sunshine Coast Respiratory and Sleep (PFT Facility)
      • Buderim, Australia, 4556
        • Queensland Medical Laboratory (QML) pathology, QML Buderim Laboratory - Healius Pathology Pty Ltd
    • New South Wales
      • Liverpool, New South Wales, Australia, 2170
        • Liverpool Hospital
    • Queensland
      • Birtinya, Queensland, Australia, 4575
        • Sunshine Coast University Private Hospital
      • Bowen Hills, Queensland, Australia, 4006
        • Sullivan Nicolaides Pathology
      • Buderim, Queensland, Australia, 4556
        • Buderim Eye Centre( OCT and Ophthalmoscopy Facility)
      • Mackay, Queensland, Australia, 4740
        • Dr Shiran DeSilva Respiratory Clinic
      • Mackay, Queensland, Australia, 4740
        • Mater Misericordiae Hospital
      • Mackay, Queensland, Australia, 4740
        • Queensland X-Ray
      • Mackay, Queensland, Australia, 4740
        • Vision Eye Institute Mackay
      • Mackay, Queensland, Australia, 4740
        • Coral Sea Clinical Research Institute Pty.Ltd
      • Maroochydore, Queensland, Australia, 4558
        • Coastal Digestive Helath Pty. Ltd
      • North Mackey, Queensland, Australia, 4740
        • Dr Pranav Kumar (PFT Facility)
    • Victoria
      • Heidelberg, Victoria, Australia, 3084
        • Austin Health
      • Melbourne, Victoria, Australia, 3004
        • The Alfred Hospital
  • Belgia
      • Ghent, Belgia, 9000
        • Hospital AZ Sint-Lucas
      • Roeselare, Belgia, 8800
        • AZ Delta
      • Roeselare, Belgia, 8800
        • AZ Delta campus Brugsesteenweg
  • Bulgaria
      • Rousse, Bulgaria, 7002
        • "UMHAT "Kanev"" AD, Ruse
      • Sliven, Bulgaria, 8800
        • Diagnostic-Consultative Center I - Sliven, EOOD
      • Sofia, Bulgaria, 1407
        • Acibadem City Clinic Tokuda Hospital Ead
      • Sofia, Bulgaria, 1680
        • Diagnostic Consultation Center CONVEX EOOD
      • Sofia, Bulgaria, 1407
        • Acibadem City clinic University Hospital EOOD
      • Sofia, Bulgaria, 1431
        • "DCC Alexandrovska", EOOD
      • Sofia, Bulgaria, 1431
        • UMHAT "Sv. Ivan Rilski" EAD'
      • Sofia, Bulgaria, 1527
        • UMHAT "Tsaritsa Yoanna - ISUL" EAD
      • Sofia, Bulgaria, 1606
        • "University multiprofile hospital for active treatment and emergency medicine N.I. Pirogov"EAD
      • Veliko Tarnovo, Bulgaria, 5000
        • Medical Centre MEDICA Plus OOD
  • Canada
    • Ontario
      • Toronto, Ontario, Canada, M5G 1X5
        • Mount Sinai Hospital
  • Chile
    • Los Ríos Region
      • Valdivia, Los Ríos Region, Chile
        • Clinical Research Chile
  • Danmark
      • Aalborg, Danmark, 9000
        • Aalborg University Hospital, department of medical gastroenterology,
      • Herlev, Danmark, 2730
        • Herlev Hospital, Stomach, -Bowel and Liver disease, Clinic 1
  • Estland
      • Tallinn, Estland, 10617
        • West Tallinn Central Hospital
      • Tallinn, Estland, 13419
        • North Estonia Medical Centre Foundation
      • Tallinn, Estland, 10120
        • OCT: Eye Clinic Dr. Krista Turman
      • Tallinn, Estland, 10138
        • DLCO: East Tallinn Central Hospital
      • Tallinn, Estland, 13149
        • Endoscopy: North Estonia Medical Centre Foundation
    • Harju
      • Tallinn, Harju, Estland, 10117
        • Innomedica OU
  • Forente stater
    • Alabama
      • Dothan, Alabama, Forente stater, 36301
        • Center for Digestive Health (Colonoscopy Location)
      • Dothan, Alabama, Forente stater, 36301
        • Pulmonary Associates (Secondary PFT Location)
      • Dothan, Alabama, Forente stater, 36301
        • Digestive Health Specialists (IP Address)
      • Dothan, Alabama, Forente stater, 36305
        • Gut P.C., dba Digestive Health Specialists of the Southeast (IP Address)
      • Dothan, Alabama, Forente stater, 36301
        • Flowers Hospital (PFT Location)
    • California
      • Lake Elsinore, California, Forente stater, 92532
        • Inland Pulmonary Specialists [PFT Only]
      • Lancaster, California, Forente stater, 93534
        • OM Research LLC
      • Lancaster, California, Forente stater, 93534
        • A V Pediatrics,Allergy and Family Medicine
      • Lancaster, California, Forente stater, 93534
        • Advanced Endoscopy and Pain Center(Colonoscopy)
      • Lancaster, California, Forente stater, 93534
        • Antelope Valley Eye Care(Ophthalmologist)
      • Lancaster, California, Forente stater, 93534
        • Jatinder S.Pruthi,MD FACG CPI
      • Lancaster, California, Forente stater, 93534
        • Renaissance Imaging Center(Chest X-Ray only)
      • Murrieta, California, Forente stater, 92563
        • United Medical Doctors
      • Murrieta, California, Forente stater, 92562
        • United Surgery Center Murrieta [Endoscopy Only]
      • Palmdale, California, Forente stater, 93551
        • Advanced Imaging (Chest X-Ray)
      • Temecula, California, Forente stater, 92591
        • California Eye Professionals [OCT Only]
      • Temecula, California, Forente stater, 92592
        • United Surgery Center Temecula [Endoscopy Only]
    • Colorado
      • Colorado Springs, Colorado, Forente stater, 80920
        • Peak Gastroenterology Associates
      • Colorado Springs, Colorado, Forente stater, 80903
        • Front Range Endoscopy Center
    • Florida
      • Clearwater, Florida, Forente stater, 33762
        • Gastro Florida (Regulatory & Administrative Duties)
      • Clearwater, Florida, Forente stater, 33756
        • Bay Area Chest Physicians, P.A.,-(Pulmonary Function Test)
      • Clearwater, Florida, Forente stater, 33756
        • West Coast Endoscopy Center (Endoscopy Procedures)
      • Clearwater, Florida, Forente stater, 33761
        • Northwood Vision- Optical Coherence Tomography (OCT)
      • Clearwater, Florida, Forente stater, 33761
        • Northwood Vision-Optical Coherence Tomography-(OCT)
      • Clearwater, Florida, Forente stater, 33761
        • Safety Harbor Surgery (Endoscopy Facility)
      • Clearwater, Florida, Forente stater, 33762
        • Gastro Florida-(Regulatory & Administrative Duties)
      • Clearwater, Florida, Forente stater, 33765
        • West Coast Endoscopy Center (Endoscopy Procedures)
      • Largo, Florida, Forente stater, 33771
        • Dr Lee Shettle
      • Largo, Florida, Forente stater, 33771
        • Florida Center for Gastroenterology
      • Largo, Florida, Forente stater, 33771
        • Tampa Bay Regional Surgery Center
      • New Smyrna Beach, Florida, Forente stater, 32168
        • NSB Research
      • Tampa, Florida, Forente stater, 33612
        • Usf Health Morsani Center For Advanced Healthcare
      • Tampa, Florida, Forente stater, 33606
        • USF Health South Tampa Center for Advanced Healthcare
      • Tampa, Florida, Forente stater, 33603
        • Tampa Bay Endoscopy Center
      • Tampa, Florida, Forente stater, 33614
        • Guardian Angel Research Center, INC
      • Tampa, Florida, Forente stater, 33609
        • GCP Clinical Research,LLC
      • Tampa, Florida, Forente stater, 33609
        • LoCicero Medical Group (PFT Procedure Only)
      • Tampa, Florida, Forente stater, 33603
        • Tampa Bay Endoscopy Center (ENDO Only)
      • Tampa, Florida, Forente stater, 33606
        • Lab - Processing / Storage
      • Tampa, Florida, Forente stater, 33607
        • Pulmonary and Sleep of Tampa Bay (PFT Only)
      • Tampa, Florida, Forente stater, 33609
        • Newsome Eye Specialist (OCT Procedures Only)
      • Tampa, Florida, Forente stater, 33614
        • Perez Eye Center (OCT only)
      • Tampa, Florida, Forente stater, 33609
        • Lyracore Health Alliance (PFT Procedure only)
      • Zephyrhills, Florida, Forente stater, 33542
        • Florida Medical Clinic, LLC
      • Zephyrhills, Florida, Forente stater, 33542
        • Florida Medical Clinic, LLC (Endoscopy)
      • Zephyrhills, Florida, Forente stater, 33542
        • Florida Medical Clinic, LLC (OCT)
      • Zephyrhills, Florida, Forente stater, 33542
        • Florida Medical Clinic, LLC (PFT)
    • Georgia
      • Atlanta, Georgia, Forente stater, 30342
        • Atlanta Gastroenterology Associates
      • Atlanta, Georgia, Forente stater, 30342
        • Atlanta Gastroenterology Associates (endoscopy only)
      • Atlanta, Georgia, Forente stater, 30342
        • Atlanta Gastroenterology Associates(IP only)
      • Atlanta, Georgia, Forente stater, 30322
        • Emory Pulmonary Function Tedt Lab
      • Atlanta, Georgia, Forente stater, 30324
        • Emory Pulmonary Group (PFT only)
      • Atlanta, Georgia, Forente stater, 30342
        • Atlanta Gastroenterology Associates (Endoscopy Location)
      • Atlanta, Georgia, Forente stater, 30342
        • Atlanta Gastroenterology Associates (Screening and Recruitment)
      • Atlanta, Georgia, Forente stater, 30342
        • Emory Saint Joseph Pulmonary Function Test Lab
      • Sandy Springs, Georgia, Forente stater, 30328
        • Thomas Eye Group (OCT only)
    • Illinois
      • Gurnee, Illinois, Forente stater, 60031
        • Medical Eye Services LTD (Ophthalmoscopy with OCT)
      • Gurnee, Illinois, Forente stater, 60031
        • Illinois Gastroenterology Group dba GI Alliance (Patients seen; IP Delivered)
      • Lake Bluff, Illinois, Forente stater, 60044
        • North Shore Endoscopy Center (Endoscopy)
      • Libertyville, Illinois, Forente stater, 60048
        • Libertyville Imaging Center (Diagnostic Imaging)
    • Louisiana
      • Baton Rouge, Louisiana, Forente stater, 70808
        • Eye Medical Center (OCT location)
      • Baton Rouge, Louisiana, Forente stater, 70809
        • Baton Rouge LA Endoscopy
    • Maryland
      • Chevy Chase, Maryland, Forente stater, 20815
        • Chevy Chase Pulmonary Associate (PFT Only)
      • Chevy Chase, Maryland, Forente stater, 20815
        • Retina Group Of Washington (OCT Only)
      • Chevy Chase, Maryland, Forente stater, 20815
        • Friendship Heights Endoscopy Center (Endoscopy Facility Only)
    • Missouri
      • Creve Coeur, Missouri, Forente stater, 63141
        • Barnes-Jewish West County Hospital (Additional Endoscopy Location)
      • St Louis, Missouri, Forente stater, 63110
        • Barnes-Jewish Hospital
      • St Louis, Missouri, Forente stater, 63110
        • Washington University School of Medicine
      • St Louis, Missouri, Forente stater, 63108
        • Washington University School of Medicine
    • Nevada
      • Las Vegas, Nevada, Forente stater, 89113
        • Durango Surgical Center
      • Las Vegas, Nevada, Forente stater, 89148
        • Abrams Eye Institute (OCT)
      • Las Vegas, Nevada, Forente stater, 89148
        • Lung Center of Nevada
    • North Carolina
      • Durham, North Carolina, Forente stater, 27710
        • Duke University Medical Center
      • Durham, North Carolina, Forente stater, 27704
        • Duke Medical Plaza North Duke Street
      • Durham, North Carolina, Forente stater, 27710
        • Investigational Drug Services (Pharmacy)
      • Durham, North Carolina, Forente stater, 27705
        • Duke Eye Center (OCT only)
      • Raleigh, North Carolina, Forente stater, 27617
        • Brier Creek Medical Pavilion
    • Ohio
      • Chardon, Ohio, Forente stater, 44024
        • Geauga Sleep Center (PFT Only)
      • Cincinnati, Ohio, Forente stater, 45219
        • UC Health Physicians Office
      • Cincinnati, Ohio, Forente stater, 45229
        • UC Health (Pulmonary Function Testing)
      • Cincinnati, Ohio, Forente stater, 45219
        • UC Health Hoxworth (OCT only)
      • Cincinnati, Ohio, Forente stater, 45219
        • University of Cincinnati Medical Center (PFT and Endoscopy location)
      • Mentor, Ohio, Forente stater, 44060
        • Great Lakes Gastroenterology Research, LLC
      • Mentor, Ohio, Forente stater, 44060
        • The Endoscopy Center of Lake County
      • Mentor, Ohio, Forente stater, 44060
        • Ophthalmic Physicians Incorporated (OCT Only)
      • Mentor, Ohio, Forente stater, 44060
        • Vitreo Retinal Consultants (OCT only)
      • Willoughby Hills, Ohio, Forente stater, 44094
        • Lake Pulmonary Associates (PFT only)
      • Willoughby Hills, Ohio, Forente stater, 44094
        • Retina Specialist of Ohio (OCT only)
    • Oklahoma
      • Oklahoma City, Oklahoma, Forente stater, 73112
        • Digestive Disease Specialists, Inc. Endoscopy Lab
      • Oklahoma City, Oklahoma, Forente stater, 73112
        • Pulmonary Physicians of Oklahoma
      • Oklahoma City, Oklahoma, Forente stater, 73112
        • Retina Center of Oklahoma
    • Pennsylvania
      • Camp Hill, Pennsylvania, Forente stater, 17011
        • West Shore Endoscopy Center
      • Camp Hill, Pennsylvania, Forente stater, 17011
        • Susquehanna Research Group
      • Harrisburg, Pennsylvania, Forente stater, 17110
        • Susquehanna Research Group, LLC
      • Harrisburg, Pennsylvania, Forente stater, 17111
        • Harrisburg Eye Associates (OCT only)
      • Harrisburg, Pennsylvania, Forente stater, 17110
        • Farrell Ophthalmology (OCT only)
      • Harrisburg, Pennsylvania, Forente stater, 17111
        • Medical Arts Allergy,PC (PFT Only)
      • Lemoyne, Pennsylvania, Forente stater, 17043
        • Pulmonary and Critical Care Medicine Associates (PFT only)
    • Texas
      • Arlington, Texas, Forente stater, 76012
        • Texas Clinical Research Institute
      • Arlington, Texas, Forente stater, 76012
        • Cross Timbers Surgery Center(Proctosigmoidoscopy)
      • Arlington, Texas, Forente stater, 76012
        • Envision Imaging(Chest X-Ray)
      • Arlington, Texas, Forente stater, 76012
        • Texas Pulmonary and Critical Care Associates(Pulmonary Function Test)
      • Arlington, Texas, Forente stater, 76012
        • Texas Retina Associates(Ophthalmoscopy)
      • Baytown, Texas, Forente stater, 77521
        • Inquest Clinical Research
      • Grapevine, Texas, Forente stater, 76051
        • Texas Retina Associates (OCT Location)
      • Houston, Texas, Forente stater, 77030
        • Baylor College of Medicine- Baylor Medical Center
      • Houston, Texas, Forente stater, 77004
        • Plaza Medical Center
      • Houston, Texas, Forente stater, 77029
        • East Houston Physicians Group
      • Houston, Texas, Forente stater, 77401
        • Cross Eye Center (Optical Coherence Tomography)
      • Keller, Texas, Forente stater, 76248
        • Lonestar Endoscopy(Endoscopy Location)
      • New Braunfels, Texas, Forente stater, 78130
        • Tyrus Schroeder (PFT)
      • New Braunfels, Texas, Forente stater, 78130
        • Christus Santa Rosa Physicians Ambulatory Surgery Center New Braunfels (Endoscopy)
      • San Marcos, Texas, Forente stater, 78666
        • Central Texas Eye Center (OCT)
      • San Marcos, Texas, Forente stater, 78666
        • Christus Santa Rosa Physicians Ambulatory Surgery Center San Marcos (Endoscopy)
      • Southlake, Texas, Forente stater, 76092
        • Lonestar Endoscopy (Endoscopy Location)
      • Southlake, Texas, Forente stater, 76092
        • Envision Imaging (Chest X-ray location)
      • Tyler, Texas, Forente stater, 75701
        • Christus Trinity Mother Frances Endosopy Center ( endoscopies only)
      • Tyler, Texas, Forente stater, 75701
        • UT Health East Texas Physicians (pulmonary functions only)
      • Tyler, Texas, Forente stater, 75701
        • Heaton Eye Associates (OCT only)
      • Tyler, Texas, Forente stater, 75701
        • Touchstone Imaging Tyler (chest x-rays only)
      • Tyler, Texas, Forente stater, 75701
        • Tyler Internal Medicine (PFT's only)
      • Victoria, Texas, Forente stater, 77904
        • Gastro Health & Nutrition
    • Virginia
      • Forest, Virginia, Forente stater, 24551
        • Harman Eye Center (OCT only)
      • Lynchburg, Virginia, Forente stater, 24502
        • Blue Ridge Medical Research
      • Lynchburg, Virginia, Forente stater, 24501
        • Lynchburg Pulmonary Associates, Inc. (PFT only)
    • Washington
      • Issaquah, Washington, Forente stater, 98029
        • Swedish Endoscopy Center - Issaquah
      • Seattle, Washington, Forente stater, 98122
        • Swedish Medical Center First Hill
      • Seattle, Washington, Forente stater, 98104
        • Swedish Gastroenterology
      • Seattle, Washington, Forente stater, 98122
        • Swedish Medical Center First Hill Endoscopy Center
      • Seattle, Washington, Forente stater, 98104
        • Pacific Northwest Retina
      • Seattle, Washington, Forente stater, 98104
        • Richard Bensinger, MD
    • Wisconsin
      • Milwaukee, Wisconsin, Forente stater, 53226
        • Froedtert Memorial Lutheran Hospital
  • Frankrike
      • Amiens, Frankrike, 80054
        • Chu Amiens Picardie
      • Amiens, Frankrike, 80054
        • Endoscopy: CHU Amiens-Picardie
      • Amiens, Frankrike, 80054
        • Pulmonary examination: CHU Amiens-Picardie
      • Amiens, Frankrike, 80054
        • Tomography: CHU Amiens-Picardie
      • Grenoble, Frankrike, 38043
        • CHU Grenoble Alpes -Hopital Michallon
      • Grenoble, Frankrike, 38043
        • Endoscopy: CHU Grenoble Alpes- Hopital Michallon
      • Grenoble, Frankrike, 38043
        • Pulmonary examination: CHU Grenoble Alpes - Hopital Michallon
      • Grenoble, Frankrike, 38043
        • Tomography: CHU Grenoble Alpes - Hopital Michallon
      • Montpellier, Frankrike, 34295
        • CHU Montpellier Hopital Saint-Eloi
      • Montpellier, Frankrike, 34295
        • Endoscopy: Hopital Saint-Eloi
      • Montpellier, Frankrike, 34295
        • Pulmonary examination: Hopital Arnaud de Villeneuve
      • Montpellier, Frankrike, 34295
        • Tomography: Hopital Gui de Chauliac
      • Nantes, Frankrike, 44093
        • CHu hotel dieu
      • Nice, Frankrike, 06202
        • CHU de Nice - Hopital de l'Archet 2
      • Toulouse, Frankrike, 31059
        • CHU de Toulouse-Hopital Rangueil
      • Toulouse, Frankrike, 31059
        • Tomography: CHU RANGUEIL
      • Toulouse, Frankrike, 31059
        • Endoscopy: CHU RANGUEIL
      • Toulouse, Frankrike, 31059
        • Pulmonary examination: CHU RANGUEIL
  • Georgia
      • Tbilisi, Georgia, 0131
        • LLC Vivamedi
      • Tbilisi, Georgia, 0160
        • LTD Aversi Clinic
      • Tbilisi, Georgia, 0159
        • LTD Institute of Clinical Cardiology
      • Tbilisi, Georgia, 0112
        • Llc Todua Clinic
      • Tbilisi, Georgia, 0159
        • Medical Center CITO LTD
      • Tbilisi, Georgia, 0160
        • LTD Academician Nikoloz Kipshidze Central University Clinic
      • Tbilisi, Georgia, 0160
        • Aversi Clinic, LTD
      • Tbilisi, Georgia, 0119
        • Llc Todua Clinic
      • Tbilisi, Georgia
        • Malkhaz Katsiashvili Multiprofile Emergency Medicine Center, LTD
      • Tbilisi, Georgia, 0159
        • JSC T. Tsertsvadze Infectious Diseases, AIDS and Clinical Immunology Research Center
      • Tbilisi, Georgia, 0119
        • Israeli-Georgian Medical Research Clinic Healthycore LLC
  • Hviterussland
      • Grodno, Hviterussland, 230023
        • Foreign Medical and Pharmaceutical Unitary Enterprise "Medical Center" Novoe Zrenie"
      • Grodno, Hviterussland, 230026
        • Health Care Institution "City Clinical Hospital #4 Grodno"
      • Grodno, Hviterussland, 230030
        • Healthcare Institution "Grodno University Hospital"
      • Homyel, Hviterussland, 246027
        • Institution "Gomel Regional Specialized Clinical Hospital"
      • Homyel, Hviterussland, 246029
        • Institution "Gomel Regional Clinical Hospital
      • Minsk, Hviterussland, 220096
        • Health care Institution "10th City Clinical Hospital"
      • Vitebsk, Hviterussland, 210009
        • Educational Establishment "Vitebsk State Medical University"
      • Vitebsk, Hviterussland, 210037
        • Health Care Institution "Vitebsk Regional Clinical Hospital"
      • Vitebsk, Hviterussland, 210604
        • Healthcare Institution: Vitebsk Regional Clinical Specialized Center
  • India
      • Nagpur, India, 440009
        • Government Medical College & Super Speciality Hospital
    • Gujarat
      • Surat, Gujarat, India, 395002
        • Surat Institute of Digestive Sciences
      • Surat, Gujarat, India, 395002
        • SIDS Hospital & Research Centre
    • Haryana
      • Gurgaon, Haryana, India, 122002
        • Fortis Memorial Research Institute
    • Maharashtra
      • Nagpur, Maharashtra, India, 440010
        • Midas Multispeciality Hospital Pvt. Ltd
      • Pune, Maharashtra, India, 411001
        • Grant Medical Foundation Ruby Hall Clinic
    • Rajasthan
      • Jaipur, Rajasthan, India, 302001
        • S.R.Kalla Memorial Gastro & General Hospital
    • Uttar Pradesh
      • Kanpur, Uttar Pradesh, India, 208002
        • Post Graduate Department Of Medicine
  • Israel
      • Haifa, Israel, 3104802, POB 4940
        • Bnai Zion Medical Center
      • Jerusalem, Israel, 9103102
        • Shaare Zedek Medical Center
      • Nahariya, Israel, 2210001
        • Galilee Medical Center
      • Petah Tikva, Israel, 4941492
        • Rabin Medical Center
      • Ramat Gan, Israel, 5262000
        • The Chaim Sheba Medical Center
      • Rehovot, Israel, 7661041
        • Kaplan Medical Center
  • Italia
      • Catania, Italia, 95100
        • Azienda Ospedalieria Ospedale Cannizzaro
      • Catanzaro, Italia, 88100
        • Azienda Ospedaliero Universitaria Mater Domini
      • Milan, Italia, 20132
        • IRCCS Ospedale San Raffaele UO di Gastroenterologia e Endoscopia Digestiva
      • Roma, Italia, 00157
        • U.O.C. Gastroenterologia ed Endoscopia Digestiva
      • Roma, Italia, 00168
        • Fondazione Policlinico Universitario Agostino Gemelli IRCCS -CEMAD -UOC di Medicina lnterna e Gastro
    • BARI
      • Castellana Grotte, BARI, Italia, 70013
        • I.R.C.C.S "Saverio De Bellis", Gastroenterologia II
    • Lombardy
      • Brescia, Lombardy, Italia, 25123
        • Spedali Civili di Brescia, U.O. Gastroenterologia
      • Milan, Lombardy, Italia, 20132
        • IRCCS Ospedale San Raffaele, Oculistica
    • Milan
      • Rho, Milan, Italia, 20017
        • ASST Rhodense - U.O.C. di Gastroenterologia ed Endoscopia Digestiva
    • Milano
      • San Donato Milanese, Milano, Italia, 20097
        • I.R.C.C.S Policlinico San Donato
    • Reggio Emilia
      • Modena, Reggio Emilia, Italia, 41124
        • A.O.U. Policlinico di Modena
    • Tuscany
      • Florence, Tuscany, Italia, 50134
        • Azienda Ospedaliero Universitaria Careggi, U.O. Gastroenterologia 2 (St.19)
    • VR
      • Negrar(vr), VR, Italia, 37024
        • Ospedale Sacro Cuore Don Calabria
  • Japan
      • Fukushima, Japan, 960-1295
        • Fukushima Medical University Hospital
      • Osaka, Japan, 540-0006
        • NHO Osaka National Hospital
      • Saga, Japan, 849-8501
        • Saga University Hospital
    • Aichi-ken
      • Nagoya, Aichi-ken, Japan, 457-8511
        • Kojunkai Daido Clinic
      • Toyohashi, Aichi-ken, Japan, 441-8570
        • Toyohashi Municipal Hospital
    • Chiba
      • Kashiwa-shi, Chiba, Japan, 277-0871
        • Tsujinaka Hospital Kashiwanoha
      • Nagareyama-shi, Chiba, Japan, 270-0116
        • Ishii Eye Clinic
      • Sakura, Chiba, Japan, 285-8741
        • Toho University Sakura Medical Center
    • Fukuoka
      • Fukuoka, Fukuoka, Japan, 814-0180
        • Fukuoka University Hospital
      • Kasuga, Fukuoka, Japan, 816-0864
        • Fukuoka Tokushukai Hospital
      • Kasuga-shi, Fukuoka, Japan, 816-0863
        • Takimoto Eye Clinic(OCT)
      • Kitakyushu, Fukuoka, Japan, 806-8501
        • Japan Community Health Care Organization Kyushu Hospital
      • Kitakyushu-shi, Fukuoka, Japan, 807-1266
        • Koyanose Eye Clinic
      • Kurume, Fukuoka, Japan, 830-8543
        • Our Lady of the Snow St. Mary's Hospital
      • Onga-gun, Fukuoka, Japan, 807-0051
        • Fukuoka Shinmizumaki Hospital
    • Gifu
      • Gifu, Gifu, Japan, 501-1194
        • Gifu University Hospital
    • Gunma
      • Ota-shi, Gunma, Japan, 373-8585
        • SUBARU Health Insurance Society Ota Memorial Hospital
    • Hiroshima
      • Fukuyama, Hiroshima, Japan, 720-8520
        • National Hospital Organization Fukuyama Medical Center
      • Fukuyama-shi, Hiroshima, Japan, 720-0822
        • Nakayama EYE Clinic
      • Hiroshima, Hiroshima, Japan, 734-8551
        • Hiroshima University Hospital
    • Hokkaido
      • Asahikawa-shi, Hokkaido, Japan, 070-8610
        • Asahikawa City Hospital
      • Sapporo, Hokkaido, Japan, 004-0041
        • Tokushukai Sapporo Tokushukai Hospital
    • Ibaraki
      • Higashiibaraki-gun, Ibaraki, Japan, 311-3193
        • NHO Mito Medical Center
      • Toride-shi, Ibaraki, Japan, 302-0014
        • Matsumoto Eye Clinic
    • Ishikawa-ken
      • Kanazawa, Ishikawa-ken, Japan, 920-8650
        • NHO Kanazawa Medical Center
    • Iwate
      • Morioka, Iwate, Japan, 020-8505
        • Iwate Medical University Uchimaru Medical Center
    • Kagawa-ken
      • Takainatsu-shi, Kagawa-ken, Japan, 760-8557
        • Kagawa Prefectural Central Hospital
      • Takamatsu, Kagawa-ken, Japan, 760-0017
        • Takamatsu Red Cross Hospital
    • Kagoshima-ken
      • Kagoshima, Kagoshima-ken, Japan, 892-0846
        • Sameshima Hospital
      • Kagoshima, Kagoshima-ken, Japan, 890-0062
        • JA- Kagoshima Koseiren Hospital (PET/DLCO)
      • Kagoshima, Kagoshima-ken, Japan, 892-0824
        • Jiaikai Idzuro Imamura Hospital
      • Kagoshima, Kagoshima-ken, Japan, 892-0825
        • Sameshima Eye Clinic (OCT)
    • Kanagawa
      • Sagamihara, Kanagawa, Japan, 252-5188
        • Sagamihara Kyodo Hospital
      • Yokohama, Kanagawa, Japan, 234-0054
        • Social Welfare Organization Imperial Gift Foundation,Inc.Saiseikai Yokohamashi Nanbu Hospital
    • Kumamoto
      • Kumamoto, Kumamoto, Japan, 861-8520
        • Japanese Red Cross Kumamoto Hospital
    • Kyoto
      • Kyoto, Kyoto, Japan, 602-8566
        • University Hospital Kyoto Prefectural University of Medicine
      • Kyoto, Kyoto, Japan, 612-8555
        • National Hospital Organization Kyoto Medical Center
    • Mie-ken
      • Tsu, Mie-ken, Japan, 514-8507
        • Mie University Hospital
      • Yokkaichi- Shi, Mie-ken, Japan, 510-0891
        • Hinaga Nishi Ophthalmology Clinic
      • Yokkaichi-shi, Mie-ken, Japan, 510-8561
        • Mie Prefectural General Medical Center
    • Miyagi
      • Sendai, Miyagi, Japan, 981-8563
        • JOHAS Tohoku Rosai Hospital
      • Sendai, Miyagi, Japan, 982-8502
        • Sendai City Hospital
    • Niigata
      • Nagaoka-shi, Niigata, Japan, 940-2085
        • Nagaoka Red Cross Hospital
    • Osaka
      • Hirakata-shi, Osaka, Japan, 573-1191
        • Kansai Medical University Hospital
      • Osaka, Osaka, Japan, 553-0003
        • Japan Community Health care Organization Osaka Hospital
    • Shizuoka
      • Hamamatsu, Shizuoka, Japan, 431-3192
        • Hamamatsu University Hospital
      • Hamamatsu, Shizuoka, Japan, 432-8580
        • Hamamatsu Medical Center
      • Hamamatsu, Shizuoka, Japan, 432-8061
        • Matsuda Hospital
    • Tokyo
      • Chuo-ku, Tokyo, Japan, 104-8560
        • St. Luke's International Hospital
      • Itabashi-ku, Tokyo, Japan, 173-8606
        • Teikyo University Hospital
      • Kodaira-shi, Tokyo, Japan, 187-8510
        • Showa General Hospital
      • Minato-ku, Tokyo, Japan, 108-8642
        • Kitasato University Kitasato Institute Hospital
      • Shinjuku-ku, Tokyo, Japan, 169-0073
        • JCHO Tokyo Yamate Medical Center
    • Wakayama
      • Wakayama, Wakayama, Japan, 641-8510
        • Wakayama Medical University Hospital
    • Yamanashi
      • Kofu, Yamanashi, Japan, 400-8506
        • Yamanashi Prefectural Central Hospital
  • Kroatia
      • Zadar, Kroatia, 23000
        • General Hospital Zadar
      • Zagreb, Kroatia, 10000
        • University Hospital Center Zagreb
  • Latvia
      • Riga, Latvia, LV-1002
        • P. Stradins Clinical University Hospital, Gastroenterology, Hepatology and Nutrition Therapy Center
  • Libanon
      • Beirut, Libanon
        • American University of Beirut Medical center
  • Litauen
      • Panevezys, Litauen, LT-35144
        • Consultancy Polyclinic of Republican Panevezys Hospital
      • Panevezys, Litauen, LT-35144
        • Republican Panevezys Hospital
      • Vilnius, Litauen, LT-08661
        • Vilnius University Hospital Santaros Klinikos
      • Vilnius, Litauen, 08661
        • Vilnius University Hospital Santaros Klinikos
      • Vilnius, Litauen, 08234
        • UAB "Northway", Medical and Surgical Centre
      • Vilnius, Litauen, 08406
        • UAB "Inlita", Santaros Clinical Trials Centre
  • Mexico
      • Chihuahua City, Mexico, 31203
        • Scientia, Investigacion Clinica S.C.
      • Chihuahua City, Mexico, 31207
        • Scientia Investigación Clínica S.C
      • Irapuato, Mexico, 36520
        • Invesclinic MX
      • Veracruz, Mexico, 91900
        • FAICIC S. de R.L. de C.V.
      • Veracruz, Mexico, 91900
        • Servicios Medicos y de lnvestigacion Clinica Inspirepharma S. de R.L. de C.V.
    • Jalisco
      • Guadalajara, Jalisco, Mexico, 44130
        • Centro de lnvestigacion Medico Biologica y Terapia Avanzada S.C.
    • Nuevo León
      • Monterrey, Nuevo León, Mexico, 64660
        • Servicios Medicos y de lnvestigacion Clinica Inspirepharma S. de R.L. de C.V.
  • Moldova
      • Chisinau, Moldova, 2025
        • IMSP Institutul de Ftiziopneumologie "Chiril Draganiuc"
      • Chisinau, Moldova, 2025
        • IMSP Spitalul Clinic Republican "Timofei Mosneaga"
      • Chisinau, Moldova, 2038
        • Spitalul Polivalent Novamed
  • Polen
      • Bialystok, Polen, 15-044
        • Centrum Medycyny Oddechowej, Mroz Spolka Jawna (PFT, DLCO)
      • Bialystok, Polen, 15-322
        • Gastromed Kralisz, Romatowski, Stachurska sp.j.
      • Bialystok, Polen, 15-453
        • LSSP Eskulap (OCT, Ophthalmoscopy)
      • Będzin, Polen, 42-500
        • Centrum Dentystyczno-Lekarskie PROMEDICA Joanna Markiewicz
      • Gdansk, Polen, 80-402
        • Dobry Wzrok (OCT)
      • Gdynia, Polen, 81-366
        • Poradnia Pulmonologiczna
      • Jelenia Góra, Polen, 58-500
        • Karkonoskie Centrum Badan Klinicznych - Lexmedica Spolka z ograniczona odpowiedzialnoscia
      • Jelenia Góra, Polen, 58-506
        • PROMED Centrum Medyczne (OCT, ophthalmoscopy)
      • Lodz, Polen, 90-752
        • IP Clinic Sp. z o.o.
      • Nowy Targ, Polen, 34-400
        • Allmedica Badania Kliniczne Sp. z o.o. Sp. k.
      • Oświęcim, Polen, 32-600
        • Medicome Sp. z o.o.
      • Rzeszów, Polen, 35-326
        • Centrum Medyczne Medyk
      • Sopot, Polen, 81-756
        • Endoskopia Sp. z o.o.
      • Sosonowiec, Polen, 41-209
        • Kiepury Clinic Malgorzata Jarnot Specjalistyczna Praktyka Ginekologiczno
      • Swidnica, Polen, 58-100
        • DC-MED Sp. z o.o.
      • Szczecin, Polen, 71-434
        • Twoja Przychodnia-Szczecinskie Centrum Medyczne
      • Warsaw, Polen, 00-635
        • Centrum Zdrowia MDM
      • Warsaw, Polen, 02-507
        • Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych Administracji
      • Wroclaw, Polen, 52-416
        • Centrum Medyczne Oporow
    • Greater Poland Voivodeship
      • Poznan, Greater Poland Voivodeship, Polen, 60-681
        • NSZOZ Termedica - Centrum Badan Klinicznych
    • Other
      • Wroclaw, Other, Polen, 54-239
        • Penta Hospitals Przychodnie
    • Łódź Voivodeship
      • Lodz, Łódź Voivodeship, Polen, 91-495
        • Amicare Sp. z o.o. Sp.k.
  • Portugal
      • Coimbra, Portugal, 3004-561
        • Unidade Local de Saude de Coimbra, E.P.E
      • Guimarães, Portugal, 4835-044
        • Hospital Senhora da Oliveira Guimaraes, E.P.E
      • Porto, Portugal, 4200-319
        • Centro Hospitalar Universitario de Sao Joao, E.P.E
    • Porto District
      • Vila Nova de Gaia, Porto District, Portugal, 4434-502
        • Centro Hospitalar de Vila Nova de Gaia/Espinho, EPE
  • Romania
      • Bucharest, Romania, 014461
        • S.C. Euroclinic Hospital S.A.
      • Bucharest, Romania, 13823
        • Spitalul de Oncologie Monza
      • Cluj-Napoca, Romania, 400371
        • Spitalul Clinic de Pneumoftiziologie Leon Daniello Cluj-Napoca
    • Bihor County
      • Oradea, Bihor County, Romania, 410469
        • SC Pelican lmpex SRL
    • Cluj
      • Cluj-Napoca, Cluj, Romania, 400501
        • Oculens Med S.R.L.
    • JUD. CLUJ
      • Cluj-Napoca, JUD. CLUJ, Romania, 400006
        • Spitalul Clinic Judetean de Urgenta Cluj-Napoca
  • Russland
      • Irkutsk, Russland, 664049
        • Irkutsk State Medical Academy of Postgraduate Education
      • Irkutsk, Russland, 664049
        • Professional Education" of MoH of RF
      • Izhevsk, Russland, 426061
        • LLC "Alliance Biomedical -Ural Group"
      • Kemerovo, Russland, 650066
        • SAIH "Kemerovo Regional Clinical Hospital"
      • Nizhny Novgorod, Russland, 603126
        • State Budgetary Healthcare Instit. of Nizhniy Novgorod region
      • Novosibirsk, Russland, 630005
        • LLC "SibNovoMed"
      • Novosibirsk, Russland, 630007
        • LLC "Novosibirsk GastroCenter"
      • Novosibirsk, Russland, 630084
        • State Budgetary Healthcare Institution of Novosibirsk region "City clinical hospital # 12"
      • Novosibirsk, Russland, 63009
        • Medical center "AVITSENNA"
      • Omsk, Russland, 644024
        • Clinicodiagnostic center "Ultramcd"
      • Penza, Russland, 440026
        • State Budgetary Healthcare Institution "Penza Region Clinical Hospital n.a. N.N. Burdenko"
      • Saint Petersburg, Russland, 191015
        • Federal State Budgetary Ed. Inst. of Higher Education "North-Western Medical University n.a. I.I.
      • Saint Petersburg, Russland, 191015
        • FSBEI of Higher Education "North-Western State Medical University n.a. I.I. Mechnikov" of MoH RF
      • Saint Petersburg, Russland, 194104
        • Spb SBIH "City Mariinskaya Hospital"
      • Saint Petersburg, Russland, 195279
        • LLC "Medi com" (SM-Clinic)
      • Saint Petersburg, Russland, 197022
        • FSBEI of Higher Education "First Saint Petersburg State Medical University n.a. I.P. Pavlov"
      • Saint Petersburg, Russland, 197110
        • LLC "Gastroenterological centre Expert"
      • Saint Petersburg, Russland, 197706
        • St.Petersburg State Budgetary Healthcare Institution "City Hospital #40 of Kurortnyi region"
      • Samara, Russland, 443001
        • Private Educational Institution of Higher Education "Medical University "Reaviz", Multifield Clinic
      • Samara, Russland, 443093
        • LLC Medical company "Hepatologist"
      • Stavropol, Russland, 355017
        • Autonomous Noncommercial Medical Organizations "Stavropol Regional Clinical Diagnostic Centre''
      • Stavropol, Russland, 355032
        • Autonomous Noncommercial Medical Organizations " Stavropol Regional Clinical Diagnostic Centre ''
      • Stavropol, Russland, 355044
        • City Polyclinic #9
      • Yaroslavl, Russland, 150030
        • State Healthcare Institution of Yaroslavl Region "Clinical Hospital No 2"
    • Altayskiy Kray
      • Barnaul, Altayskiy Kray, Russland, 656043
        • LLC "Multidisciplinary Medical Clinic "Anturium"
    • Samara Oblast
      • Samara, Samara Oblast, Russland, 443063
        • LLC Medical company "Hepatologist"
    • Stavropol Kray
      • Pyatigorsk, Stavropol Kray, Russland, 357500
        • LLC "Polyclinic of ultrasonography 4D"
  • Serbia
      • Belgrade, Serbia, 11000
        • Clinical Center Zvezdara
      • Belgrade, Serbia, 11000
        • Clinical Center " Dr Dragisa Misovic-Dedinje"
      • Sremska Mitrovica, Serbia, 22000
        • General Hospital Sremska Mitrovica
  • Slovakia
      • Banská Bystrica, Slovakia, 97517
        • Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica, II. Interna klinika SZU
      • Bardejov, Slovakia, 08501
        • ALIAN, s.r.o.
      • Bardejov, Slovakia, 08501
        • GASTROMART s.r.o., Gastroenterologicka ambulancia
      • Košice, Slovakia, 04011
        • 3F, s.r.o., Oftalmologicka ambulancia
      • Levice, Slovakia, 934 01
        • OCULOSANUS, s.r.o., Oftalmologicka ambulancia
      • Lipany, Slovakia, 053 04
        • MUDr. Michal Popovec, s.r.o., Oftalmologicka ambulancia
      • Nitra, Slovakia, 950 01
        • Fakultna nemocnica Nitra
      • Nitra, Slovakia, 94901
        • KM Management, spol. s r.o .. Gastroenterologicke a hepatologicke centrum
      • Nitra, Slovakia, 950 01
        • Fakultna nemocnica Nitra, Oftalmologicka ambulancia
      • Nitra, Slovakia, 950 01
        • Fakultna nemocnica Nitra, Pneumologicka ambulancia
      • Prešov, Slovakia, 080 01
        • GASTRO I., s.r.o. Gastroenterologicka ambulancia
      • Prešov, Slovakia, 080 01
        • PULMO, s.r.o., Plucna ambulancia
      • Vranov nad Topľou, Slovakia, 093 01
        • PULMOX spol. s r.o., Pneumologicko-ftizeologicka ambulancia
      • Vranov nad Topľou, Slovakia, 093 01
        • ENDOMED. s.r.o., Gastroenterologicka ambulancia
      • Šahy, Slovakia, 936 01
        • Accout Center, s.r.o., Gastroenterologická ambulancia
      • Šahy, Slovakia, 936 01
        • COR, s.r.o., Pneumologicko-ftizeologicka ambulancia
  • Spania
      • Madrid, Spania, 28046
        • Hospital Universitario La Paz
    • Valencia
      • Alicante, Valencia, Spania, 03010
        • Hospital General Universitario de Alicante
  • Storbritannia
      • London, Storbritannia, SE1 9RT
        • Guy's and St Thomas' NHS Foundation Trust
      • London, Storbritannia, E11 1NR
        • Barts Health NHS Trust - Whipps Cross University Hospital
    • Somerset
      • Yeovil, Somerset, Storbritannia, BA21 4AT
        • Yeovil District Hospital NHS Foundation Trust
  • Sør -Korea
      • Busan, Sør -Korea, 49201
        • Dong-A University Hospital
      • Daegu, Sør -Korea, 41404
        • Kyungpook National University Chilgok Hospital
      • Daegu, Sør -Korea, 41944
        • Kyungpook National University Hospital
      • Daegu, Sør -Korea, 41404
        • Endoscopy Facility in Kyungpook National University Chilgok Hospital
      • Daegu, Sør -Korea, 41404
        • OCT Facility in Kyungpook National University Chilgok Hospital
      • Daegu, Sør -Korea, 41404
        • PFT Facility in Kyungpook National University Chilgok Hospital
    • Gangwon-do
      • Wŏnju, Gangwon-do, Sør -Korea, 26426
        • Yonsei University Wonju Severance Christian Hospital
    • Gyeonggi-do
      • Suwon, Gyeonggi-do, Sør -Korea, 16247
        • Endoscopy Facility in The Catholic University of Korea, St. Vincent's Hospital
      • Suwon, Gyeonggi-do, Sør -Korea, 16247
        • OCT Facility in The Catholic University of Korea, St. Vincent's Hospital
      • Suwon, Gyeonggi-do, Sør -Korea, 16247
        • PFT Facility in The Catholic University of Korea, St. Vincent's Hospital
      • Suwon, Gyeonggi-do, Sør -Korea, 16427
        • The Catholic University of Korea, St. Vincent's Hospital
  • Sør-Afrika
      • Centurion, Sør-Afrika, 1692
        • Dr Fritz Potgieter, Midstream Medi Clinic
    • Gauteng
      • Centurion, Gauteng, Sør-Afrika, 0157
        • Unitas Hospital
      • Centurion, Gauteng, Sør-Afrika, 0157
        • Johese Clinical Research:Unitas
      • Centurion, Gauteng, Sør-Afrika, 0157
        • Johese Clinical Research: Midstream
    • Western Cape
      • Cape Town, Western Cape, Sør-Afrika, 7708
        • Dr John Philip Wright
  • Thailand
      • Bangkok, Thailand, 10330
        • Chulalongkorn University, King Chulalongkorn Memorial Hospital
    • Bangkok
      • Bangkoknoi, Bangkok, Thailand, 10700
        • Siriraj Hospital, Mahidol University
  • Tsjekkia
      • Brno, Tsjekkia, 656 91
        • Fakultni nemocnice u svate Anny v Brne
      • Hradec Králové, Tsjekkia, 500 12
        • Hepato-gastroenterologie HK, s.r.o.
      • Klatovy, Tsjekkia, 339 01
        • GASTRO JeKa, s.r.o.
      • Olomouc, Tsjekkia, 779 00
        • PreventaMed s.r.o.
      • Ostrava-Poruba, Tsjekkia, 708 52
        • Fakultni nemocnice Ostrava
      • Prague, Tsjekkia, 150 00
        • Axon Clinical, s.r.o.
      • Prague, Tsjekkia, 190 00
        • ISCARE a.s.
      • Prague, Tsjekkia, 180 81
        • Nemocnice Na Bulovce
      • Slaný, Tsjekkia, 274 01
        • Nemocnice Slany
  • Tyrkia (Türkiye)
      • Ankara, Tyrkia (Türkiye), 06500
        • Gazi University Medical Faculty
      • Ankara, Tyrkia (Türkiye), 06100
        • Hacettepe University Medical Faculty
      • Ankara, Tyrkia (Türkiye), 06560
        • Gazi University Medical Faculty
      • Antalya, Tyrkia (Türkiye), 07030
        • Saglik Bilimleri Universitesi Antalya Egitim ve Arastirma Hastanesi
      • Bursa, Tyrkia (Türkiye), 16059
        • Uludag University Medical Faculty
      • Kocaeli, Tyrkia (Türkiye), 41380
        • Kocaeli University Medical Faculty
  • Tyskland
      • Berlin, Tyskland, 14163
        • Krankenhaus Waldfriede e.V.,
      • Berlin, Tyskland, 10117
        • Charite Universitaetsmedizin Berlin - Campus Charite Mitte Medizinische Klinik m. S. Hepatologie
      • Berlin, Tyskland, 14163
        • Dr. med Zacharias A. R.Sherif
      • Bonn-Duisdorf, Tyskland, 53123
        • Schwerpunktpraxis Bonn
      • Neuss, Tyskland, 41462
        • Johanna-Etienne-Krankenhaus
      • Neuss, Tyskland, 41462
        • OCT address: AOZNeuss Dr. Kersten
      • Remscheid, Tyskland, 42859
        • Praxis Dr. Jorgensen
  • Ukraina
      • Dnipro, Ukraina, 49005
        • Communal Institution I.I. Mechnykov Dnipropetrovsk Regional Clinical Hospital, Department of
      • Ivano-Frankivsk, Ukraina, 76000
        • Clinical Diagnostical Center "Simedgroup"
      • Ivano-Frankivsk, Ukraina, 76000
        • Communal Non-commercial Enterprise Regional Clinical Hospital of lvano-Frankivsk Regional Council,
      • Kharkiv, Ukraina, 61022
        • Llc "Ldts-Skaymed"
      • Kharkiv, Ukraina, 61045
        • Llc Medical Center Oftalmika
      • Kharkiv, Ukraina, 61018
        • Municipal Health Care "Kharkiv City Hospital Ambulance and Emergency Medical care named alter prof.
      • Kharkiv, Ukraina, 61024
        • LLC "EyeQClinic"
      • Kharkiv, Ukraina, 61037
        • Communal Noncommercial Enterprise Prof. O.O.Shalimov City Clinical Hospital #2 of Kharkiv City
      • Kharkiv, Ukraina, 61124
        • Communal Noncommercial Enterprise City Clinical Hospital # 13 of Kharkiv City Council,
      • Kherson, Ukraina, 73000
        • Communal Noncommercial Enterprise Ye.Ye. Karabelesh Kherson City
      • Kherson, Ukraina, 73003
        • LLC "Diagnostic center"
      • Kyiv, Ukraina, 02091
        • Kyiv City Clinical Hosptial #1, Department of Clinical Research at the Special Fund
      • Lviv, Ukraina, 79059
        • Communal Noncommercial Enterprise Lviv Clinical Emergency Hospital, 1st Department of Therapy
      • Odesa, Ukraina, 65025
        • Communal Institution Odesa Regional Clinical Hospital, Regional Center of Gastroenterology,
      • Odesa, Ukraina, 65025
        • LLC GLB Clinik
      • Uzhagorod, Ukraina, 88018
        • Andrii Novak Transcarpathian Regional Clinical Hospital, Department of Gastroenterology
      • Uzhhorod, Ukraina, 88017
        • Transcarpathian Center of Eye Microsurgery
      • Vinnytsia, Ukraina, 21009
        • Medical Clinical Investigational Center of Med Center LLC Health Clinic, Unit of Gastroenterology,
      • Vinnytsia, Ukraina, 21018
        • Communal Nonprofit Enterprise M.I.Pyrogov Vinnytsia Regional Clinical Hospital of Vinnytsia Regional
      • Vinnytsia, Ukraina, 21029
        • Scientific and Research Institute of Invalid Rehabilitation (Educational and Scientific Treatment
      • Vinnytsia, Ukraina, 21036
        • Llc "Optimal M"
  • Ungarn
      • Budapest, Ungarn, 1088
        • Semmelweis Egyetem
      • Budapest, Ungarn, 1136
        • Pannonia Maganorvosi Centrum
      • Budapest, Ungarn, 1062
        • Pulmonary function tests: Vasutegeszsegugyi Nonprofit Kozhasznu Kft.
      • Budapest, Ungarn, 1068
        • Ophthalmology tests: Magyar Honvedseg Egeszsegugyi Kozpont
      • Gyöngyös, Ungarn, 3200
        • Gyongyosi Bugat Pal Korhaz
      • Szekszárd, Ungarn, 7100
        • Tolna Varmegyei Balassa Janos Korhaz
      • Veszprém, Ungarn, 8230
        • Ophthalmology tests: RETINASZERVIZ Kft.
    • Bekes County
      • Gyula, Bekes County, Ungarn, 5700
        • Ophthalmology tests:Bekes Megyei Kozponti Korhaz, Pady Kalman Tagkorhaz, Szemeszeti Osztaly
      • Gyula, Bekes County, Ungarn, 5600
        • Bekes Megyei Kozponti Korhaz Dr. Rethy Pal Tagkorhaz, 4. Belgyogyaszat es 2. Gasztroenterologia
    • Fejér
      • Székesfehérvár, Fejér, Ungarn, 8000
        • Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
    • Tolna County
      • Szekszárd, Tolna County, Ungarn, 7100
        • Clinfan Szolgaltato Kft.
    • Veszprém megye
      • Ajka, Veszprém megye, Ungarn, 8400
        • Endoscopy: Magyar Imre Korhaz
      • Balatonfüred, Veszprém megye, Ungarn, 8230
        • DRC Gyogyszervizsgalo Kozpont Kft.
      • Tapolca, Veszprém megye, Ungarn, 8300
        • Pulmonary function tests, endoscopy: Deak Jeno Korhaz
  • Østerrike
      • Vienna, Østerrike, 1090
        • Department of Internal Medicine III, Clinical Division of Gastroenterology and Hepatology

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

16 år til 80 år (Barn, Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Beskrivelse

Inklusjonskriterier:

  • Må ha oppfylt kvalifikasjonskriteriene og ha blitt registrert i de kvalifiserte fase 2 eller 3 foreldrestudiene og oppfylle følgende tilleggskriterier:

    1. Deltakere som tidligere er registrert i studien APD334-301 (NCT03945188) eller APD334-210 (NCT04607837) må ha fullført uke 12-besøket og ha blitt vurdert til å ha aktiv UC som ikke har forbedret seg eller har forverret seg fra baseline eller fullført uke 52-besøket
    2. Deltakere som tidligere er registrert i APD334-302 (NCT03996369) må ha fullført uke 12-besøket

Ekskluderingskriterier:

  • Hvis etterforsker anser deltakeren for å være uegnet av en eller annen grunn til å delta i Open-Label Extension-studien
  • Opplevde en uønsket hendelse som førte til seponering fra foreldrestudien

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Behandling
  • Tildeling: N/A
  • Intervensjonsmodell: Enkeltgruppeoppdrag
  • Masking: Ingen (Open Label)

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Eksperimentell: Etrasimod 2 mg
Legemiddel: Etrasimod
Etrasimod 2 mg tablett gjennom munnen, én gang daglig i opptil ca. 8 år eller inntil markedsføringstillatelse er oppnådd i deltakerens land, avhengig av hva som kommer først
Andre navn:
  • APD334

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Antall og alvorlighetsgrad av sikkerhetstiltak
Tidsramme: Opptil ca 8 år
Sikkerhet som vurderes ved evaluering av uønskede hendelser
Opptil ca 8 år

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Andel av deltakere som oppnår klinisk remisjon vurdert av Mayo Component Sub-scores
Tidsramme: Uke 52 og uke 104
Uke 52 og uke 104
Andel deltakere som oppnår klinisk remisjon ved uke 52 og 104 blant deltakere som oppnår klinisk remisjon ved studiestart
Tidsramme: Uke 52 og uke 104
Uke 52 og uke 104
Endring fra baseline i den totale Mayo-score
Tidsramme: Baseline, uke 52 og uke 104
Den totale Mayo-score er et verktøy utviklet for å måle sykdomsaktivitet for ulcerøs kolitt. Poengsummen varierer fra 0 til 12 poeng og består av 4 komponenter (endoskopisk poengsum, rektal blødning, avføringsfrekvens og legenes globale vurdering), hver gradert 0 til 3 (0 = normal, 1 = mild, 2 = moderat, 3 = alvorlig) med høyere poengsum som indikerer mer alvorlig sykdom.
Baseline, uke 52 og uke 104
Andel av deltakere som oppnår endoskopisk forbedring vurdert av Mayo Component Sub-scores
Tidsramme: Uke 52 og uke 104
Uke 52 og uke 104
Andel av deltakere som oppnår klinisk respons vurdert av Mayo Component Sub-scores
Tidsramme: Uke 52 og uke 104
Uke 52 og uke 104
Endring fra baseline i delvis Mayo-score
Tidsramme: Baseline, uke 52, uke 104, uke 156, uke 208 og uke 260
Den delvise Mayo-skåren er et verktøy utviklet for å måle sykdomsaktivitet for ulcerøs kolitt. Poengsummen varierer fra 0 til 9 poeng og består av 3 ikke-invasive komponenter (rektal blødning, avføringsfrekvens og legenes globale vurdering), hver gradert 0 til 3 (0 = normal, 1 = mild, 2 = moderat, 3 = alvorlig) med høyere poengsum som indikerer mer alvorlig sykdom.
Baseline, uke 52, uke 104, uke 156, uke 208 og uke 260

Andre resultatmål

Resultatmål
Tidsramme
Prosentandel av deltakere med histologisk forbedring vurdert av Geboes, Robarts og Nancy Histopatology-poeng
Tidsramme: Uke 52 og uke 104
Uke 52 og uke 104
Prosentandel av deltakere med histologisk remisjon vurdert av Geboes, Robarts og Nancy Histopatology Scores
Tidsramme: Uke 52 og uke 104
Uke 52 og uke 104
Tid til tap av respons Vurdert av Mayo Component Sub-scores
Tidsramme: Opp til uke 260
Opp til uke 260
Andel deltakere som oppnår forbedring i ekstraintestinale manifestasjoner (EIM) hos deltakere med EIM ved baseline
Tidsramme: Grunnlinje, uke 12, uke 52, uke 104, uke 156, uke 208 og uke 260
Grunnlinje, uke 12, uke 52, uke 104, uke 156, uke 208 og uke 260

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Pfizer

Samarbeidspartnere

Arena is a wholly owned subsidiary of Pfizer

Etterforskere

  • Studieleder: Pfizer CT.gov Call Center, Pfizer

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Hjelpsomme linker

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

5. september 2019

Primær fullføring (Antatt)

19. juni 2029

Studiet fullført (Antatt)

19. juni 2029

Datoer for studieregistrering

Først innsendt

13. mai 2019

Først innsendt som oppfylte QC-kriteriene

13. mai 2019

Først lagt ut (Faktiske)

15. mai 2019

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

9. juli 2026

Siste oppdatering sendt inn som oppfylte QC-kriteriene

8. juli 2026

Sist bekreftet

1. juli 2026

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

  • APD334-303
  • C5041012 (Annen identifikator: Alias Study Number)
  • 2024-515156-21-00 (Registeridentifikator: CTIS (EU))

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

JA

IPD-planbeskrivelse

Pfizer vil gi tilgang til individuelle avidentifiserte deltakerdata og relaterte studiedokumenter (f.eks. protokoll, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) på forespørsel fra kvalifiserte forskere, og underlagt visse kriterier, betingelser og unntak. Ytterligere detaljer om Pfizers datadelingskriterier og prosess for å be om tilgang finnes på: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Ja

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Abonnere