Renal Tubular Disorders in Egyptian Children

Patterns of Renal Tubular Disorders in Egyptian Children: a Single Center Study

Renal tubules play an important role in fluid, electrolyte, and acid-base homeostasis. Defect of these functions can give rise to a host of disorders. These disorders can lead to life threatening disturbances in electrolytes and acid-base balance. In Egypt, there is little data about these disorders. Many of these cases are diagnosed late, therefore Early suspicion for diagnosis can improve the overall clinical outcome of these children.

Study Overview

• Status: Completed
• Conditions: Renal Tubular Disorders in Children

Detailed Description

Renal tubules play an important role in fluid, electrolyte, and acid-base homeostasis. Defect of these functions can give rise to a host of disorders. These disorders can lead to life threatening disturbances in electrolytes and acid-base balance. In Egypt, there is little data about these disorders. Many of these cases are diagnosed late, therefore Early suspicion for diagnosis can improve the overall clinical outcome of these children. As a result, starting management early will help those children have a better life. Therefore awareness about these disorders and long-term outcome is really important. The investigators present the clinical characterizations of many tubular disorder and the follow up in our center.

The aim of this study is to reveal the different clinical presentations and the main lab features of renal tubular disorders in children to promote early recognition and management.

• Study Type: Observational
• Enrollment (Actual): 58

Contacts and Locations

Study Locations

• Egypt
  • Sohag, Egypt, 82516
    • pediatric department, Sohag university hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 1 month to 18 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

all children who have renal tubular disorders (inpatient and outpatient) in the Paediatric Department, Sohage University Hospital.

Description

Inclusion Criteria:

• All children aged from one month to 18 years who have renal tubular disorders.

Exclusion Criteria:

• Children who have renal tubular disorders secondary to drugs, intoxication, obstructive uropathy or transient in nature.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
weight	in kilograms	1 years
Glomerular function	The glomerular function was assessed by estimated glomerular filtration rate (eGFR) calculated using Schwartz formula. Chronic kidney disease (CKD) was defined in the presence of a permanent reduction in GFR (e-GFR; <60 ml/min/1.73 m2 Kidney Disease Outcomes Quality Initiative < stage 3).	1 years
height	in meters	1 years

Collaborators and Investigators

• Sponsor: Sohag University

Study record dates

Study Major Dates

• Study Start (Actual): April 23, 2021
• Primary Completion (Actual): December 9, 2021
• Study Completion (Actual): January 7, 2022

Study Registration Dates

• First Submitted: April 12, 2021
• First Submitted That Met QC Criteria: April 13, 2021
• First Posted (Actual): April 15, 2021

Study Record Updates

• Last Update Posted (Actual): February 7, 2022
• Last Update Submitted That Met QC Criteria: January 22, 2022
• Last Verified: April 1, 2021

More Information

Terms related to this study

• Keywords: hypokalemia; metabolic acidosis; failure to thrive; renal tubular disorders; metabolic alkalosis
• Additional Relevant MeSH Terms: Pathologic Processes; Disease
• Other Study ID Numbers: Soh-Med-21-04-04

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: undecided

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No