Hangzhou Hospital Staff Cohort (HHSC)

April 26, 2022 updated by: Westlake University
The Hangzhou Hospital Staff Cohort (HHSC) is a prospective cohort study among staffs from three hospitals located in Hangzhou, China, including the Hangzhou First People's Hospital, Hangzhou Women's Hospital, and Hangzhou Red Cross Hospital. Participants recruitment and baseline survey including anthropometric, lifestyle and clinical measurement, as well as biological samples collection are initiated in January 2021. Recruited hospital staff are followed up every year during the medical examination organized by their employer. The primary aim of the HHSC study is to investigate the prospective associations of diet, physical activities, sleep, and other lifestyle factors with the long-term metabolic health of the hospital staffs. The secondary aim of the HHSC study is to integrate multi-omics data including genomics, metabolomics, proteomics and microbiome by a machine learning algorithm, to probe into the complex mediating roles of gene, metabolism and gut microbiota linking lifestyle factors with metabolic health.

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Anticipated)

3000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310058
        • Hangzhou First People's Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients who are serving staffs from the Hangzhou Frirst People's Hospital, Hangzhou Women's Hospital, and Hangzhou Red Cross Hospital are recruited.

Description

Inclusion Criteria:

  • Participants aged 18 years or older
  • Serving staffs of designated hospitals

Exclusion Criteria:

  • Participants with cancer
  • Participants with other serious medical disorders

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L
Time Frame: 3 years after enrollment
Fasting blood glucose is measured every year during follow-up
3 years after enrollment
Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L
Time Frame: 6 years after enrollment
Fasting blood glucose is measured every year during follow-up
6 years after enrollment
Incidence of type 2 diabetes diagnosed as fasting blood glucose larger than 7.0 mmol/L
Time Frame: 9 years after enrollment
Fasting blood glucose is measured every year during follow-up
9 years after enrollment

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change of body mass index
Time Frame: Change from baseline at 3 years
Participants' body weight and height was measured to calculate body mass index every year during follow-up
Change from baseline at 3 years
Change of body mass index
Time Frame: Change from baseline at 6 years
Participants' body weight and height was measured to calculate body mass index every year during follow-up
Change from baseline at 6 years
Change of body mass index
Time Frame: Change from baseline at 9 years
Participants' body weight and height was measured to calculate body mass index every year during follow-up
Change from baseline at 9 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Westlake University

Collaborators

First People's Hospital of Hangzhou
Red Cross Hospital, Hangzhou, China
Hangzhou Women's Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 30, 2020

Primary Completion (Anticipated)

December 31, 2029

Study Completion (Anticipated)

December 31, 2029

Study Registration Dates

First Submitted

April 5, 2021

First Submitted That Met QC Criteria

May 26, 2021

First Posted (Actual)

June 2, 2021

Study Record Updates

Last Update Posted (Actual)

April 28, 2022

Last Update Submitted That Met QC Criteria

April 26, 2022

Last Verified

April 1, 2022

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 20201221ZJS001

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

IPD Plan Description

Undecided

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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