- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05228548
Machine Learning Model for Perioperative Transfusion Prediction
March 7, 2022 updated by: DILEK YAZICIOGLU, Diskapi Teaching and Research Hospital
Development and Interpretation of a Machine Learning Model for Perioperative Transfusion Prediction
This study aimed to develop and interpret a machine learning model to predict red blood cell (RBC) transfusion.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
A dataset from a multicenter study involving 6121 patients underwent elective major surgery was analysed.
Data concerning patients who received inappropriate RBC transfusion were excluded.
Twenty one perioperative features were used to predict RBC transfusion.
The data set was randomly split into train and validation sets (70-30).
Decision tree, random forest, k-nearest neighbors, logistic regression, and eXtreme garadient boosting (XGBoost) methods were used for prediction.
The area under the curves (AUC) of the receiver operating characteristics curves for the machine learning models used for RBC transfusion prediction were compared.
Study Type
Observational
Enrollment (Actual)
6121
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Ankara, Turkey, 06110
- Dilek D Unal
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 100 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Patients undergoing major elective surgical procedures were considered eligible.
All age groups and both genders were included.
The surgical procedures were predefined according to the Classification of Diagnostic, Therapeutic, and Surgical Procedures of the National Social Insurance Institution, in which every procedure has a unique cod
Description
Inclusion Criteria:
- Adult
- Underwent major elective surgery
Exclusion Criteria:
- Pediatric patients
- Emergency cases
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Number of patients received Red blood cell transfusion
Time Frame: Perioperative period
|
Number of patients received Red blood cell transfusion
|
Perioperative period
|
The area under the curve
Time Frame: Perioperative period
|
The the area under the curve of the receiver operating characteristics curves
|
Perioperative period
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Dilek D Unal, Prof, UNIVERSITY OF HEALTH SCIENCES TURKEY DISKAPI YILDIRIM BEYAZIT TRAINING RESEARCH HOSPITAL ANKARA
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Murphy GJ, Reeves BC, Rogers CA, Rizvi SI, Culliford L, Angelini GD. Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation. 2007 Nov 27;116(22):2544-52. doi: 10.1161/CIRCULATIONAHA.107.698977. Epub 2007 Nov 12.
- Bernard AC, Davenport DL, Chang PK, Vaughan TB, Zwischenberger JB. Intraoperative transfusion of 1 U to 2 U packed red blood cells is associated with increased 30-day mortality, surgical-site infection, pneumonia, and sepsis in general surgery patients. J Am Coll Surg. 2009 May;208(5):931-7, 937.e1-2; discussion 938-9. doi: 10.1016/j.jamcollsurg.2008.11.019. Epub 2009 Mar 26.
- Walczak S, Velanovich V. Prediction of perioperative transfusions using an artificial neural network. PLoS One. 2020 Feb 24;15(2):e0229450. doi: 10.1371/journal.pone.0229450. eCollection 2020.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 13, 2022
Primary Completion (Actual)
February 1, 2022
Study Completion (Actual)
February 1, 2022
Study Registration Dates
First Submitted
January 13, 2022
First Submitted That Met QC Criteria
January 27, 2022
First Posted (Actual)
February 8, 2022
Study Record Updates
Last Update Posted (Actual)
March 8, 2022
Last Update Submitted That Met QC Criteria
March 7, 2022
Last Verified
January 1, 2022
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- Machine learning DiskapiTRH
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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