Double Pet Project : A Comparison Between 11C-Acetate and 11C-acetoacetate Heart and Kidney Uptake

January 16, 2023 updated by: Université de Sherbrooke

Double Pet Project : A Comparison Between 11C-Acetate and 11C-acetoacetate Heart and

The objective of this study is to make a comparison between 11C-acetate and 11C-Acetoacetate heart and kidney metabolism

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Healthy people will have two positron emission tomography scan to perform. One, with a 11C-Acetate Tracer and the other with 11C-Acetoacetate. The results will allow to determine if both tracers are used in a similar way but the organs and see if the investigators can use the already validated analyse method for acetate to make acetoacetate analysis

Study Type

Interventional

Enrollment (Actual)

10

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Canada
    • Quebec
      • Sherbrooke, Quebec, Canada, J1H 4C4
        • Research Center on Aging

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 55 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Aged between 18 and 55
  • BMI between 18,5 and 28
  • Healthy
  • Normal value for blood pressure

Exclusion Criteria:

  • Taking drugs that could influence metabolism
  • Diabetes or prediabetes
  • Pregnancy or lactation
  • Participation in a intensive sport program
  • Being on a ketogenic diet
  • Any clinical abnomally in prescreen blood sample

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Health Services Research
  • Allocation: N/A
  • Interventional Model: Sequential Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Other: Observational heart and kidney metabolism
Participants will have a PET scan with 11C-Acetate followed by a TEP Scan with 11C-Acetoacetate all in the same day.
Radiation: Observational heart and kidney on siemens TEP scan
Same as arm description

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mean in left ventricule myocradial blood flow
Time Frame: 30 minutes
Heart acetate metabolism measured by TEP scan
30 minutes
Mean in left ventricule myocardial blood flow
Time Frame: 30 minutes
Heart acetoacetate metabolism measured by TEP scan
30 minutes
Mean in Kidney acetate uptake
Time Frame: 30 minutes
Kidney acetate uptake measured by TEP scan
30 minutes
Mean in Kidney acetoacetate uptake
Time Frame: 30 minutes
Kidney acetoacetate uptake measured by TEP scan.
30 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Université de Sherbrooke

Collaborators

Nestlé Health Science Spain

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 14, 2022

Primary Completion (Actual)

August 14, 2022

Study Completion (Actual)

August 14, 2022

Study Registration Dates

First Submitted

January 4, 2022

First Submitted That Met QC Criteria

February 3, 2022

First Posted (Actual)

February 14, 2022

Study Record Updates

Last Update Posted (Actual)

January 18, 2023

Last Update Submitted That Met QC Criteria

January 16, 2023

Last Verified

January 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2022-4540

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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