Ketone Supplementation and Exercise Performance

July 22, 2019 updated by: Western University, Canada

Can Ketone Supplementation Enhance Exercise Performance?

The purpose of this study is to observe the effects of exogenous ketone supplements during shorter bouts of exercise testing on twenty collegiate endurance trained athletes (18-25 years of age).

Study Overview

Detailed Description

Some believe very high fat diets (>70% energy) can enhance exercise performance by providing additional fuel (ketones) for energy metabolism, at least for very prolonged exercise (>3-4h). Regardless, this diet is difficult to maintain so it has been suggested that ingesting ketone salts along with a normal carbohydrate (CHO) diet might be more practical. The purpose of this study is to observe the effects of ketone salt ingestion on shorter term (up to ~15 min) exercise performance. Endurance trained (≥2 year training experience; ≥7 h/week) collegiate athletes (n=20) of similar body mass (♀; 55-60kg; ♂; 75-80kg) and age 18-25y) consuming 5-6g CHO•kg-1•d-1) will be tested before and after 1 and 7d of ketone salt (Prüvit, Carrollton TX, US) supplementation (0.6-0.8g•kg-1•d-1). Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) before and after supplementation. Blood samples (glucose, lactic acid, and ketone concentration) will be taken at: baseline and following each performance test. It is hypothesized that ketone salt supplementation will increase blood ketone concentration but will not enhance these exercise performance tests.

Study Type

Interventional

Enrollment (Anticipated)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

  • Name: Sydney EL Isbell, BSc
  • Phone Number: 5196612111
  • Email: sisbell@uwo.ca

Study Contact Backup

  • Name: Manuel D Quinones, MSc
  • Phone Number: 5196612111

Study Locations

    • Ontario
      • London, Ontario, Canada, N6A3K7
        • Exercise Nutrition Laboratory, Western University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 25 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy male or female Collegiate Endurance Trained Athletes
  • ≥2 year training experience; ≥7 h/week
  • Ages 18-25

Exclusion Criteria:

  • Smoker
  • Injury that will affect exercise performance
  • Sedentary Behaviour
  • Currently following a High Fat diet/Ketogenic diet
  • Taking Beta Blockers or Hypertension Medication
  • Has Respiratory, Cardiovascular and/or Neuromuscular disease that is not cleared for exercise by a physician.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: OTHER
  • Allocation: RANDOMIZED
  • Interventional Model: SINGLE_GROUP
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
ACTIVE_COMPARATOR: Baseline Testing
Baseline testing for a 10km cycle time trial and a 30s Wingate cycle test.
A baseline 10 km Cycling time trial test will be conducted
A baseline 30s all-out test to measure peak power output
EXPERIMENTAL: Dietary Supplement: Exogenous Ketone Salt
Ketone salt supplementation (0.6-0.8g•kg-1•d-1) 7-days. Participants will perform two exercise performance tests (a 10km cycle time trial and a 30s Wingate cycle test on separate days) after supplementation.
10 km Cycling time trial test will be conducted to examine the effects of the Exogenous Ketone Salts on time
30s all-out test to measure peak power output
Supplement containing exogenous ketone salts

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
10 km Time trial
Time Frame: 15-20 Minutes
10km time trial where participants will be measured on time to completion
15-20 Minutes
30s Wingate
Time Frame: 30 seconds
30s Wingate all out test where participants will be measured on their peak power output
30 seconds

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Blood Ketones
Time Frame: 1-2 hours
Blood Ketones will be measured using a ketone meter
1-2 hours
Blood Glucose
Time Frame: 1-2 hours
Blood Glucose will be measured using a Blood glucose meter
1-2 hours
Blood Lactate
Time Frame: 1-2 hours
Blood Lactate will be measured using a lactate meter
1-2 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ANTICIPATED)

September 1, 2019

Primary Completion (ANTICIPATED)

January 1, 2020

Study Completion (ANTICIPATED)

March 1, 2020

Study Registration Dates

First Submitted

May 6, 2019

First Submitted That Met QC Criteria

May 16, 2019

First Posted (ACTUAL)

May 17, 2019

Study Record Updates

Last Update Posted (ACTUAL)

July 23, 2019

Last Update Submitted That Met QC Criteria

July 22, 2019

Last Verified

April 1, 2019

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 113761

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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