Relationship of PNI and Clinical Outcome in Patients Undergoing Brain Tumor Surgery

February 9, 2026 updated by: Youn Joung Cho, MD, PhD, Seoul National University Hospital
There are several predictors of clinical outcome in patients undergoing brain tumor surgery. Among those, nutritional parameters and calculated nutritional index are known to have ability to predict mortality and clinical outcomes in some patients with brain tumor. However, there are lack of consistent results on predictability of nutritional index and clinical outcome in patients undergoing brain tumor surgery.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

In this retrospective study, we evaluated the relationship between prognostic nutritional index, which was calculated from laboratory parameters, and clinical outcome including mortality in patients undergoing brain tumor surgery.

Study Type

Observational

Enrollment (Actual)

3263

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • South Korea
      • Seoul, South Korea, 03080
        • Seoul National University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Adult patients undergoing brain tumor surgery at Seoul National University Hospital, South Korea

Description

Inclusion Criteria:

  • adult patients undergoing brain tumor surgery at Seoul National University Hospital, South Korea

Exclusion Criteria:

  • Lack of results of laboratory parameters, such as serum albumin, lymphocyte count, cholesterol
  • Lack of data on clinical outcome, including mortality, acute kidney injury, renal replacement therapy, length of hospital stay, and other major adverse outcome

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Retrospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
brain tumor surgery
adult patients undergoing brain tumor surgery
Diagnostic test: prognostic nutritional index calculated from laboratory parameters
Calculated nutritional index using laboratory results of serum albumin, lymphocyte count, and cholesterol

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
predictability of prognostic nutritional index for mortality after brain tumor surgery
Time Frame: From date of surgery until the date of death from any cause, whichever came first, assessed up to 50 years
Odds ratio of prognostic nutritional index for postoperative mortality
From date of surgery until the date of death from any cause, whichever came first, assessed up to 50 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
predictability of prognostic nutritional index for acute kidney injury after brain tumor surgery
Time Frame: From date of surgery until the date of acute kidney injury from any cause, whichever came first, assessed up to 50 years
Odds ratio of prognostic nutritional index for postoperative acute kidney injury
From date of surgery until the date of acute kidney injury from any cause, whichever came first, assessed up to 50 years
predictability of prognostic nutritional index for renal replacement therapy after brain tumor surgery
Time Frame: From date of surgery until the date of renal replacement therapy from any cause, whichever came first, assessed up to 50 years
Odds ratio of prognostic nutritional index for postoperative renal replacement therapy
From date of surgery until the date of renal replacement therapy from any cause, whichever came first, assessed up to 50 years
relationship of prognostic nutritional index for length of hospital stay after brain tumor surgery
Time Frame: From date of surgery until the date of hospital discharge
Odds ratio of prognostic nutritional index for length of hospital stay
From date of surgery until the date of hospital discharge

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Seoul National University Hospital

Investigators

  • Principal Investigator: Youn Joung Cho, MD, PhD, Seoul National University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 12, 2024

Primary Completion (Actual)

December 1, 2025

Study Completion (Actual)

December 31, 2025

Study Registration Dates

First Submitted

April 24, 2022

First Submitted That Met QC Criteria

May 9, 2022

First Posted (Actual)

May 13, 2022

Study Record Updates

Last Update Posted (Actual)

February 12, 2026

Last Update Submitted That Met QC Criteria

February 9, 2026

Last Verified

February 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PNI_Brain tumor

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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