Relationship of PNI and Clinical Outcome in Patients Undergoing Brain Tumor Surgery
February 9, 2026 updated by: Youn Joung Cho, MD, PhD, Seoul National University Hospital
There are several predictors of clinical outcome in patients undergoing brain tumor surgery.
Among those, nutritional parameters and calculated nutritional index are known to have ability to predict mortality and clinical outcomes in some patients with brain tumor.
However, there are lack of consistent results on predictability of nutritional index and clinical outcome in patients undergoing brain tumor surgery.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
In this retrospective study, we evaluated the relationship between prognostic nutritional index, which was calculated from laboratory parameters, and clinical outcome including mortality in patients undergoing brain tumor surgery.
Study Type
Observational
Enrollment (Actual)
3263
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Seoul, South Korea, 03080
- Seoul National University Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Sampling Method
Non-Probability Sample
Study Population
Adult patients undergoing brain tumor surgery at Seoul National University Hospital, South Korea
Description
Inclusion Criteria:
- adult patients undergoing brain tumor surgery at Seoul National University Hospital, South Korea
Exclusion Criteria:
- Lack of results of laboratory parameters, such as serum albumin, lymphocyte count, cholesterol
- Lack of data on clinical outcome, including mortality, acute kidney injury, renal replacement therapy, length of hospital stay, and other major adverse outcome
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
|
brain tumor surgery
adult patients undergoing brain tumor surgery
|
Calculated nutritional index using laboratory results of serum albumin, lymphocyte count, and cholesterol
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
predictability of prognostic nutritional index for mortality after brain tumor surgery
Time Frame: From date of surgery until the date of death from any cause, whichever came first, assessed up to 50 years
|
Odds ratio of prognostic nutritional index for postoperative mortality
|
From date of surgery until the date of death from any cause, whichever came first, assessed up to 50 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
predictability of prognostic nutritional index for acute kidney injury after brain tumor surgery
Time Frame: From date of surgery until the date of acute kidney injury from any cause, whichever came first, assessed up to 50 years
|
Odds ratio of prognostic nutritional index for postoperative acute kidney injury
|
From date of surgery until the date of acute kidney injury from any cause, whichever came first, assessed up to 50 years
|
|
predictability of prognostic nutritional index for renal replacement therapy after brain tumor surgery
Time Frame: From date of surgery until the date of renal replacement therapy from any cause, whichever came first, assessed up to 50 years
|
Odds ratio of prognostic nutritional index for postoperative renal replacement therapy
|
From date of surgery until the date of renal replacement therapy from any cause, whichever came first, assessed up to 50 years
|
|
relationship of prognostic nutritional index for length of hospital stay after brain tumor surgery
Time Frame: From date of surgery until the date of hospital discharge
|
Odds ratio of prognostic nutritional index for length of hospital stay
|
From date of surgery until the date of hospital discharge
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: Youn Joung Cho, MD, PhD, Seoul National University Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
December 12, 2024
Primary Completion (Actual)
December 1, 2025
Study Completion (Actual)
December 31, 2025
Study Registration Dates
First Submitted
April 24, 2022
First Submitted That Met QC Criteria
May 9, 2022
First Posted (Actual)
May 13, 2022
Study Record Updates
Last Update Posted (Actual)
February 12, 2026
Last Update Submitted That Met QC Criteria
February 9, 2026
Last Verified
February 1, 2026
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- PNI_Brain tumor
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.