Non-invasive Left Ventricle Contractility dp/dt as Prognostic Marker in Chest Unit Patients (dp/dt)

Non Invasive Left Ventricle Contractility dp/dt Could be Used as a Prognostic Marker in Patients Admitted to the Emergency Department for Chest Pain

Ischemic heart disease is a major public health problem with high mortality rate despite the progress in management and the resources mobilized. The idea is that myocardial ischemia is generally associated with left ventricular dysfunction and, consequently, a possible alteration of the dp/dt index. As dp/dt could be assessed non-invasively by plethysmographic method, it is interesting to investigate its prognostic performance in patients with indifferentiate chest pain.

Study Overview

• Status: Recruiting
• Conditions: Chest Pain

Detailed Description

Ischemic heart disease remains a major public health problem. Despite all the advances in the prognostic approach to ischemic heart disease, the risk of occurrence of major cardiovascular events is not negligible. Several scores have been proposed for chest pain stratification risk, the most widely used are the TIMI and the GRACE scores.

The dP/dt max is therefore an excellent index of contractility, corresponding to the maximum level of tension developed by an isolated cardiac muscle during the isovolumic contraction phase.

the investigator theorized that a less value of dp/dt would be associated with more major cardiovascular events (MACE), because ischemia reduces myocardial contractility.

The current study describes non-invasive plethysmographic dp/dt changes, which could be used as a prognostic marker in patients presenting at the emergency department with acute chest pain.

• Study Type: Observational
• Enrollment (Anticipated): 500

Contacts and Locations

• Study Contact: Name: Nouira Semir, professor; Phone Number: 00216 73106046; Email: semir.nouira@rns.tn

Study Locations

• Tunisia
  • Monastir, Tunisia, 5000
    • Recruiting
    • Emergency Departement
    • Contact: Semir Nouira, professor; Phone Number: 216 73 106 085; Email: semir.nouira@rns.tn
    • Principal Investigator: semir nouira, professor

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

patients presenting to the emergency department with acute chest pain

Description

Inclusion criteria:

• age over 18 years old,
• acute chest pain

Exclusion criteria:

• traumatic chest pain,
• hemodynamic instability;
• arrhythmias;
• holders of a pacemaker;
• STEMI

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
MACE	the occurrence of a major cardiovascular event (MACE)	one month
MACE	: the occurrence of a major cardiovascular event (MACE)	SIX MONTHS

Collaborators and Investigators

• Sponsor: University of Monastir
• Investigators: Principal Investigator: Nouira Semir, professor, Monastir University Hospital, Monastir, Tunisia, 5000

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2022
• Primary Completion (Anticipated): May 31, 2023
• Study Completion (Anticipated): September 30, 2023

Study Registration Dates

• First Submitted: June 8, 2022
• First Submitted That Met QC Criteria: June 8, 2022
• First Posted (Actual): June 13, 2022

Study Record Updates

• Last Update Posted (Actual): May 16, 2023
• Last Update Submitted That Met QC Criteria: May 13, 2023
• Last Verified: May 1, 2023

More Information

Terms related to this study

• Keywords: plethysmography,; chest pain,; myocardial ischemia,; acute myocardial dysfunction,; non invasive dp/dt.
• Additional Relevant MeSH Terms: Pain; Neurologic Manifestations; Chest Pain
• Other Study ID Numbers: dp/dt

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No