Prevention and Treatment of Perioperative Lung Injury in Elderly Patients

This study aims to verify the prediction model of postoperative pulmonary complications by collecting clinical information on elderly patients. In addition, the incidence of postoperative pulmonary complications in elderly patients before and after using the prediction model was compared.

Study Overview

• Status: Not yet recruiting
• Conditions: Elderly Patients; Postoperative Pulmonary Complications

Detailed Description

More than 300 million major operations are performed worldwide each year, and older patients account for about a third of elective operations. Compared with young people, the elderly are more prone to postoperative complications due to age-related degeneration of the physiological functions of various organs and tissues. Postoperative pulmonary complications, including pneumonia, atelectasis, and respiratory failure, are common. Even mild pulmonary complications can lead to the prolonged hospital stay and increased postoperative mortality.

Although there have been many studies on postoperative lung complications, there have been few studies on elderly patients. In our country, the real incidence data of elderly patients after a perioperative period of pulmonary complications, the lack of effective prevention, intervention measures, and targeted prevention and treatment technology, these reasons lead to the clinical diagnosis and treatment of elderly patients after a perioperative period of pulmonary complications are very difficult. Therefore, the research team intends to verify the established prediction model of postoperative pulmonary complications and compare the incidence of postoperative pulmonary complications in elderly patients before and after using the prediction model.

• Study Type: Observational
• Enrollment (Anticipated): 5000

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients aged 65 years or older

Description

Inclusion Criteria:

1. Age 65 years or older
2. receiving invasive ventilation during general anesthesia for surgery

Exclusion Criteria:

1. preoperative mechanical ventilation
2. procedures related to a previous surgical complication
3. a second operation after surgery within one week
4. organ transplantation
5. discharged within 24 hours after surgery

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Other

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Patients applying a prediction model for postoperative pulmonary complications
Patients non-applying a prediction model for postoperative pulmonary complications

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Postoperative pulmonary complications	within one week after surgery

Secondary Outcome Measures

Outcome Measure	Time Frame
Length of postoperative hospital stay	6 weeks after surgery
Postoperative Death	6 weeks after surgery

Collaborators and Investigators

• Sponsor: Wuhan Union Hospital, China
• Collaborators: Chinese PLA General Hospital; First Affiliated Hospital of Zhejiang University; China-Japan Friendship Hospital; Qinghai People's Hospital; Wuhan No.1 Hospital; Shanxi Cardiovascular Hospital; First Affiliated Hospital of Guangxi Medical University; Shiyan Taihe Hospital; Xiangyang Central Hospital; Xiangyang No.1 People's Hospital; Shiyan City Renmin Hospital; Dongfeng General Hospital of Chinese Medicine; Suizhou Central Hospital; Yunxi Renmin Hospital; Yunyang Renmin Hospital; Zhuxi Renmin Hospital; Danjiangkou First Hospital; Shiyan Integrated Traditional and Western Medicine Hospital; Shiyan Traditional Chinese Medicine Hospital

Study record dates

Study Major Dates

• Study Start (Anticipated): January 1, 2023
• Primary Completion (Anticipated): December 1, 2023
• Study Completion (Anticipated): December 1, 2023

Study Registration Dates

• First Submitted: January 18, 2023
• First Submitted That Met QC Criteria: January 18, 2023
• First Posted (Actual): January 27, 2023

Study Record Updates

• Last Update Posted (Actual): January 27, 2023
• Last Update Submitted That Met QC Criteria: January 18, 2023
• Last Verified: January 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Lung Diseases; Wounds and Injuries; Thoracic Injuries; Lung Injury
• Other Study ID Numbers: PPCS192023

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No