China Nutrition Fundamental Data 2022 (CNFD 2022)

Malnutrition caused by reduced food intake or assimilation and varying degrees of acute or chronic inflammation is a serious and underappreciated risk factor for adverse clinical outcomes. Despite the substantial health and economic burden, malnutrition remains to affect a considerable proportion of hospitalized patients worldwide. Nationally representative studies from the USA, Australia, and European countries have reported prevalence figures in the range of 8.9% to 80.4%. However, national data in some resource-poor countries, such as China, the largest developing country in the world, are scarce.

During 2020 to 2022, the investigators conducted the China Nutrition Fundamental Data 2020 (CNFD 2020). This project provides a reference for nutritional risk assessment, malnutrition diagnosis, and treatment criteria for hospitalized patients in China. This project also provides data to promote the construction of clinical nutrition departments and improve the nutritional status of hospitalized patients. Thus, the investigators plan to conduct the China Nutrition Fundamental Data 2022 in a large, nationally representative sample of Chinese adult inpatients to 1) To further explore the relationship between nutrition and health; 2) To further understand the capacity of nutrition services in Chinese medical institutions.

This project will adopt a multistage, stratified, cluster-sampling procedure based on administrative divisions in China. For each participant, a structured interview will be done by trained nutritionists or clinicians. The following data will be acquired: weight change within and beyond six months, food intake change within two weeks, nutrition therapy during this hospitalization, Karnofsky score, clinical outcome, total hospitalization costs, and laboratory tests. The investigators will also collect information on participants' sociodemographic characteristics and medical history. The investigators will take physical measurements, including height, weight, waist circumference, hip circumference, mid-arm circumference, calf circumference, handgrip strength, and blood pressure following standard protocols. Body composition will be measured using bioimpedance analysis (BIA).

In addition, the investigators plan to collect information on the number of beds, the nutrition support team, the nutrition treatment plan and the construction of a full-time nutrition physician or nutrition nurse, the routine monitoring methods, interventions, and distribution of brochures for patients with malnutrition or nutritional risk in each project hospital.

Study Overview

• Status: Not yet recruiting
• Conditions: Nutritional Status of Chinese Inpatients; Nutritional Service Capacity of Medical Institutions in China
• Intervention / Treatment: Other: Malnutrition

• Study Type: Observational
• Enrollment (Anticipated): 40000

Contacts and Locations

• Study Contact: Name: Wei Chen, Ph.D.; Phone Number: 010-69154095; Email: txchenwei@sina.com
• Study Contact Backup: Name: Yan Liu, Ph.D.; Phone Number: 010-69154095; Email: shyneeliu@163.com

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China, 100010
      • Dongcheng district，Peking union medical college hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

A large, nationally representative sample of Chinese adult inpatients

Description

Inclusion Criteria:

• Aged 18 years or older
• Admitted to hospital within 24-48 hours (not emergency) due to tumor or digestive system, respiratory system, cardiovascular system, endocrine system, nervous system, and urinary system disease.

Exclusion Criteria:

• With mental illness or memory disorder who were unable to answer questions correctly
• Critically ill patients
• Lack behavioral ability

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Prevalence of malnutrition	For the diagnosis of malnutrition, the investigators adopted the Global Leadership Initiative on Malnutrition (GLIM) scheme based on three phenotypic criteria (non-volitional weight loss, low body mass index, and reduced muscle mass) and two etiologic criteria (reduced food intake or assimilation, and inflammation or disease burden). To diagnose malnutrition at least one phenotypic criterion and one etiologic criterion should be present in patients with nutritional risk.	The day of the survey (day 1)
Prevalence of nutritional risk	Prevalence of nutritional risk was evaluated by Nutritional Risk Screening 2002 (NRS 2002). The minimum and maximum values were 0 and 7 respectively. Nutritional risk was defined as NRS 2002 score≥3. Higher scores mean higher nutritional risk.	The day of the survey (day 1)

Collaborators and Investigators

• Sponsor: Peking Union Medical College Hospital
• Collaborators: National Institute of Hospital Administration, National Health Commission

Study record dates

Study Major Dates

• Study Start (ANTICIPATED): February 15, 2023
• Primary Completion (ANTICIPATED): September 30, 2023
• Study Completion (ANTICIPATED): December 31, 2023

Study Registration Dates

• First Submitted: January 12, 2023
• First Submitted That Met QC Criteria: January 27, 2023
• First Posted (ACTUAL): January 31, 2023

Study Record Updates

• Last Update Posted (ACTUAL): January 31, 2023
• Last Update Submitted That Met QC Criteria: January 27, 2023
• Last Verified: January 1, 2023

More Information

Terms related to this study

• Other Study ID Numbers: I-22PJ744

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No