Protein Intake Distribution to Support Muscle Anabolism in Healthy Young Adults

November 20, 2025 updated by: Maastricht University Medical Center
The purpose of the study is to evaluate whether the distribution pattern of daily protein intake affects how much muscle protein can be built in the muscle after resistance exercise and at rest.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

36

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Netherlands
      • Maastricht, Netherlands
        • Maastricht University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Aged between 18-40 years
  • Healthy
  • 18.5 ≤ BMI 30 ≤ kg・m-2

Exclusion Criteria:

  • Smoking
  • Sports/exercise >4 sessions/week or a structured resistance or endurance training schedule
  • Lactose intolerant or allergies to milk protein
  • A history of neuromuscular problems
  • Use of anticoagulation medication
  • Individuals on any medications known to affect protein metabolism (i.e. , non-steroidal anti-inflammatories, or prescription acne medications).
  • Strict vegetarian
  • Injury or condition that would limit the participant from performing the resistance exercise.
  • Pregnancy
  • Hormone replacement therapy
  • Blood donation within the past 2 months

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: BALANCED
Dietary supplement: protein intake
1x 100g
Dietary supplement: protein intake
4x 25 g
Experimental: SIP
Dietary supplement: Protein intake
15x 7 g
Experimental: BOLUS
Dietary supplement: protein intake
1x 100g
Dietary supplement: protein intake
4x 25 g

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
fractional synthetic rate
Time Frame: 24 hours
24 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Maastricht University Medical Center

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

January 1, 2026

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

January 1, 2027

Study Registration Dates

First Submitted

October 2, 2025

First Submitted That Met QC Criteria

November 20, 2025

First Posted (Actual)

November 24, 2025

Study Record Updates

Last Update Posted (Actual)

November 24, 2025

Last Update Submitted That Met QC Criteria

November 20, 2025

Last Verified

September 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • NL-010056 / METC25-038 (Other Identifier: Maastricht University Medical Center)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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