Clinico-radiological Correlations in Cerebro-VASCULAR Disease

Clinico-radiological Correlations in Cerebro-VASCULAR Disease: Toward a BetteR understAndINg of Their Heterogeneous Manifestations in a Retrospective and Prospective Observational Registry

This observational retrospective and prospective registry aims to explore the relationships between clinical manifestations and radiological findings in cerebrovascular diseases. These conditions are characterized by heterogeneous radiological presentations and different etiologies, posing challenges for accurate diagnosis and effective treatment. Understanding these correlations is essential for advancing diagnostic accuracy and therapeutic strategies.

Study Overview

• Status: Not yet recruiting
• Conditions: Cerebro Vascular Disease

• Study Type: Observational
• Enrollment (Estimated): 1143

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

The registry will focus on adults aged 18 to 100 of both genders diagnosed with various cerebrovascular diseases based on clinical and imaging evaluations. Participants will be selected from a retrospective registry of patients who have undergone MRI or CT scans for clinical indications. In addition to the retrospective cohort, the registry will also include a prospective component, enrolling newly diagnosed patients who meet the same eligibility criteria.

Description

Inclusion Criteria:

• Age Range: 18-100 years old.
• Must have undergone a CT or MRI scan of the central nervous system (CNS) (for clinical reasons).

Exclusion Criteria:

• Alternative diagnosis to vascular pathology that explains clinical symptoms.
• MRI or CT non-diagnostic or non-evaluable MRI due to motion artifacts.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Proportion of patients with each key MRI/CT finding in cerebrovascular disease (lesion location, vessel involvement, hemorrhagic transformation)	Primary Outcome Measure: Diagnostic imaging trends in cerebrovascular disease Description: Key imaging findings from first MRI/CT (e.g., lesion location, vessel involvement; %).	Baseline (at diagnosis), up to 20 years

Collaborators and Investigators

• Sponsor: IRCCS San Raffaele

Study record dates

Study Major Dates

• Study Start (Estimated): April 1, 2026
• Primary Completion (Estimated): April 1, 2046
• Study Completion (Estimated): April 1, 2046

Study Registration Dates

• First Submitted: March 5, 2026
• First Submitted That Met QC Criteria: March 20, 2026
• First Posted (Actual): March 25, 2026

Study Record Updates

• Last Update Posted (Actual): March 30, 2026
• Last Update Submitted That Met QC Criteria: March 25, 2026
• Last Verified: March 1, 2026

More Information

Terms related to this study

• Other Study ID Numbers: VASCULAR-BRAIN

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No