Early-Onset Colorectal Cancer Patients Too Young for Screening

Early-Onset Colorectal Cancer Patients Too Young for Screening: Outcomes and Treatment Patterns

This is a population-based retrospective study using the Surveillance, Epidemiology, and End Results (SEER) registry and National Cancer Data Base (NCDB) to look at colorectal cancer (CRC) patients younger than 35 and comparing them against CRC patients older than 35 years of age.

Study Overview

• Status: Recruiting
• Conditions: Colorectal Cancer
• Intervention / Treatment: Other: Colorectal cancer

Detailed Description

Specifically, investigator want to investigate the effect of having a diagnosis of CRC before the age of 35 years on:disease stage at presentation, insurance status at diagnosis, treatment patterns by stage, and adjusted cancer-specific survival. The hypothesis is that patients younger than 35 years of age with CRC will present with more advanced disease at diagnosis but will have longer survival overall through more aggressive therapy.

• Study Type: Observational
• Enrollment (Estimated): 100

Contacts and Locations

• Study Contact: Name: Crystee Cooper, DHEd; Phone Number: 214-947-1280; Email: ClinicalResearch@mhd.com
• Study Contact Backup: Name: Kavya Mankulangara; Phone Number: 214-947-4604; Email: ClinicalResearch@mhd.com

Study Locations

• United States
  • Texas
    • Dallas, Texas, United States, 75203
      • Recruiting
      • Methodist Dallas Medical Center- Clinical Research Institute
      • Contact: Kavya Mankulangara; Phone Number: 214-947-4604; Email: ClinicalResearch@mhd.com
      • Contact: Colette Ngo Ndjom; Phone Number: 214-947-1289; Email: ClinicalResearch@mhd.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: N/A

• Sampling Method: Non-Probability Sample

Study Population

This is a population-based retrospective study using the Surveillance, Epidemiology, and End Results (SEER) registry and National Cancer Data Base (NCDB) to look at colorectal cancer (CRC) patients younger than 35 and comparing them against CRC patients older than 35 years of age.

Description

Inclusion Criteria:

• Colorectal cancer

Exclusion Criteria:

• No Colorectal cancer

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Intervention / Treatment

colorectal cancer (CRC) patients younger than 35; The hypothesis is that patients younger than 35 years of age with CRC will present with more advanced disease at diagnosis but will have longer survival overall through more aggressive therapy.

Other: Colorectal cancer; CRC is a disease that is often associated with older adults (<50 years). CRC remains the second most common cause of cancer death in males and the third most common cancer death in women. Despite this, CRC incidence has steadily declined in older adults; however, there is a concerning rise of incidence of colorectal cancer in young patients. The incidence of CRC in men and women under the age of 50 steadily increased 2.1 percent per year from 1992 through 2012.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Age	colorectal cancer (CRC) patients younger than 35 years and comparing them against CRC patients older than 35 years of age.	20 years

Collaborators and Investigators

• Sponsor: Methodist Health System
• Investigators: Principal Investigator: Rohan Jeyarajah, MD, Methodist Health System

Study record dates

Study Major Dates

• Study Start (Actual): January 31, 2020
• Primary Completion (Estimated): January 1, 2027
• Study Completion (Estimated): January 1, 2028

Study Registration Dates

• First Submitted: March 18, 2026
• First Submitted That Met QC Criteria: April 27, 2026
• First Posted (Actual): April 30, 2026

Study Record Updates

• Last Update Posted (Actual): April 30, 2026
• Last Update Submitted That Met QC Criteria: April 27, 2026
• Last Verified: January 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Neoplasms by Site; Neoplasms; Intestinal Diseases; Gastrointestinal Neoplasms; Digestive System Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Intestinal Neoplasms; Rectal Diseases; Colonic Diseases; Colorectal Neoplasms
• Other Study ID Numbers: 036.HBP.2020.R

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES
• IPD Plan Description: The data attained will be de-identified prior to sharing via presentation and/or publication in relevant research mediums.
• IPD Sharing Time Frame: Not mentioned in protocol.
• IPD Sharing Access Criteria: Not mentioned in protocol.
• IPD Sharing Supporting Information Type: STUDY_PROTOCOL

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No