Mucosal and Nasal Involvement and Their Correlation With Smell and Taste Functions in Lichen Planus Patients (LP-NOSE)

Correlation of Mucosal and Nasal Involvement With Smell and Taste Functions in Patients With Lichen Planus

This study investigates smell and taste function in patients diagnosed with lichen planus, a chronic inflammatory condition affecting the skin and mucous membranes.

Adults aged 18-65 with lichen planus participated in taste and smell tests. Oral and nasal examinations were performed to check for mucosal involvement, and nasal endoscopy was used to further evaluate nasal involvement.

A healthy control group of similar age also underwent taste and smell tests to compare results with the lichen planus patients.

The study aims to better understand how lichen planus affects smell and taste, which may help improve patient care. Participation is voluntary, and all information collected will be kept confidential.

Study Overview

• Status: Completed
• Conditions: Lichen Planus
• Intervention / Treatment: Other: Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess

Detailed Description

The study aims to evaluate the impact of lichen planus on olfactory and gustatory functions in adults aged 18-65. Participants with lichen planus underwent taste and smell testing, oral and nasal mucosal examinations, and nasal endoscopy to detect potential mucosal involvement. A matched healthy control group also completed taste and smell tests to provide comparative data. This design allows the assessment of whether mucosal involvement in lichen planus correlates with changes in taste and smell, which may contribute to better clinical understanding and management of the disease.

• Study Type: Observational
• Enrollment (Actual): 88

Contacts and Locations

Study Locations

• Turkey (Türkiye)
  • Istanbul
    • Istanbul, Istanbul, Turkey (Türkiye), 34098
      • S.B.U. Istanbul Training and Research Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

The study includes adults aged 18-65 years with a clinical diagnosis of lichen planus, as well as healthy volunteers without lichen planus. Participants were assessed for smell and taste function, and the patient group also underwent oral and nasal mucosal examinations, including nasal endoscopy. Both male and female participants were included.

Description

Inclusion Criteria:

Age 18-65 years Clinically diagnosed with lichen planus (patient group) Healthy individuals without lichen planus (control group) Willing and able to provide informed consent

Exclusion Criteria:

Nasal septum deviation Nasal polyposis, congenital olfactory dysfunction, chronic rhinosinusitis, or allergic rhinitis History of head trauma History of nasal or paranasal surgery Psychiatric or neurological disorders (e.g., Parkinson's disease, Alzheimer's disease) Persistent loss of smell following COVID-19 infection Pregnancy or breastfeeding

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Group 1- Lichen Planus Patients; Participants undergo taste and smell testing, oral and nasal examinations, and nasal endoscopy to assess mucosal involvement.	Other: Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess; Group 1 - Lichen Planus Patients: Participants undergo taste and smell testing to assess sensory function, oral and nasal examinations to evaluate mucosal involvement, and nasal endoscopy for detailed nasal assessment. Group 2 - Healthy Controls: Participants undergo taste and smell testing to provide comparative data for the lichen planus group.
Group 2 - Healthy Controls; Participants undergo taste and smell testing to provide comparative data with the lichen planus group.	Other: Grup 1 - Lichen Planus Patients Intervention Name: Taste and Smell Testing, Oral and Nasal Examination, Nasal Endoscopy Intervention Description: Participants undergo taste and smell testing to assess; Group 1 - Lichen Planus Patients: Participants undergo taste and smell testing to assess sensory function, oral and nasal examinations to evaluate mucosal involvement, and nasal endoscopy for detailed nasal assessment. Group 2 - Healthy Controls: Participants undergo taste and smell testing to provide comparative data for the lichen planus group.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Smell and Taste Function	Participants underwent standardized smell (olfactory) and taste (gustatory) tests to assess sensory function. Tests were performed on both lichen planus patients and healthy controls to compare results and evaluate the impact of mucosal involvement on smell and taste function. Time Frame: Single visit assessment	Day 1
Smell and taste function in patients with lichen planus	Participants underwent standardized smell (olfactory) and taste (gustatory) tests to assess sensory function. Tests were performed on both lichen planus patients and healthy controls to compare results and evaluate the impact of mucosal involvement on smell and taste function.	Day 1

Collaborators and Investigators

• Sponsor: Istanbul Training and Research Hospital
• Investigators: Principal Investigator: Yasemin Bolat Eren, MD, S.B.U. Istanbul Eğitim ve Araştırma Hastanesi, Dermatology Department

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2026
• Primary Completion (Actual): March 20, 2026
• Study Completion (Actual): April 2, 2026

Study Registration Dates

• First Submitted: April 9, 2026
• First Submitted That Met QC Criteria: April 29, 2026
• First Posted (Actual): May 6, 2026

Study Record Updates

• Last Update Posted (Actual): May 6, 2026
• Last Update Submitted That Met QC Criteria: April 29, 2026
• Last Verified: April 1, 2026

More Information

Terms related to this study

• Keywords: Nasal Mucosa; Healthy Controls; Lichen Planus; Oral Mucosa; Nasal Endoscopy; Taste Function; Smell Function; Olfactory Testing; Gustatory Testing; Mucosal Involvement
• Additional Relevant MeSH Terms: Lichenoid Eruptions; Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases; Lichen Planus
• Other Study ID Numbers: LP-Nasal-2026-01; LP-NOSE (Other Identifier: ISTANBUL TRH)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Individual participant data (IPD) will not be shared due to privacy and confidentiality considerations for study participants.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No