- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01375101
Therapeutic Effect of Quercetin and the Current Treatment of Erosive and Atrophic Oral Lichen Planus
Lichen planus (LP) is a common chronic inflammatory mucocutaneous disease with an immunologic etiology ,which has number of different clinical forms. Alternative natural or herbal origine drugs with antioxidant and anti-inflammatory properties have been used individually or in combination with systemic corticosteroids in order to decrease adverse drug reactions.
This study was conducted to evaluate the effect of quercetin on treatment of erosive -atrophic lesions of oral lichen planus (OLP).
Study Overview
Status
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Phase
- Phase 1
Contacts and Locations
Study Contact
- Name: maryam amirchaghmaghi, assistant professor
- Phone Number: 0098-0511889201
- Email: amirchakhmaghim@mums.ac.ir
Study Locations
-
-
Khorasan Razavi
-
Mashhad, Khorasan Razavi, Iran, Islamic Republic of, 91735
- Recruiting
- Mashhad university of Medical science, Research Center of oral and maxillofacial medicine
-
Contact:
- maryam amirchaghmaghi, assistant professor
- Phone Number: 0098-0511882901
- Email: amirchakhmaghim@mums.ac.ir
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- confirmation of clinical diagnosis of Atrophic and erosive lichen planus by histological examination
- two weeks wash out periods after the last treatment
- having the experience of atrophic and erosive lesion greater than 1 cm having the experience of pain and burning greater than 3.5 in VAS Score
Exclusion Criteria:
- confirmation of dysplasia and malignancy in histologic examination
- confirmation of lichenoid reaction in histologic examination
- pregnancy and breast feeding
- using fluorokinolon and cyclosporin which interact with quercetin
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: quercetin
quercetin is one of flavonoids , and having therapeutical anti-inflammatory and antioxidant action
|
The patient is directed to digest quercetin hydrate capsule two times a day,until one mouth
|
Placebo Comparator: placebo
placebo capsul is produced with lactose for using in placebo/ control group.
|
The patient is directed to use placebo capsule two times a day, ,until the one mouth
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
the effects of this Drug on OLP measured with VAS scale for pain and evaluation of intensity of lesions.
Time Frame: 2 months
|
In the present work the Analogical Visual Scale is used TO evaluate pain,and we also record the intensity of lesions weekly and any side effect of this Drug
|
2 months
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 88705
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Erosive Oral Lichen Planus
-
Alexandria UniversityCompletedEvaluation of Diode Laser and Topical Steroid Therapy in the Treatment of Erosive Oral Lichen PlanusErosive Oral Lichen PlanusEgypt
-
Nourhan M.AlyAlexandria UniversityCompleted
-
Cairo UniversityCompletedErosive Oral Lichen PlanusEgypt
-
Centre Hospitalier Universitaire de NiceTerminatedOral Erosive Lichen Planus
-
Mashhad University of Medical SciencesCompleted
-
Cairo UniversityUnknownPatients With Oral Lichen PlanusEgypt
-
Pia Lopez JornetCompletedOral Lichen Planus | Oral Lichen Planus Related StressSpain
-
Panineeya Mahavidyalaya Institute of Dental Sciences...CompletedOral Lichen Planus Related StressIndia
-
University of North Carolina, Chapel HillEli Lilly and CompanyRecruitingLichen Planus, Oral | Oral Lichen Planus | Lichen Planus, MucosalUnited States
Clinical Trials on Quercetin
-
Factors Group of Nutritional Companies Inc.Completed
-
Kanuni Sultan Suleyman Training and Research HospitalOrbiteratec (funding)Completed
-
Temple UniversityNational Center for Complementary and Integrative Health (NCCIH); Quercegen...RecruitingChronic Obstructive Pulmonary Disease | Emphysema | Chronic Bronchitis With Airway ObstructionUnited States
-
University of Alabama at BirminghamNational Institutes of Health (NIH)CompletedCystic FibrosisUnited States
-
Maastricht University Medical CenterZonMw: The Netherlands Organisation for Health Research and DevelopmentCompleted
-
Brigham and Women's HospitalNational Institute on Aging (NIA)CompletedStroke | Problem of AgingUnited States
-
Children's Hospital Medical Center, CincinnatiActive, not recruitingFanconi Anemia | Squamous Cell CarcinomaUnited States
-
Azienda di Servizi alla Persona di PaviaCompletedSleep | Body Composition | Chronic Fatigue Syndrome | Physical PerformanceItaly
-
Children's Hospital Medical Center, CincinnatiFood and Drug Administration (FDA)Completed
-
Mashhad University of Medical SciencesCompletedChemotherapy Induced Oral MucositisIran, Islamic Republic of