Perioperative Prospective Follow Up Of Cannabis Consumers and Discrepancy Use

Perioperative Prospective Follow Up Of Cannabis Consumers

This study includes a prospective non interventional study that aims to asses the prevalence of cannabis use among patients undergoing elective surgery and evaluates its impact on perioperative outcomes, including pain, opioid consumption, nausea, anxiety, and sleep disturbances. A matched control cohort will provide comparative data. Discrepancies between self-reported and objectively measured cannabis use will be assessed using blood samples and urine samples. Participants will be requested to complete preoperative and postoperative questionnaires on days 1, 2, 3, 7, and 30 to monitor cannabis use and perioperative symptoms. This study aims to clarify the perioperative effects of cannabis use and the accuracy of patient-reported consumption.

Study Overview

• Status: Active, not recruiting
• Conditions: Cannabinoid; Discrepancy With Clinical Examination
• Intervention / Treatment: Other: This study is non interventional and will only include filling in questionnaires and providing blood and urine sample

Detailed Description

This study aims to assess the proportion of cannabis users who undergo surgery. In addition, we seek to evaluate whether chronic cannabis use affects the perioperative period. Specifically, we will examine whether cannabis use around the time of surgery influences levels of pain, opioid consumption, nausea, anxiety, and sleep disturbances.

A matched control cohort with similar patient characteristics will be used for comparison.

Another key objective is to assess discrepancies between patients' self-reported cannabis use and their actual usage. This will be evaluated by comparing patient-reported data to objective measures such as blood test results and documented cannabis levels in medical records. We hypothesize that patients tend to underreport their cannabis use relative to the levels detected through clinical testing.

Following signing an informed consent, study participants will be asked to complete a preoperative questionnaire to assess their cannabis consumption habits.

Prior to anesthesia adminsatration, a 6 cc blood sample will be collected from the patient's intravenous line. This sample will be used to measure cannabis levels in the blood, allowing for a comparison between self-reported cannabis use and actual detected levels. The sample will be immediately labeled with a unique serial number in the operating room. After plasma separation via centrifugation, the sample will be frozen for later analysis using high-performance liquid chromatography (HPLC . All samples will be deidentified to external personal.

Following surgery, participants will be asked to complete questions postoperatively up to 7 days. These follow-ups will gather information on any changes in cannabis use as well as symptoms such as pain intensity, nausea, sleep quality, and use of rescue medications.

• Study Type: Observational
• Enrollment (Estimated): 600

Contacts and Locations

Study Locations

• Israel
  • Jerusalem, Israel, 9210141
    • Hadassah Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

The study population will consist of patients scheduled to undergo elective surgery.

This will include individuals who regularly use cannabis, as well as a matched control cohort with similar demographics who do not use cannabis.

Description

Inclusion Criteria:

• Patients who use cannabis and are scheduled to undergo elective surgery.
• A matched control cohort of patients with similar demographics who are also scheduled for elective surgery.

Exclusion Criteria:

None

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Study cohort: patients undergoing elective surgery who use cannabis.; Control cohort: patients undergoing elective surgery who do not regularly use cannabis.	Other: This study is non interventional and will only include filling in questionnaires and providing blood and urine sample; urine sample
control group; Patients undergoing elective surgery who do not use cannabis regularly	Other: This study is non interventional and will only include filling in questionnaires and providing blood and urine sample; urine sample

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
discrepancy percentage between reported cannabis users and actual cannabis usage among patients undergoing elective surgery.		up to 7 days
Use of Cannabis	Doasge Use of Cannabis	up to 7 days postopertively

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pain levels during surgery as assesed using VAS	We aim to assess whether pain levels during surgery are affected by cannabis use of the VAS questionaire	up to 7 days

Collaborators and Investigators

• Sponsor: Hadassah Medical Organization
• Investigators: Principal Investigator: Elyad Davidson, MD, Hadassah medical center/ Hebrew univeristy

Study record dates

Study Major Dates

• Study Start (Actual): May 6, 2026
• Primary Completion (Estimated): July 10, 2026
• Study Completion (Estimated): December 10, 2027

Study Registration Dates

• First Submitted: September 7, 2025
• First Submitted That Met QC Criteria: May 7, 2026
• First Posted (Actual): May 12, 2026

Study Record Updates

• Last Update Posted (Actual): May 12, 2026
• Last Update Submitted That Met QC Criteria: May 7, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Health Care Quality, Access, and Evaluation; Investigative Techniques; Epidemiologic Methods; Data Collection; Health Care Evaluation Mechanisms; Quality of Health Care; Public Health; Environment and Public Health; Surveys and Questionnaires
• Other Study ID Numbers: 0001-25-HMO

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No