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Perioperative Prospective Follow Up Of Cannabis Consumers and Discrepancy Use

7. maj 2026 opdateret af: Elyad Davidson, Hadassah Medical Organization

Perioperative Prospective Follow Up Of Cannabis Consumers

This study includes a prospective non interventional study that aims to asses the prevalence of cannabis use among patients undergoing elective surgery and evaluates its impact on perioperative outcomes, including pain, opioid consumption, nausea, anxiety, and sleep disturbances. A matched control cohort will provide comparative data. Discrepancies between self-reported and objectively measured cannabis use will be assessed using blood samples and urine samples. Participants will be requested to complete preoperative and postoperative questionnaires on days 1, 2, 3, 7, and 30 to monitor cannabis use and perioperative symptoms. This study aims to clarify the perioperative effects of cannabis use and the accuracy of patient-reported consumption.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

This study aims to assess the proportion of cannabis users who undergo surgery. In addition, we seek to evaluate whether chronic cannabis use affects the perioperative period. Specifically, we will examine whether cannabis use around the time of surgery influences levels of pain, opioid consumption, nausea, anxiety, and sleep disturbances.

A matched control cohort with similar patient characteristics will be used for comparison.

Another key objective is to assess discrepancies between patients' self-reported cannabis use and their actual usage. This will be evaluated by comparing patient-reported data to objective measures such as blood test results and documented cannabis levels in medical records. We hypothesize that patients tend to underreport their cannabis use relative to the levels detected through clinical testing.

Following signing an informed consent, study participants will be asked to complete a preoperative questionnaire to assess their cannabis consumption habits.

Prior to anesthesia adminsatration, a 6 cc blood sample will be collected from the patient's intravenous line. This sample will be used to measure cannabis levels in the blood, allowing for a comparison between self-reported cannabis use and actual detected levels. The sample will be immediately labeled with a unique serial number in the operating room. After plasma separation via centrifugation, the sample will be frozen for later analysis using high-performance liquid chromatography (HPLC . All samples will be deidentified to external personal.

Following surgery, participants will be asked to complete questions postoperatively up to 7 days. These follow-ups will gather information on any changes in cannabis use as well as symptoms such as pain intensity, nausea, sleep quality, and use of rescue medications.

Undersøgelsestype

Observationel

Tilmelding (Anslået)

600

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Israel
      • Jerusalem, Israel, 9210141
        • Hadassah Medical Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ja

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

The study population will consist of patients scheduled to undergo elective surgery.

This will include individuals who regularly use cannabis, as well as a matched control cohort with similar demographics who do not use cannabis.

Beskrivelse

Inclusion Criteria:

  • Patients who use cannabis and are scheduled to undergo elective surgery.
  • A matched control cohort of patients with similar demographics who are also scheduled for elective surgery.

Exclusion Criteria:

None

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
Study cohort: patients undergoing elective surgery who use cannabis.
Control cohort: patients undergoing elective surgery who do not regularly use cannabis.
Andet: This study is non interventional and will only include filling in questionnaires and providing blood and urine sample
urine sample
control group
Patients undergoing elective surgery who do not use cannabis regularly
Andet: This study is non interventional and will only include filling in questionnaires and providing blood and urine sample
urine sample

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
discrepancy percentage between reported cannabis users and actual cannabis usage among patients undergoing elective surgery.
Tidsramme: up to 7 days
up to 7 days
Use of Cannabis
Tidsramme: up to 7 days postopertively
Doasge Use of Cannabis
up to 7 days postopertively

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Pain levels during surgery as assesed using VAS
Tidsramme: up to 7 days
We aim to assess whether pain levels during surgery are affected by cannabis use of the VAS questionaire
up to 7 days

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Hadassah Medical Organization

Efterforskere

  • Ledende efterforsker: Elyad Davidson, MD, Hadassah medical center/ Hebrew univeristy

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

6. maj 2026

Primær færdiggørelse (Anslået)

10. juli 2026

Studieafslutning (Anslået)

10. december 2027

Datoer for studieregistrering

Først indsendt

7. september 2025

Først indsendt, der opfyldte QC-kriterier

7. maj 2026

Først opslået (Faktiske)

12. maj 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

12. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

7. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 0001-25-HMO

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

UBESLUTET

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

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Betingelser

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Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

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