Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial

May 14, 2026 updated by: Ipek Eraslan Akyuz, TC Erciyes University
The relationship between different root canal irrigation techniques and pain after root canal treatment

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

100

Phase

  • Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Turkey (Türkiye)
      • Kayseri, Turkey (Türkiye)
        • Recruiting
        • Erciyes University
        • Contact:
          • Erciyes University Erciyes University
          • Phone Number: +9 (0352) 207 66 00
          • Email: dent@erciyes.edu.tr

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • o Patients aged 18-60 years who are classified as medically healthy (ASA I or II),

    • Mature, single-rooted and canal teeth that had root canal treatment at least four years ago,
    • Teeth with previous root canal obturation 2-4 mm short of the apex,
    • Teeth that do not need periodontal and prosthetic treatment and whose periapical index score (PAI) is between 2 and 4 ,
    • Teeth with single root and canal diagnosed with asymptomatic apical periodontitis,
    • Teeth suitable for rubber dam isolation.

Exclusion Criteria:

  • o Patients who had taken analgesics, antibiotics, or corticosteroids within two weeks before root canal retreatment,

    • Teeth exhibiting periodontal attachment loss,
    • Presence of vertical root fractures, external root resorption, or perforations,
    • Teeth with retained broken instruments,
    • Non-restorable teeth,
    • Patients in the pregnancy and breastfeeding period.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: NaOCl/EDTA+CNI Group
İrrigation
Drug: root canal irrigation
Root canal irrigation and postoperative pain
Experimental: NaOCl/EDTA+PUA Group
Drug: root canal irrigation
Root canal irrigation and postoperative pain
Experimental: NaOCl/Dual Rinse HEDP+CNI Group
Drug: root canal irrigation
Root canal irrigation and postoperative pain
Experimental: NaOCl/Dual Rinse HEDP+PUA Group
Drug: root canal irrigation
Root canal irrigation and postoperative pain

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Evaluation of the relationship between different root canal irrigation techniques and post-canal treatment pain using surveys.
Time Frame: 3-5 month
3-5 month

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

TC Erciyes University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2025

Primary Completion (Estimated)

June 5, 2026

Study Completion (Estimated)

July 15, 2026

Study Registration Dates

First Submitted

May 1, 2025

First Submitted That Met QC Criteria

May 14, 2026

First Posted (Actual)

May 20, 2026

Study Record Updates

Last Update Posted (Actual)

May 20, 2026

Last Update Submitted That Met QC Criteria

May 14, 2026

Last Verified

May 1, 2025

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2025/2 (Other Identifier: Atatürk University Clinical Research Ethics Committee)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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