Electrolyte Beverage Combined With Polyethylene Glycol for Colonoscopy Bowel Preparation

Randomized Controlled Trial of Different Ratios of Electrolyte Beverage and Water Combined With Polyethylene Glycol on Bowel Preparation Quality and Ingestion Rhythm Before Colonoscopy

This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy. Participants undergoing elective colonoscopy will be randomly assigned to one of three bowel preparation regimens: PEG prepared with water only, PEG prepared with a low ratio of electrolyte beverage and water, or PEG prepared with a medium ratio of electrolyte beverage and water. The primary outcome is adequate bowel preparation assessed by the Boston Bowel Preparation Scale (BBPS). Secondary outcomes include bowel preparation completion rate, tolerability, adverse events, repeat colonoscopy rate, adenoma detection rate, and ingestion rhythm characteristics during bowel preparation. This study also aims to explore whether electrolyte beverage-assisted bowel preparation may improve bowel cleansing quality by influencing participants' ingestion rhythm and adherence during PEG intake.

Study Overview

• Status: Recruiting
• Conditions: Bowel Preparation Solutions; Colonoscopy; Colorectal Cancer Screening
• Intervention / Treatment: Other: PEG With Water; Other: PEG With Low-dose Electrolyte Beverage; Other: PEG With Medium-dose Electrolyte Beverage

• Study Type: Interventional
• Enrollment (Estimated): 405
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Aimin Li; Phone Number: +86 13580317630; Email: lam0725@163.com

Study Locations

• China
  • Guangdong
    • Guangzhou, Guangdong, China
      • Recruiting
      • Nanfang Hospital, Southern Medical University
      • Contact: Aimin Li; Phone Number: +86 13580317630; Email: lam0725@163.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Adults aged 18-75 years scheduled to undergo elective colonoscopy
• Meet the standard clinical indications for colonoscopy;
• Able to understand and comply with the bowel preparation procedure and complete oral polyethylene glycol (PEG) intake as required;
• Able to comply with study-related data collection and follow-up;
• Provide written informed consent voluntarily.

Exclusion Criteria:

• Previously diagnosed colorectal cancer, intestinal obstruction, or suspected intestinal obstruction;
• Active gastrointestinal bleeding or a definite history of gastrointestinal bleeding within the past 4 weeks (including melena, hematochezia, or hematemesis);
• Severe renal insufficiency, decompensated heart failure, significant electrolyte imbalance, or other conditions unsuitable for PEG bowel preparation;
• Known allergy to polyethylene glycol or components of the electrolyte beverage used in the study;
• Pregnant or breastfeeding women;
• Any other condition considered by the investigators to make the participant unsuitable for the study.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: Water Group; Participants receive polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy.	Other: PEG With Water; Polyethylene glycol (PEG) prepared with water only for bowel preparation before colonoscopy.
Experimental: Low-dose Electrolyte Beverage Group; Participants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy.	Other: PEG With Low-dose Electrolyte Beverage; Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:3 ratio for bowel preparation before colonoscopy.
Experimental: Medium-dose Electrolyte Beverage Group; Participants receive polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy.	Other: PEG With Medium-dose Electrolyte Beverage; Polyethylene glycol (PEG) prepared with electrolyte beverage and water at a 1:1 ratio for bowel preparation before colonoscopy.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Adequate Bowel Preparation Rate	Adequate bowel preparation is defined as a total Boston Bowel Preparation Scale (BBPS) score ≥6 with each colonic segment score ≥2 during colonoscopy.	At the time of colonoscopy on Day 1

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Total Boston Bowel Preparation Scale Score	Total Boston Bowel Preparation Scale (BBPS) score assessed during colonoscopy.	At the time of colonoscopy on Day 1
Bowel Preparation Completion Rate	Proportion of participants who complete the planned polyethylene glycol bowel preparation within 60 minutes.	During bowel preparation within 1 hour before colonoscopy on Day 1
Adverse Event Rate	Incidence of adverse events during bowel preparation, including nausea, vomiting, abdominal distension, abdominal pain, dizziness, and fatigue.	During bowel preparation within 1 hour before colonoscopy on Day 1

Collaborators and Investigators

• Sponsor: Nanfang Hospital, Southern Medical University

Study record dates

Study Major Dates

• Study Start (Actual): May 18, 2026
• Primary Completion (Estimated): January 31, 2027
• Study Completion (Estimated): May 31, 2027

Study Registration Dates

• First Submitted: May 18, 2026
• First Submitted That Met QC Criteria: May 24, 2026
• First Posted (Actual): May 27, 2026

Study Record Updates

• Last Update Posted (Actual): May 27, 2026
• Last Update Submitted That Met QC Criteria: May 24, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Inorganic Chemicals; Anions; Ions; Electrolytes; Hydroxides; Alkalies; Oxides; Oxygen Compounds; Water
• Other Study ID Numbers: NFEC-2026-307

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No